Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells

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Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20011948
P932PMC publication ID2193695
P698PubMed publication ID11956287
P5875ResearchGate publication ID236239583

P2093author name stringYang Liu
Huiming Zhang
Jian-Xin Gao
Jing Wen
Xincheng Zheng
Pan Zheng
Xue-Feng Bai
Jinqing Liu
P2860cites workB7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetesQ28143530
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4Q28284177
Several different cell surface molecules control negative selection of medullary thymocytesQ28591321
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4Q29619280
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T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.Q33658811
CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.Q34300766
Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune diseaseQ34418063
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytesQ34829321
Functional differences between memory and naive CD8 T cellsQ35064049
Peripheral T cell toleranceQ36135224
CTLA-4 is a second receptor for the B cell activation antigen B7Q36230356
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28Q36362727
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouseQ36364541
Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: normal development but restrained effector function in vivo.Q36367821
B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)Q36367912
Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitisQ36375265
Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.Q36376299
CD4 T cell tolerance to human C-reactive protein, an inducible serum protein, is mediated by medullary thymic epitheliumQ36851767
Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in a sf thymic environment: potential model for thymic educationQ37537286
Acquisition of immunologic self-toleranceQ38254157
CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytesQ41147514
Medullary thymic epithelium expresses a ligand for CTLA4 in situ and in vitro.Q41529091
Cutting edge: thymic selection and autoreactivity are regulated by multiple coreceptors involved in T cell activationQ41691002
Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytesQ41969127
Tissue-specific expression of messenger RNAs encoding endogenous viral superantigensQ42612328
Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytesQ42971801
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytesQ44851100
Genetic analysis of the Mls system. Formal Mls typing of the commonly used inbred strainsQ45308744
Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell toleranceQ46048571
Requirement for a complex array of costimulators in the negative selection of autoreactive thymocytes in vivoQ46109034
Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunityQ46183952
Does T-cell tolerance require a dedicated antigen-presenting cell?Q46491587
Impaired negative selection in CD28-deficient mice.Q52184694
Positive and negative selection of an antigen receptor on T cells in transgenic mice.Q52249517
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.Q54067406
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.Q55035366
The Role of B7 Costimulation in CD4/CD8 T Cell HomeostasisQ56888913
Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsideredQ56905407
Is CTLA-4 a negative regulator for T-cell activation?Q56908067
CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient miceQ56908363
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formationQ56908531
T cell tolerance by clonal elimination in the thymusQ56922465
The threshold for autoimmune T cell killing is influenced by B7-1Q57228048
T-cell apoptosis detected in situ during positive and negative selection in the thymusQ59087078
Tolerogenicity of thymic epitheliumQ68368626
B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytesQ71616339
Antigen-specific and nonspecific deletion of immature cortical thymocytes caused by antigen injectionQ73878097
CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitisQ77320543
Glucocorticoid-mediated regulation of thymic dendritic cell functionQ78045627
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)959-971
P577publication date2002-04-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titlePerinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells
P478volume195

Reverse relations

cites work (P2860)
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Q40900024CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens
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Q44703263Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity
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