| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.8128249 |
| P698 | PubMed publication ID | 8128249 |
| P2093 | author name string | T W Mak | |
| P S Ohashi | |||
| J Mayer | |||
| R S Yeung | |||
| V A Wallace | |||
| E Sebzda | |||
| P433 | issue | 5153 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | thymocyte | Q7799635 |
| P304 | page(s) | 1615-1618 | |
| P577 | publication date | 1994-03-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Positive and negative thymocyte selection induced by different concentrations of a single peptide | |
| P478 | volume | 263 |
| Q35834589 | A T cell receptor-specific blockade of positive selection |
| Q77372675 | A caspase inhibitor protects thymocytes from diverse signal-mediated apoptosis but not from clonal deletion in fetal thymus organ culture |
| Q36369989 | A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex |
| Q56922218 | A little of what you fancy . . |
| Q36380664 | A mechanism for the major histocompatibility complex-linked resistance to autoimmunity |
| Q36369498 | A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor |
| Q39285418 | A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire |
| Q37461924 | A single-amino-acid variant of the H60 CD8 epitope generates specific immunity with diverse TCR recruitment |
| Q33857220 | Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus |
| Q33639952 | Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression |
| Q40438837 | Altered MHC class I expression: A role for transplantation and IDDM autoimmunity |
| Q36171567 | Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes |
| Q34982958 | Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection |
| Q33596728 | Altered thymic positive selection and intracellular signals in Cbl-deficient mice |
| Q35729215 | An alternative to current thinking about positive selection, negative selection and activation of T cells |
| Q36402496 | An antagonist peptide mediates positive selection and CD4 lineage commitment of MHC class II-restricted T cells in the absence of CD4 |
| Q36401332 | Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response |
| Q36401775 | Antagonist peptide selects thymocytes expressing a class II major histocompatibility complex-restricted T cell receptor into the CD8 lineage |
| Q37638193 | Antigen presentation in the thymus for positive selection and central tolerance induction |
| Q40615110 | Are MHC-bound peptides a nuisance for positive selection? |
| Q37365849 | Autoimmunity caused by disruption of central T cell tolerance. A murine model of drug-induced lupus |
| Q33638598 | Avidity-dependent programming of autoreactive T cells in T1D |
| Q37689611 | Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires |
| Q41440548 | Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity |
| Q36370736 | CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells |
| Q36400625 | CD3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity |
| Q74299648 | CD4 regulates the efficiency of an endogenous superantigen-induced clonal deletion of TCRV beta 11+ cells in the periphery |
| Q52518610 | CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. |
| Q73468032 | CD45 enhances positive selection and is expressed at a high level in large, cycling, positively selected CD4+CD8+ thymocytes |
| Q35202754 | CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion |
| Q37241773 | Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch |
| Q35694446 | Central and peripheral autoantigen presentation in immune tolerance |
| Q73115340 | Collaboration of TCR-, CD4- and CD28-mediated signalling in antigen-specific MHC class II-restricted T-cells |
| Q41837728 | Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection |
| Q63408331 | Control of pre-T cell proliferation and differentiation by the GTPase Rac-1 |
| Q34829321 | Costimulatory signals are required for induction of transcription factor Nur77 during negative selection of CD4(+)CD8(+) thymocytes |
| Q41305375 | Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis? |
| Q27649963 | Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules |
| Q41515285 | Death and dying in the immune system |
| Q36678563 | Decrypting the structure of major histocompatibility complex class I-restricted cytotoxic T lymphocyte epitopes with complex peptide libraries |
| Q35070028 | Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR |
| Q60641123 | Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides |
| Q35901203 | DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2. |
| Q47877315 | Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes |
| Q47700492 | Development of T-cells during fish embryogenesis |
| Q52208053 | Developmental changes predispose the fetal thymus to positive selection of CD4+CD8- T cells |
| Q71930359 | Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells |
| Q51111516 | Differential induction of helper and killer T cells from isolated CD4+CD8+ thymocytes in suspension culture. |
| Q41390449 | Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice |
| Q44556255 | Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes. |
| Q34048781 | Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation |
| Q77328529 | Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire |
| Q35575391 | Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact. |
| Q73814879 | Double-positive T cell receptor(high) thymocytes are resistant to peptide/major histocompatibility complex ligand-induced negative selection |
| Q74122543 | Elevated Bcl-2 is not a causal event in the positive selection of T cells |
| Q36366390 | Endogenous altered peptide ligands can affect peripheral T cell responses |
| Q36401074 | Endogenous myelin basic protein inactivates the high avidity T cell repertoire |
| Q73295972 | Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide |
| Q40973329 | Essential flexibility in the T-cell recognition of antigen |
| Q72691884 | Evidence for a selective and multi-step model of T cell differentiation: CD4+CD8low thymocytes selected by a transgenic T cell receptor on major histocompatibility complex class I molecules |
| Q33735998 | Function and regulation of memory CD4 T cells |
| Q36399661 | Functional reprogramming of the primary immune response by T cell receptor antagonism |
| Q36365389 | Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide |
| Q30156848 | Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection |
| Q28504958 | H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection |
| Q42024302 | Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain |
| Q73302832 | Identification of a naturally occurring ligand for thymic positive selection |
| Q37358062 | Identification of an immunodominant mouse minor histocompatibility antigen (MiHA). T cell response to a single dominant MiHA causes graft-versus-host disease |
| Q79074350 | In Vivo Treatment of Class II MHC-Deficient Mice with Anti-TCR Antibody Restores the Generation of Circulating CD4 T Cells and Optimal Architecture of Thymic Medulla |
| Q36959354 | In vivo expansion of the residual tumor antigen-specific CD8+ T lymphocytes that survive negative selection in simian virus 40 T-antigen-transgenic mice. |
| Q73304537 | Induction of long-term heart graft survival by intrathymic injection of HLA class I peptide: a study with HLA class I transgenic mice model |
| Q77633378 | Induction of long-term heart graft survival in HLA class I transgenic mice by intrathymic injection of HLA class I peptides |
| Q58598501 | Influence of correlated antigen presentation on T-cell negative selection in the thymus |
| Q36734207 | Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide |
| Q41225290 | Inhibition of thymocyte negative selection by T cell receptor antagonist peptides |
| Q33653653 | Inhibitory pathways triggered by ITIM-containing receptors. |
| Q52196099 | Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. |
| Q34012661 | Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity |
| Q36096780 | Interactions with multiple peptide ligands determine the fate of developing thymocytes. |
| Q36364575 | Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type |
| Q74319130 | Intranasal peptide-induced peripheral tolerance: the role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis |
| Q33917389 | Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling |
| Q52193798 | Intrathymic delta selection events in gammadelta cell development. |
| Q37693679 | Involvement of p21ras distinguishes positive and negative selection in thymocytes |
| Q34285825 | Kinetic proofreading in T-cell receptor signal transduction |
| Q34572115 | Knockout mice: a paradigm shift in modern immunology |
| Q77436009 | Level of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmentation |
| Q74058882 | Limiting dilution analysis of primary cytotoxic T-cell precursors |
| Q38266751 | Lymphocyte repertoire selection and intracellular self/non-self-discrimination: historical overview |
| Q34065191 | Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype |
| Q37387696 | MHC haplotype-dependent regulation of MOG-induced EAE in rats. |
| Q73396262 | Magnitude of protein tyrosine phosphorylation-linked signals determines growth versus death of thymic T lymphocytes |
| Q46509216 | Maturational stage-dependent thymocyte responses to TCR engagement |
| Q41881444 | Mature T cell reactivity altered by peptide agonist that induces positive selection |
| Q41628489 | Mechanisms underlying the loss of self tolerance in NOD mice |
| Q28253285 | Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex |
| Q34916448 | Models of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection |
| Q43741057 | Modulatory effects of octreotide on anti-CD3 and dexamethasone-induced apoptosis of murine thymocytes |
| Q40460116 | Molecular Events in Thymocyte Apoptosis |
| Q34293468 | Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein |
| Q37737987 | Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease |
| Q28504777 | Murine Schnurri-2 is required for positive selection of thymocytes |
| Q34067924 | Negative selection of thymocytes expressing the D10 TCR |
| Q35136005 | Negative selection--clearing out the bad apples from the T-cell repertoire |
| Q34967410 | On the issue of peptide recognition in T cell development |
| Q41709069 | Ontogeny of synonymous T cell populations with specificity for a self MHC epitope mimicked by a bacterial homologoue: an antigen-specific T cell analysis in a non-transgenic system |
| Q33930556 | Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide |
| Q57228141 | Peptide antagonists that promote positive selection are inefficient at T cell activation and thymocyte deletion |
| Q36364528 | Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains |
| Q51103760 | Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. |
| Q33801059 | Peripheral Tolerization of Effector and Memory T Cells: Implications for Autoimmunity and Tumor-Immunity |
| Q34715443 | Peripheral antigen-expressing cells and autoimmunity |
| Q62590795 | Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus |
| Q36367050 | Positive and negative selection invoke distinct signaling pathways. |
| Q52214778 | Positive selection of CD4+ T cells by TCR ligation without aggregation even in the absence of MHC. |
| Q52182454 | Positive selection of CD4+ T cells by TCR-specific antibodies requires low valency TCR cross-linking: implications for repertoire selection in the thymus. |
| Q41429700 | Positive selection of T cells: fastidious or promiscuous? |
| Q40937456 | Positive selection of an H2-M3 restricted T cell receptor |
| Q41429671 | Positive selection of thymocytes bearing alpha beta T cell receptors. |
| Q36401236 | Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells |
| Q36376999 | Presentation of a T cell receptor antagonist peptide by immunoglobulins ablates activation of T cells by a synthetic peptide or proteins requiring endocytic processing |
| Q36368472 | Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo |
| Q73669907 | Quantitation of the cell surface level of Ld resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo |
| Q36400972 | Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex |
| Q73152040 | Quantitative analysis of the T cell repertoire that escapes negative selection |
| Q30844919 | Rare, structurally homologous self-peptides promote thymocyte positive selection |
| Q36375360 | Receptor avidity and costimulation specify the intracellular Ca2+ signaling pattern in CD4(+)CD8(+) thymocytes |
| Q24672952 | Recognition of six-transmembrane epithelial antigen of the prostate-expressing tumor cells by peptide antigen-induced cytotoxic T lymphocytes |
| Q44815361 | Reduced expression of peptide‐loaded HLA class I molecules on multiple sclerosis lymphocytes |
| Q41725582 | Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals of different populations to type I diabetes |
| Q28592092 | Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45 |
| Q43148564 | Regulatory role of leukocyte-common-antigen-related molecule (LAR) in thymocyte differentiation |
| Q90162783 | Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens |
| Q33942111 | Role of self-major histocompatibility complex/peptide ligands in selection and maintenance of a diverse T cell repertoire |
| Q36376884 | Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire |
| Q30436912 | SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels |
| Q24797491 | SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus |
| Q28592251 | Schlafen, a new family of growth regulatory genes that affect thymocyte development |
| Q73669902 | Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice |
| Q36380789 | Selection of antigen-specific T cells by a single IEk peptide combination |
| Q40473381 | Self and non-self antigen in diabetic autoimmunity: Molecules and mechanisms |
| Q28359868 | Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs |
| Q34625501 | Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs |
| Q47631646 | Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells |
| Q40495484 | Signalling and Chromatin Fragmentation in Thymocyte Apoptosis |
| Q41096347 | Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes |
| Q42644707 | Specificity and flexibility in thymic selection |
| Q73170826 | Split tolerance to the MHC class I molecule H-2Dd in animals transgenic for its soluble analog |
| Q40567134 | Stem cell therapy for autoimmune disease: overview of concepts from the Snowbird 2002 tolerance and tissue regeneration meeting |
| Q42265829 | Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway |
| Q38353298 | Strength of TCR signal from self-peptide modulates autoreactive thymocyte deletion and Foxp3(+) Treg-cell formation |
| Q36367500 | Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands |
| Q56909495 | Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses |
| Q35583489 | Surface T‐cell antigen receptor expression and availability for long‐term antigenic signaling |
| Q28732174 | T Cell Adaptive Immunity Proceeds through Environment-Induced Adaptation from the Exposure of Cryptic Genetic Variation |
| Q56922149 | T Cells Can Be Activated by Peptides That Are Unrelated in Sequence to Their Selecting Peptide |
| Q36475871 | T cell positive selection by a high density, low affinity ligand |
| Q34976927 | T cell receptor interactions with class I heavy-chain influence T cell selection |
| Q36364509 | T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection. |
| Q44251540 | T cell repertoire formation displays characteristics of qualitative models of thymic selection |
| Q41312334 | T cell selection and autoimmunity: flexibility and tuning |
| Q33756668 | T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression |
| Q36526360 | T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. |
| Q33632307 | T-cell development: a role for self-peptides in positive selection |
| Q37969840 | T-cell receptor affinity in thymic development. |
| Q33886507 | T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection. |
| Q46139464 | T-cell responses to myelin basic protein in normal and MBP-deficient mice |
| Q74591317 | T-cell selection |
| Q41192128 | T-cell-receptor affinity and thymocyte positive selection |
| Q35589560 | T-helper cell tolerance to ubiquitous nuclear antigens |
| Q56953631 | TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity |
| Q92998487 | TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells |
| Q45866968 | Tap-1 and Tap-2 Gene Therapy Selectively Restores Conformationally Dependent HLA Class I Expression in Type I Diabetic Cells |
| Q38181087 | Th17 cells in immunity and autoimmunity. |
| Q46014500 | The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. |
| Q41393104 | The agonist-antagonist balance in positive selection. |
| Q52199699 | The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells. |
| Q36368110 | The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis |
| Q50562460 | The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: A modeling investigation. |
| Q35762283 | The effects of thymic selection on the range of T cell cross-reactivity |
| Q36376752 | The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands |
| Q73838326 | The imprint of intrathymic self-peptides on the mature T cell receptor repertoire |
| Q71918555 | The influence of invariant chain on the positive selection of single T cell receptor specificities |
| Q34580927 | The insulin gene in diabetes |
| Q52196097 | The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. |
| Q41096340 | The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. |
| Q41077099 | The molecular jury: deciding whether immature thymocytes should live or die. |
| Q40734979 | The regulation of DNAse activities in subcellular compartments of activated thymocytes |
| Q52887226 | The repertoire of T cells shaped by a single MHC/peptide ligand. |
| Q36010523 | The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells |
| Q35758643 | The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice |
| Q36375626 | The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus |
| Q46259603 | The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor |
| Q28592120 | The specificity and orientation of a TCR to its peptide-MHC class II ligands |
| Q40561573 | The thymic stromal cell line MTSC4 induced thymocyte apoptosis in a non-MHC-restricted manner |
| Q36365359 | The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire |
| Q41848248 | Thromboxane A2 receptor blocking abrogates donor-specific unresponsiveness to renal allografts induced by thymic recognition of major histocompatibility allopeptides |
| Q81416925 | Thymic cortical epithelium induces self tolerance |
| Q37360649 | Thymic microenvironments for T-cell repertoire formation |
| Q36363937 | Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus |
| Q42943203 | Thymic selection and cell division |
| Q43484431 | Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells. |
| Q73688337 | Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide |
| Q35076679 | Thymic selection revisited: how essential is it? |
| Q39773899 | Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling |
| Q40460172 | Thymocyte Apoptosis by Glucocorticoids and cAMP |
| Q74171891 | Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice |
| Q36367667 | Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage |
| Q93371103 | Thymus machinery for T-cell selection |
| Q77368905 | Use of explant technology in the study of in vitro immune responses |
| Q36401225 | Vav regulates peptide-specific apoptosis in thymocytes |
| Q34329801 | Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation |
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