Quantitative analysis of the T cell repertoire that escapes negative selection

scientific article published on 01 October 1999

Quantitative analysis of the T cell repertoire that escapes negative selection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1074-7613(00)80120-X
P698PubMed publication ID10549627

P2093author name stringO Kanagawa
E R Unanue
D A Peterson
R J DiPaolo
P2860cites workThreshold detection of self-antigen/MHC class II complexes formed in vivo: constitutive presentation of an immunodominant epitope of hen egg lysozyme (HEL) in HEL-transgenic miceQ70480160
Immune responses to self peptides naturally presented by murine class II major histocompatibility complex moleculesQ71405229
A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic miceQ71606864
An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance inductionQ72105874
Dose-dependent T cell tolerance to an immunodominant self peptideQ72119394
Positive and negative thymocyte selection induced by different concentrations of a single peptideQ72293139
Processing and Presentation of Hen Egg-White Lysozyme by MacrophagesQ72382525
T Cell Receptor Recognition of MHC Class II–Bound Peptide Flanking Residues Enhances Immunogenicity and Results in Altered TCR V Region UsageQ73767636
The minimal number of antigen‐major histocompatibility complex class II complexes required for activation of naive and primed T cellsQ74179334
Inhibition of thymocyte positive selection by natural MHC: peptide ligandsQ74578783
An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stabilityQ77714941
Autoreactivity of T cells from nonobese diabetic mice: An I-Ag7-dependent reactionQ32123429
How some T cells escape tolerance inductionQ34418421
Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II moleculesQ35958588
T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypesQ36229970
In vivo and in vitro clonal deletion of double-positive thymocytesQ36231231
Mechanisms influencing the immunodominance of T cell determinantsQ36355734
The inability to process a self-peptide allows autoreactive T cells to escape toleranceQ36361234
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.Q36363106
Exogenously Provided Peptides of a Self-antigen Can Be Processed into Forms that Are Recognized by Self–T CellsQ36400766
Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell RepertoireQ36401074
Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complexQ36555812
Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinantsQ36778058
Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-AkQ37147375
Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic miceQ37384851
Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptidesQ37513296
Determinant selection for T-cell tolerance in HEL-transgenic mice: dissociation between immunogenicity and tolerogenicityQ41116405
Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen.Q41162214
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.Q41423746
Direct binding of autoimmune disease related T cell epitopes to purified Lewis rat MHC class II moleculesQ41472037
Fine specificity of cytotoxic T lymphocytes primed in vivo either with virus or synthetic lipopeptide vaccine or primed in vitro with peptideQ41654974
Low avidity recognition of self-antigen by T cells permits escape from central tolerance.Q41671634
Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunityQ41900190
A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic miceQ45764639
Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cellsQ45788545
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic miceQ45854348
A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.Q46650203
Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic ProteinQ47992214
Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibodyQ52827100
Lower receptor avidity required for thymic clonal deletion than for effector T-cell functionQ59093837
Crystallization and preliminary x-ray diffraction studies of two new antigen-antibody (lysozyme-Fab) complexesQ67982015
Ligand thresholds at different stages of T cell developmentQ68442292
Antibody-mediated activation of T cell clones as a method for screening hybridomas producing antibodies to the T cell receptorQ69029053
P433issue4
P304page(s)453-462
P577publication date1999-10-01
P1433published inImmunityQ6005457
P1476titleQuantitative analysis of the T cell repertoire that escapes negative selection
P478volume11

Reverse relations

cites work (P2860)
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