| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1003871924 |
| P356 | DOI | 10.1038/351482A0 |
| P953 | full work available online at | http://www.nature.com/articles/351482a0 |
| http://www.nature.com/articles/351482a0.pdf | ||
| P698 | PubMed publication ID | 1710780 |
| P50 | author | Rolf M. Zinkernagel | Q116064 |
| P2093 | author name string | Hengartner H | |
| Pircher H | |||
| Moskophidis D | |||
| Rohrer UH | |||
| P2860 | cites work | A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products | Q34297630 |
| The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype | Q36349414 | ||
| Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities | Q36350681 | ||
| Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus | Q36353793 | ||
| The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells | Q36356068 | ||
| Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen | Q43554100 | ||
| Characterization of virus-specific cytotoxic T cell clones from allogeneic bone marrow chimeras | Q44433442 | ||
| Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities | Q44704873 | ||
| Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes | Q44851100 | ||
| Molecular analysis of the antigen receptor of virus-specific cytotoxic T cells and identification of a new V alpha family | Q45839321 | ||
| Preferential usage of V alpha 4 and V beta 10 T cell receptor genes by lymphocytic choriomeningitis virus glycoprotein-specific H-2Db-restricted cytotoxic T cells | Q45852082 | ||
| Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo | Q45860175 | ||
| Positive and negative selection of an antigen receptor on T cells in transgenic mice | Q52249517 | ||
| T cell tolerance by clonal elimination in the thymus | Q56922465 | ||
| Ligand thresholds at different stages of T cell development | Q68442292 | ||
| A nondeletional mechanism of thymic self tolerance | Q69252942 | ||
| A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex | Q70063323 | ||
| P433 | issue | 6326 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell function | Q95674809 |
| P304 | page(s) | 482-485 | |
| P577 | publication date | 1991-06-01 | |
| 1991-06-06 | |||
| P1433 | published in | Nature | Q180445 |
| P1476 | title | Lower receptor avidity required for thymic clonal deletion than for effector T-cell function | |
| P478 | volume | 351 |
| Q34069130 | A Spontaneous Low-Pathogenic Variant of Theiler’s Virus Contains an Amino Acid Substitution within the Predominant VP1233–250T-Cell Epitope |
| Q71654385 | A Study of Mast Cells in Autoimmune Mice: The Proliferative Response of Autoimmune Mast Cells to Cytokines |
| Q36380664 | A mechanism for the major histocompatibility complex-linked resistance to autoimmunity |
| Q36981848 | A novel virus carrier state to evaluate immunotherapeutic regimens: regulatory T cells modulate the pathogenicity of antiviral memory cells |
| Q34873201 | A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change |
| Q77324273 | A very high level of crossreactivity is an essential feature of the T-cell receptor |
| Q36230944 | Acquired Mls-1a-like clonal deletion in Mls-1b mice |
| Q33639952 | Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression |
| Q35936035 | Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues |
| Q40903645 | Are there cellular superantigens? |
| Q36367099 | Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation |
| Q36278041 | Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. |
| Q36851767 | CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium |
| Q73035416 | CD4+ T cell survival is not directly linked to self-MHC-induced TCR signaling |
| Q70527012 | CD8 is needed for positive selection but differentially required for negative selection of T cells during thymic ontogeny |
| Q48065352 | CTX, a novel molecule specifically expressed on the surface of cortical thymocytes in Xenopus. |
| Q45868334 | Characterization of T-cell tolerance to hepatitis B virus (HBV) antigen in transgenic mice |
| Q89865149 | Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection |
| Q40777946 | Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer |
| Q36325316 | Clonal deletion, anergy and immunosuppressionare connected in series to guarantee self-tolerance |
| Q78053724 | Constitutive expression of interleukin 4 in vivo does not lead to the development of T helper 2 type CD8+ T cells secreting interleukin 4 or interleukin 5 |
| Q33647526 | CpG-containing oligonucleotides are efficient adjuvants for induction of protective antiviral immune responses with T-cell peptide vaccines. |
| Q57275521 | Crippling of CD3-ζ ITAMs Does Not Impair T Cell Receptor Signaling |
| Q36367821 | Cytotoxic T lymphocytes to an unmutated tumor rejection antigen P1A: normal development but restrained effector function in vivo. |
| Q60641123 | Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides |
| Q77328529 | Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire |
| Q61419908 | Early degenerate selection of thymocytes by class I major histocompatibility complex |
| Q36988106 | Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity |
| Q33822824 | Effects of MHC class I alleles on licensing of Ly49A+ NK cells. |
| Q36366390 | Endogenous altered peptide ligands can affect peripheral T cell responses |
| Q40973329 | Essential flexibility in the T-cell recognition of antigen |
| Q24674109 | Estimating the precursor frequency of naive antigen-specific CD8 T cells |
| Q45155438 | Evidence for a differential avidity model of T cell selection in the thymus |
| Q34019945 | Evolution of the CD8 T-cell repertoire during infections |
| Q79300148 | Factors involved in peripheral T cell tolerance: the extent of clonal deletion or clonal anergy depends on the age of the tolerized lymphocytes |
| Q48495983 | From variation in genetic information to clonal deletion: Joshua Lederberg's immunological legacy |
| Q36951583 | Functional Development of the T Cell Receptor for Antigen |
| Q38066211 | Functional avidity: a measure to predict the efficacy of effector T cells? |
| Q36365389 | Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide |
| Q34162213 | HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes |
| Q68052306 | Hierarchy of responsiveness in vivo and in vitro among T cells expressing distinct Mls-1a-reactive v beta domains |
| Q40495443 | High‐Dose Soluble Antigen: Peripheral T‐Cell Proliferation or Apoptosis |
| Q36380676 | How Many Thymocytes Audition for Selection? |
| Q37977320 | How the TCR balances sensitivity and specificity for the recognition of self and pathogens. |
| Q37499321 | How the immune system achieves self-nonself discrimination during adaptive immunity |
| Q34439868 | How the immune system protects the host from infection |
| Q34320311 | How the immune system talks to itself: the varied role of synapses |
| Q52045269 | Human leukocyte antigen phenotype imposes complex constraints on the antigen-specific cytotoxic T lymphocyte repertoire |
| Q73302832 | Identification of a naturally occurring ligand for thymic positive selection |
| Q35615758 | Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice |
| Q41326897 | Immune deviation--the third dimension of nondeletional T cell tolerance |
| Q40807223 | Immune protection vs. immunopathology vs. autoimmunity: a question of balance and of knowledge |
| Q42996317 | Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant |
| Q35837479 | Immunobiology of cytotoxic T-cell escape mutants of lymphocytic choriomeningitis virus |
| Q60073490 | Immunological function of a defined T-cell population tolerized to low-affinity self antigens |
| Q34005455 | Immunostimulatory DNA sequences help to eradicate intracellular pathogens |
| Q73406538 | Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion |
| Q51970307 | Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein |
| Q41522244 | In vitro negative selection of alpha beta T cell receptor transgenic thymocytes by conditionally immortalized thymic cortical epithelial cell lines and dendritic cells |
| Q37640068 | In vitro selection of lymphocytic choriomeningitis virus escape mutants by cytotoxic T lymphocytes |
| Q36231231 | In vivo and in vitro clonal deletion of double-positive thymocytes |
| Q27012849 | Indoctrinating T cells to attack pathogens through homeschooling |
| Q45099017 | Influence of Retinoic Acid on the Differentiation Pathway of T Cells in the Thymus |
| Q40853592 | Influence of viral superantigens on V beta- and V alpha-specific positive and negative selection |
| Q37026523 | Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol |
| Q36231933 | Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays |
| Q33741226 | Initiation of autoimmunity by a reactive metabolite of a lupus-inducing drug in the thymus |
| Q37684415 | Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. |
| Q37175343 | Lymphocytic choriomeningitis infection of the central nervous system |
| Q37464963 | MHC restriction and allogeneic immune responses. |
| Q41881444 | Mature T cell reactivity altered by peptide agonist that induces positive selection |
| Q33815430 | Mechanisms and consequences of peptide selection by the I-Ak class II molecule |
| Q37139786 | Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells |
| Q99635125 | MicroRNA miR-181-A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function |
| Q37060274 | Micromanagement of the immune system by microRNAs |
| Q36364377 | Modulation of T cell development by an endogenous altered peptide ligand |
| Q52018420 | Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients |
| Q36078038 | Natural regulatory T cells and self-tolerance |
| Q35213326 | Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists |
| Q34067924 | Negative selection of thymocytes expressing the D10 TCR |
| Q41091839 | On T cell memory: arguments for antigen dependence |
| Q35076686 | On the role of self-recognition in T cell responses to foreign antigen |
| Q90454264 | Opposing peripheral fates of tissue-restricted self antigen-specific conventional and regulatory CD4+ T cells |
| Q58377596 | PTPN2 attenuates T-cell lymphopenia-induced proliferation |
| Q33930556 | Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide |
| Q73814851 | Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation |
| Q36361753 | Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus |
| Q71785385 | Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4+ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma |
| Q40774129 | Peripheral T-cell reactivity to bacterial superantigens in vivo: the response/anergy paradox. |
| Q40774179 | Peripheral tolerance as a multi-step mechanism |
| Q62590795 | Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus |
| Q67493052 | Positive and negative selection of Tcrb-V6+ T cells |
| Q36366715 | Positive selection is not required for thymic maturation of transgenic gamma delta T cells |
| Q40801698 | Positive selection of TcR alpha beta thymocytes: is cortical thymic epithelium an obligatory participant in the presentation of major histocompatibility complex protein? |
| Q36401236 | Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells |
| Q35890964 | Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)β-mediated suppression |
| Q36529035 | Protective 'immunity' by pre-existent neutralizing antibody titers and preactivated T cells but not by so-called 'immunological memory'. |
| Q35635463 | Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought |
| Q45788376 | Quantitation of endogenous mouse mammary tumor virus superantigen expression by lymphocyte subsets |
| Q73152040 | Quantitative analysis of the T cell repertoire that escapes negative selection |
| Q35077155 | Quantitative constraints on the scope of negative selection |
| Q41988156 | Reduced thymic maturation but normal effector function of CD8+ T cells in CD8 beta gene-targeted mice. |
| Q44072201 | Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selection |
| Q88779050 | Regulatory mechanisms in T cell receptor signalling |
| Q36684496 | Roadmap to a better therapeutic tumor vaccine |
| Q24309394 | Role of CD4 and CD8 in T cell activation and differentiation |
| Q36376884 | Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire |
| Q38952548 | Self-reactivity as the necessary cost of maintaining a diverse memory T-cell repertoire |
| Q36698144 | Suppression of virus-specific antibody production by CD8+ class I-restricted antiviral cytotoxic T cells in vivo |
| Q36369516 | T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase |
| Q72224498 | T cell receptor targeting to thymic cortical epithelial cells in vivo induces survival, activation and differentiation of immature thymocytes |
| Q71548594 | T cell responses are governed by avidity and co-stimulatory thresholds |
| Q35646164 | T cells causing immunological disease |
| Q36325290 | T cells causing immunological disease: immunopathology or autoimmunity? |
| Q37415070 | T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity |
| Q77903156 | T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms |
| Q40853617 | T-cell receptor repertoire selection by mouse mammary tumor viruses and MHC molecules. |
| Q41441623 | T-cell receptors: is the repertoire inherently MHC-specific? |
| Q34716347 | T-cell signalling and autoimmunity: molecular mechanisms of disease |
| Q35589560 | T-helper cell tolerance to ubiquitous nuclear antigens |
| Q38683647 | THEMIS: Two Models, Different Thresholds |
| Q33638172 | Targeting p53 as a general tumor antigen |
| Q34418401 | The MHC reactivity of the T cell repertoire prior to positive and negative selection. |
| Q34734561 | The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens |
| Q25256839 | The cancer stem cell: evidence for its origin as an injured autoreactive T cell |
| Q35348304 | The development of functionally responsive T cells |
| Q36529895 | The fail-safe paradigm of immunological self-tolerance |
| Q34561055 | The level of CD8 expression can determine the outcome of thymic selection |
| Q36362806 | The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells |
| Q52887226 | The repertoire of T cells shaped by a single MHC/peptide ligand. |
| Q36010523 | The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells |
| Q41326875 | The significance of immune suppression in normal self tolerance |
| Q36376819 | The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex |
| Q37034827 | The specificity of T cell regulation that enables self-nonself discrimination in the periphery |
| Q41571855 | Thymic and peripheral apoptosis of antigen-specific T cells might cooperate in establishing self tolerance. |
| Q37319686 | Thymic depletion and peripheral activation of class I major histocompatibility complex-restricted T cells by soluble peptide in T-cell receptor transgenic mice |
| Q36363937 | Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus |
| Q36426341 | Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction |
| Q61454446 | Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells |
| Q36376876 | Tolerance to p53 by A2.1-restricted cytotoxic T lymphocytes. |
| Q36955494 | Transgenic expression of non-structural genes of Theiler's virus suppresses initial viral replication and pathogenesis of demyelination |
| Q45757704 | Virus-specific major MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection |
| Q83061611 | microRNAs at the regulatory frontier: an investigation into how microRNAs impact the development and effector functions of CD4 T cells |
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