The level of peptide-MHC complex determines the susceptibility to autoimmune diabetes: studies in HEL transgenic mice

scientific article published on 01 December 2001

The level of peptide-MHC complex determines the susceptibility to autoimmune diabetes: studies in HEL transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/1521-4141(200112)31:12<3453::AID-IMMU3453>3.0.CO;2-H
P953full work available online athttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2F1521-4141(200112)31:12%3C3453::AID-IMMU3453%3E3.0.CO;2-H
https://onlinelibrary.wiley.com/doi/full/10.1002/1521-4141(200112)31:12%3C3453::AID-IMMU3453%3E3.0.CO;2-H
P698PubMed publication ID11745364

P50authorRichard J Di PaoloQ98222229
P2093author name stringE. R. Unanue
P2860cites workClass I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T CellsQ24653129
Crystal Structure of I-Ak in Complex with a Dominant Epitope of LysozymeQ27749020
Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsivenessQ35157542
Hindering auxiliary anchors are potent modulators of peptide binding and selection by I-Ak class II moleculesQ35300270
Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.Q36363106
Constitutive class I-restricted exogenous presentation of self antigens in vivoQ36367249
Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodesQ36367942
Cross-tolerance: A Pathway for Inducing Tolerance to Peripheral Tissue AntigensQ36400803
CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting CellsQ36400881
Ontogeny of T cell tolerance to peripherally expressed antigensQ36453129
CD8 T cell ignorance or tolerance to islet antigens depends on antigen doseQ36552144
Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-AkQ37147375
Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune responseQ40341897
Limited capacity for tolerization of CD4+ T cells specific for a pancreatic beta cell neo-antigen.Q41337228
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenesQ43470250
Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune responseQ43986613
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic modelQ45783598
Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic miceQ45854348
Coexpression of B7-1 and viral ("self") transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetesQ46495737
A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.Q46650203
Characterization and quantitation of peptide-MHC complexes produced from hen egg lysozyme using a monoclonal antibodyQ52827100
The threshold for autoimmune T cell killing is influenced by B7-1Q57228048
Peripheral tolerance of CD4 T cells following local activation in adolescent miceQ57258533
Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cellsQ61140647
On the various manifestations of spontaneous autoimmune diabetes in rodent modelsQ71665322
Very-low-dose streptozotocin induces diabetes in insulin promoter-mB7-1 transgenic miceQ71698039
A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunityQ72628270
Autoimmune insulitis and diabetes in the absence of antigen-specific contact between T cells and islet beta-cellsQ73129283
Quantitative analysis of the T cell repertoire that escapes negative selectionQ73152040
Quantitation of lysozyme peptides bound to class II MHC molecules indicates very large differences in levels of presentationQ73785346
Inhibition of thymocyte positive selection by natural MHC: peptide ligandsQ74578783
Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigensQ77658430
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectantigen presentationQ575296
P304page(s)3453-3459
P577publication date2001-12-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleThe level of peptide-MHC complex determines the susceptibility to autoimmune diabetes: studies in HEL transgenic mice
P478volume31

Reverse relations

cites work (P2860)
Q57244914Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
Q37969489Antigen presentation events in autoimmune diabetes.
Q36232748Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?
Q37267230Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis
Q34792432Perspective on antigen processing and presentation.
Q33986306The central role of antigen presentation in islets of Langerhans in autoimmune diabetes

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