| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NRI842 |
| P698 | PubMed publication ID | 12094223 |
| P2093 | author name string | Stephen M Anderton | |
| David C Wraith | |||
| P2860 | cites work | Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire | Q77328529 |
| TNF type 2 receptor (p75) lowers the threshold of T cell activation | Q77337876 | ||
| Changes in the strength of co-stimulation through the B7/CD28 pathway alter functional T cell responses to altered peptide ligands | Q77378969 | ||
| A new look at MHC and autoimmune disease | Q77771995 | ||
| Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition | Q77879066 | ||
| CD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1 | Q24554515 | ||
| Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling | Q28279660 | ||
| Antigen presentation and T cell development in H2-M-deficient mice | Q28587240 | ||
| T cell receptor antagonist peptides induce positive selection | Q29618820 | ||
| Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment | Q33652471 | ||
| The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation | Q33652505 | ||
| Selection of the T cell repertoire. | Q33652536 | ||
| Selecting and maintaining a diverse T-cell repertoire | Q33783983 | ||
| Molecular mimicry and autoimmunity. | Q33806107 | ||
| How can dendritic cells cause autoimmune disease? | Q33899271 | ||
| Nonclassical MHC class II molecules | Q33932678 | ||
| CD8 binding to MHC class I molecules is influenced by T cell maturation and glycosylation | Q34106394 | ||
| Homeostasis of alpha beta TCR+ T cells. | Q34180992 | ||
| On the relationship between viral infection and autoimmunity. | Q34239703 | ||
| Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein | Q34293468 | ||
| Post-translational protein modifications in antigen recognition and autoimmunity | Q34319948 | ||
| Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin | Q34337961 | ||
| Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? | Q34348969 | ||
| Regulatory T cells in the control of immune pathology. | Q34348983 | ||
| Autoreactivity, dynamic tuning and selectivity | Q34418068 | ||
| An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. | Q34485526 | ||
| Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities | Q34567730 | ||
| The enemy within: keeping self-reactive T cells at bay in the periphery | Q34573771 | ||
| Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity | Q35675262 | ||
| Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice | Q36355148 | ||
| Role of CD4 in thymocyte selection and maturation | Q36356408 | ||
| T cell determinants of myelin basic protein include a unique encephalitogenic I-E-restricted epitope for Lewis rats. | Q36356697 | ||
| Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands | Q36367500 | ||
| T cell affinity maturation by selective expansion during infection | Q36367796 | ||
| Microbial epitopes act as altered peptide ligands to prevent experimental autoimmune encephalomyelitis | Q36368042 | ||
| Dynamic tuning of T cell reactivity by self-peptide-major histocompatibility complex ligands | Q36369018 | ||
| The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope | Q36375353 | ||
| High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire | Q36376026 | ||
| Negative selection during the peripheral immune response to antigen | Q36376090 | ||
| Sensory adaptation in naive peripheral CD4 T cells | Q36376411 | ||
| Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice | Q36376784 | ||
| Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft | Q36400752 | ||
| Endogenous myelin basic protein inactivates the high avidity T cell repertoire | Q36401074 | ||
| Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells | Q36401236 | ||
| In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephalomyelitis | Q36401750 | ||
| T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo | Q36404561 | ||
| An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro | Q36433369 | ||
| In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen. | Q36757834 | ||
| Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses | Q37277286 | ||
| Expression of a second receptor rescues self-specific T cells from thymic deletion and allows activation of autoreactive effector function | Q37385909 | ||
| Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts | Q37463129 | ||
| A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis | Q37611832 | ||
| Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. | Q37684415 | ||
| Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing. | Q40812914 | ||
| Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands | Q40813107 | ||
| Control of antigen presentation by a single protease cleavage site | Q40882359 | ||
| Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology | Q41039639 | ||
| Serial triggering of many T-cell receptors by a few peptide-MHC complexes | Q41346263 | ||
| Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells | Q41607754 | ||
| A kinetic basis for T cell receptor repertoire selection during an immune response | Q41649927 | ||
| Low avidity recognition of self-antigen by T cells permits escape from central tolerance. | Q41671634 | ||
| The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery | Q41690259 | ||
| Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation | Q41725217 | ||
| Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells | Q41864164 | ||
| Mature T cell reactivity altered by peptide agonist that induces positive selection | Q41881444 | ||
| Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules | Q41922560 | ||
| Fine tuning of TCR signaling by CD5. | Q42503170 | ||
| Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding | Q43806398 | ||
| Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. | Q43867716 | ||
| Influence of a dominant cryptic epitope on autoimmune T cell tolerance | Q43867718 | ||
| Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response | Q43986613 | ||
| Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity | Q44765063 | ||
| Evidence for a differential avidity model of T cell selection in the thymus | Q45155438 | ||
| Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice | Q45854348 | ||
| Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor | Q45986774 | ||
| Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy. | Q45997264 | ||
| Ligand recognition by alpha beta T cell receptors | Q46222293 | ||
| Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein | Q47992214 | ||
| A kinetic window constricts the T cell receptor repertoire in the thymus. | Q52930208 | ||
| T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity | Q56929107 | ||
| Induction of peripheral CD8+ T-cell tolerance by cross-presentation of self antigens | Q57228016 | ||
| T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis | Q59049915 | ||
| T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis | Q59049925 | ||
| Characterization of CD8+ T Lymphocytes That Persist After Peripheral Tolerance to a Self Antigen Expressed in the Pancreas | Q61140467 | ||
| Expression of two T cell receptor alpha chains: dual receptor T cells | Q61268447 | ||
| Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression | Q62078536 | ||
| pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells | Q63226061 | ||
| Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand | Q67903498 | ||
| T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis | Q71611171 | ||
| Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy | Q71988127 | ||
| Negative regulation of antigen receptor-mediated signaling by constitutive association of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 B cells | Q73129268 | ||
| Antigen-specific elimination of T cells induced by oligomerized hemagglutinin (HA) 306-318 | Q73166239 | ||
| Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms | Q73270557 | ||
| Tuning T cell activation threshold and effector function with cross-reactive peptide ligands | Q73399534 | ||
| Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion | Q73406538 | ||
| Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance | Q73701505 | ||
| Antigen-presenting cell activation: a link between infection and autoimmunity? | Q73831735 | ||
| Autoantigen-responsive T cell clones demonstrate unfocused TCR cross-reactivity toward multiple related ligands: implications for autoimmunity | Q74007991 | ||
| The minimal number of antigen-major histocompatibility complex class II complexes required for activation of naive and primed T cells | Q74179334 | ||
| TCR avidity: it's not how strong you make it, it's how you make it strong | Q74286634 | ||
| Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR | Q74286685 | ||
| Adaptive tolerance of CD4+ T cells in vivo: multiple thresholds in response to a constant level of antigen presentation | Q74321454 | ||
| A very high level of crossreactivity is an essential feature of the T-cell receptor | Q77324273 | ||
| P433 | issue | 7 | |
| P304 | page(s) | 487-498 | |
| P577 | publication date | 2002-07-01 | |
| P1433 | published in | Nature Reviews Immunology | Q43355 |
| P1476 | title | Selection and fine-tuning of the autoimmune T-cell repertoire | |
| P478 | volume | 2 |
| Q37515426 | A novel mechanism of alternative promoter and splicing regulates the epitope generation of tumor antigen CML66-L. |
| Q51997239 | Activation-threshold tuning in an affinity model for the T-cell repertoire. |
| Q52010045 | Age-related thymic involution in C57BL/6J x DBA/2J recombinant-inbred mice maps to mouse chromosomes 9 and 10. |
| Q37229016 | Alloreactivity of virus-specific T cells: possible implication of graft-versus-host disease and graft-versus-leukemia effects |
| Q37297941 | Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development |
| Q35092544 | Antigen-induced regulatory T cells in autoimmunity |
| Q35918521 | Antigen-tailored therapy based on the inflammatory theory of atherosclerosis |
| Q36922991 | Apoptotic signal transduction and T cell tolerance |
| Q35733829 | Biology of T lymphocytes |
| Q38020955 | Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis |
| Q24804208 | CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis |
| Q36326582 | Characterization of genetically modified T-cell receptors that recognize the CEA:691-699 peptide in the context of HLA-A2.1 on human colorectal cancer cells |
| Q44967035 | Citrullination of self-proteins and autoimmunity |
| Q38891100 | Clinical value of non-HLA antibodies in kidney transplantation: Still an enigma? |
| Q35762444 | Concomitant regulation of T-cell activation and homeostasis |
| Q36717167 | Control of T cell antigen reactivity via programmed TCR downregulation. |
| Q51905872 | Coreceptor CD8-driven modulation of T cell antigen receptor specificity. |
| Q42617070 | Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg |
| Q35086727 | Dendritic cells under investigation in autoimmune disease |
| Q47547004 | Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression. |
| Q33782527 | Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7 |
| Q37259961 | Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-kappaB: a study on induced arthritis in rats |
| Q36143622 | Enhanced expression of interferon-gamma-induced antigen-processing machinery components in a spontaneously occurring cancer |
| Q42204470 | Fibroblastic reticular cells of the lymphoid tissues modulate T cell activation threshold during homeostasis via hyperactive cyclooxygenase-2/prostaglandin E2 axis. |
| Q38066211 | Functional avidity: a measure to predict the efficacy of effector T cells? |
| Q39704344 | Generation of functional CD8+ T cells by human dendritic cells expressing glypican-3 epitopes |
| Q38895446 | Heat shock proteins and their immunomodulatory role in inflammatory arthritis |
| Q37499321 | How the immune system achieves self-nonself discrimination during adaptive immunity |
| Q51050539 | IL-10/TGF-beta-treated dendritic cells, pulsed with insulin, specifically reduce the response to insulin of CD4+ effector/memory T cells from type 1 diabetic individuals. |
| Q37864698 | Immunological perspective of self versus tumor antigens: insights from the RIP-gp model. |
| Q38438865 | In situ expansion of T cells that recognize distinct self-antigens sustains autoimmunity in the CNS. |
| Q39245827 | In vivo reprogramming of immune cells: Technologies for induction of antigen-specific tolerance. |
| Q57817458 | Long Pentraxin-3 Modulates the Angiogenic Activity of Fibroblast Growth Factor-2 |
| Q33838467 | Manipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE. |
| Q37317297 | Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to Models |
| Q36707550 | Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors |
| Q38852548 | Molecular mimicry and autoimmune thyroid disease |
| Q38437451 | Myelin oligodendrocyte glycoprotein induces incomplete tolerance of CD4(+) T cells specific for both a myelin and a neuronal self-antigen in mice |
| Q39673844 | Parenteral adenoviral boost enhances BCG induced protection, but not long term survival in a murine model of bovine TB. |
| Q41990602 | Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide |
| Q37760872 | Processing and presentation of (pro)-insulin in the MHC class II pathway: the generation of antigen-based immunomodulators in the context of type 1 diabetes mellitus |
| Q37364480 | Prospects for antigen-specific tolerance based therapies for the treatment of multiple sclerosis |
| Q35077155 | Quantitative constraints on the scope of negative selection |
| Q42080808 | Recognition of a high affinity MHC class I-restricted epitope of myelin oligodendrocyte glycoprotein by CD8⁺ T cells derived from autoantigen-deficient mice. |
| Q35129983 | Regulator T cells: specific for antigen and/or antigen receptors? |
| Q61046250 | Role of Apoptosis in Autoimmunity |
| Q37549648 | SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells |
| Q37033846 | Searching for alternative hematopoietic stem cell donors for pediatric patients |
| Q27666863 | Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection |
| Q36526360 | T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity. |
| Q37993692 | T-cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man. |
| Q36310443 | Targeting T lymphocytes for immune monitoring and intervention in autoimmune diabetes |
| Q36327367 | Targeting the TCR: T-cell receptor and peptide-specific tolerance-based strategies for restoring self-tolerance in CNS autoimmune disease |
| Q35022552 | The basis of T-cell-mediated immunity to chronic myelogenous leukemia |
| Q37551442 | Theories and quantification of thymic selection |
| Q36456483 | Trial watch: Prognostic and predictive value of the immune infiltrate in cancer |
| Q35590061 | Vaccination and autoimmune disease: what is the evidence? |
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