Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity

scientific article published on 16 October 2013

Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNINS.2013.00187
P8608Fatcat IDrelease_jfgez26k7zhm3cpobdpw5zv2um
P932PMC publication ID3797387
P698PubMed publication ID24137108
P5875ResearchGate publication ID258056546

P50authorHenri J MartensQ55426458
Didier HoberQ88545603
P2093author name stringVincent Geenen
Olivier Dardenne
Séverine Henry
Chantal Charlet-Renard
Gwennaëlle Bodart
Hélène Michaux
P2860cites workThe neuroendocrine thymus: coexistence of oxytocin and neurophysin in the human thymusQ22299404
New member of the winged-helix protein family disrupted in mouse and rat nude mutationsQ24308068
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domainsQ24313206
Thymic hyperplasia in patients with Graves' disease. Identification of thyrotropin receptors in human thymusQ24561889
Transcriptional regulation by AIRE: molecular mechanisms of central toleranceQ24648384
Deletional tolerance mediated by extrathymic Aire-expressing cellsQ24652952
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
The role of Hoxa-3 in mouse thymus and thyroid developmentQ28512245
Defective autoimmune regulator-dependent central tolerance to myelin protein zero is linked to autoimmune peripheral neuropathyQ28588498
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergenceQ28589335
Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4⁺ T cellsQ28593219
An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptideQ32063760
Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetopeQ33937758
Variations in organ size caused by chronic treatment with adrenal cortical compounds: An example of a dissociated adaptation to a hormoneQ34077844
A thymus candidate in lampreys.Q34162555
Control of central and peripheral tolerance by AireQ34177944
Tolerance induced by thymic epithelial grafts in birdsQ34185771
Thymus-specific deletion of insulin induces autoimmune diabetesQ34610806
Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetesQ34718808
Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humansQ34755279
Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23Q34797949
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD miceQ34968027
Emerging strategies to boost thymic functionQ35069523
Developing a new paradigm for thymus organogenesis.Q35730814
Insulin Transactivator MafA Regulates Intrathymic Expression of Insulin and Affects Susceptibility to Type 1 DiabetesQ35757146
Back to central toleranceQ35772859
The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Q52196097
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Q52196099
Association of an SNP with intrathymic transcription of TSHR and Graves' disease: a role for defective thymic tolerance.Q54367442
IMMUNOLOGICAL FUNCTION OF THE THYMUSQ56623510
T cell tolerance by clonal elimination in the thymusQ56922465
Induction of Autoimmune Diabetes by Oral Administration of AutoantigenQ57228112
Changes in thymic function with age and during the treatment of HIV infectionQ59066353
Contribution of Neural Crest-Derived Cells in the Embryonic and Adult ThymusQ60418387
Expression of preprotachykinin-A and neuropeptide-Y messenger RNA in the thymusQ67683601
The identification of tyrosine as a common key residue in unrelated H-2Kd restricted antigenic peptidesQ67707063
Identification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with major histocompatibility complex class I moleculesQ73418750
Involvement of insulin-like growth factors in early T cell development: a study using fetal thymic organ culturesQ73500728
A defect in central tolerance in NOD miceQ74825850
Lymphoepithelial structures and autoimmune diseaseQ76458920
Factors regulating stem cell recruitment to the fetal thymusQ77320326
Thymic expression of neuroendocrine self-peptide precursors: role in T cell survival and self-toleranceQ77608837
Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigensQ77620066
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetesQ78014697
Prolonged viral RNA detection in blood and lymphoid tissues from coxsackievirus B4 E2 orally-inoculated Swiss miceQ79442349
Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clonesQ80175303
An insulin-like growth factor 2-derived self-antigen inducing a regulatory cytokine profile after presentation to peripheral blood mononuclear cells from DQ8+ type 1 diabetic adolescents: preliminary design of a thymus-based tolerogenic self-vaccinaQ81378688
Insulin alleles and autoimmune regulator (AIRE) gene expression both influence insulin expression in the thymusQ81397084
Defective central tolerance induction in NOD mice: genomics and geneticsQ81552095
Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient miceQ83059304
The thymus as an obligatory intersection between the immune and neuroendocrine systems: pharmacological implicationsQ84439350
Thymic negative selection is functional in NOD miceQ35826021
Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8⁺ T cells in type 1 diabetesQ35891952
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouseQ35918236
Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude miceQ36140403
Persistent infection of thymic epithelial cells with coxsackievirus B4 results in decreased expression of type 2 insulin-like growth factorQ36276241
Role of impaired central tolerance to α-myosin in inflammatory heart diseaseQ36319822
A central role for central toleranceQ36427372
Selection of self-reactive T cells in the thymusQ36456282
Aire's plant homeodomain(PHD)-2 is critical for induction of immunological toleranceQ36583154
The evolutionary history of lymphoid organsQ36715278
Subcellular localization of immunoreactive oxytocin within thymic epithelial cells of the male mouseQ36768465
Dynamics of thymus organogenesis and colonization in early human developmentQ36783140
Messenger RNA expression for a TSH receptor variant in the thymus of a two-year-old childQ36812825
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medullaQ36946557
Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiatedQ36949091
Generating intrathymic microenvironments to establish T-cell tolerance.Q36997113
At the cutting edge biosynthesis and paracrine/cryptocrine actions of ‘self’ neurohypophysial-related peptides in the thymusQ37061936
Coxsackievirus B4 infection of human fetal thymus cellsQ37492730
Antigen presentation in the thymus for positive selection and central tolerance inductionQ37638193
Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetesQ37740399
Design principles of adaptive immune systemsQ37862986
The evolution of adaptive immunity in vertebratesQ37875302
Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cellsQ39299541
Persistent infection of human thymic epithelial cells by coxsackievirus B4.Q39683493
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune systemQ41011364
Neurohypophysial peptides stimulate the phosphorylation of pre-T cell focal adhesion kinasesQ41042227
The thymic repertoire of neuroendocrine self-antigens: physiological implications in T-cell life and death.Q41078409
A reassessment of the forbidden clone hypothesis of autoimmune diseaseQ41509427
Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat.Q41618017
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaQ41868543
Cytokine production by human thymic epithelial cells: control by the immune recognition of the neurohypophysial self-antigen.Q42527817
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expressionQ42923236
Thymus transplantation and disease prevention in the diabetes-prone Bio-Breeding rat.Q43746213
At the cutting edge. Paracrine, cryptocrine, acrocrineQ44415403
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytesQ44851100
Evidence for a differential avidity model of T cell selection in the thymusQ45155438
Complex formation between bovine neurophysin-I and oxytocin, vasopressin, and tripeptide analogs of their NH2-terminal region. Absorbance and circular dichroism difference spectroscopic studiesQ45155929
Ontogenesis and functional aspects of oxytocin and vasopressin gene expression in the thymus networkQ45180806
Regulation of insulin gene expression by cytokines and cell-cell interactions in mouse medullary thymic epithelial cells.Q45927229
Coxsackievirus B4 infection of murine foetal thymus organ cultures.Q46735577
Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.Q52136674
P304page(s)187
P577publication date2013-10-16
P1433published inFrontiers in NeuroscienceQ2177807
P1476titleProgramming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity
P478volume7

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cites work (P2860)
Q37576363Approaches Mediating Oxytocin Regulation of the Immune System
Q37022010Beneficial bacteria inhibit cachexia
Q41909759Brain-immune interactions in health and disease.
Q26801632How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?
Q40478350In-utero coxsackievirus B4 infection of the mouse thymus.
Q51550756T regulatory lymphocytes in type 1 diabetes: Impaired CD25 expression and IL-2 induced STAT5 phosphorylation in pediatric patients.
Q39189740Thymus: Conservation in evolution

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