Thymic negative selection is functional in NOD mice (scientific article published on 13 February 2012)

Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice

Q30644510

Lineage diversion of T cell receptor transgenic thymocytes revealed by lineage fate mapping.

Q33317281

ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis

Q33686997

Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells

Q33763027

The Erk2 MAPK regulates CD8 T cell proliferation and survival

Q33763059

Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice

Q33865120

The Ras/MAPK pathway is required for generation of iNKT cells

Q33900265

Positive and negative selection of T cells

Q34157557

Conditional control of gene expression in the mouse

Q34389488

T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells

Q34534123

Distinct structure and signaling potential of the gamma delta TCR complex

Q74471806

Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice

Q74506166

A defect in central tolerance in NOD mice

Q74825850

Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes

Q77192908

Defective central tolerance induction in NOD mice: genomics and genetics

Q81552095

TCR signal strength influences alphabeta/gammadelta lineage fate

Q81747999

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling

Q35724760

The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice

Q35758643

Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes.

Q36231460

Mice lacking major histocompatibility complex class I and class II molecules

Q36271130

Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation

Q36361502

Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells

Q36368690

Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes.

Q36371424

Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-zeta-Cbl pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice

Q36380617

The why and how of thymocyte negative selection

Q36387271

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

Q36399562

Apoptosis during negative selection of autoreactive thymocytes

Q36893056

The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors

Q37018786

Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells

Q37208578

Aire

Q37419376

ERK and cell death: ERK location and T cell selection

Q37618290

Key role of ERK pathway signaling in lupus

Q37644503

Determining γδ versus αß T cell development.

Q37781276

Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development

Q42392644

Defective activation of p21ras in peripheral blood mononuclear cells from patients with insulin dependent diabetes mellitus

Q42475727

Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells

Q42806482

Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function

Q42839859

New insights into the proliferation and differentiation of early mouse thymocytes

Q44936590

Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells

Q47631646

The role of erk1 and erk2 in multiple stages of T cell development.

Q50954940

Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.

Q50969471

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

Q52196097

The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

Q52199699

Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.

Q53877408

Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.

Q53886008

Regulation of diabetes development by regulatory T cells in pancreatic islet antigen-specific TCR transgenic nonobese diabetic mice.

Q53968558

Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor Editing

Q57078475

Characterization of the ovalbumin-specific TCR transgenic line OT-I: MHC elements for positive and negative selection

Q57227959

Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

Q57228054

Through Regulation of TCR Expression Levels, an Idd7 Region Gene(s) Interactively Contributes to the Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in Nonobese Diabetic Mice

Q58054691

Implication of the CD47 pathway in autoimmune diabetes

Q61483548

Efficient T cell receptor–mediated apoptosis in nonobese diabetic mouse thymocytes

Q62817731

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

Q67939725

Following a diabetogenic T cell from genesis through pathogenesis

Q70488192

Evidence for down-regulation of highly expressed TCR by CD4 and CD45 on non-selected CD4+CD8+ thymocytes

Q71784356

Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse

Q71930272

Competitive displacement of pT alpha by TCR-alpha during TCR assembly prevents surface coexpression of pre-TCR and alpha beta TCR

Q73163114

Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules

Q73358770

P433

issue

P407

language of work or name

English

Q1860

P304

page(s)

623-637

P577

publication date

2012-02-13

P1433

published in

Journal of Experimental Medicine

Q3186912

P1476

title

Thymic negative selection is functional in NOD mice

P478

volume

209

Reverse relations

cites work (P2860)

Q37202316	Accelerated turnover of MHC class II molecules in nonobese diabetic mice is developmentally and environmentally regulated in vivo and dispensable for autoimmunity
Q34506291	BDC12-4.1 T-cell receptor transgenic insulin-specific CD4 T cells are resistant to in vitro differentiation into functional Foxp3+ T regulatory cells
Q37279333	Children who develop type 1 diabetes early in life show low levels of carnitine and amino acids at birth: does this finding shed light on the etiopathogenesis of the disease?
Q41239289	Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla
Q89674051	Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression
Q39014243	High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies
Q26801632	How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes?
Q37114342	Hydrophobic CDR3 residues promote the development of self-reactive T cells
Q36717799	Loss of T cell progenitor checkpoint control underlies leukemia initiation in Rag1-deficient nonobese diabetic mice
Q26781296	Lower Affinity T Cells are Critical Components and Active Participants of the Immune Response
Q27014040	Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients
Q34382829	Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers
Q34150236	On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes
Q37246540	Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes.
Q38153686	Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity
Q34473302	Reduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome
Q34581371	Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice
Q30863890	Systems biology. Conditional density-based analysis of T cell signaling in single-cell data
Q51152901	The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis.
Q40905788	The transcriptional landscape of αβ T cell differentiation
Q37636838	Thymic Nurse Cells Participate in Heterotypic Internalization and Repertoire Selection of Immature Thymocytes; Their Removal from the Thymus of Autoimmune Animals May be Important to Disease Etiology
Q49200196	Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response