MerTK regulates thymic selection of autoreactive T cells

scholarly article

MerTK regulates thymic selection of autoreactive T cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2009PNAS..106.4810W
P356DOI10.1073/PNAS.0900683106
P932PMC publication ID2660755
P698PubMed publication ID19251650
P5875ResearchGate publication ID24146187

P50authorClayton E MathewsQ61109150
Shelton EarpQ90859139
Roland TischQ97091835
Bo WangQ97093714
Mark A WalletQ102378324
Glenn K MatsushimaQ114526151
Charles J KrogerQ114526153
P2093author name stringYaming Wang
Rafael R Flores
Zuoan Yi
P2860cites workMertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cellsQ28582501
Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 familyQ28585446
TAM receptors are pleiotropic inhibitors of the innate immune responseQ28592484
Regulatory T cells and immune toleranceQ29616864
Autoreactivity of T cells from nonobese diabetic mice: an I-Ag7-dependent reactionQ32123429
Genetic susceptibility to type 1 diabetesQ33341695
Immunobiology of the TAM receptorsQ33796991
Phagocytosis and clearance of apoptotic cells is mediated by MER.Q33946282
TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancerQ34794927
Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cellsQ35615917
Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selectionQ36067105
The NOD mouse: a model of immune dysregulationQ36072434
Immunoregulation of dendritic cellsQ36256306
Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitroQ36349915
Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinaseQ36371130
MerTK is required for apoptotic cell-induced T cell toleranceQ36446918
The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophagesQ36739689
Immunomodulation of autoimmune diabetes by dendritic cellsQ37150509
Cellular interactions in thymocyte development.Q41039662
MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytesQ41057423
Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivoQ42113339
The mer receptor tyrosine kinase: expression and function suggest a role in innate immunityQ44528093
Evidence for a differential avidity model of T cell selection in the thymusQ45155438
The Mer receptor tyrosine kinase is required for the loss of B cell tolerance in the chronic graft-versus-host disease model of systemic lupus erythematosusQ46587187
The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritisQ47569532
Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice.Q53855687
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.Q53877408
Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.Q54139892
Insulin-dependent diabetes mellitusQ71046915
Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletionQ73406538
The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic miceQ79818775
Defective central tolerance induction in NOD mice: genomics and geneticsQ81552095
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)4810-4815
P577publication date2009-02-27
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMerTK regulates thymic selection of autoreactive T cells
P478volume106

Reverse relations

cites work (P2860)
Q37381687A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells
Q42578734Antigen-Specific Immune Modulation Targets mTORC1 Function To Drive Chemokine Receptor-Mediated T Cell Tolerance.
Q33692556Association of plasma levels of Protein S with disease severity in multiple sclerosis
Q37690725Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity
Q35962257Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status.
Q34982085Dendritic cell control of tolerogenic responses
Q21195358Disturbances of apoptotic cell clearance in systemic lupus erythematosus
Q37792913Dysregulation of Thymic Clonal Deletion and the Escape of Autoreactive T Cells
Q36301713Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction
Q52716571Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion.
Q61483536Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice
Q97522406In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
Q35093012Increased plasma levels of the soluble Mer tyrosine kinase receptor in systemic lupus erythematosus relate to disease activity and nephritis
Q41983866Intrinsic unresponsiveness of Mertk-/- B cells to chronic graft-versus-host disease is associated with unmodulated CD1d expression
Q28742974Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with multiple sclerosis susceptibility
Q37030992Recovery from overt type 1 diabetes ensues when immune tolerance and β-cell formation are coupled with regeneration of endothelial cells in the pancreatic islets
Q26785900The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity
Q43233982The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses

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