Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo

scientific article published on February 1997

Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.185.3.541
P932PMC publication ID2196043
P698PubMed publication ID9053454
P5875ResearchGate publication ID277534185

P2093author name stringKarjalainen K
Brocker T
Riedinger M
P2860cites workcDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95Q24298077
Genomic structure of an integrin alpha subunit, the leukocyte p150,95 moleculeQ24300254
Positive selection of thymocytesQ33366862
Evidence for a single-niche model of positive selectionQ35930529
Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient miceQ36199291
The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cellsQ36231530
Two subsets of epithelial cells in the thymic medullaQ36231612
The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodiesQ36351071
The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cellsQ36356068
Fibroblasts can induce thymocyte positive selection in vivoQ36647981
Cellular and peptide requirements for in vitro clonal deletion of immature thymocytesQ37217909
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypesQ37601008
Thymic dendritic cells: phenotype and functionQ37869636
The surface of dendritic cells in the mouse as studied with monoclonal antibodiesQ37869640
Negative selection of lymphocytesQ40807431
Cellular interactions in thymocyte development.Q41039662
Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short-term cultureQ41206625
Compartmentalization of MHC class II gene expression in transgenic miceQ41422626
Positive selection of T lymphocytes on fibroblastsQ41534256
Studies on T cell maturation on defined thymic stromal cell populations in vitroQ42034172
Requirement of dendritic cells and B cells in the clonal deletion of Mls-reactive T cells in the thymusQ42110138
Bone marrow-derived cells fail to induce positive selection in thymus reaggregation culturesQ42134209
Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitroQ42136342
The phenotypic heterogeneity of mouse thymic stromal cellsQ42481348
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigensQ42801460
Targeted disruption of the MHC class II Aa gene in C57BL/6 miceQ42809952
Bone marrow origin of Ia-positive cells in the medulla rat thymusQ42935566
The thymic compartment responsible for positive selection of CD4+ T cellsQ43997933
CD4 and CD8 expression by human and mouse thymic dendritic cellsQ44486843
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.Q45999974
Inefficient positive selection of T cells directed by haematopoietic cellsQ46211796
Positive selection of the T cell repertoire: where and when does it occur?Q46212274
Does T-cell tolerance require a dedicated antigen-presenting cell?Q46491587
Transgenic mice selectively lacking MHC class II (I-E) antigen expression on B cells: an in vivo approach to investigate Ia gene functionQ48336686
The effect of thymus environment on T cell development and toleranceQ56922431
Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cellsQ61454446
Effects of the thymic microenvironment on the response of thymocytes to stimulationQ67554435
Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cellsQ68083664
Class I and class II MHC gene products differentially affect the fate of V beta 5 bearing thymocytesQ68157348
Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cellsQ69834637
The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymusQ69936089
Clonal deletion of V beta 5+ T cells by transgenic I-E restricted to thymic medullary epitheliumQ70503946
Phenotypic and functional characterization of CD11c+ dendritic cell population in mouse Peyer's patchesQ71420915
A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic miceQ71606864
Differential expression of Mtv loci in MHC class II-positive thymic stromal cellsQ72404605
The role of macrophages in antigen presentation and T cell toleranceQ72609353
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
thymocyteQ7799635
P304page(s)541-550
P577publication date1997-02-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleTargeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
P478volume185

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