Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice

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Class II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1993PNAS...90.2779M
P356DOI10.1073/PNAS.90.7.2779
P932PMC publication ID46179
P698PubMed publication ID8464889
P5875ResearchGate publication ID14734201

P50authorLaurie GlimcherQ6501587
Michael J GrusbyQ114438980
P2093author name stringJ S Markowitz
H Auchincloss
P2860cites workMice lacking MHC class II moleculesQ28588991
In a fully H-2 incompatible chimera, T cells of donor origin can respond to minor histocompatibility antigens in association with either donor or host H-2 typeQ34321361
Two subsets of epithelial cells in the thymic medullaQ36231612
On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?Q36340069
H-2 antigens of the thymus determinelymphocyte specificityQ36341908
Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cellsQ36344877
Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cellsQ36347155
Selection of restriction specificities of virus-specific cytotoxic T cells in the thymus: no evidence for a crucial role of antigen-presenting cellsQ36347236
Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cellsQ36349635
H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cellsQ36419616
Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytesQ37531226
In a radiation chimaera, host H–2 antigens determine immune responsiveness of donor cytotoxic cellsQ40658124
Cytotoxic T cells learn specificity for self H–2 during differentiation in the thymusQ40666806
Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epitheliumQ41325052
Mechanisms of tolerance in murine radiation bone marrow chimeras. I. Nonspecific suppression of alloreactivity by spleen cells from early, but not late, chimerasQ41546747
Differentiation of an immature T cell line: a model of thymic positive selectionQ41597930
Restriction specificities, alloreactivity, and allotolerance expressed by T cells from nude mice reconstituted with H-2-compatible or -incompatible thymus graftsQ41846714
Thymic selection of H-2-incompatible bone marrow cells in SCID mice. Differences in T help for induction of B cell IgG responses versus cytotoxic T cellsQ41995156
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.Q45999974
Inefficient positive selection of T cells directed by haematopoietic cellsQ46211796
Positive selection of the T cell repertoire: where and when does it occur?Q46212274
Positive selection of CD4+ T cells mediated by MHC class II-bearing stromal cell in the thymic cortexQ52244580
Depletion of CD4+ T cells in major histocompatibility complex class II-deficient miceQ52481758
Extrathymic positive selection of alpha beta T-cell precursors in nude miceQ59033812
T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cellsQ59061484
Positive selection of antigen-specific T cells in thymus by restricting MHC moleculesQ59080081
Implantation of cultured thymic fragments in congenitally athymic nude rats: ignorance of thymic epithelial haplotype in generation of alloreactivityQ69621637
Identity of cells that imprint H-2-restricted T-cell specificity in the thymusQ69989585
Early appearance of donor-type antigen-presenting cells in the thymuses of 1200 R radiation-induced bone marrow chimeras correlates with self-recognition of donor I region gene productsQ70434640
Differences in the MHC-restricted self-recognition repertoire of intra-thymic and extra-thymic cytotoxic T lymphocyte precursorsQ70982232
The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude miceQ72097431
The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymicallyQ72762935
P433issue7
P407language of work or nameEnglishQ1860
P1104number of pages5
P304page(s)2779-2783
P577publication date1993-04-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleClass II-positive hematopoietic cells cannot mediate positive selection of CD4+ T lymphocytes in class II-deficient mice
P478volume90