p53 and thymic 'death by neglect': thymic epithelial cell-induced apoptosis of CD4+8+ thymocytes is p53-independent

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p53 and thymic 'death by neglect': thymic epithelial cell-induced apoptosis of CD4+8+ thymocytes is p53-independent is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1044094386
P356DOI10.1038/SJ.CDD.4400657
P698PubMed publication ID10745269
P5875ResearchGate publication ID12571604

P2093author name stringGuy R
Yefenof E
Rosenheimer-Goudsmid N
Zilberman Y
Haupt Y
P2860cites workp53, the cellular gatekeeper for growth and divisionQ27860990
p53 mutations in human cancersQ28302973
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometryQ29617253
Tumor spectrum analysis in p53-mutant miceQ29617436
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
Steroid production in the thymus: implications for thymocyte selection.Q36363220
p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.Q36366527
Heterogeneity of thymic epithelial cells in promoting T-lymphocyte differentiation in vivoQ37379357
The p53 tumour suppressor geneQ37751892
T cell selection in the thymusQ39633830
Monoclonal antibody analysis of p53 expression in normal and transformed cellsQ40127251
Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.Q40872252
Apoptosis of thymic lymphoma clones by thymic epithelial cells: a putative model for 'death by neglect'.Q40956043
Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possiblein vitro model for positive selection of the T cell repertoireQ41152049
Induction of apoptosis and p53 expression in immature thymocytes by direct interaction with thymic epithelial cellsQ41164236
T cell receptor-independent apoptosis of thymocyte clones induced by a thymic epithelial cell line is mediated by steroidsQ41197643
Apoptosis by p53: mechanisms, regulation, and clinical implicationsQ41737530
Evidence for a differential avidity model of T cell selection in the thymusQ45155438
Mutant p53 protein expression interferes with p53-independent apoptotic pathwaysQ47775780
Thymocyte selection: not by TCR alone.Q52181530
Mutations in the p53 and SCID genes cooperate in tumorigenesis.Q52200235
Induction of apoptosis in HeLa cells by trans-activation-deficient p53Q53461564
Functional Activity of a Transformed Thymic Epithelial Cell LineQ53562875
Thymocyte apoptosis induced by p53-dependent and independent pathways.Q54242475
DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2Q57338694
Self-nonself discrimination by T cellsQ68090702
Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patientsQ71169983
The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivoQ73903403
Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell developmentQ77755751
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapyQ77932308
P433issue3
P304page(s)241-249
P577publication date2000-03-01
P1433published inCell Death & DifferentiationQ2943974
P1476titlep53 and thymic 'death by neglect': thymic epithelial cell-induced apoptosis of CD4+8+ thymocytes is p53-independent
P478volume7

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cites work (P2860)
Q40697341CD44 co-stimulates apoptosis in thymic lymphomas and T cell hybridomas
Q64092955Cernunnos/Xlf Deficiency Results in Suboptimal V(D)J Recombination and Impaired Lymphoid Development in Mice
Q36602853MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies
Q53492117The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response.

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