Limited expansion of virus-specific CD8 T cells in the aged environment.

scientific article

Limited expansion of virus-specific CD8 T cells in the aged environment. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.MAD.2009.08.007
P932PMC publication ID2839881
P698PubMed publication ID19744506
P5875ResearchGate publication ID26802789

P50authorAndrew J BennettQ57420533
P2093author name stringHao Shen
Donna M Murasko
Jiu Jiang
Erin Fisher
Yolanda Williams-Bey
P2860cites workHigh accumulation of T regulatory cells prevents the activation of immune responses in aged animalsQ79401056
No intrinsic deficiencies in CD8+ T cell-mediated antitumor immunity with agingQ80304529
The instructive role of dendritic cells on T-cell responsesQ21195249
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infectionQ33720391
Initial T cell frequency dictates memory CD8+ T cell lineage commitmentQ33768584
Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution.Q34032209
T cell senescenceQ34136955
Regulation of T cell immunity by dendritic cellsQ34339191
Mucosal dendritic cellsQ34611254
The assessment of antigen-specific CD8+ T cells through the combination of MHC class I tetramer and intracellular stainingQ34815539
Age-related changes in Type 1 and Type 2 cytokine production in humansQ34867266
The formation and functions of the 21- and 23-kDa tyrosine-phosphorylated TCR zeta subunitsQ35076675
Quantitative studies of CD8+ T-cell responses during microbial infectionQ35192602
Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection.Q36008100
Intrinsic versus environmental influences on T-cell responses in agingQ36121052
Response of aged mice to primary virus infectionsQ36121083
Aging and the dendritic cell system: implications for cancerQ36796469
Potent T cell agonism mediated by a very rapid TCR/pMHC interactionQ39418908
Evidence for a differential avidity model of T cell selection in the thymusQ45155438
Age-associated decrease in virus-specific CD8+ T lymphocytes during primary influenza infectionQ45732295
Antigen-specific CD4 T cell clonal expansion and differentiation in the aged lymphoid microenvironment. I. The primary T cell response is unaffectedQ47284255
Defective generation but normal maintenance of memory T cells in old mice.Q52011697
Early antigen-specific response by naive CD8 T cells is not altered with aging.Q52012316
Aging affects initiation and continuation of T cell proliferation.Q53563568
Antigen-specific CD4 T cell clonal expansion and differentiation in the aged lymphoid microenvironmentQ56795436
Defective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic MiceQ61140426
Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell functionQ64133052
Effect of aging on epidermal dendritic cell populations in C57BL/6J miceQ68700573
Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin EQ73194856
Unimpaired dendritic cells can be derived from monocytes in old age and can mobilize residual function in senescent T cellsQ73480267
Phenotype, antigen-presenting capacity, and migration of antigen-presenting cells in young and old ageQ74734253
Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to InfectionQ79125476
Murine [corrected] myeloid dendritic cell-dependent toll-like receptor immunity is preserved with agingQ79385275
P433issue11-12
P304page(s)713-721
P577publication date2009-11-01
P1433published inMechanisms of Ageing and DevelopmentQ1839797
P1476titleLimited expansion of virus-specific CD8 T cells in the aged environment
P478volume130

Reverse relations

cites work (P2860)
Q36498687Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium
Q35201154Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity
Q36345382Age-related changes in CD8 T cell homeostasis and immunity to infection
Q37840341CD8 T cell responses to influenza virus infection in aged mice
Q37935622Cognitive and behavioral consequences of impaired immunoregulation in aging
Q35943193CpG Improves Influenza Vaccine Efficacy in Young Adult but Not Aged Mice
Q87218659Disorganization of the splenic microanatomy in ageing mice
Q37151977Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza
Q34172515Enhancement of virus-specific expansion of transgenic CD8 T cells in aged mice by dendritic cells.
Q26822938Human Metapneumovirus: lessons learned over the first decade
Q35874111Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population.
Q34388458Impact of aging on viral infections
Q55049359Impaired CD8 T cell antiviral immunity following acute spinal cord injury.
Q37152076Impaired specific CD8 T cell response with aging is not due to decreased expression of CD90 on TCR transgenic T cells
Q36410026Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna(Dhe) mice.
Q36363186Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections
Q36914330Intrinsic defects in CD8 T cells with aging contribute to impaired primary antiviral responses
Q59357739Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection
Q36417221Lifelong persistent viral infection alters the naive T cell pool, impairing CD8 T cell immunity in late life
Q36276683NS1-truncated live attenuated virus vaccine provides robust protection to aged mice from viral challenge
Q43615736Phenotype and functions of conventional dendritic cells are not compromised in aged mice
Q57296308Sex and sex steroids impact influenza pathogenesis across the life course
Q90195655Testosterone treatment of aged male mice improves some but not all aspects of age-associated increases in influenza severity
Q58045474The ageing immune system and its clinical implications
Q41246444The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age.

Search more.