| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1111/J.1600-065X.1998.TB01237.X |
| P698 | PubMed publication ID | 9850859 |
| P50 | author | Josef Penninger | Q1674391 |
| P2093 | author name string | Mak TW | |
| P2860 | cites work | Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes | Q24295016 |
| Profound block in thymocyte development in mice lacking p56lck | Q24298882 | ||
| Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk | Q24303475 | ||
| Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells | Q24312369 | ||
| Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked | Q24318845 | ||
| Essential role for ZAP-70 in both positive and negative selection of thymocytes | Q24321424 | ||
| Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells | Q24322070 | ||
| Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2 | Q24322699 | ||
| Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation | Q24329121 | ||
| Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter | Q24602245 | ||
| An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex | Q27733448 | ||
| Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 | Q27733853 | ||
| Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen | Q27748865 | ||
| Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product | Q28114879 | ||
| The SH3 domain of Bruton's tyrosine kinase interacts with Vav, Sam68 and EWS | Q28242138 | ||
| Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis | Q28250587 | ||
| Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements | Q28297821 | ||
| Selective modulation of protein kinase C-theta during T-cell activation | Q28300613 | ||
| Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases | Q28301106 | ||
| Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3 | Q28301735 | ||
| Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase | Q28507508 | ||
| CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation | Q28511906 | ||
| Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs | Q28565211 | ||
| The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling | Q28586244 | ||
| Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn | Q28586314 | ||
| Syk tyrosine kinase required for mouse viability and B-cell development | Q28586985 | ||
| TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells | Q28589574 | ||
| Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase | Q28593717 | ||
| Lck regulates Vav activation of members of the Rho family of GTPases | Q28610619 | ||
| Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav | Q28646540 | ||
| Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs | Q29547308 | ||
| Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection | Q29614956 | ||
| The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis | Q29616513 | ||
| T cell receptor antagonist peptides induce positive selection | Q29618820 | ||
| T-cell antigen receptor genes and T-cell recognition | Q29619721 | ||
| p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells | Q30176832 | ||
| Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes | Q30193572 | ||
| Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. | Q30193575 | ||
| Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes | Q33888899 | ||
| Actin cleavage by CPP-32/apopain during the development of apoptosis | Q34419577 | ||
| CD4/CD8 lineage commitment: back to instruction? | Q40994026 | ||
| Cellular interactions in thymocyte development. | Q41039662 | ||
| T cell antigen receptor signal transduction pathways | Q41039700 | ||
| Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains | Q41041097 | ||
| The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. | Q41096340 | ||
| Dynamin self-assembly stimulates its GTPase activity | Q41168345 | ||
| Signaling from G protein-coupled receptors to c-Jun kinase involves beta gamma subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway | Q41226993 | ||
| Dynamin GTPase, a force-generating molecular switch. | Q41237357 | ||
| Defective B cell development and function in Btk-deficient mice | Q41306033 | ||
| Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton | Q41334369 | ||
| Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene | Q41358116 | ||
| Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. | Q41358742 | ||
| Bar Mitzvah for B-1 cells: how will they grow up? | Q41416484 | ||
| Early alpha beta T cell development in the thymus of normal and genetically altered mice | Q41429677 | ||
| Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. | Q41460849 | ||
| Neutralizing antiviral B cell responses | Q41464284 | ||
| Views on Vav. | Q41472325 | ||
| Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates | Q41635684 | ||
| The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. | Q41643996 | ||
| Natural and engineered disorders of lymphocyte development | Q41735894 | ||
| Mature T cell reactivity altered by peptide agonist that induces positive selection | Q41881444 | ||
| Differential requirements for survival and proliferation of CD8 naïve or memory T cells | Q34430192 | ||
| Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis | Q34451533 | ||
| A novel family of genes encoding putative pheromone receptors in mammals | Q34720194 | ||
| Allelic inactivation regulates olfactory receptor gene expression | Q34726828 | ||
| Regulation of TCR alpha and beta gene allelic exclusion during T-cell development | Q35232298 | ||
| Cellular aspects of early T-cell development | Q35257634 | ||
| Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin. | Q36276559 | ||
| Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes | Q36362146 | ||
| Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules | Q36362480 | ||
| Expression of two alpha chains on the surface of T cells in T cell receptor transgenic mice | Q36362577 | ||
| Two waves of recombinase gene expression in developing thymocytes | Q36362988 | ||
| Role of interferon regulatory factor 1 in induction of nitric oxide synthase | Q36363736 | ||
| T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production | Q36365100 | ||
| Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death | Q36365164 | ||
| Dual T cell receptor alpha chain T cells in autoimmunity | Q36365722 | ||
| Mitochondrial control of nuclear apoptosis. | Q36366491 | ||
| Bcl-2 inhibits the mitochondrial release of an apoptogenic protease | Q36367392 | ||
| Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. | Q36380593 | ||
| Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus. | Q36380824 | ||
| T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus | Q36380948 | ||
| Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein | Q36645161 | ||
| Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras | Q36667927 | ||
| Identification and characterization of T-cell antigen receptor-related genes in phylogenetically diverse vertebrate species | Q36690460 | ||
| Btk dosage determines sensitivity to B cell antigen receptor cross-linking | Q36720312 | ||
| Function of the pre-T-cell receptor alpha chain in T-cell development and allelic exclusion at the T-cell receptor beta locus | Q37712369 | ||
| Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition | Q37714426 | ||
| Towards an integrated view of thymopoiesis | Q37769128 | ||
| The thymus selects the useful, neglects the useless and destroys the harmful | Q38255315 | ||
| Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development | Q38315288 | ||
| Exclusion and inclusion of α and β T cell receptor alleles | Q38329183 | ||
| Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies | Q38363009 | ||
| Regulation of interferon-beta gene: structure and function of cis-elements and trans-acting factors | Q38750326 | ||
| Protein kinase C-theta isoenzyme selective stimulation of the transcription factor complex AP-1 in T lymphocytes | Q40018644 | ||
| The thymic microenvironment. | Q40769611 | ||
| Inhibition of apoptosis by the actin-regulatory protein gelsolin | Q41903972 | ||
| Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules | Q41922560 | ||
| Actin is cleaved during constitutive apoptosis | Q41968458 | ||
| kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire | Q42043636 | ||
| Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro | Q42136342 | ||
| Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway. | Q42829329 | ||
| Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton | Q42942785 | ||
| Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities | Q44704873 | ||
| Evidence for a differential avidity model of T cell selection in the thymus | Q45155438 | ||
| The wisdom of hindsight. | Q45993248 | ||
| Intracellular signals that mediate thymic negative selection | Q46221245 | ||
| Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes | Q46477859 | ||
| Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction | Q46517603 | ||
| Allelic exclusion of mouse T cell receptor α chains occurs at the time of thymocyte TCR up-regulation | Q46739496 | ||
| Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes. | Q46778527 | ||
| Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76. | Q47720762 | ||
| Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development | Q47837774 | ||
| CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. | Q47992167 | ||
| Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene | Q48076531 | ||
| Unique expression pattern of protein kinase C-theta: high mRNA levels in normal mouse testes and in T-lymphocytic cells and neoplasms. | Q48249265 | ||
| In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes | Q48327246 | ||
| Optic flow: A brain region devoted to optic flow analysis? | Q48409799 | ||
| Another view of the selective model of thymocyte selection. | Q51142565 | ||
| Lymphocyte survival: a red queen hypothesis. | Q52041519 | ||
| Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. | Q52052343 | ||
| Regulation of LMP2 and TAP1 genes by IRF-1 explains the paucity of CD8+ T cells in IRF-1-/- mice. | Q52199698 | ||
| Altered peptidase and viral-specific T cell response in LMP2 mutant mice. | Q52508504 | ||
| A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness. | Q52522639 | ||
| Organization and reorganization of immunoglobulin genes in A-MuLV-transformed cells: Rearrangement of heavy but not light chain genes | Q52826363 | ||
| Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1. | Q53517183 | ||
| Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. | Q53957276 | ||
| Viral myocarditis leading to cardiomyopathy: do cytokines contribute to pathogenesis? | Q54234050 | ||
| T cell tolerance by clonal elimination in the thymus | Q56922465 | ||
| Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ | Q56922556 | ||
| Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells | Q58991849 | ||
| An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes | Q59067290 | ||
| Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells | Q59070257 | ||
| Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage | Q59081725 | ||
| T-cell apoptosis detected in situ during positive and negative selection in the thymus | Q59087078 | ||
| pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells | Q63226061 | ||
| A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes | Q63408334 | ||
| Fyn can partially substitute for Lck in T lymphocyte development | Q71814468 | ||
| Alterations in synaptic strength preceding axon withdrawal | Q71970925 | ||
| Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2 | Q73386407 | ||
| Gelsolin activates DNase I in vitro and cystic fibrosis sputum | Q73678393 | ||
| The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1 | Q74299216 | ||
| P921 | main subject | thymocyte | Q7799635 |
| P304 | page(s) | 149-166 | |
| P577 | publication date | 1998-10-01 | |
| P1433 | published in | Immunological Reviews | Q15724582 |
| P1476 | title | Thymocyte selection in Vav and IRF-1 gene-deficient mice | |
| P478 | volume | 165 |
| Q36071442 | CD4-CD8 lineage differentiation: Thpok-ing into the nucleus |
| Q34707439 | Epigenetic control of IRF1 responses in HIV-exposed seronegative versus HIV-susceptible individuals |
| Q78250112 | From basic immunobiology to the upcoming WHO-classification of tumors of the thymus. The Second Conference on Biological and Clinical Aspects of Thymic Epithelial Tumors and related recent developments |
| Q33753039 | Interferon regulatory factors: the next generation |
| Q24554307 | Regulatory and signaling properties of the Vav family |
| Q35551149 | Small-molecule cyclin-dependent kinase modulators |
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