Post-translational modifications and activation of p53 by genotoxic stresses

scientific article (publication date: May 2001)

Post-translational modifications and activation of p53 by genotoxic stresses is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1046/J.1432-1327.2001.02225.X
P3181OpenCitations bibliographic resource ID357913
P698PubMed publication ID11358490
P5875ResearchGate publication ID11978608

P2093author name stringAppella E
Anderson CW
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectgenotoxicityQ1009245
P304page(s)2764-72
P577publication date2001-05-01
P1433published inFEBS JournalQ1388041
P1476titlePost-translational modifications and activation of p53 by genotoxic stresses
P478volume268

Reverse relations

cites work (P2860)
Q2430638014-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation
Q5172627217β-Estradiol Protects Skeletal Myoblasts From Apoptosis Through p53, Bcl-2, and FoxO Families.
Q337399065-Lipoxygenase regulates senescence-like growth arrest by promoting ROS-dependent p53 activation
Q47137519A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence
Q28202389A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins
Q37834073A novel oncoprotein Pirh2: rising from the shadow of MDM2.
Q51116828A plausible model for bimodal p53 switch in DNA damage response.
Q42563644A pool of peptides extracted from wheat bud chromatin inhibits tumor cell growth by causing defective DNA synthesis
Q34572898A role for p53 in the frequency and mechanism of mutation
Q39991228A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model
Q35158037A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.
Q39246185A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways
Q34385189ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53.
Q36282831AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells
Q34753639ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage
Q53169706ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage.
Q40747424ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation
Q39961624ATR-dependent activation of p38 MAP kinase is responsible for apoptotic cell death in cells depleted of Cdc7.
Q79423580Ablation of a peptidyl prolyl isomerase Pin1 from p53-null mice accelerated thymic hyperplasia by increasing the level of the intracellular form of Notch1
Q35403658Absence of Wip1 partially rescues Atm deficiency phenotypes in mice
Q37543781Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
Q43970143Accumulation of an inactive form of p53 protein in cells treated with TNF alpha
Q37190330Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer
Q35071254Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage
Q34520098Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).
Q28215308Activation of p53 by protein inhibitor of activated Stat1 (PIAS1)
Q33562197Activation of p53 promotes renal injury in acute aristolochic acid nephropathy
Q34605518Activation of the p53 tumor suppressor protein
Q44746842Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer
Q39123275Alarmins: Feel the Stress.
Q36560030Altered binding site selection of p53 transcription cassettes by hepatitis B virus X protein
Q41679630Altered global gene expression profiles in human gastrointestinal epithelial Caco2 cells exposed to nanosilver
Q28218469Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity
Q38296791An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment
Q34326755An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.
Q40175886An essential role of human Ada3 in p53 acetylation
Q42803501Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cells.
Q40003995Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells
Q30433930Anxiety and the aging brain: stressed out over p53?
Q37011615Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2.
Q91650984Aristolochic Acid-Induced Genotoxicity and Toxicogenomic Changes in Rodents
Q51775699Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.
Q24519076Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors
Q40146768Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents
Q39922066Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine
Q34410831Attenuation of BPDE-induced p53 accumulation by TPA is associated with a decrease in stability and phosphorylation of p53 and downregulation of NFkappaB activation: role of p38 MAP kinase
Q39241369Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage
Q39430447Aurora A mediates cross-talk between N- and C-terminal post-translational modifications of p53
Q53022205BIRC6 promotes hepatocellular carcinogenesis: interaction of BIRC6 with p53 facilitating p53 degradation.
Q34775325BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination
Q73905084BRCA1: a scaffold for p53 response?
Q35082715Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc
Q38282236Battle against cancer: an everlasting saga of p53.
Q30492381Bax shuttling after neonatal hypoxia-ischemia: hyperoxia effects
Q38267182Biomarkers to assess the efficiency of treatment with platinum-based drugs: what can metallomics add?
Q41051383Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women
Q37683765C/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes
Q57461774C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event
Q39498948Cancer cells activate p53 in response to 10-formyltetrahydrofolate dehydrogenase expression
Q36697632Cell Differentiation and Checkpoint
Q27011729Cell cycle progression by the repression of primary cilia formation in proliferating cells
Q28201863Cell cycle regulation and p53 activation by protein phosphatase 2C alpha
Q41842385Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.
Q38351593Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses
Q99575524Central and Peripheral Actions of Melatonin on Reproduction in Seasonal and Continuous Breeding Mammals
Q38355401Central and carboxy‐terminal regions of human p53 protein are essential for interaction and complex formation with PARP‐1
Q53253493Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans.
Q24299815Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation
Q44938220Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS).
Q40408481Checkpoint kinase 1 regulates diallyl trisulfide-induced mitotic arrest in human prostate cancer cells
Q42089922Cheliensisin A inhibits EGF-induced cell transformation with stabilization of p53 protein via a hydrogen peroxide/Chk1-dependent axis
Q34149479Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
Q24607826Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells
Q29615385Cisplatin: mode of cytotoxic action and molecular basis of resistance
Q47756444Classification of in vitro genotoxicants using a novel multiplexed biomarker assay compared to the flow cytometric micronucleus test
Q33250663Cloning and characterization of the human gene DERP6, which activates transcriptional activities of p53.
Q47427915Co-expressions of casein kinase 2 (CK2) subunits restore the down-regulation of tubulin levels and disruption of microtubule structures caused by PrP mutants
Q41472341Combination of proteasomal inhibitors lactacystin and MG132 induced synergistic apoptosis in prostate cancer cells
Q30382652Comparing models of evolution for ordered and disordered proteins.
Q38787249Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination
Q38359899Constitutive DNase I hypersensitivity of p53-regulated promoters
Q28236097Control of the G2/M transition
Q40127941Cooperation between JNK1 and JNK2 in activation of p53 apoptotic pathway
Q34241074Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo
Q24655602Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2
Q42371971Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications.
Q34614596Crippling p53 activities via knock-in mutations in mouse models
Q38984847Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters
Q46985048Crosstalk between site-specific modifications on p53 and histone H3.
Q24311663Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
Q40114433Cyclosporine A induces senescence in renal tubular epithelial cells
Q34040102Cys-141 glutathionylation of human p53: Studies using specific polyclonal antibodies in cancer samples and cell lines
Q39777007Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis.
Q40203768DNA binding and selective gene induction by different forms of the p53 protein
Q36325437DNA damage checkpoints in mammals
Q42807917DNA damage promotes histone deacetylase 4 nuclear localization and repression of G2/M promoters, via p53 C-terminal lysines
Q38212164DNA damage response in plants: conserved and variable response compared to animals
Q24338364DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation
Q40696914DNA damage-induced translocation of the Werner helicase is regulated by acetylation
Q53598752DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner.
Q34353609DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.
Q26775866DNA repair and aging: the impact of the p53 family
Q33759285DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
Q42435054DNA-dependent acetylation of p53 by the transcription coactivator p300.
Q24339462DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]
Q40775865Decision Making by p53: Life versus Death
Q34089507Deconstructing PML-induced premature senescence
Q44867450Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function
Q46772713Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.
Q37524264Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.
Q36516076Defective p53 engagement after the induction of DNA damage in cells deficient in topoisomerase 3beta
Q40626844Defective p53 post-translational modification required for wild type p53 inactivation in malignant epithelial cells with mdm2 gene amplification
Q50316561Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis
Q28578074Delta(9)-tetrahydrocannabinol regulates the p53 post-translational modifiers Murine double minute 2 and the Small Ubiquitin MOdifier protein in the rat brain
Q29619786Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
Q37351323Diabetes and apoptosis: neural crest cells and neural tube.
Q28567929Diabetes-induced oxidative DNA damage alters p53-p21CIP1/Waf1 signaling in the rat testis
Q40439624Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination
Q34459620Differential effects of 5-aminolaevulinic acid photodynamic therapy and psoralen + ultraviolet A therapy on p53 phosphorylation in normal human skin in vivo.
Q35290386Differential modulatory effects of GSK-3β and HDM2 on sorafenib-induced AIF nuclear translocation (programmed necrosis) in melanoma
Q34443272Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.
Q40540255Differentiation-induced radioresistance in muscle cells
Q43690470Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway
Q42724753Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.
Q37343700Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.
Q44830479Discrete signaling pathways participate in RB-dependent responses to chemotherapeutic agents
Q35078774Disrupting TP53 in mouse models of human cancers
Q39310490Disruption of the p53-p21 pathway inhibits efficiency of the lytic-replication cycle of herpes simplex virus type 2 (HSV-2).
Q39848157Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein
Q36908396Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation.
Q36117542Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.
Q42035568Does control of mutant p53 by Mdm2 complicate cancer therapy?
Q34736706Does p53 affect organismal aging?
Q38150426Doxorubicin-induced death in tumour cells and cardiomyocytes: is autophagy the key to improving future clinical outcomes?
Q34181652Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells
Q39109039E2F1 activates p53 transcription through its distal site and participates in apoptosis induction in HPV-positive cells.
Q34284001E2F1 induces phosphorylation of p53 that is coincident with p53 accumulation and apoptosis
Q34869507EDD inhibits ATM-mediated phosphorylation of p53.
Q40150740Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells
Q36377767Effect of maternal Tp53 gene G412C polymorphism on neural tube defects: A study from North India
Q37729128Effects of NS1 variants of H5N1 influenza virus on interferon induction, TNFalpha response and p53 activity
Q40339093Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells
Q41863996Effects of gamma irradiation on cell cycle, apoptosis and telomerase activity in p53 wild-type and deficient HCT116 colon cancer cell lines
Q64387009Effects of l-ascorbic acid on two cycles of cisplatin-induced DNA double-strand breaks and phosphorylation of p53 in the liver
Q38590435Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes
Q34097322Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta
Q24306430Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
Q79610624Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus
Q41850633Etoposide induces cell death via mitochondrial-dependent actions of p53.
Q34545941Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradation
Q40290190Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.
Q37277722Expression and clinical significance of the nin one binding protein and p38 MAPK in prostate carcinoma
Q28266839Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor
Q46965910Expression of RAD51, BRCA1 and P53 does not correlate with cellular radiosensitivity of normal human fibroblasts
Q47336389Expression of SIRT1 and P53 in Rat Lens Epithelial cells in Experimentally Induced DM.
Q54770033Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.
Q44887454Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures
Q58080272Extensive Characterization of Heavily Modified Histone Tails by 193 nm Ultraviolet Photodissociation Mass Spectrometry via a Middle–Down Strategy
Q36659141FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage
Q35861153FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53.
Q35098597Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity
Q39340920Fludarabine nucleoside induces accumulations of p53, p63 and p73 in the nuclei of human B-lymphoid cell lines, with cytosolic and mitochondrial increases in p53.
Q29248201Functional activation of mutant p53V172F by platinum analogs in cisplatin-resistant human tumor cells is dependent on serine-20 phosphorylation
Q33863075Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
Q41832274Functional census of mutation sequence spaces: the example of p53 cancer rescue mutants.
Q39080969Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling
Q36661575Gene activation by bioactive glasses
Q23912208Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubes
Q82489428Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery
Q42347022Gene expression profiling of human blastocysts from in vivo and 'rescue IVM' with or without melatonin treatment
Q34417108Genotoxic and non-genotoxic pathways of p53 induction
Q47706011Genotoxic effects of food contact recycled paperboard extracts on two human hepatic cell lines
Q34320186Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation
Q38867373Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A.
Q40421589HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage
Q33292477HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.
Q24338503HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function
Q80603062HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway
Q24301527HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
Q89634774Harnessing the vulnerabilities of p53 mutants in lung cancer - Focusing on the proteasome: a new trick for an old foe?
Q43047407Hepatitis C virus core protein expression leads to biphasic regulation of the p21 cdk inhibitor and modulation of hepatocyte cell cycle
Q39641751High glucose promotes nascent nephron apoptosis via NF-kappaB and p53 pathways
Q26775761Histone deacetylase inhibitors in castration-resistant prostate cancer: molecular mechanism of action and recent clinical trials
Q28082123Histone methylation modifiers in cellular signaling pathways
Q40598361Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis
Q37107268Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense
Q36879036How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Q35700328How the nucleolar sequestration of p53 protein or its interplayers contributes to its (re)-activation
Q24297146Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
Q28386709Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis
Q45729740Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription
Q39904691Human inhibitor of growth 1 inhibits hepatoma cell growth and influences p53 stability in a variant-dependent manner
Q40890409Human papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways
Q47784931Human papillomavirus type 77 E6 protein selectively inhibits p53-dependent transcription of proapoptotic genes following UV-B irradiation.
Q27004438Hydrogen peroxide sensing, signaling and regulation of transcription factors
Q38914905Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells
Q40155261Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma
Q38310551Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis
Q21245725Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity
Q37137685Hypoxia ischemia-mediated cell death in neonatal rat brain
Q24529998ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation
Q37212448Identification of new p53 acetylation sites in COS-1 cells
Q91980040Image analysis of mechanistic protein biomarkers for the characterization of genotoxicants: aneugens, clastogens and ROS inducers
Q30460515Immunohistochemical detection of P53 and Mdm2 in vitiligo
Q37258978Impairment of p53 acetylation, stability and function by an oncogenic transcription factor
Q34227874Increased DNA methyltransferase 3b (Dnmt3b)-mediated CpG island methylation stimulated by oxidative stress inhibits expression of a gene required for neural tube and neural crest development in diabetic pregnancy.
Q40747033Increased K+ efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3beta in prostate cancer cells
Q46976925Increased glomerular cell (podocyte) apoptosis in rats with streptozotocin-induced diabetes mellitus: role in the development of diabetic glomerular disease.
Q37527427Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.
Q34344606Induction and bypass of p53 during productive infection by polyomavirus
Q37014644Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites
Q40639210Induction of p53-dependent activation of the human proliferating cell nuclear antigen gene in chromatin by ionizing radiation.
Q34324710Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells
Q40340028Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
Q36964274Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage
Q33781782Inhibition of cell division by the human cytomegalovirus IE86 protein: role of the p53 pathway or cyclin-dependent kinase 1/cyclin B1.
Q34434681Inhibition of the ATM/p53 signal transduction pathway by Kaposi's sarcoma-associated herpesvirus interferon regulatory factor 1.
Q90146998Inhibitory effect of Korean Red Ginseng extract on DNA damage response and apoptosis in Helicobacter pylori-infected gastric epithelial cells
Q48185356Inhibitory effects of different substituted transition metal-based krebs-type sandwich structures on human hepatocellular carcinoma cells.
Q38177769Insights into wild-type and mutant p53 functions provided by genetically engineered mice
Q21129288Interactomic and pharmacological insights on human sirt-1
Q24310030Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53
Q37456901Intracellular regulation of matrix metalloproteinase-2 activity: new strategies in treatment and protection of heart subjected to oxidative stress
Q37932415Intrinsically disordered regions as affinity tuners in protein-DNA interactions
Q43205198Isoform specific phosphorylation of p53 by protein kinase CK1.
Q54190030JHDM1B expression regulates ribosome biogenesis and cancer cell growth in a p53 dependent manner.
Q27320018JNK Inhibition Inhibits Lateral Line Neuromast Hair Cell Development
Q44480063Jun N-terminal kinase activation and upregulation of p53 and p21(WAF1/CIP1) in selenite-induced apoptosis of regenerating liver
Q34409029KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes
Q33894543Ku86 is essential in human somatic cells
Q39386130Lack of p53 induction in fish cells by model chemotherapeutics
Q27009209Lessons learned from next-generation sequencing in head and neck cancer
Q40570035Limited role of N-terminal phosphoserine residues in the activation of transcription by p53.
Q41488339Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.
Q28205515Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53
Q62448159Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain
Q35002156Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a
Q28477245Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis
Q33290438Loss of robustness and addiction to IGF1 during early keratinocyte transformation by human Papilloma virus 16
Q41701656Low dose arsenite confers resistance to UV induced apoptosis via p53-MDM2 pathway in ketatinocytes
Q38769335Lysines in the tetramerization domain of p53 selectively modulate G1 arrest
Q40323831MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
Q24537700MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
Q24650130Mapping the interactions of the p53 transactivation domain with the KIX domain of CBP
Q37099799Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells
Q38059700Mdm2 and MdmX as Regulators of Gene Expression
Q35857003Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest
Q35572466Mdm2: A regulator of cell growth and death
Q42141601Mechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment
Q40954179Mechanistic clues to the protective effect of chrysin against doxorubicin-induced cardiomyopathy: Plausible roles of p53, MAPK and AKT pathways
Q35853626Mediterranean diet supplemented with coenzyme Q10 induces postprandial changes in p53 in response to oxidative DNA damage in elderly subjects.
Q24307834Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylation
Q40103473Methylation-acetylation interplay activates p53 in response to DNA damage
Q30374671Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.
Q52624676Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway.
Q33249208Mode of interaction between butyroyloxymethyl-diethyl phosphate (AN-7) and doxorubicin in MCF-7 and resistant MCF-7/Dx cell lines
Q34082945Modeling the basal dynamics of p53 system
Q42484105Modeling the heterogeneity of p53 dynamics in DNA damage response
Q33471807Modeling the role of p53 pulses in DNA damage- induced cell death decision.
Q29615657Modes of p53 regulation
Q38337938Modification of serine 392 is a critical event in the regulation of p53 nuclear export and stability
Q45302322Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin
Q83235743Modulation of p53 by mitogen-activated protein kinase pathways and protein kinase C delta during avian reovirus S1133-induced apoptosis
Q40532008Modulation of p53 cellular function and cell death by African swine fever virus
Q24337822Modulation of p53 function by SET8-mediated methylation at lysine 382
Q37926477Molecular mechanisms of cisplatin resistance
Q24295012Monoubiquitylation promotes mitochondrial p53 translocation
Q33752174Mouse models of p53 functions
Q41890892Multiple stress signals activate mutant p53 in vivo
Q35018012Multisite phosphorylation provides sophisticated regulation of transcription factors
Q36033101Murine protein serine-threonine kinase 38 activates p53 function through Ser15 phosphorylation
Q34277066Mutation of mouse p53 Ser23 and the response to DNA damage
Q53623512Mutational analysis of the p53 core domain L1 loop.
Q24337056NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner
Q45171395Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation
Q47881235Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y.
Q24303893Negative regulation of p53 functions by Daxx and the involvement of MDM2
Q34758670New insights into p53 activation
Q44893903Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and Bax-dependent pathways
Q33361623Noncanonical DNA motifs as transactivation targets by wild type and mutant p53
Q51759892Notch signaling and neuronal death in stroke.
Q28262425Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?
Q47918094Nuclear localization of Y-box factor YB1 requires wild-type p53
Q36190104Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells.
Q38107795Nucleolar control of p53: a cellular Achilles' heel and a target for cancer therapy.
Q37833502Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases.
Q37424634Nucleophosmin sets a threshold for p53 response to UV radiation
Q38656647Nutlin-3, A P53-Mdm2 Antagonist For Nasopharyngeal Carcinoma Treatment
Q35785876Of flies and men; p53, a tumour suppressor
Q33406279Oscillations of the p53-Akt network: implications on cell survival and death
Q38045766Overexpression of p53 protein in human tumors
Q35250855P53 and p73 differ in their ability to inhibit glucocorticoid receptor (GR) transcriptional activity
Q28513393PACT is a negative regulator of p53 and essential for cell growth and embryonic development
Q35006415PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells.
Q36358632PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells
Q28080023PXR variants: the impact on drug metabolism and therapeutic responses
Q44827793Pathway analysis using random forests classification and regression
Q37212228Perspectives for cancer prevention with natural compounds
Q34198570Phosphatases in the cellular response to DNA damage.
Q33197915Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
Q24701734Phosphorylation of Single Stranded RNA Virus Proteins and Potential for Novel Therapeutic Strategies
Q40506599Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis
Q33693493Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis
Q24685095Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1
Q24322729Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression
Q44513266Phosphorylation site interdependence of human p53 post-translational modifications in response to stress
Q39097149Phosphorylation: Implications in Cancer
Q28609772Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
Q24338733Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation
Q36251670Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells
Q35450753Poly(ADP-ribosyl)ation of p53 contributes to TPEN-induced neuronal apoptosis
Q39764452Porcine circovirus type 2 ORF3 protein competes with p53 in binding to Pirh2 and mediates the deregulation of p53 homeostasis
Q39669697Post-translational Modification of p53 by Ubiquitin
Q35930703Post-translational modification of p53 in tumorigenesis
Q34173442Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells
Q33899450Posttranslational modification of p53: cooperative integrators of function
Q36527456Posttranslational phosphorylation of mutant p53 protein in tumor development
Q36288249Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma
Q40154434Prevention of p53 degradation in human MCF-7 cells by proteasome inhibitors does not mimic the action of roscovitine
Q36082116Processive phosphorylation: mechanism and biological importance
Q34831541Programmed cell death in amyotrophic lateral sclerosis
Q48193766Protective effect of metoclopramide against organophosphate-induced apoptosis in the murine skin fibroblast L929.
Q37800060Protein acetylation within the cellular response to radiation.
Q36379368Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML.
Q28749465Proximal events in 7,12-dimethylbenz[a]anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling
Q35927931Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation
Q36685003Quantitative proteomics analysis of the effects of ionizing radiation in wild type and p53 K317R knock-in mouse thymocytes
Q44374509Questioning the role of checkpoint kinase 2 in the p53 DNA damage response
Q39597077RNA content in the nucleolus alters p53 acetylation via MYBBP1A.
Q39952719Radiobiologic response of medulloblastoma cell lines: involvement of beta-catenin?
Q28537881Reactive oxygen species mediate Epstein-Barr virus reactivation by N-methyl-N'-nitro-N-nitrosoguanidine
Q37285111Reactive oxygen species-independent oxidation of thioredoxin in hypoxia: inactivation of ribonucleotide reductase and redox-mediated checkpoint control
Q34794627Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis
Q38355560Recognition of DNA modified by antitumor cisplatin by “latent” and “active” protein p53
Q28214575Recombinational DNA repair and human disease
Q37861632Redox modulation of p53: mechanisms and functional significance
Q41619942Regulation of Eaf2 in mouse lens cells apoptosis induced by ultraviolet radiation
Q42506403Regulation of P53 stability in p53 mutated human and mouse hepatoma cells
Q38287796Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes
Q28210189Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2
Q24311514Regulation of p53 activity through lysine methylation
Q40346478Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death
Q35009505Regulation of p53 by jagged1 contributes to angiotensin II-induced impairment of myocardial angiogenesis
Q35149921Regulation of p53 function by lysine methylation
Q74285071Regulation of p53 sequence-specific DNA-binding by covalent poly(ADP-ribosyl)ation
Q35047240Regulation of tumor suppressors by nuclear-cytoplasmic shuttling
Q28586399Regulation of ubiquitin ligase dynamics by the nucleolus
Q38739516Renal Protective Effects of 17β-Estradiol on Mice with Acute Aristolochic Acid Nephropathy
Q35116649Renewing the debate over the p53 apoptotic response
Q35005937Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis
Q27006998Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53
Q44635839Resistance to UV‐induced apoptosis in human keratinocytes during accelerated senescence is associated with functional inactivation of p53
Q43101429Response to DNA damage: why do we need to focus on protein phosphatases?
Q39032730Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells
Q38333341Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells.
Q37831934Resveratrol and apoptosis
Q41816825Resveratrol inhibits β-amyloid-induced neuronal apoptosis via regulation of p53 acetylation in PC12 cells
Q35075426Retracted: Residues 240-250 in the C-Terminus of the Pirh2 Protein Complement the Function of the RING Domain in Self-Ubiquitination of the Pirh2 Protein
Q37000240Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling
Q36863596Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells
Q38883419Role of p53 isoforms and aggregations in cancer
Q39687338Role of tumor suppressor p53 domains in selective binding to supercoiled DNA.
Q37518662Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest
Q38926772SIRT1 Protects Human Lens Epithelial Cells Against Oxidative Stress by Inhibiting p53-Dependent Apoptosis
Q34341091SIRT1 and p53, effect on cancer, senescence and beyond
Q40182201SMAR1-derived P44 peptide retains its tumor suppressor function through modulation of p53.
Q48166923SO2 inhalation modulates the expression of apoptosis-related genes in rat hippocampus via its derivatives in vivo
Q97516927SUMOylation in α-Synuclein Homeostasis and Pathology
Q91931124Selection and characterization of FcεRI phospho-ITAM specific antibodies
Q35206381Signaling to p53: ribosomal proteins find their way.
Q28481334Simulating molecular mechanisms of the MDM2-mediated regulatory interactions: a conformational selection model of the MDM2 lid dynamics
Q40251384Single-nucleotide polymorphisms in the p53 pathway
Q24303857Sirtuin functions in health and disease
Q37806669Small-Molecule Inhibitors of the p53-MDM2 Interaction
Q40005223Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells
Q40630934Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents.
Q52827047Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
Q36185135Stress-mediated Sin3B activation leads to negative regulation of subset of p53 target genes.
Q35569661Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding
Q92327944Stretching magnitude-dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis
Q24653926Structural basis for p300 Taz2-p53 TAD1 binding and modulation by phosphorylation
Q40373998Structural details on mdm2-p53 interaction
Q27658473Structure of the Taz2 domain of p300: insights into ligand binding
Q46289632Study of p53 expression and post-transcriptional modifications after GSM-900 radiofrequency exposure of human amniotic cells.
Q37423898Suberoylanilide hydroxamic acid represses glioma stem-like cells.
Q37612047Substrate Stiffness Influences Doxorubicin-Induced p53 Activation via ROCK2 Expression.
Q24551106Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response
Q35967111Surf the post-translational modification network of p53 regulation
Q24292042TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence
Q50088140TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice
Q53809236TP53 overexpression in recurrent endometrial carcinoma.
Q34568607TP53: a key gene in human cancer.
Q90232350Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma
Q34011368Targeting protein inactivation through an oligomerization chain reaction
Q37728628Targets and consequences of protein SUMOylation in neurons.
Q51864239Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging.
Q40700411Temperature-sensitive ovarian carcinoma cell line (OvBH-1).
Q44374511The Chk2 tumor suppressor is not required for p53 responses in human cancer cells
Q36149280The DNA binding and accumulation of p53 from breast cancer cell lines and the link with serine 15 phosphorylation
Q34350684The Epstein-Barr virus immediate-early protein BZLF1 regulates p53 function through multiple mechanisms
Q27664677The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression
Q36430168The P53 pathway: what questions remain to be explored?
Q47307122The Roles of P53 and its Family Proteins, P63 and P73, in the DNA Damage Stress Response in Organogenesis Stage Mouse Embryos.
Q24297633The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
Q36497975The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts.
Q34519833The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes
Q37687474The cell death machinery governed by the p53 tumor suppressor in response to DNA damage
Q36443523The complexity of p53 stabilization and activation
Q42806263The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.
Q37859721The dual role of p53: DNA protection and antioxidant.
Q26851138The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2
Q34199692The impact of acetylation and deacetylation on the p53 pathway
Q36649149The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
Q33343721The metastasis-associated protein S100A4 exists in several charged variants suggesting the presence of posttranslational modifications
Q28201932The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity
Q36661071The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells
Q92062954The multiple mechanisms that regulate p53 activity and cell fate
Q37596345The nucleolar protein Myb-binding protein 1A (MYBBP1A) enhances p53 tetramerization and acetylation in response to nucleolar disruption
Q35078417The p53 network in head and neck cancer
Q34935933The p53 network in lung carcinogenesis.
Q28206425The processing of Holliday junctions by BLM and WRN helicases is regulated by p53
Q24295229The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
Q44480812The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation
Q47135845The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation
Q44418946The role of p53 deacetylation in p21Waf1 regulation by laminar flow
Q24337220The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines
Q24293463The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain
Q52651121Tip60: updates.
Q30394774Towards understanding the crosstalk between protein post-translational modifications: Homo- and heterotypic PTM pair distances on protein surfaces are not random
Q52940731Toxicogenomic responses of human liver HepG2 cells to silver nanoparticles.
Q27679224Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code
Q35127007Transcription factor p53 influences microglial activation phenotype
Q38344277Transcription factors and cognate signalling cascades in the regulation of autophagy
Q40251375Transcriptional regulation by p53 and p73.
Q36436698Transcriptional regulation by p53: one protein, many possibilities
Q36430154Translational research? Ribosome integrity and a new p53 tumor suppressor checkpoint
Q24796110Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide
Q37412688Tumor suppressive functions of p53
Q35162377Tumour suppressors--a fly's perspective
Q33764044Two distinct motifs within the p53 transactivation domain bind to the Taz2 domain of p300 and are differentially affected by phosphorylation
Q24296967USP10 regulates p53 localization and stability by deubiquitinating p53
Q33707419USP7/HAUSP Promotes the Sequence-Specific DNA Binding Activity of p53
Q40724097UVB-mediated activation of p38 mitogen-activated protein kinase enhances resistance of normal human keratinocytes to apoptosis by stabilizing cytoplasmic p53.
Q53467454Ubiquitin over-expression promotes E6AP autodegradation and reactivation of the p53/MDM2 pathway in HeLa cells.
Q35089377Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
Q28118867Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation
Q34322386Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?
Q33300777Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer
Q43254285Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.
Q37748214Using mice to examine p53 functions in cancer, aging, and longevity
Q37087404Versatile functions of p53 protein in multicellular organisms
Q49700166Vitamin D receptor deficit induces activation of renin angiotensin system via SIRT1 modulation in podocytes
Q34989369Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress
Q39807046Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression.
Q39523533XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification
Q37484473YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.
Q53622636c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF.
Q24338336hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes
Q36560478hnRNP Q regulates translation of p53 in normal and stress conditions
Q36064954miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis
Q35648431p21Waf1/Cip1 and the prevention of oxidative stress
Q35941622p38 MAP kinase's emerging role as a tumor suppressor
Q33734522p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.
Q35679117p53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo
Q41811657p53 Loses grip on PIK3CA expression leading to enhanced cell survival during platinum resistance
Q44607626p53 N-terminal Ser-15 approximately P and Ser-20 approximately P levels in squamous cell lung cancer after radio/chemotherapy.
Q28079390p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept
Q36088355p53 RNA interactions: new clues in an old mystery
Q36777320p53 alterations in human cancer: more questions than answers.
Q53561930p53 and Delta Np63 alpha differentially bind and regulate target genes involved in cell cycle arrest, DNA repair and apoptosis.
Q44592743p53 and mitogen-activated protein kinase pathway protein profiles in fresh and frozen spermatozoa
Q33569713p53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element
Q37376012p53 polymorphisms: cancer implications
Q28210026p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex
Q27302884p53 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion
Q39061575p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3.
Q42362115p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance
Q34515770p53, p63 and p73--solos, alliances and feuds among family members
Q42098836p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.
Q44945710p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress
Q38247164p53-independent effects of Mdm2.
Q36846083p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo
Q24338379p53: 25 years after its discovery
Q38333104p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.
Q38319824tumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes

Search more.