Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases.

scientific article published on 31 January 2011

Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2010.646
P698PubMed publication ID21278791

P50authorMyriam AlcalayQ58883437
P2093author name stringP G Pelicci
E Colombo
P2860cites workNucleolar protein B23 has molecular chaperone activitiesQ22009438
Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplicationQ24290438
Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperoneQ24291795
Nucleophosmin sets a threshold for p53 response to UV radiationQ37424634
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significanceQ38321981
Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activityQ39025073
ARF function does not require p53 stabilization or Mdm2 relocalizationQ39675987
Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.Q39771508
Acetylated NPM1 localizes in the nucleoplasm and regulates transcriptional activation of genes implicated in oral cancer manifestationQ39828468
Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stabilityQ39883157
SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosminQ39959494
Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcriptionQ39997668
Influence of nucleophosmin/B23 on DNA binding and transcriptional activity of the androgen receptor in prostate cancer cellQ40044845
Involvement of nPKC-MAPK pathway in the decrease of nucleophosmin/B23 during megakaryocytic differentiation of human myelogenous leukemia K562 cells.Q40143098
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.Q40321232
Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cellsQ40407663
Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.Q40525549
Stability of nucleolar versus non-nucleolar forms of human p14(ARF).Q40529860
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.Q40613625
Nucleolar Arf tumor suppressor inhibits ribosomal RNA processingQ40666241
Nucleophosmin (B23) targets ARF to nucleoli and inhibits its functionQ41036948
Assisted protein foldingQ41397424
Identification of Ag-NOR Proteins, Markers of Proliferation Related to Ribosomal Gene ActivityQ41441034
Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcriptionQ41813111
Evidence for the ability of nucleophosmin/B23 to bind ATPQ42032009
Nucleophosmin/B23 regulates ubiquitin dynamics in nucleoli by recruiting deubiquitylating enzyme USP36.Q42126825
Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutantQ42804288
A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin, and ARF.Q42806442
Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor proteinQ42809562
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradationQ24293167
Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligaseQ24295278
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiationQ24298255
The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtypeQ24299527
Nucleophosmin regulates the stability and transcriptional activity of p53Q24300176
Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3Q24301019
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplicationQ24305141
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplicationQ24309486
Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKRQ24311493
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processingQ24312057
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosomeQ24315004
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.Q24321321
Nucleophosmin is essential for ribosomal protein L5 nuclear exportQ24322766
PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoliQ24329068
Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 geneQ24337067
Phosphoproteome analysis of the human mitotic spindleQ24547339
N-terminal polyubiquitination and degradation of the Arf tumor suppressorQ24561681
p53-independent functions of the p19(ARF) tumor suppressorQ24600863
Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23Q24629309
Shuttling imbalance of MLF1 results in p53 instability and increases susceptibility to oncogenic transformationQ24642177
Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survivalQ24650827
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosminQ24652323
Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteasesQ24657753
DNMT3A Mutations in Acute Myeloid LeukemiaQ27559610
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Structural Consequences of Nucleophosmin Mutations in Acute Myeloid LeukemiaQ27650716
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotypeQ27824827
Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutationsQ27824843
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotypeQ27824844
Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).Q27824861
Mutations and treatment outcome in cytogenetically normal acute myeloid leukemiaQ27851430
Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.Q27851460
Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML.Q27851476
The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: ...Q27856359
Tumor suppression by Ink4a-Arf: progress and puzzlesQ28207959
The human CENP-A centromeric nucleosome-associated complexQ28235264
CTCF tethers an insulator to subnuclear sites, suggesting shared insulator mechanisms across speciesQ28242132
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphomaQ28250347
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assemblyQ28271991
MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemiaQ28272533
A B-cell-specific DNA Recombination ComplexQ28274822
Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemiasQ28301353
ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathwayQ28506702
Defining the molecular basis of Arf and Hdm2 interactionsQ28507075
Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CADQ28567152
Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonucleaseQ28568636
Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase alpha activityQ28571658
Protein B23/nucleophosmin/numatrin nuclear dynamics in relation to protein kinase CK2 and apoptotic activity in prostate cellsQ28574087
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gammaQ28589317
Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processingQ28590167
Role of nucleophosmin in embryonic development and tumorigenesisQ28591282
Nucleophosmin is required for DNA integrity and p19Arf protein stabilityQ28593126
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growthQ28910214
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalizationQ29614701
Post-translational modifications and activation of p53 by genotoxic stressesQ29615659
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpointsQ29617405
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replicationQ29617915
Restoration of p53 function leads to tumour regression in vivoQ29618727
Nucleolar Arf sequesters Mdm2 and activates p53Q29620244
Major nucleolar proteins shuttle between nucleus and cytoplasmQ29620425
Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classificationQ33254865
Nucleophosmin is a novel Bax chaperone that regulates apoptotic cell death.Q33261981
Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutationsQ33327492
Nucleophosmin is selectively deposited on mRNA during polyadenylationQ33611294
NPM phosphorylation stimulates Cdk1, overrides G2/M checkpoint and increases leukemic blasts in miceQ33615300
Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fractionQ33722630
Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instabilityQ33773430
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse modelQ33806066
Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Q33806096
Sumoylation induced by the Arf tumor suppressor: a p53-independent functionQ33821331
Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.Q33940550
The ribonuclease activity of nucleolar protein B23.Q34775233
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.Q34864658
Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.Q34942101
Nuclear transport as a target for cell growthQ35058962
INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.Q35208402
Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survivalQ35834460
Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome predictionQ35848938
The incidence and clinical significance of nucleophosmin mutations in childhood AML.Q35901721
Pathobiology of ALK+ anaplastic large-cell lymphomaQ36007756
Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouseQ36508976
Nucleophosmin: a versatile molecule associated with hematological malignancies.Q36597677
New insights into the nucleophosmin/nucleoplasmin family of nuclear chaperonesQ36691603
Influence of new molecular prognostic markers in patients with karyotypically normal acute myeloid leukemia: recent advancesQ36719212
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulationQ36842905
Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphomaQ36851904
TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in miceQ36868764
Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiationQ36898985
Histone chaperones: 30 years from isolation to elucidation of the mechanisms of nucleosome assembly and disassemblyQ36978890
Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformationQ36999887
Identification of nuclear export inhibitors with potent anticancer activity in vivoQ37081966
Nucleophosmin blocks mitochondrial localization of p53 and apoptosisQ37269134
Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expressionQ42820510
Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutantsQ42826742
Recruitment of phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugatesQ42936127
Late relapse of acute myeloid leukemia with mutated NPM1 after eight years: evidence of NPM1 mutation stabilityQ43188148
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.Q43594592
Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cellsQ43757315
NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.Q44211040
NPM1 mutations in therapy-related acute myeloid leukemia with uncharacteristic featuresQ44257677
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cellsQ44714283
B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.Q44931323
Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.Q45083325
Successful all-trans retinoic acid treatment of acute promyelocytic leukemia in a patient with NPM/RAR fusionQ46910183
Nucleophosmin is required for chromosome congression, proper mitotic spindle formation, and kinetochore-microtubule attachment in HeLa cellsQ47275104
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic featuresQ47834838
Identification of nucleophosmin/B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins.Q48352383
Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albuminQ50335728
Nucleophosmin regulates cell cycle progression and stress response in hematopoietic stem/progenitor cellsQ50941059
RNA aptamers interfering with nucleophosmin oligomerization induce apoptosis of cancer cellsQ51926763
B23 acts as a nucleolar stress sensor and promotes cell survival through its dynamic interaction with hnRNPU and hnRNPA1.Q52598299
The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.Q53332784
Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosisQ53520827
C-terminal nucleophosmin mutations are uncommon in chronic myeloid disordersQ53622524
Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signalQ53778913
Increased expression of a COOH-truncated nucleophosmin resulting from alternative splicing is associated with cellular resistance to ionizing radiation in HeLa cells.Q53960148
NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.Q54546998
Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements.Q54627394
The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia.Q54693168
Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinaseQ57985211
Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemiaQ58882378
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenanceQ58882381
CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised miceQ60171380
Modification of Nucleolar Protein B23 after Exposure to Ionizing RadiationQ71947164
Over-expression of nucleophosmin/B23 decreases the susceptibility of human leukemia HL-60 cells to retinoic acid-induced differentiation and apoptosisQ73131404
Mapping the functional domains of nucleolar protein B23Q73829236
Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiationQ77441044
Role of protein kinase CK2 phosphorylation in the molecular chaperone activity of nucleolar protein b23Q78744755
Identification and functional characterization of a cytoplasmic nucleophosmin leukaemic mutant generated by a novel exon-11 NPM1 mutationQ79777403
Effects of interphase and mitotic phosphorylation on the mobility and location of nucleolar protein B23Q80121350
Nek2A kinase regulates the localization of numatrin to centrosome in mitosisQ80606618
B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrestQ81255797
Therapy-related acute myeloid leukaemia with mutated NPM1: treatment induced or de novo in origin?Q81270867
Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotypeQ81712971
Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemiaQ81919725
NPM1 mutations in myelodysplastic syndromes and acute myeloid leukemia with normal karyotypeQ83296699
A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemiasQ84386374
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectcomplex networkQ665189
P304page(s)2595-2609
P577publication date2011-01-31
P13046publication type of scholarly workreview articleQ7318358
P1433published inOncogeneQ1568657
P1476titleNucleophosmin and its complex network: a possible therapeutic target in hematological diseases
P478volume30

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cites work (P2860)
Q3696102214-3-3γ Prevents Centrosome Amplification and Neoplastic Progression
Q28543087A novel phthalimide derivative, TC11, has preclinical effects on high-risk myeloma cells and osteoclasts
Q24297713A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF
Q34545871A redox mechanism underlying nucleolar stress sensing by nucleophosmin
Q34227622AKT regulates NPM dependent ARF localization and p53mut stability in tumors
Q42580457AML cells carrying NPM1 mutation are resistant to nucleophosmin displacement from nucleoli caused by the G-quadruplex ligand TmPyP4.
Q91895710APE1 and NPM1 protect cancer cells from platinum compounds cytotoxicity and their expression pattern has a prognostic value in TNBC
Q36328692Aberrant expression of ALK and EZH2 in Merkel cell carcinoma
Q38535094Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP
Q47242292B23/nucleophosmin interacts with bovine immunodeficiency virus Rev protein and facilitates viral replication
Q38242945Berberine, an epiphany against cancer.
Q35857057Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.
Q42635149Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
Q38961549Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program
Q37932085Current findings for recurring mutations in acute myeloid leukemia
Q92144514DNA damage corrects the aberrant cytoplasmic localisation of nucleophosmin in NPM1 mutated acute myeloid leukaemia
Q42321110Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia.
Q39062444Different functions of HOPS isoforms in the cell: HOPS shuttling isoform is determined by RIP cleavage system
Q42290643Downregulation of NPM expression by Her-2 reduces resistance of gastric cancer to oxaliplatin
Q35504874Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B.
Q34645436Dysregulation of RNA polymerase I transcription during disease.
Q64078574Emerging Role of the Nucleolar Stress Response in Autophagy
Q27026649Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical example
Q36116345Expression of Nucleophosmin/NPM1 correlates with migration and invasiveness of colon cancer cells
Q42546269Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD.
Q37141959Far upstream element binding protein 1: a commander of transcription, translation and beyond
Q39126232Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer
Q39129437Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.
Q30032659GLTSCR2 is an upstream negative regulator of nucleophosmin in cervical cancer
Q39298018Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19 Arf network.
Q35343013Humoral autoimmune response to nucleophosmin in the immunodiagnosis of hepatocellular carcinoma
Q33877215Identification of Microprotein-Protein Interactions via APEX Tagging
Q47239822Identification of a novel nucleophosmin-interaction motif in the tumor suppressor p14arf.
Q37553863Identification of chaperones in a MPP+-induced and ATRA/TPA-differentiated SH-SY5Y cell PD model
Q35981110Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes
Q35072625Impact of NPM, TFF3 and TACC1 on the prognosis of patients with primary gastric cancer
Q64259145Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Q35599868Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties
Q39181954Interactomic approach for evaluating nucleophosmin‐binding proteins as biomarkers for Ewing's sarcoma
Q34683193Loss of nucleolar histone chaperone NPM1 triggers rearrangement of heterochromatin and synergizes with a deficiency in DNA methyltransferase DNMT3A to drive ribosomal DNA transcription
Q26750653Molecules that target nucleophosmin for cancer treatment: an update
Q34086334Mutated NPM1 in patients with acute myeloid leukemia in remission and relapse
Q89777322Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia
Q39997449Myeloid leukemia factor: a return ticket from human leukemia to fly hematopoiesis
Q42254184NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases.
Q83117850NPM-MLF1 synergizes with Npm haploinsufficiency to enhance myeloid progenitor activity
Q38820099NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape.
Q39113519NPM–RAR, not the RAR–NPM reciprocal t(5;17)(q35;q21) acute promyelocytic leukemia fusion protein, inhibits myeloid differentiation
Q37931279Nuclear phosphoinositides and their roles in cell biology and disease
Q92932241Nucleolar Stress: hallmarks, sensing mechanism and diseases
Q36781105Nucleolar repression facilitates initiation and maintenance of senescence
Q34183329Nucleolar stress with and without p53.
Q34047444Nucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair
Q50074509Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.
Q38824781Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways
Q56058269Nucleolus: Structure and Function
Q24316988Nucleophosmin (NPM1/B23) interacts with activating transcription factor 5 (ATF5) protein and promotes proteasome- and caspase-dependent ATF5 degradation in hepatocellular carcinoma cells
Q39174595Nucleophosmin 1, upregulated in adenomas and cancers of the colon, inhibits p53‐mediated cellular senescence
Q36534039Nucleophosmin Mutants Promote Adhesion, Migration and Invasion of Human Leukemia THP-1 Cells through MMPs Up-regulation via Ras/ERK MAPK Signaling
Q38780814Nucleophosmin Regulates Intracellular Oxidative Stress Homeostasis via Antioxidant PRDX6.
Q41908850Nucleophosmin contributes to the transcriptional activation function of the Epstein-Barr virus EBNA1 protein
Q36673676Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.
Q42254875Nucleophosmin is essential for c-Myc nucleolar localization and c-Myc-mediated rDNA transcription
Q30577959Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.
Q34035133Nucleophosmin mutations alter its nucleolar localization by impairing G-quadruplex binding at ribosomal DNA
Q38084251Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.
Q89768685Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemia
Q47397272Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells
Q59134798Phosphoproteome Profiling Reveals Multifunctional Protein NPM1 as part of the Irradiation Response of Tumor Cells
Q28554321Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3
Q38977653Physical and functional interaction of the TPL2 kinase with nucleophosmin
Q44197854Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.
Q100736995Preferential transcription of the mutated allele in NPM1 mutated acute myeloid leukaemia
Q34648744Proteasome activity influences UV-mediated subnuclear localization changes of NPM.
Q39365630Proteomic Profiling of EBNA1-Host Protein Interactions in Latent and Lytic Epstein-Barr Virus Infections
Q39407617Proteomic analysis of UVB-induced protein expression- and redox-dependent changes in skin fibroblasts using lysine- and cysteine-labeling two-dimensional difference gel electrophoresis
Q38496343Quantitative proteomic analysis and functional studies reveal that nucleophosmin is involved in cell death in glioblastoma cell line transfected with siRNA.
Q92720720RNA-Binding Protein HuR Regulates Rac1 Nucleocytoplasmic Shuttling Through Nucleophosmin in the Intestinal Epithelium
Q48297862Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2.
Q37115966Regulation of host gene expression by HIV-1 TAR microRNAs.
Q42710172Role of cysteine 288 in nucleophosmin cytoplasmic mutations: sensitization to toxicity induced by arsenic trioxide and bortezomib
Q39317353S-Nitrosylation Regulates Cell Survival and Death in the Central Nervous System
Q38836332Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery.
Q33739307Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients
Q37678494Stressing on the nucleolus in cardiovascular disease
Q41842682Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ.
Q27682111Structural polymorphism in the N-terminal oligomerization domain of NPM1
Q28114773Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin
Q30585577Synergic role of nucleophosmin three-helix bundle and a flanking unstructured tail in the interaction with G-quadruplex DNA.
Q42244254TPL2-NPM-p53 pathway monitors nucleolar stress
Q37484539The Cell’s Nucleolus: an Emerging Target for Chemotherapeutic Intervention
Q45094905The Spatial Organization of the Intranuclear Structures of Human Brain Dopaminergic Neurons
Q39944723The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway
Q35844124The expression of B23 and EGR1 proteins is functionally linked in tumor cells under stress conditions.
Q35562110The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding
Q41091731The leukemic oncoprotein NPM1-RARA inhibits TP53 activity
Q41905674The nucleolar protein nucleophosmin is essential for autophagy induced by inhibiting Pol I transcription
Q27010254The role of MIZ-1 in MYC-dependent tumorigenesis
Q54977441Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why.
Q42979880Use of sorafenib for post-transplant relapse in FLT3/ITD-positive acute myelogenous leukemia: maturation induction and cytotoxic effect

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