Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

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Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.25.13.5389-5395.2005
P932PMC publication ID1157004
P698PubMed publication ID15964796
P5875ResearchGate publication ID7778204

P50authorTongxiang LinQ42873996
P2093author name stringYang Xu
Wei Gu
Hiroaki Uranishi
Lijin Feng
P2860cites workDeubiquitination of p53 by HAUSP is an important pathway for p53 stabilizationQ24292930
Regulation of p53 activity through lysine methylationQ24311514
Mdm2 promotes the rapid degradation of p53Q24322597
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53Q24328775
SUMO-1 modification activates the transcriptional response of p53Q24529948
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageQ24530584
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitmentQ52590496
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferasesQ77456357
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal DomainQ27860534
Regulation of p53 stability by Mdm2Q27860744
p53, the cellular gatekeeper for growth and divisionQ27860990
Surfing the p53 networkQ28032484
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.Q28117154
The ubiquitin ligase COP1 is a critical negative regulator of p53Q28258057
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activityQ28270986
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteinsQ28273233
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expressionQ28300071
p53 mutations in human cancersQ28302973
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradationQ28609772
Live or let die: the cell's response to p53Q29547663
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighborsQ29614306
Post-translational modifications and activation of p53 by genotoxic stressesQ29615659
DNA damage activates p53 through a phosphorylation–acetylation cascadeQ29616294
p53: puzzle and paradigmQ29618407
Regulation of Mdm2-Directed Degradation by the C Terminus of p53Q33779929
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivoQ33896638
Signaling to p53: breaking the posttranslational modification codeQ33945840
Mutation of mouse p53 Ser23 and the response to DNA damageQ34277066
Putting the stress on senescenceQ34430830
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.Q34585107
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulationQ35089377
Regulation of p53 responses by post-translational modificationsQ35116637
p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damageQ35123816
Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damageQ35352915
The p53 response to DNA damageQ35848498
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivoQ36601373
Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responsesQ38351593
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradationQ39540070
Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitinationQ39540284
How phosphorylation regulates the activity of p53.Q41206472
p53 heterozygosity alters the mRNA expression of p53 target genes in the bone marrow in response to inhaled benzeneQ43918887
Acetylation of p53 inhibits its ubiquitination by Mdm2.Q44209228
p53 linear diffusion along DNA requires its C terminusQ45138454
Essential roles of the kappa light chain intronic enhancer and 3' enhancer in kappa rearrangement and demethylationQ46053556
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)5389-5395
P577publication date2005-07-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleFunctional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
P478volume25

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