Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.

scientific article

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Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M710186200
P8608Fatcat IDrelease_hox7lqddq5gmzenntkpyvweq6u
P932PMC publication ID3258953
P698PubMed publication ID18492669
P5875ResearchGate publication ID5357054

P50authorGiannino Del SalQ57002121
Andrea LunardiQ79095999
Fulvio ChiacchieraQ81037839
P2093author name stringLicio Collavin
Michael H Brodsky
Laura M McNamee
Federico Mauri
P2860cites workRegulation of p53 activity in nuclear bodies by a specific PML isoformQ24290520
Chk2 regulates irradiation-induced, p53-mediated apoptosis in DrosophilaQ24304184
SUMO-1 modification activates the transcriptional response of p53Q24529948
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activityQ24531180
A Drosophila protein-interaction map centered on cell-cycle regulatorsQ24791344
Structural evolution of C-terminal domains in the p53 familyQ27646113
Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.Q28117154
Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotypeQ28118442
Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motifQ28144708
Activation of p53 by Protein Inhibitor of Activated Stat1 (PIAS1)Q28215308
The role of PML in tumor suppressionQ28217779
SUMO: a history of modificationQ28243325
Something about SUMO inhibits transcriptionQ28266843
Daxx: death or survival protein?Q28291053
Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradationQ28367104
Regulating the p53 pathway: in vitro hypotheses, in vivo veritasQ29615658
The p53 pathway: positive and negative feedback loopsQ29617535
p53 in health and diseaseQ29619939
Identification and characterization of a SUMO-1 conjugation system that modifies neuronal calcium/calmodulin-dependent protein kinase II in Drosophila melanogasterQ30655836
Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila fliesQ30832005
Protein interaction mapping: a Drosophila case studyQ33211911
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activityQ33863075
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivationQ33900545
SUMO, ubiquitin's mysterious cousinQ33939449
The Daxx enigmaQ34166615
Drosophila p53 preserves genomic stability by regulating cell deathQ34959692
SUMO-1 and p53.Q34995629
Ubiquitin and ubiquitin-like modifications of the p53 familyQ35082705
Regulation of p53 functions: let's meet at the nuclear bodies.Q35145846
Identification and characterization of a p53 homologue in Drosophila melanogasterQ35157222
Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damageQ35544595
SUMO: a regulator of gene expression and genome integrity.Q35691533
Post-translational modification of p53 in tumorigenesisQ35930703
Ubiquitin and ubiquitin-like proteins in cancer pathogenesisQ36601000
Coping with stress: multiple ways to activate p53.Q36745375
Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.Q40014061
Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylationQ40174655
The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation.Q40478393
Drosophila p53 is a structural and functional homolog of the tumor suppressor p53.Q41731870
Drosophila p53 binds a damage response element at the reaper locusQ41731875
Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathwaysQ42834927
Functional analysis and intracellular localization of p53 modified by SUMO-1.Q43649352
p53 directs focused genomic responses in DrosophilaQ47070122
In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in DrosophilaQ47071042
Daxx-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level.Q47071260
c-Jun and p53 Activity Is Modulated by SUMO-1 ModificationQ58377962
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
apoptotic processQ14599311
P304page(s)20848-20856
P577publication date2008-05-20
P1433published inJournal of Biological ChemistryQ867727
P1476titleModification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions
P478volume283

Reverse relations

cites work (P2860)
Q37273127A platform for interrogating cancer-associated p53 alleles
Q22061736Classification of intrinsically disordered regions and proteins
Q39282736Dmp53 is sequestered to nuclear bodies in spermatogonia of Drosophila melanogaster
Q47072064Drosophila Sal and Salr are transcriptional repressors.
Q42607353In vivo analysis of a fluorescent SUMO fusion in transgenic Drosophila
Q34685759Inhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes
Q42211570Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication
Q28118946MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity
Q36305932PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence
Q28751278Phylogeny and function of the invertebrate p53 superfamily
Q24314588Plk1-mediated phosphorylation of Topors regulates p53 stability
Q37038779RpL22e, but not RpL22e-like-PA, is SUMOylated and localizes to the nucleoplasm ofDrosophilameiotic spermatocytes
Q38131751SUMO and Parkinson's disease
Q28592859SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation
Q38223674SUMOylation in Drosophila Development
Q34733953SUMOylation of Mouse p53b by SUMO-1 Promotes Its Pro-Apoptotic Function in Ovarian Granulosa Cells
Q37415135Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance
Q51137583The Role of Sumoylation in Senescence
Q34020353The p53 orchestra: Mdm2 and Mdmx set the tone
Q42017233Transcription factor fork head regulates the promoter of diapause hormone gene in the cotton bollworm, Helicoverpa armigera, and the modification of SUMOylation

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