| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/978-1-4419-6676-6_10 |
| P953 | full work available at URL | http://link.springer.com/content/pdf/10.1007/978-1-4419-6676-6_10.pdf |
| P698 | PubMed publication ID | 21222278 |
| P50 | author | Dimitris P Xirodimas | Q89280833 |
| P2093 | author name string | Martin Scheffner | |
| P2860 | cites work | Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53 | Q22009955 |
| Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein | Q22010970 | ||
| EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors | Q33261811 | ||
| Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex | Q33489621 | ||
| Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes | Q33720458 | ||
| Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity | Q33863075 | ||
| Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53 | Q33883959 | ||
| Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. | Q33888123 | ||
| The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. | Q33889383 | ||
| A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking | Q33890625 | ||
| The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation | Q33900545 | ||
| Nedd8 on cullin: building an expressway to protein destruction. | Q33976667 | ||
| Polyubiquitination of p53 by a ubiquitin ligase activity of p300. | Q34190044 | ||
| Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. | Q34233412 | ||
| Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. | Q34283106 | ||
| Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. | Q34368432 | ||
| The p53 proto-oncogene can act as a suppressor of transformation | Q34440370 | ||
| Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo | Q34480082 | ||
| Identification of a cryptic nucleolar-localization signal in MDM2 | Q22253304 | ||
| Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 | Q22253350 | ||
| A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis | Q24291283 | ||
| Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization | Q24292930 | ||
| Monoubiquitylation promotes mitochondrial p53 translocation | Q24295012 | ||
| The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2 | Q24296502 | ||
| Critical role for Daxx in regulating Mdm2 | Q24297332 | ||
| Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53 | Q24299024 | ||
| A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response | Q24299489 | ||
| Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development | Q24300985 | ||
| Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 | Q24303581 | ||
| ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor | Q24306428 | ||
| Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis | Q24306444 | ||
| Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53 | Q24309310 | ||
| Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding | Q24311663 | ||
| Binding and modulation of p53 by p300/CBP coactivators | Q24312018 | ||
| FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity | Q24314409 | ||
| Plk1-mediated phosphorylation of Topors regulates p53 stability | Q24314588 | ||
| Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 | ||
| E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification | Q24316067 | ||
| Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway | Q24316207 | ||
| The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53 | Q24317677 | ||
| CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation | Q24318767 | ||
| p53 isoforms can regulate p53 transcriptional activity. | Q24319034 | ||
| Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. | Q40783221 | ||
| A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation | Q40800224 | ||
| Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. | Q41063629 | ||
| Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells | Q41128329 | ||
| The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1 | Q41594394 | ||
| An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. | Q42797525 | ||
| SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination | Q42833939 | ||
| Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish | Q43286701 | ||
| Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. | Q43594592 | ||
| Hdmx and Mdm2 can repress transcription activation by p53 but not by p63. | Q43700547 | ||
| The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo | Q43941701 | ||
| The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. | Q44192183 | ||
| The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53. | Q44509784 | ||
| Hdmx protein stability is regulated by the ubiquitin ligase activity of Mdm2. | Q44521310 | ||
| Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication | Q44703400 | ||
| A post-ubiquitination role for MDM2 and hHR23A in the p53 degradation pathway | Q44830484 | ||
| Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. | Q44896717 | ||
| A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. | Q45985375 | ||
| Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential | Q46706127 | ||
| Chaperone-dependent stabilization and degradation of p53 mutants | Q46788559 | ||
| Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7 | Q58376444 | ||
| Three birds with one stone | Q59053988 | ||
| The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots | Q72693767 | ||
| Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development | Q72718760 | ||
| Hdmx stabilizes Mdm2 and p53 | Q73825764 | ||
| The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha) | Q81357417 | ||
| p53 ubiquitination: Mdm2 and beyond | Q29619502 | ||
| p53 in health and disease | Q29619939 | ||
| Nucleolar Arf sequesters Mdm2 and activates p53 | Q29620244 | ||
| E6AP gene suppression and characterization with in vitro selected hammerhead ribozymes. | Q30732777 | ||
| Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. | Q30941966 | ||
| ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways | Q24321528 | ||
| Mdm2 promotes the rapid degradation of p53 | Q24322597 | ||
| The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex | Q24323508 | ||
| Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 | Q24328775 | ||
| Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin' | Q24336917 | ||
| Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis | Q24338676 | ||
| Trim24 targets endogenous p53 for degradation | Q24339423 | ||
| The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase | Q24521626 | ||
| SUMO-1 modification activates the transcriptional response of p53 | Q24529948 | ||
| Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity | Q24531180 | ||
| Human TAFII31 protein is a transcriptional coactivator of the p53 protein | Q24562978 | ||
| Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53 | Q24609153 | ||
| UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells | Q24609948 | ||
| Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1 | Q24630964 | ||
| Involvement of the DNA repair protein hHR23 in p53 degradation | Q24633456 | ||
| P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2 | Q24650492 | ||
| Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53 | Q24672736 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| Solution structure of the tetrameric minimum transforming domain of p53 | Q27730258 | ||
| Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms | Q27730393 | ||
| Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations | Q27730815 | ||
| Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain | Q27860534 | ||
| Regulation of p53 stability by Mdm2 | Q27860744 | ||
| Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation | Q27934506 | ||
| Surfing the p53 network | Q28032484 | ||
| Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. | Q28117154 | ||
| Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase | Q28139082 | ||
| MDM2 interacts with MDMX through their RING finger domains | Q28142437 | ||
| An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo | Q28144965 | ||
| Involvement of PIAS1 in the sumoylation of tumor suppressor p53 | Q28189956 | ||
| MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination | Q28210052 | ||
| The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults | Q28210433 | ||
| Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 | Q28214793 | ||
| The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis | Q28247891 | ||
| A dynamic role of HAUSP in the p53-Mdm2 pathway | Q28253645 | ||
| Tumour suppression: disruption of HAUSP gene stabilizes p53 | Q28254102 | ||
| The ubiquitin ligase COP1 is a critical negative regulator of p53 | Q28258057 | ||
| ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation | Q28265951 | ||
| The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 | Q28266637 | ||
| Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo | Q28268988 | ||
| Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas | Q28269089 | ||
| Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest | Q28270478 | ||
| Amplification of a gene encoding a p53-associated protein in human sarcomas | Q28270924 | ||
| Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity | Q28270986 | ||
| Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo | Q28274471 | ||
| The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation | Q28280330 | ||
| The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation | Q28280958 | ||
| Identification of p53 as a sequence-specific DNA-binding protein | Q28282745 | ||
| COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas | Q28288506 | ||
| p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60 | Q28304820 | ||
| Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation | Q28508240 | ||
| Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53. | Q28590239 | ||
| Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation | Q28609772 | ||
| The p53-mdm-2 autoregulatory feedback loop | Q28609811 | ||
| Mdmx and Mdm2: brothers in arms? | Q28611384 | ||
| Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex | Q29041391 | ||
| Blinded by the Light: The Growing Complexity of p53 | Q29547590 | ||
| The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53 | Q29547773 | ||
| Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 | Q29614430 | ||
| Papillomaviruses and cancer: from basic studies to clinical application | Q29614745 | ||
| Modes of p53 regulation | Q29615657 | ||
| Regulating the p53 pathway: in vitro hypotheses, in vivo veritas | Q29615658 | ||
| Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 | Q29615851 | ||
| Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 | Q29617850 | ||
| T antigen is bound to a host protein in SY40-transformed cells | Q29618321 | ||
| Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development | Q34480087 | ||
| E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. | Q34582315 | ||
| The p53-Mdm2 module and the ubiquitin system. | Q35036580 | ||
| Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system | Q35036585 | ||
| Critical contribution of the MDM2 acidic domain to p53 ubiquitination | Q35107890 | ||
| Regulation of p53 localization and activity by Ubc13. | Q35131633 | ||
| MDM2 promotes ubiquitination and degradation of MDMX | Q35161842 | ||
| hHR23B is required for genotoxic-specific activation of p53 and apoptosis | Q35648717 | ||
| HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. | Q36347917 | ||
| Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. | Q36423924 | ||
| ARF-BP1 as a potential therapeutic target | Q36461587 | ||
| Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway | Q36648425 | ||
| Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. | Q36660357 | ||
| Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. | Q36665942 | ||
| Molecular characterization of the hdm2-p53 interaction | Q36871109 | ||
| Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53 | Q36980764 | ||
| Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. | Q37115176 | ||
| JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation | Q37238734 | ||
| Control of p53 multimerization by Ubc13 is JNK-regulated | Q37293253 | ||
| The mitochondrial p53 pathway | Q37325095 | ||
| Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse | Q37331246 | ||
| Ubiquitination of p53 at multiple sites in the DNA-binding domain | Q37382534 | ||
| An additional role for SUMO in ubiquitin-mediated proteolysis | Q37498263 | ||
| Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation | Q37543781 | ||
| Regulation of the specific DNA binding function of p53 | Q38324290 | ||
| Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation | Q39540070 | ||
| Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination | Q39540284 | ||
| Critical role for a central part of Mdm2 in the ubiquitylation of p53. | Q39777866 | ||
| Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. | Q39879529 | ||
| MSL2 promotes Mdm2-independent cytoplasmic localization of p53 | Q39912357 | ||
| The adenovirus E1B-55K oncoprotein induces SUMO modification of p53. | Q39984817 | ||
| Ubiquitination and degradation of mutant p53. | Q40073806 | ||
| C-terminal modifications regulate MDM2 dissociation and nuclear export of p53. | Q40157263 | ||
| Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2. | Q40170945 | ||
| Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells | Q40237209 | ||
| Structural details on mdm2-p53 interaction | Q40373998 | ||
| The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation | Q40418287 | ||
| Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation | Q40763347 | ||
| Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms | Q40773986 | ||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | tumor protein p53 | Q283350 |
| ubiquitin | Q407111 | ||
| P304 | page(s) | 116-135 | |
| P577 | publication date | 2010-01-01 | |
| P1433 | published in | Sub-cellular biochemistry | Q26853962 |
| P1476 | title | Ubiquitin Family Members in the Regulation of the Tumor Suppressor p53 | |
| P478 | volume | 54 |
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