Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment

scientific article published in July 2001

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1097-2765(01)00283-0
P698PubMed publication ID11511360
P5875ResearchGate publication ID11834760

P2093author name stringEmerson BM
Espinosa JM
P2860cites workPromoter structure and transcriptional activation with chromatin templates assembled in vitro. A single Gal4-VP16 dimer binds to chromatin or to DNA with comparable affinityQ46113275
DNA-conformation is an important determinant of sequence-specific DNA binding by tumor suppressor p53Q73615085
Scanning force microscopy of the complexes of p53 core domain with supercoiled DNAQ73843198
Signaling to p53: breaking the MDM2-p53 circuitQ77430977
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitroQ22003978
Functional selectivity of recombinant mammalian SWI/SNF subunitsQ24290358
High mobility group protein-1 (HMG-1) is a unique activator of p53Q24311393
Binding and modulation of p53 by p300/CBP coactivatorsQ24312018
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageQ24530584
ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assemblyQ24602406
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal DomainQ27860534
p53, the cellular gatekeeper for growth and divisionQ27860990
WAF1, a potential mediator of p53 tumor suppressionQ27861121
Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3Q27931527
Surfing the p53 networkQ28032484
Deacetylation of p53 modulates its effect on cell growth and apoptosisQ28138967
Atmospheric carbon dioxide concentrations over the past 60 million yearsQ28144787
Recruitment of p300/CBP in p53-dependent signal pathwaysQ28243213
p21 is a universal inhibitor of cyclin kinasesQ28257305
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneQ28306186
Activation and repression mechanisms in yeastQ33671494
Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300.Q33921258
Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templatesQ33960598
Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53Q35205701
p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twistingQ37161582
Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivoQ37167696
Regulation of the specific DNA binding function of p53Q38324290
Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitinationQ39540284
Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specificationQ40843110
Influence of promoter DNA topology on sequence-specific DNA binding and transactivation by tumor suppressor p53.Q40911280
Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53.Q41000380
The N terminus of p53 regulates its dissociation from DNA.Q42055738
P433issue1
P304page(s)57-69
P577publication date2001-07-01
P1433published inMolecular CellQ3319468
P1476titleTranscriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
P478volume8

Reverse relations

cites work (P2860)
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Q53335869Epigenetic control of cellular senescence in disease: opportunities for therapeutic intervention.
Q39647839Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells
Q40290190Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.
Q42476896Exploring a minimal two-component p53 model
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Q33863075Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
Q33772124Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.
Q28584780GCN5 and p300 share essential functions during early embryogenesis
Q33839575Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding.
Q35906476Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-kappaB and other signal transcription factors in head and neck squamous cell carcinoma.
Q33659512Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.
Q40421589HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage
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Q24301527HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53
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Q33802917How does SIRT1 affect metabolism, senescence and cancer?
Q36879036How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
Q39997408How p53 wields the scales of fate: arrest or death?
Q39565523Human EHMT2/G9a activates p53 through methylation-independent mechanism
Q24294875Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response
Q24297146Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
Q36738940Human T-cell leukemia virus type-1-encoded protein HBZ represses p53 function by inhibiting the acetyltransferase activity of p300/CBP and HBO1.
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Q35640132Identification of Kinase Inhibitors that Target Transcription Initiation by RNA Polymerase II
Q34366021Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis
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Q36906240Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics
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Q29615657Modes of p53 regulation
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Q91626701Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation
Q24791476Mutant p53 proteins bind DNA in a DNA structure-selective mode
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Q74631439NMR spectroscopy reveals the solution dimerization interface of p53 core domains bound to their consensus DNA
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Q33361623Noncanonical DNA motifs as transactivation targets by wild type and mutant p53
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Q40616826PCAF is a coactivator for p73-mediated transactivation
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Q47319323The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1.
Q91643306The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors
Q40163084The MDM2 ubiquitination signal in the DNA-binding domain of p53 forms a docking site for calcium calmodulin kinase superfamily members
Q31023819The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53
Q39927575The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis
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Q40682154The acetylase activity of p300 is dispensable for MDM2 stabilization
Q34770071The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells
Q40667519The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein.
Q24297814The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes
Q34519833The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes
Q35191541The complex interactions of p53 with target DNA: we learn as we go.
Q36443523The complexity of p53 stabilization and activation
Q36259624The contribution of transactivation subdomains 1 and 2 to p53-induced gene expression is heterogeneous but not subdomain-specific
Q90113081The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network
Q34487385The evolution of diverse biological responses to DNA damage: insights from yeast and p53
Q37602507The expanding universe of p53 targets
Q39673506The expression ofp53-regulated genes in human cultured lymphoblastoid TSCE5 and WTK1 cell lines during spaceflight
Q36542788The impact of post-transcriptional regulation in the p53 network
Q89289431The mechanistic basis for chromatin regulation by pioneer transcription factors
Q92062954The multiple mechanisms that regulate p53 activity and cell fate
Q58430752The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain
Q33724426The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA binding
Q28588064The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
Q41225724The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion
Q44418946The role of p53 deacetylation in p21Waf1 regulation by laminar flow
Q38977312The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity
Q34888585The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.
Q36423929The versatile interactions of p53 with DNA: when flexibility serves specificity
Q35095843Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis.
Q34100529Tracing the protectors path from the germ line to the genome
Q33598618Transcription coactivator CBP has direct DNA binding activity and stimulates transcription factor DNA binding through small domains
Q39005896Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.
Q29617650Transcriptional control of human p53-regulated genes
Q37777267Transcriptional regulation by p53.
Q36436698Transcriptional regulation by p53: one protein, many possibilities
Q34814407Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells
Q24537716Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes
Q39991040Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis
Q36717623Tumor suppressor p53 slides on DNA with low friction and high stability
Q33707419USP7/HAUSP Promotes the Sequence-Specific DNA Binding Activity of p53
Q35089377Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
Q36318145Viruses - seeking and destroying the tumor program
Q24594980Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail
Q53252468Whole-exome sequencing to identify novel somatic mutations in squamous cell lung cancers
Q34486036Why Is p53 Acetylated?
Q39822156Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation
Q40142210hAda3 regulates p14ARF-induced p53 acetylation and senescence
Q38959783hERG1 potassium channel in cancer cells: a tool to reprogram immortality
Q33905382p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels
Q35779695p300/CBP and cancer
Q58918367p53
Q28609701p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage
Q36401999p53 N-terminal phosphorylation: a defining layer of complex regulation
Q28215076p53 Transcriptional Activity Is Mediated through the SRC1-interacting Domain of CBP/p300
Q35646680p53 and p73 display common and distinct requirements for sequence specific binding to DNA
Q36052576p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes
Q47140890p53 binding sites in normal and cancer cells are characterized by distinct chromatin context.
Q33569713p53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element
Q38341581p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy
Q27305159p53 dynamics upon response element recognition explored by molecular simulations
Q33376888p53 induces distinct epigenetic states at its direct target promoters
Q39714641p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
Q43293646p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity
Q57929625p53 latency – out of the blind alley
Q40344795p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene
Q40715545p53 requires an intact C-terminal domain for DNA binding and transactivation
Q36567469p53 sumoylation: mechanistic insights from reconstitution studies
Q42660335p53 targets chromatin structure alteration to repress alpha-fetoprotein gene expression
Q42098836p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.
Q44945710p53-dependent transcription can exhibit both on/off and graded response after genotoxic stress
Q34517061p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network.
Q58543844p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion
Q38319824tumor suppressor p53 binds with high affinity to CTG.CAG trinucleotide repeats and induces topological alterations in mismatched duplexes
Q36654367ΔNp63α utilizes multiple mechanisms to repress transcription in squamous cell carcinoma cells.

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