Transcriptional regulation by p53.

scientific article published on 28 April 2010

Transcriptional regulation by p53. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1101/CSHPERSPECT.A000935
P932PMC publication ID2908772
P698PubMed publication ID20679336
P5875ResearchGate publication ID45461475

P50authorCarol PrivesQ28112996
P2093author name stringRachel Beckerman
P2860cites workA novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulationQ22008779
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53Q24290402
The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradationQ24291244
ASPP proteins specifically stimulate the apoptotic function of p53Q24291844
p53 is regulated by the lysine demethylase LSD1Q24292925
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPPQ24295229
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.Q24297694
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damageQ24299608
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damageQ24299870
An acetylation switch in p53 mediates holo-TFIID recruitmentQ24300158
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosisQ24300728
Wild-type p53 binds to the TATA-binding protein and represses transcriptionQ24300991
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcriptionQ24306465
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activationQ24308905
Regulation of p53 activity through lysine methylationQ24311514
Binding and modulation of p53 by p300/CBP coactivatorsQ24312018
Acetylation is indispensable for p53 activationQ24313477
Repression of p53 activity by Smyd2-mediated methylationQ24315991
Identification of redox/repair protein Ref-1 as a potent activator of p53Q24316161
p53 isoforms can regulate p53 transcriptional activity.Q24319034
Modulation of p53 function by SET8-mediated methylation at lysine 382Q24337822
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivationQ24338320
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genesQ24338336
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damageQ24530584
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradationQ24537700
p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interactionQ24550965
Repression of RNA polymerase I transcription by the tumor suppressor p53Q24552501
p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent mannerQ24647526
Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damageQ24655422
CBP/p300 interact with and function as transcriptional coactivators of BRCA1Q24673965
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domainQ27860534
The role of chromatin during transcriptionQ27860995
Arginine methylation regulates the p53 responseQ28116284
Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1Q28190792
Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53Q28198423
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1Q28203791
Definition of a consensus binding site for p53Q28207794
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insultsQ28210433
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathwayQ28215330
p21 transcription is regulated by differential localization of histone H2A.Z.Q35917048
Post-translational modification of p53 in tumorigenesisQ35930703
RNA polymerases I and III, growth control and cancerQ36028214
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.Q36117542
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelopeQ36402588
Sliding into home: facilitated p53 search for targets by the basic DNA binding domainQ36430175
Transcriptional regulation by p53: one protein, many possibilitiesQ36436698
Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo.Q36561445
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivoQ36601373
The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcriptionQ36685220
Tumor suppressor p53 slides on DNA with low friction and high stabilityQ36717623
A role for caspase 2 and PIDD in the process of p53-mediated apoptosisQ36882985
p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twistingQ37161582
A complex barcode underlies the heterogeneous response of p53 to stressQ37249372
The mitochondrial p53 pathwayQ37325095
p53-Induced DNA bending: the interplay between p53-DNA and p53-p53 interactionsQ37370175
Transcriptional repression by p53 through direct binding to a novel DNA elementQ38300895
p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the coreQ38307731
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.Q38313400
DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53.Q38345163
Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response elementQ38345165
Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domainQ38363728
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunitQ38774316
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targetsQ39674825
Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 proteinQ39675422
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.Q39859206
Chromium-mediated apoptosis: involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genesQ39964858
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia.Q39968880
Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cellsQ40048856
Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modificationsQ40085549
p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agentsQ40093621
Methylation-acetylation interplay activates p53 in response to DNA damageQ40103473
Site-specific acetylation of p53 directs selective transcription complex assembly.Q40205369
Transcriptional regulation by p53 and p73.Q40251375
Cdk9 phosphorylates p53 on serine 392 independently of CKII.Q40272241
Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.Q40290190
Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcriptionQ40296499
The Rb/E2F pathway: expanding roles and emerging paradigmsQ34052659
Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activationQ34080682
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.Q34108288
A polymorphic microsatellite that mediates induction of PIG3 by p53.Q34120918
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.Q34190044
p300/CBP/p53 interaction and regulation of the p53 responseQ34254607
Selenomethionine regulation of p53 by a ref1-dependent redox mechanismQ34394902
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Q34443272
BRCA1 physically associates with p53 and stimulates its transcriptional activity.Q34467604
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional programQ34471112
The general transcription machinery and general cofactorsQ34549899
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53.Q34565058
The RNA polymerase II machinery: structure illuminates functionQ34574312
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.Q34582315
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damageQ35071254
Transcriptional repression mediated by the p53 tumour suppressorQ35116644
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.Q35207550
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expressionQ35568362
p53 function and dysfunctionQ35721291
p53's double life: transactivation-independent repression of homologous recombination.Q35774503
CDK8 is a stimulus-specific positive coregulator of p53 target genesQ28235350
Recruitment of p300/CBP in p53-dependent signal pathwaysQ28243213
p21 is a universal inhibitor of cyclin kinasesQ28257305
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageQ28263101
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53Q28265932
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing pumaQ28281602
p300/MDM2 complexes participate in MDM2-mediated p53 degradationQ28288274
The general transcription factors of RNA polymerase IIQ28298663
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expressionQ28300071
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60Q28304820
Y-box factor YB1 controls p53 apoptotic functionQ28578217
p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA DamageQ28609701
Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplicationQ28611456
Allosteric activation of latent p53 tetramersQ28623087
Divergent evolution of human p53 binding sites: cell cycle versus apoptosisQ28757271
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expressionQ28771498
Blinded by the Light: The Growing Complexity of p53Q29547590
A global map of p53 transcription-factor binding sites in the human genomeQ29614400
Elongation by RNA polymerase II: the short and long of itQ29614529
Modes of p53 regulationQ29615657
Regulating the p53 pathway: in vitro hypotheses, in vivo veritasQ29615658
DNA damage activates p53 through a phosphorylation-acetylation cascadeQ29616294
Transcriptional control of human p53-regulated genesQ29617650
p53: puzzle and paradigmQ29618407
The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53Q31023819
Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 familyQ32078382
Noncanonical DNA motifs as transactivation targets by wild type and mutant p53Q33361623
Kinetics of p53 binding to promoter sites in vivoQ33558659
The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA bindingQ33724426
p53-mediated repression of alpha-fetoprotein gene expression by specific DNA bindingQ33868917
p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53Q33888115
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.Q33912006
Definition of the p53 functional domains necessary for inducing apoptosisQ33917509
p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrestQ33925109
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivationQ34016183
Mechanisms of regulatory diversity within the p53 transcriptional networkQ34039841
MUC1 oncoprotein stabilizes and activates estrogen receptor alphaQ40326798
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cellsQ40419093
Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells.Q40450785
Insights into selective activation of p53 DNA binding by c-Abl.Q40468371
DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.Q40485978
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression.Q40491393
MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradationQ40591224
p21/CDKN1A mediates negative regulation of transcription by p53.Q40647697
A transcriptionally active DNA-binding site for human p53 protein complexesQ40655196
p53 and translational controlQ40971271
How p53 binds DNA as a tetramerQ41787604
Tumor suppressor protein p53 binds preferentially to supercoiled DNA.Q42061462
p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled.Q42098836
p53 represses ribosomal gene transcriptionQ42468055
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activationQ42508925
A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53.Q42558710
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.Q42724753
Acetylation of the p53 DNA-binding domain regulates apoptosis inductionQ43019120
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpointQ43106462
The IARC TP53 database: new online mutation analysis and recommendations to usersQ43714274
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.Q44192183
High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops.Q44915895
Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cellsQ45000475
p53 linear diffusion along DNA requires its C terminusQ45138454
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosisQ45345472
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethalityQ46111122
Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stressQ46868426
The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo modelQ46891002
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.Q50335767
Comparative binding of p53 to its promoter and DNA recognition elements.Q51503955
Chromatin immunoprecipitation-on-chip reveals stress-dependent p53 occupancy in primary normal cells but not in established cell lines.Q51569733
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.Q52590496
Structural basis of DNA recognition by p53 tetramers.Q53616174
Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damageQ59098609
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor proteinQ64382309
Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domainQ73011234
Control of E2F activity by p21Waf1/Cip1Q73023858
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activityQ73615074
RB regulates the stability and the apoptotic function of p53 via MDM2Q74607074
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferasesQ77456357
Phosphorylation of p53 serine 15 increases interaction with CBPQ77604720
Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expressionQ77726350
CDK9 phosphorylates p53 on serine residues 33, 315 and 392Q82904823
P433issue8
P304page(s)a000935
P577publication date2010-04-28
P1433published inCold Spring Harbor Perspectives in BiologyQ3927509
P1476titleTranscriptional regulation by p53.
P478volume2

Reverse relations

cites work (P2860)
Q89636325A circular RNA from the MDM2 locus controls cell cycle progression by suppressing p53 levels
Q34178824A functional p53 responsive polymorphism in KITLG, rs4590952, does not affect the risk of breast cancer
Q38946984A nanobody modulates the p53 transcriptional program without perturbing its functional architecture
Q34957187A pathophysiological view of the long non-coding RNA world.
Q34228309A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection
Q28253043A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time
Q42256808AAVPG: a vigilant vector where transgene expression is induced by p53.
Q64087905AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair
Q89424441Aberrant expression of ETS1 and ETS2 proteins in cancer
Q37306546Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer
Q36615629Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity
Q24322033Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor
Q48264201Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation.
Q64914374An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea.
Q94554707Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017)
Q27026310Another fork in the road--life or death decisions by the tumour suppressor p53
Q33898584Apoptosis by [Pt(O,O'-acac)(γ-acac)(DMS)] requires PKC-δ mediated p53 activation in malignant pleural mesothelioma
Q55306287Apoptosis in inner ear sensory hair cells.
Q34964647Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters
Q34621019Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma
Q92797426Bicistronic transfer of CDKN2A and p53 culminates in collaborative killing of human lung cancer cells in vitro and in vivo
Q40592113CMV promoter is repressed by p53 and activated by JNK pathway
Q41853899CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage
Q47965098Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
Q38911126Census and evaluation of p53 target genes.
Q42119671CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress
Q47132240Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma.
Q38812141Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies
Q92153177Characterization of p53 Family Homologs in Evolutionary Remote Branches of Holozoa
Q34961997Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.
Q34079481Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism
Q89735096Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill
Q36482972Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression
Q57461758Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine
Q26777412Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis
Q41872966Crosstalk between p53 and TGF-β Signalling.
Q61446075Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells
Q39218048DNA damage response and hematological malignancy
Q39309267DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation
Q35130588Defining genome maintenance pathways using functional genomic approaches
Q34550194Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis
Q36094396Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.
Q38729291Disposable Amperometric Immunosensor for the Determination of Human P53 Protein in Cell Lysates Using Magnetic Micro-Carriers.
Q39095914Dominant effects of Δ40p53 on p53 function and melanoma cell fate
Q52772321Drosophila p53 controls Notch expression and balances apoptosis and proliferation.
Q54977589Dual Roles of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) in Redox-Sensitive Signaling Pathways Related to Cancer Development.
Q36396607E2F1 and p53 transcription factors as accessory factors for nucleotide excision repair.
Q24293588E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression
Q37635616E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells
Q97587379ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage
Q34104165ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells
Q38190819Effects of honey and its mechanisms of action on the development and progression of cancer.
Q51032102Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction.
Q64956800Emerging Roles of p53 Related lncRNAs in Cancer Progression: A Systematic Review.
Q51643191Epidermal growth factor prevents thallium(I)- and thallium(III)-mediated rat pheochromocytoma (PC12) cell apoptosis.
Q33568800Essential role for centromeric factors following p53 loss and oncogenic transformation
Q38860158Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells.
Q26827810Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.
Q35558858Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay
Q38468872Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling.
Q35869772Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics
Q35916594Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells
Q39411422Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription
Q51794453Functional studies of a novel germline p53 splicing mutation identified in a patient with Li-Fraumeni-like syndrome.
Q27313430G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53.
Q34984471GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis
Q54255820Genetics and Biology of Pancreatic Ductal Adenocarcinoma.
Q42228944Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis
Q40537164Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo
Q38927148Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature
Q35311763Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA.
Q37417024Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
Q38867373Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A.
Q37183586Growth hormone is permissive for neoplastic colon growth
Q33864922Haploinsufficient tumor suppressor genes
Q36031533Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo
Q34701793Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm.
Q38217666Histone deacetylase inhibitors and cell death
Q33663060Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53
Q36390683Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.
Q89597805How p53 Molecules Solve the Target DNA Search Problem: A Review
Q92962230Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine
Q39044368Id4 dependent acetylation restores mutant-p53 transcriptional activity
Q40991008Identification of p53-target genes in Danio rerio
Q33877751Identification of two novel functional p53 responsive elements in the herpes simplex virus-1 genome
Q38310745Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex
Q33934010Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma
Q37933073Inhibiting eukaryotic transcription: Which compound to choose? How to evaluate its activity?
Q38848287Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound
Q38735257Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice.
Q37197461Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.
Q34258129Interaction between the Cockayne syndrome B and p53 proteins: implications for aging
Q28000133Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity
Q37615064Is p53 Involved in Tissue-Specific Insulin Resistance Formation?
Q50565186Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.
Q64943265Key mechanisms involved in ionizing radiation-induced systemic effects. A current review.
Q38956592Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity
Q39041480Li-Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition
Q42682133Life or death: p53-induced apoptosis requires DNA binding cooperativity.
Q41488339Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.
Q38176848LncRNAs: new players in gliomas, with special emphasis on the interaction of lncRNAs With EZH2.
Q36133137Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells
Q40055589Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.
Q39042974Long noncoding RNAs in the p53 network.
Q36880005Long story short: p53 mediates innate immunity
Q45393476Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response
Q34165710Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells
Q91302990MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53
Q55319096MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.
Q38802454Major apoptotic mechanisms and genes involved in apoptosis
Q41142436Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis
Q38059700Mdm2 and MdmX as Regulators of Gene Expression
Q39404029MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress
Q47416965Mechanisms of transcriptional regulation by p53.
Q46900782Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells
Q47737123Modelling the propagation of a dynamical signature in gene expression mediated by the transport of extracellular microRNAs.
Q42787889Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ.
Q34464874Molecular basis for modulation of the p53 target selectivity by KLF4.
Q39657304Molecular signatures of ovarian diseases: Insights from network medicine perspective.
Q39455093Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2.
Q36922983Multifaceted functions of Siva-1: more than an Indian God of Destruction
Q39752696Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic
Q54985026Multivalency regulates activity in an intrinsically disordered transcription factor.
Q38844605Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication
Q38204111Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks
Q33687048Mutant p53 gain-of-function in cancer
Q93367358Mutant p53 in colon cancer
Q39297236Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity
Q30313610Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.
Q89323796Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4
Q42367753Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling.
Q36812554Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression
Q55504431Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells.
Q46243584Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice.
Q30370843NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.
Q43123230Not all p53 gain-of-function mutants are created equal
Q36701116Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis
Q40551859Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation.
Q36978256NuMA is required for the selective induction of p53 target genes
Q37330844Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding.
Q50954935One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain.
Q41108776P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?
Q34828404P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements.
Q24594648PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53
Q34364654PTEN interacts with histone H1 and controls chromatin condensation
Q58699214Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer
Q37191174Pharmacological activation of p53 in cancer cells
Q35196159Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
Q47772405Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer
Q38945300Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition
Q34038331Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
Q28512750Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts
Q38125728Post-transcriptional regulation of DNA damage-responsive gene expression
Q47835030Post-translational regulation of p53 function through 20S proteasome-mediated cleavage.
Q38717184Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells.
Q38457645Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites
Q37978967Present status and perspectives in functional analysis of p53 in chronic lymphocytic leukemia
Q42176122Preservation of cardiac function in left ventricle cardiac hypertrophy using an AAV vector which provides VEGF-A expression in response to p53.
Q34483943Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage
Q42224471Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment
Q28239216Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response
Q36185474Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation
Q36451639Quantification of damage due to low-dose radiation exposure in mice: construction and application of a biodosimetric model using mRNA indicators in circulating white blood cells
Q38136333Quantifying transcription factor kinetics: at work or at play?
Q41876865RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3' Nuclease-resistant Mini-hairpin Structure.
Q39456968RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance
Q38761174Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?
Q35266600Reciprocally regulated chromatin association of Cockayne syndrome protein B and p53 protein
Q35558646Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance
Q45316789Regulation of TP53 Activity through Association with Co-factors
Q92876161Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players
Q38678579Reprogramming the oncogenic response: SET protein as a potential therapeutic target in cancer
Q24613365Reverse transcriptase-coupled quantitative real time PCR analysis of cell-free transcription on the chromatin-assembled p21 promoter
Q28077590Review of Osteosarcoma and Current Management
Q64980081Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
Q37632783Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy
Q34364288SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation
Q36293819Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin
Q92298222Salusin-β mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway
Q38760554Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor
Q36238666Selective killing of p53-deficient cancer cells by SP600125.
Q38072351Senescence regulation by the p53 protein family
Q24299676Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells
Q58091188Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes
Q46514101Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress.
Q30586293Single-molecule analysis of transcription factor binding at transcription sites in live cells
Q34979878Splice-acceptor site mutation in p53 gene of hu888 zebrafish line.
Q38838490Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α.
Q35178418Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.
Q38130678Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease.
Q27679121Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions
Q30832097Structural visualization of the p53/RNA polymerase II assembly
Q27678998Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion
Q51017453Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS).
Q36036120Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population.
Q50318406TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation.
Q41499355TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription
Q35368917TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma
Q35042948TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity
Q37702327TP53 mutations, expression and interaction networks in human cancers
Q35795073Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils
Q38059739Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy
Q92408468The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer
Q35888903The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition
Q50448531The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene.
Q41914260The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl
Q92455257The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing
Q28078288The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System
Q90419845The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics
Q47182725The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.
Q38753361The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress
Q63358990The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells
Q38243969The miRNA network: micro-regulator of cell signaling in cancer
Q54979108The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas.
Q58780971The p53/Adipose-Tissue/Cancer Nexus
Q47159298The pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury.
Q42070740The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma
Q41752605The role of SIRT1 in cancer: the saga continues
Q38981518The role of the p53 protein in nitrosative stress-induced apoptosis of PC12 rat pheochromocytoma cells
Q24273295The transcription factor p53: not a repressor, solely an activator
Q62127714The transcription-independent mitochondrial cell death pathway is defective in non-transformed cells containing the Pro47Ser variant of p53
Q93023467Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC
Q41628379Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells
Q92636264Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence
Q39005896Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.
Q38029330Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage
Q91276897Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis
Q33618252Transcriptome profiling of the theca interna in transition from small to large antral ovarian follicles
Q38306855Tumour suppressors and cellular senescence
Q36974861USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.
Q36944526USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation
Q35137557Uncovering the basis of ATP hydrolysis activity in purified human p53 protein: a reinvestigation
Q38205099Unravelling mechanisms of p53-mediated tumour suppression
Q35665438Whole-genome cartography of p53 response elements ranked on transactivation potential.
Q34989369Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress
Q91611040YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1
Q36094135Zn(II)-curc targets p53 in thyroid cancer cells
Q92508193iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
Q36604636mTORC1 and p53: clash of the gods?
Q48218608p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction.
Q34377287p53 Family and Cellular Stress Responses in Cancer
Q37093496p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis
Q41811657p53 Loses grip on PIK3CA expression leading to enhanced cell survival during platinum resistance
Q36401999p53 N-terminal phosphorylation: a defining layer of complex regulation
Q35659515p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA
Q34313764p53 Research: the past thirty years and the next thirty years.
Q36231932p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways
Q39111656p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks
Q92083193p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death
Q36356298p53 attenuates AKT signaling by modulating membrane phospholipid composition
Q36052576p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes
Q47140890p53 binding sites in normal and cancer cells are characterized by distinct chromatin context.
Q34755812p53 binding to human genome: crowd control navigation in chromatin context
Q41924608p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells
Q38540071p53 in survival, death and metabolic health: a lifeguard with a licence to kill
Q38711897p53 induction and cell viability modulation by genotoxic individual chemicals and mixtures
Q36997572p53 regulation upon genotoxic stress: intricacies and complexities
Q40715545p53 requires an intact C-terminal domain for DNA binding and transactivation
Q39061575p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3.
Q89783061p53's Extended Reach: The Mutant p53 Secretome
Q54941377p53-Autophagy-Metastasis Link.
Q55515332p53-Dependent and -Independent Epithelial Integrity: Beyond miRNAs and Metabolic Fluctuations.
Q89881980β-Actin facilitates etoposide-induced p53 nuclear import
Q37163437β-Catenin C-terminal signals suppress p53 and are essential for artery formation

Search more.