review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Carol Prives | Q28112996 |
P2093 | author name string | Rachel Beckerman | |
P2860 | cites work | A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation | Q22008779 |
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 | Q24290402 | ||
The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation | Q24291244 | ||
ASPP proteins specifically stimulate the apoptotic function of p53 | Q24291844 | ||
p53 is regulated by the lysine demethylase LSD1 | Q24292925 | ||
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP | Q24295229 | ||
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. | Q24297694 | ||
DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage | Q24299608 | ||
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage | Q24299870 | ||
An acetylation switch in p53 mediates holo-TFIID recruitment | Q24300158 | ||
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis | Q24300728 | ||
Wild-type p53 binds to the TATA-binding protein and represses transcription | Q24300991 | ||
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription | Q24306465 | ||
Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation | Q24308905 | ||
Regulation of p53 activity through lysine methylation | Q24311514 | ||
Binding and modulation of p53 by p300/CBP coactivators | Q24312018 | ||
Acetylation is indispensable for p53 activation | Q24313477 | ||
Repression of p53 activity by Smyd2-mediated methylation | Q24315991 | ||
Identification of redox/repair protein Ref-1 as a potent activator of p53 | Q24316161 | ||
p53 isoforms can regulate p53 transcriptional activity. | Q24319034 | ||
Modulation of p53 function by SET8-mediated methylation at lysine 382 | Q24337822 | ||
Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation | Q24338320 | ||
hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes | Q24338336 | ||
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage | Q24530584 | ||
MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation | Q24537700 | ||
p53 Stimulates TFIID-TFIIA-promoter complex assembly, and p53-T antigen complex inhibits TATA binding protein-TATA interaction | Q24550965 | ||
Repression of RNA polymerase I transcription by the tumor suppressor p53 | Q24552501 | ||
p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner | Q24647526 | ||
Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage | Q24655422 | ||
CBP/p300 interact with and function as transcriptional coactivators of BRCA1 | Q24673965 | ||
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain | Q27860534 | ||
The role of chromatin during transcription | Q27860995 | ||
Arginine methylation regulates the p53 response | Q28116284 | ||
Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1 | Q28190792 | ||
Physical interaction and functional antagonism between the RNA polymerase II elongation factor ELL and p53 | Q28198423 | ||
A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1 | Q28203791 | ||
Definition of a consensus binding site for p53 | Q28207794 | ||
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults | Q28210433 | ||
Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway | Q28215330 | ||
p21 transcription is regulated by differential localization of histone H2A.Z. | Q35917048 | ||
Post-translational modification of p53 in tumorigenesis | Q35930703 | ||
RNA polymerases I and III, growth control and cancer | Q36028214 | ||
Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. | Q36117542 | ||
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope | Q36402588 | ||
Sliding into home: facilitated p53 search for targets by the basic DNA binding domain | Q36430175 | ||
Transcriptional regulation by p53: one protein, many possibilities | Q36436698 | ||
Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo. | Q36561445 | ||
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo | Q36601373 | ||
The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription | Q36685220 | ||
Tumor suppressor p53 slides on DNA with low friction and high stability | Q36717623 | ||
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis | Q36882985 | ||
p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting | Q37161582 | ||
A complex barcode underlies the heterogeneous response of p53 to stress | Q37249372 | ||
The mitochondrial p53 pathway | Q37325095 | ||
p53-Induced DNA bending: the interplay between p53-DNA and p53-p53 interactions | Q37370175 | ||
Transcriptional repression by p53 through direct binding to a novel DNA element | Q38300895 | ||
p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core | Q38307731 | ||
Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants. | Q38313400 | ||
DNA bending is essential for the site-specific recognition of DNA response elements by the DNA binding domain of the tumor suppressor protein p53. | Q38345163 | ||
Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element | Q38345165 | ||
Specific interaction of p53 with target binding sites is determined by DNA conformation and is regulated by the C-terminal domain | Q38363728 | ||
Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit | Q38774316 | ||
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets | Q39674825 | ||
Efficient specific DNA binding by p53 requires both its central and C-terminal domains as revealed by studies with high-mobility group 1 protein | Q39675422 | ||
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. | Q39859206 | ||
Chromium-mediated apoptosis: involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes | Q39964858 | ||
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. | Q39968880 | ||
Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cells | Q40048856 | ||
Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications | Q40085549 | ||
p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents | Q40093621 | ||
Methylation-acetylation interplay activates p53 in response to DNA damage | Q40103473 | ||
Site-specific acetylation of p53 directs selective transcription complex assembly. | Q40205369 | ||
Transcriptional regulation by p53 and p73. | Q40251375 | ||
Cdk9 phosphorylates p53 on serine 392 independently of CKII. | Q40272241 | ||
Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. | Q40290190 | ||
Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription | Q40296499 | ||
The Rb/E2F pathway: expanding roles and emerging paradigms | Q34052659 | ||
Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation | Q34080682 | ||
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. | Q34108288 | ||
A polymorphic microsatellite that mediates induction of PIG3 by p53. | Q34120918 | ||
Polyubiquitination of p53 by a ubiquitin ligase activity of p300. | Q34190044 | ||
p300/CBP/p53 interaction and regulation of the p53 response | Q34254607 | ||
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism | Q34394902 | ||
Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. | Q34443272 | ||
BRCA1 physically associates with p53 and stimulates its transcriptional activity. | Q34467604 | ||
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program | Q34471112 | ||
The general transcription machinery and general cofactors | Q34549899 | ||
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. | Q34565058 | ||
The RNA polymerase II machinery: structure illuminates function | Q34574312 | ||
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. | Q34582315 | ||
Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage | Q35071254 | ||
Transcriptional repression mediated by the p53 tumour suppressor | Q35116644 | ||
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. | Q35207550 | ||
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression | Q35568362 | ||
p53 function and dysfunction | Q35721291 | ||
p53's double life: transactivation-independent repression of homologous recombination. | Q35774503 | ||
CDK8 is a stimulus-specific positive coregulator of p53 target genes | Q28235350 | ||
Recruitment of p300/CBP in p53-dependent signal pathways | Q28243213 | ||
p21 is a universal inhibitor of cyclin kinases | Q28257305 | ||
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage | Q28263101 | ||
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53 | Q28265932 | ||
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma | Q28281602 | ||
p300/MDM2 complexes participate in MDM2-mediated p53 degradation | Q28288274 | ||
The general transcription factors of RNA polymerase II | Q28298663 | ||
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression | Q28300071 | ||
p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60 | Q28304820 | ||
Y-box factor YB1 controls p53 apoptotic function | Q28578217 | ||
p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage | Q28609701 | ||
Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication | Q28611456 | ||
Allosteric activation of latent p53 tetramers | Q28623087 | ||
Divergent evolution of human p53 binding sites: cell cycle versus apoptosis | Q28757271 | ||
Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression | Q28771498 | ||
Blinded by the Light: The Growing Complexity of p53 | Q29547590 | ||
A global map of p53 transcription-factor binding sites in the human genome | Q29614400 | ||
Elongation by RNA polymerase II: the short and long of it | Q29614529 | ||
Modes of p53 regulation | Q29615657 | ||
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas | Q29615658 | ||
DNA damage activates p53 through a phosphorylation-acetylation cascade | Q29616294 | ||
Transcriptional control of human p53-regulated genes | Q29617650 | ||
p53: puzzle and paradigm | Q29618407 | ||
The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53 | Q31023819 | ||
Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family | Q32078382 | ||
Noncanonical DNA motifs as transactivation targets by wild type and mutant p53 | Q33361623 | ||
Kinetics of p53 binding to promoter sites in vivo | Q33558659 | ||
The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA binding | Q33724426 | ||
p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding | Q33868917 | ||
p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53 | Q33888115 | ||
Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA. | Q33912006 | ||
Definition of the p53 functional domains necessary for inducing apoptosis | Q33917509 | ||
p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest | Q33925109 | ||
MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation | Q34016183 | ||
Mechanisms of regulatory diversity within the p53 transcriptional network | Q34039841 | ||
MUC1 oncoprotein stabilizes and activates estrogen receptor alpha | Q40326798 | ||
A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells | Q40419093 | ||
Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells. | Q40450785 | ||
Insights into selective activation of p53 DNA binding by c-Abl. | Q40468371 | ||
DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter. | Q40485978 | ||
The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. | Q40491393 | ||
MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation | Q40591224 | ||
p21/CDKN1A mediates negative regulation of transcription by p53. | Q40647697 | ||
A transcriptionally active DNA-binding site for human p53 protein complexes | Q40655196 | ||
p53 and translational control | Q40971271 | ||
How p53 binds DNA as a tetramer | Q41787604 | ||
Tumor suppressor protein p53 binds preferentially to supercoiled DNA. | Q42061462 | ||
p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled. | Q42098836 | ||
p53 represses ribosomal gene transcription | Q42468055 | ||
Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation | Q42508925 | ||
A structural role for metal ions in the "wild-type" conformation of the tumor suppressor protein p53. | Q42558710 | ||
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. | Q42724753 | ||
Acetylation of the p53 DNA-binding domain regulates apoptosis induction | Q43019120 | ||
A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint | Q43106462 | ||
The IARC TP53 database: new online mutation analysis and recommendations to users | Q43714274 | ||
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. | Q44192183 | ||
High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops. | Q44915895 | ||
Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells | Q45000475 | ||
p53 linear diffusion along DNA requires its C terminus | Q45138454 | ||
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis | Q45345472 | ||
The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality | Q46111122 | ||
Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress | Q46868426 | ||
The tumor suppressor p53 associates with gene coding regions and co-traverses with elongating RNA polymerase II in an in vivo model | Q46891002 | ||
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. | Q50335767 | ||
Comparative binding of p53 to its promoter and DNA recognition elements. | Q51503955 | ||
Chromatin immunoprecipitation-on-chip reveals stress-dependent p53 occupancy in primary normal cells but not in established cell lines. | Q51569733 | ||
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. | Q52590496 | ||
Structural basis of DNA recognition by p53 tetramers. | Q53616174 | ||
Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage | Q59098609 | ||
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein | Q64382309 | ||
Preferential binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain | Q73011234 | ||
Control of E2F activity by p21Waf1/Cip1 | Q73023858 | ||
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity | Q73615074 | ||
RB regulates the stability and the apoptotic function of p53 via MDM2 | Q74607074 | ||
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases | Q77456357 | ||
Phosphorylation of p53 serine 15 increases interaction with CBP | Q77604720 | ||
Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression | Q77726350 | ||
CDK9 phosphorylates p53 on serine residues 33, 315 and 392 | Q82904823 | ||
P433 | issue | 8 | |
P304 | page(s) | a000935 | |
P577 | publication date | 2010-04-28 | |
P1433 | published in | Cold Spring Harbor Perspectives in Biology | Q3927509 |
P1476 | title | Transcriptional regulation by p53. | |
P478 | volume | 2 |
Q89636325 | A circular RNA from the MDM2 locus controls cell cycle progression by suppressing p53 levels |
Q34178824 | A functional p53 responsive polymorphism in KITLG, rs4590952, does not affect the risk of breast cancer |
Q38946984 | A nanobody modulates the p53 transcriptional program without perturbing its functional architecture |
Q34957187 | A pathophysiological view of the long non-coding RNA world. |
Q34228309 | A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection |
Q28253043 | A versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real time |
Q42256808 | AAVPG: a vigilant vector where transgene expression is induced by p53. |
Q64087905 | AP endonuclease 1 (Apex1) influences brain development linking oxidative stress and DNA repair |
Q89424441 | Aberrant expression of ETS1 and ETS2 proteins in cancer |
Q37306546 | Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer |
Q36615629 | Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity |
Q24322033 | Activation of p53 transcriptional activity by SMRT: a histone deacetylase 3-independent function of a transcriptional corepressor |
Q48264201 | Activation of the Akt-CREB signalling axis by a proline-rich heptapeptide confers resistance to stress-induced cell death and inflammation. |
Q64914374 | An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea. |
Q94554707 | Analysis of TP53 aflatoxin signature mutation in hepatocellular carcinomas from Guatemala: A cross-sectional study (2016-2017) |
Q27026310 | Another fork in the road--life or death decisions by the tumour suppressor p53 |
Q33898584 | Apoptosis by [Pt(O,O'-acac)(γ-acac)(DMS)] requires PKC-δ mediated p53 activation in malignant pleural mesothelioma |
Q55306287 | Apoptosis in inner ear sensory hair cells. |
Q34964647 | Ash2L enables P53-dependent apoptosis by favoring stable transcription pre-initiation complex formation on its pro-apoptotic target promoters |
Q34621019 | Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma |
Q92797426 | Bicistronic transfer of CDKN2A and p53 culminates in collaborative killing of human lung cancer cells in vitro and in vivo |
Q40592113 | CMV promoter is repressed by p53 and activated by JNK pathway |
Q41853899 | CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage |
Q47965098 | Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes |
Q38911126 | Census and evaluation of p53 target genes. |
Q42119671 | CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress |
Q47132240 | Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma. |
Q38812141 | Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies |
Q92153177 | Characterization of p53 Family Homologs in Evolutionary Remote Branches of Holozoa |
Q34961997 | Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. |
Q34079481 | Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism |
Q89735096 | Cisplatin in Combination with MDM2 Inhibition Downregulates Rad51 Recombinase in a Bimodal Manner to Inhibit Homologous Recombination and Augment Tumor Cell Kill |
Q36482972 | Combined HDAC1 and HDAC2 Depletion Promotes Retinal Ganglion Cell Survival After Injury Through Reduction of p53 Target Gene Expression |
Q57461758 | Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine |
Q26777412 | Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis |
Q41872966 | Crosstalk between p53 and TGF-β Signalling. |
Q61446075 | Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells |
Q39218048 | DNA damage response and hematological malignancy |
Q39309267 | DNA damage-induced heterogeneous nuclear ribonucleoprotein K sumoylation regulates p53 transcriptional activation |
Q35130588 | Defining genome maintenance pathways using functional genomic approaches |
Q34550194 | Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis |
Q36094396 | Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. |
Q38729291 | Disposable Amperometric Immunosensor for the Determination of Human P53 Protein in Cell Lysates Using Magnetic Micro-Carriers. |
Q39095914 | Dominant effects of Δ40p53 on p53 function and melanoma cell fate |
Q52772321 | Drosophila p53 controls Notch expression and balances apoptosis and proliferation. |
Q54977589 | Dual Roles of Serine-Threonine Kinase Receptor-Associated Protein (STRAP) in Redox-Sensitive Signaling Pathways Related to Cancer Development. |
Q36396607 | E2F1 and p53 transcription factors as accessory factors for nucleotide excision repair. |
Q24293588 | E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression |
Q37635616 | E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells |
Q97587379 | ECRG2, a novel transcriptional target of p53, modulates cancer cell sensitivity to DNA damage |
Q34104165 | ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells |
Q38190819 | Effects of honey and its mechanisms of action on the development and progression of cancer. |
Q51032102 | Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction. |
Q64956800 | Emerging Roles of p53 Related lncRNAs in Cancer Progression: A Systematic Review. |
Q51643191 | Epidermal growth factor prevents thallium(I)- and thallium(III)-mediated rat pheochromocytoma (PC12) cell apoptosis. |
Q33568800 | Essential role for centromeric factors following p53 loss and oncogenic transformation |
Q38860158 | Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells. |
Q26827810 | Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds. |
Q35558858 | Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay |
Q38468872 | Exploiting the yeast stress-activated signaling network to inform on stress biology and disease signaling. |
Q35869772 | Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics |
Q35916594 | Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells |
Q39411422 | Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription |
Q51794453 | Functional studies of a novel germline p53 splicing mutation identified in a patient with Li-Fraumeni-like syndrome. |
Q27313430 | G-actin guides p53 nuclear transport: potential contribution of monomeric actin in altered localization of mutant p53. |
Q34984471 | GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis |
Q54255820 | Genetics and Biology of Pancreatic Ductal Adenocarcinoma. |
Q42228944 | Genistein promotes cell death of ethanol-stressed HeLa cells through the continuation of apoptosis or secondary necrosis |
Q40537164 | Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo |
Q38927148 | Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature |
Q35311763 | Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA. |
Q37417024 | Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells |
Q38867373 | Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A. |
Q37183586 | Growth hormone is permissive for neoplastic colon growth |
Q33864922 | Haploinsufficient tumor suppressor genes |
Q36031533 | Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo |
Q34701793 | Hepatitis C virus NS2 protein inhibits DNA damage pathway by sequestering p53 to the cytoplasm. |
Q38217666 | Histone deacetylase inhibitors and cell death |
Q33663060 | Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53 |
Q36390683 | Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53. |
Q89597805 | How p53 Molecules Solve the Target DNA Search Problem: A Review |
Q92962230 | Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine |
Q39044368 | Id4 dependent acetylation restores mutant-p53 transcriptional activity |
Q40991008 | Identification of p53-target genes in Danio rerio |
Q33877751 | Identification of two novel functional p53 responsive elements in the herpes simplex virus-1 genome |
Q38310745 | Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex |
Q33934010 | Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma |
Q37933073 | Inhibiting eukaryotic transcription: Which compound to choose? How to evaluate its activity? |
Q38848287 | Inhibition of Human Pancreatic Cancer Cell Proliferation by Devil's Club Oplopanax horridus and Its Polyacetylene Bioactive Compound |
Q38735257 | Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice. |
Q37197461 | Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks. |
Q34258129 | Interaction between the Cockayne syndrome B and p53 proteins: implications for aging |
Q28000133 | Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity |
Q37615064 | Is p53 Involved in Tissue-Specific Insulin Resistance Formation? |
Q50565186 | Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis. |
Q64943265 | Key mechanisms involved in ionizing radiation-induced systemic effects. A current review. |
Q38956592 | Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity |
Q39041480 | Li-Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition |
Q42682133 | Life or death: p53-induced apoptosis requires DNA binding cooperativity. |
Q41488339 | Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity. |
Q38176848 | LncRNAs: new players in gliomas, with special emphasis on the interaction of lncRNAs With EZH2. |
Q36133137 | Long Noncoding RNA MEG3 Interacts with p53 Protein and Regulates Partial p53 Target Genes in Hepatoma Cells |
Q40055589 | Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer. |
Q39042974 | Long noncoding RNAs in the p53 network. |
Q36880005 | Long story short: p53 mediates innate immunity |
Q45393476 | Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response |
Q34165710 | Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells |
Q91302990 | MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53 |
Q55319096 | MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma. |
Q38802454 | Major apoptotic mechanisms and genes involved in apoptosis |
Q41142436 | Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis |
Q38059700 | Mdm2 and MdmX as Regulators of Gene Expression |
Q39404029 | MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress |
Q47416965 | Mechanisms of transcriptional regulation by p53. |
Q46900782 | Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells |
Q47737123 | Modelling the propagation of a dynamical signature in gene expression mediated by the transport of extracellular microRNAs. |
Q42787889 | Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ. |
Q34464874 | Molecular basis for modulation of the p53 target selectivity by KLF4. |
Q39657304 | Molecular signatures of ovarian diseases: Insights from network medicine perspective. |
Q39455093 | Mule determines the apoptotic response to HDAC inhibitors by targeted ubiquitination and destruction of HDAC2. |
Q36922983 | Multifaceted functions of Siva-1: more than an Indian God of Destruction |
Q39752696 | Multiplex enhancer-reporter assays uncover unsophisticated TP53 enhancer logic |
Q54985026 | Multivalency regulates activity in an intrinsically disordered transcription factor. |
Q38844605 | Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication |
Q38204111 | Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks |
Q33687048 | Mutant p53 gain-of-function in cancer |
Q93367358 | Mutant p53 in colon cancer |
Q39297236 | Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity |
Q30313610 | Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5. |
Q89323796 | Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4 |
Q42367753 | Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. |
Q36812554 | Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression |
Q55504431 | Mutations of p53 decrease sensitivity to the anthracycline treatments in bladder cancer cells. |
Q46243584 | Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice. |
Q30370843 | NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2. |
Q43123230 | Not all p53 gain-of-function mutants are created equal |
Q36701116 | Novel RNA-binding activity of MYF5 enhances Ccnd1/Cyclin D1 mRNA translation during myogenesis |
Q40551859 | Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation. |
Q36978256 | NuMA is required for the selective induction of p53 target genes |
Q37330844 | Nuclear translocation of annexin 1 following oxygen-glucose deprivation-reperfusion induces apoptosis by regulating Bid expression via p53 binding. |
Q50954935 | One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain. |
Q41108776 | P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes? |
Q34828404 | P53 family members modulate the expression of PRODH, but not PRODH2, via intronic p53 response elements. |
Q24594648 | PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53 |
Q34364654 | PTEN interacts with histone H1 and controls chromatin condensation |
Q58699214 | Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer |
Q37191174 | Pharmacological activation of p53 in cancer cells |
Q35196159 | Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53 |
Q47772405 | Phosphorylation of NTRK1 at Y674/Y675 induced by TP53-dependent repression of PTPN6 expression: a potential novel prognostic marker for breast cancer |
Q38945300 | Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition |
Q34038331 | Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2 |
Q28512750 | Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts |
Q38125728 | Post-transcriptional regulation of DNA damage-responsive gene expression |
Q47835030 | Post-translational regulation of p53 function through 20S proteasome-mediated cleavage. |
Q38717184 | Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells. |
Q38457645 | Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites |
Q37978967 | Present status and perspectives in functional analysis of p53 in chronic lymphocytic leukemia |
Q42176122 | Preservation of cardiac function in left ventricle cardiac hypertrophy using an AAV vector which provides VEGF-A expression in response to p53. |
Q34483943 | Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage |
Q42224471 | Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment |
Q28239216 | Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response |
Q36185474 | Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation |
Q36451639 | Quantification of damage due to low-dose radiation exposure in mice: construction and application of a biodosimetric model using mRNA indicators in circulating white blood cells |
Q38136333 | Quantifying transcription factor kinetics: at work or at play? |
Q41876865 | RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3' Nuclease-resistant Mini-hairpin Structure. |
Q39456968 | RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance |
Q38761174 | Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity? |
Q35266600 | Reciprocally regulated chromatin association of Cockayne syndrome protein B and p53 protein |
Q35558646 | Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance |
Q45316789 | Regulation of TP53 Activity through Association with Co-factors |
Q92876161 | Relevance of Non-Targeted Effects for Radiotherapy and Diagnostic Radiology; A Historical and Conceptual Analysis of Key Players |
Q38678579 | Reprogramming the oncogenic response: SET protein as a potential therapeutic target in cancer |
Q24613365 | Reverse transcriptase-coupled quantitative real time PCR analysis of cell-free transcription on the chromatin-assembled p21 promoter |
Q28077590 | Review of Osteosarcoma and Current Management |
Q64980081 | Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease. |
Q37632783 | Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy |
Q34364288 | SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation |
Q36293819 | Sall2 is required for proapoptotic Noxa expression and genotoxic stress-induced apoptosis by doxorubicin |
Q92298222 | Salusin-β mediates tubular cell apoptosis in acute kidney injury: Involvement of the PKC/ROS signaling pathway |
Q38760554 | Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor |
Q36238666 | Selective killing of p53-deficient cancer cells by SP600125. |
Q38072351 | Senescence regulation by the p53 protein family |
Q24299676 | Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells |
Q58091188 | Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes |
Q46514101 | Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress. |
Q30586293 | Single-molecule analysis of transcription factor binding at transcription sites in live cells |
Q34979878 | Splice-acceptor site mutation in p53 gene of hu888 zebrafish line. |
Q38838490 | Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α. |
Q35178418 | Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. |
Q38130678 | Structural disorder and the loss of RNA homeostasis in aging and neurodegenerative disease. |
Q27679121 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions |
Q30832097 | Structural visualization of the p53/RNA polymerase II assembly |
Q27678998 | Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion |
Q51017453 | Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS). |
Q36036120 | Study of Association between Pre-Senile Cataracts and the Polymorphisms rs2228000 in XPC and rs1042522 in p53 in Spanish Population. |
Q50318406 | TBP-like Protein (TLP) Disrupts the p53-MDM2 Interaction and Induces Long-lasting p53 Activation. |
Q41499355 | TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription |
Q35368917 | TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma |
Q35042948 | TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity |
Q37702327 | TP53 mutations, expression and interaction networks in human cancers |
Q35795073 | Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils |
Q38059739 | Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy |
Q92408468 | The Chemopreventive Activity of Indonesia Medicinal Plants Targeting on Hallmarks of Cancer |
Q35888903 | The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition |
Q50448531 | The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene. |
Q41914260 | The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl |
Q92455257 | The RNF20/40 complex regulates p53-dependent gene transcription and mRNA splicing |
Q28078288 | The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System |
Q90419845 | The Role of the Cyclin Dependent Kinase Inhibitor p21cip1/waf1 in Targeting Cancer: Molecular Mechanisms and Novel Therapeutics |
Q47182725 | The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14. |
Q38753361 | The absence of p53 during Human Cytomegalovirus infection leads to decreased UL53 expression, disrupting UL50 localization to the inner nuclear membrane, and thereby inhibiting capsid nuclear egress |
Q63358990 | The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells |
Q38243969 | The miRNA network: micro-regulator of cell signaling in cancer |
Q54979108 | The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. |
Q58780971 | The p53/Adipose-Tissue/Cancer Nexus |
Q47159298 | The pathogenesis of diclofenac induced immunoallergic hepatitis in a canine model of liver injury. |
Q42070740 | The pathophysiological significance of PPM1D and therapeutic targeting of PPM1D-mediated signaling by GSK2830371 in mantle cell lymphoma |
Q41752605 | The role of SIRT1 in cancer: the saga continues |
Q38981518 | The role of the p53 protein in nitrosative stress-induced apoptosis of PC12 rat pheochromocytoma cells |
Q24273295 | The transcription factor p53: not a repressor, solely an activator |
Q62127714 | The transcription-independent mitochondrial cell death pathway is defective in non-transformed cells containing the Pro47Ser variant of p53 |
Q93023467 | Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC |
Q41628379 | Thiamine antagonists trigger p53-dependent apoptosis in differentiated SH-SY5Y cells |
Q92636264 | Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence |
Q39005896 | Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53. |
Q38029330 | Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage |
Q91276897 | Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis |
Q33618252 | Transcriptome profiling of the theca interna in transition from small to large antral ovarian follicles |
Q38306855 | Tumour suppressors and cellular senescence |
Q36974861 | USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2. |
Q36944526 | USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation |
Q35137557 | Uncovering the basis of ATP hydrolysis activity in purified human p53 protein: a reinvestigation |
Q38205099 | Unravelling mechanisms of p53-mediated tumour suppression |
Q35665438 | Whole-genome cartography of p53 response elements ranked on transactivation potential. |
Q34989369 | Wild type p53 transcriptionally represses the SALL2 transcription factor under genotoxic stress |
Q91611040 | YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1 |
Q36094135 | Zn(II)-curc targets p53 in thyroid cancer cells |
Q92508193 | iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition |
Q36604636 | mTORC1 and p53: clash of the gods? |
Q48218608 | p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction. |
Q34377287 | p53 Family and Cellular Stress Responses in Cancer |
Q37093496 | p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis |
Q41811657 | p53 Loses grip on PIK3CA expression leading to enhanced cell survival during platinum resistance |
Q36401999 | p53 N-terminal phosphorylation: a defining layer of complex regulation |
Q35659515 | p53 Represses the Oncogenic Sno-MiR-28 Derived from a SnoRNA |
Q34313764 | p53 Research: the past thirty years and the next thirty years. |
Q36231932 | p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways |
Q39111656 | p53 and RAD9, the DNA Damage Response, and Regulation of Transcription Networks |
Q92083193 | p53 at the Crossroads between Different Types of HDAC Inhibitor-Mediated Cancer Cell Death |
Q36356298 | p53 attenuates AKT signaling by modulating membrane phospholipid composition |
Q36052576 | p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes |
Q47140890 | p53 binding sites in normal and cancer cells are characterized by distinct chromatin context. |
Q34755812 | p53 binding to human genome: crowd control navigation in chromatin context |
Q41924608 | p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells |
Q38540071 | p53 in survival, death and metabolic health: a lifeguard with a licence to kill |
Q38711897 | p53 induction and cell viability modulation by genotoxic individual chemicals and mixtures |
Q36997572 | p53 regulation upon genotoxic stress: intricacies and complexities |
Q40715545 | p53 requires an intact C-terminal domain for DNA binding and transactivation |
Q39061575 | p53 tumor suppressor protein stability and transcriptional activity are targeted by Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factor 3. |
Q89783061 | p53's Extended Reach: The Mutant p53 Secretome |
Q54941377 | p53-Autophagy-Metastasis Link. |
Q55515332 | p53-Dependent and -Independent Epithelial Integrity: Beyond miRNAs and Metabolic Fluctuations. |
Q89881980 | β-Actin facilitates etoposide-induced p53 nuclear import |
Q37163437 | β-Catenin C-terminal signals suppress p53 and are essential for artery formation |
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