| scholarly article | Q13442814 |
| P50 | author | Koichi Matsuda | Q40066157 |
| Hirofumi Arakawa | Q42668345 | ||
| P2093 | author name string | Y Taya | |
| K Oda | |||
| Y Nakamura | |||
| T Tanaka | |||
| H Nishimori | |||
| T Tokino | |||
| K Tamai | |||
| T Mori | |||
| C Tanikawa | |||
| P2860 | cites work | A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis | Q40019792 |
| The proto-oncogene Bcl-2 and its role in regulating apoptosis | Q41492030 | ||
| Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines | Q41708885 | ||
| p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. | Q42125448 | ||
| Molecular events underlying schistosomiasis‐related bladder cancer | Q71941384 | ||
| Signaling to p53: breaking the MDM2-p53 circuit | Q77430977 | ||
| Increased apoptosis induction by 121F mutant p53 | Q22003742 | ||
| Identification of a novel p53 functional domain that is necessary for efficient growth suppression | Q24311276 | ||
| A model for p53-induced apoptosis | Q24313374 | ||
| CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress | Q24314431 | ||
| Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system | Q24336307 | ||
| The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression | Q24533291 | ||
| Basic local alignment search tool | Q25938991 | ||
| Prediction of complete gene structures in human genomic DNA | Q27860780 | ||
| Efficient selection for high-expression transfectants with a novel eukaryotic vector | Q27860810 | ||
| p53, the cellular gatekeeper for growth and division | Q27860990 | ||
| A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage | Q28138556 | ||
| Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis | Q28144256 | ||
| DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2 | Q28254119 | ||
| A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis | Q28256067 | ||
| The complexity of p53 modulation: emerging patterns from divergent signals | Q28284854 | ||
| Tumor suppressor p53 is a direct transcriptional activator of the human bax gene | Q28306186 | ||
| Mitochondria and apoptosis | Q29547905 | ||
| Rapid and sensitive sequence comparison with FASTP and FASTA | Q29618272 | ||
| Suppression of human colorectal carcinoma cell growth by wild-type p53 | Q29618318 | ||
| p53: puzzle and paradigm | Q29618407 | ||
| A knowledge base for predicting protein localization sites in eukaryotic cells | Q29618927 | ||
| Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest | Q33774492 | ||
| Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation | Q33891341 | ||
| P53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines. | Q33899383 | ||
| Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases | Q34298718 | ||
| DNA damage induces phosphorylation of the amino terminus of p53 | Q35199554 | ||
| Identification of a novel class of genomic DNA-binding sites suggests a mechanism for selectivity in target gene activation by the tumor suppressor protein p53 | Q35205701 | ||
| Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames | Q35873486 | ||
| p53 tagged sites from human genomic DNA. | Q38305003 | ||
| Identification of a novel p53 functional domain that is necessary for mediating apoptosis | Q38337319 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | phosphorylation | Q242736 |
| apoptotic process | Q14599311 | ||
| Tumor protein p53 regulated apoptosis inducing protein 1 | Q21126614 | ||
| P304 | page(s) | 849-62 | |
| P577 | publication date | 2000-09-15 | |
| P1433 | published in | Cell | Q655814 |
| P1476 | title | p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53 | |
| P478 | volume | 102 |
| Q35994548 | 3D tumor tissue analogs and their orthotopic implants for understanding tumor-targeting of microenvironment-responsive nanosized chemotherapy and radiation |
| Q53467671 | 5-Aza-2'-deoxycytidine restores proapoptotic function of p53 in cancer cells resistant to p53-induced apoptosis. |
| Q40026569 | A balance between NF-Y and p53 governs the pro- and anti-apoptotic transcriptional response. |
| Q33416383 | A case of dedifferentiated solitary fibrous tumor in the pelvis with TP53 mutation |
| Q37249372 | A complex barcode underlies the heterogeneous response of p53 to stress |
| Q40612662 | A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells |
| Q34982704 | A conserved amphipathic helix in the N-terminal regulatory region of the papillomavirus E1 helicase is required for efficient viral DNA replication |
| Q34352878 | A decade of site- and phosphorylation state-specific antibodies: recent advances in studies of spatiotemporal protein phosphorylation |
| Q38974551 | A link between chromatin condensation mechanisms and Huntington's disease: connecting the dots. |
| Q38797735 | A modified p53 enhances apoptosis in sarcoma cell lines mediated by doxorubicin |
| Q39283910 | A novel approach to cancer treatment using structural hybrids of the p53 gene family. |
| Q33688856 | A novel oncolytic adenovirus based on simian adenovirus serotype 24 |
| Q40711394 | A novel p53 mutational hotspot in skin tumors from UV-irradiated Xpc mutant mice alters transactivation functions |
| Q24301950 | A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF) |
| Q53667066 | A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes. |
| Q33825730 | A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation |
| Q36037994 | A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. |
| Q24297172 | AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis |
| Q40776107 | APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. |
| Q28299046 | ASPP [corrected] and cancer |
| Q24336416 | ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage |
| Q40747424 | ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation |
| Q39604095 | ATR mediates cisplatin resistance in a p53 genotype-specific manner |
| Q24306227 | AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation |
| Q24301523 | Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress |
| Q45073511 | Aberrant p53 alters DNA damage checkpoints in response to cisplatin: downregulation of CDK expression and activity |
| Q36601373 | Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo |
| Q43019120 | Acetylation of the p53 DNA-binding domain regulates apoptosis induction |
| Q28366563 | Activation and activities of the p53 tumour suppressor protein |
| Q46868426 | Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress |
| Q40750164 | Activation of ATM and phosphorylation of p53 by heat shock |
| Q39516161 | Activation of p53 protein by telomeric (TTAGGG)n repeats |
| Q40783205 | Activation of p53 transcriptional activity requires ATM's kinase domain and multiple N-terminal serine residues of p53. |
| Q34605518 | Activation of the p53 tumor suppressor protein |
| Q36244173 | Adenovirus Ad-p53AIP1-mediated gene therapy and its regulation of p53-MDM2 interactions. |
| Q40599793 | Adenovirus-mediated p53AIP1 gene transfer as a new strategy for treatment of p53-resistant tumors. |
| Q33850934 | All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis |
| Q34560275 | Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity |
| Q24650534 | Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53 |
| Q35567264 | Alterations in the apoptotic machinery and their potential role in anticancer drug resistance |
| Q36560030 | Altered binding site selection of p53 transcription cassettes by hepatitis B virus X protein |
| Q36306105 | Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis |
| Q27853369 | An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model |
| Q60309696 | An RNA Aptamer Targeting the Receptor Tyrosine Kinase PDGFRα Induces Anti-tumor Effects through STAT3 and p53 in Glioblastoma |
| Q36163874 | An in vitro assessment of liposomal topotecan simulating metronomic chemotherapy in combination with radiation in tumor-endothelial spheroids |
| Q39910695 | An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. |
| Q38307906 | An integrated map of p53-binding sites and histone modification in the human ENCODE regions |
| Q54738045 | Analysing differential gene expression in cancer. |
| Q27026310 | Another fork in the road--life or death decisions by the tumour suppressor p53 |
| Q39136954 | Anti-apoptotic response during anoxia and recovery in a freeze-tolerant wood frog (Rana sylvatica) |
| Q37554263 | Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. |
| Q29248485 | Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers |
| Q35874908 | Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis. |
| Q37605156 | Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2. |
| Q38228349 | Apoptosis and molecular targeting therapy in cancer |
| Q35117847 | Apoptosis and necrosis in health and disease: Role of mitochondria |
| Q26750639 | Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies |
| Q44712404 | Apoptosis gene polymorphisms and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy |
| Q34395580 | Apoptosis regulators and their role in tumorigenesis |
| Q44489511 | Apoptotic cell death in the lens epithelium of rat sugar cataract |
| Q34275400 | Apoptotic death sensor: an organelle's alter ego? |
| Q36993540 | Apoptotic effect of tolfenamic acid on MDA-MB-231 breast cancer cells and xenograft tumors |
| Q58266145 | Appearance of Bax Protein After Preoperative Chemoradiotherapy is a Prognostic Factor in Maxillary Cancer |
| Q34017186 | Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing. |
| Q28116284 | Arginine methylation regulates the p53 response |
| Q33708112 | Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53 |
| Q40493341 | Arsenic trioxide (ATO) and MEK1 inhibition synergize to induce apoptosis in acute promyelocytic leukemia cells. |
| Q53653335 | Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage. |
| Q37318070 | Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death |
| Q42703696 | Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2. |
| Q39803554 | Axin determines cell fate by controlling the p53 activation threshold after DNA damage |
| Q24298631 | BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase |
| Q28205892 | BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria |
| Q28211208 | BID regulation by p53 contributes to chemosensitivity |
| Q48190456 | BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis |
| Q39674825 | BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets |
| Q38282236 | Battle against cancer: an everlasting saga of p53. |
| Q24290957 | Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension |
| Q46246683 | Betanodavirus B2 protein triggers apoptosis and necroptosis in lung cancer cells that suppresses autophagy |
| Q35204844 | Body language: the function of PML nuclear bodies in apoptosis regulation |
| Q40737382 | C-terminus of p53 is required for G(2) arrest |
| Q24307766 | CD27 and CD40 inhibit p53-independent mitochondrial pathways in apoptosis of B cells induced by B cell receptor ligation |
| Q55467766 | CDC20, a potential cancer therapeutic target, is negatively regulated by p53. |
| Q36370912 | CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene |
| Q35836043 | CLCA2 as a p53-inducible senescence mediator |
| Q30401329 | Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein |
| Q40757141 | Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line |
| Q40685205 | Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53. |
| Q35035620 | Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis |
| Q37262599 | Cell fate decision mediated by p53 pulses |
| Q60300970 | Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance |
| Q35628579 | Cellular senescence in cancer treatment: friend or foe? |
| Q79303236 | Central role of mitochondria and p53 in Fas-mediated apoptosis of rheumatoid synovial fibroblasts |
| Q38812141 | Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies |
| Q33370291 | Characterization of the p53 response to oncogene-induced senescence |
| Q36346917 | Che-1 modulates the decision between cell cycle arrest and apoptosis by its binding to p53. |
| Q36328705 | Che-ating death: CHE1/AATF protects from p53-mediated apoptosis |
| Q35026496 | Chemotherapy: targeting the mitochondrial cell death pathway |
| Q34324643 | Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner |
| Q34152941 | Chromosome instability in human lung cancers: possible underlying mechanisms and potential consequences in the pathogenesis |
| Q39112125 | Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry |
| Q37126082 | Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer |
| Q42154446 | Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53 |
| Q39556740 | Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels |
| Q34126651 | Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease |
| Q40134862 | Consequences of the loss of p53, RB1, and PTEN: relationship to gefitinib resistance in endometrial cancer. |
| Q51138491 | Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage. |
| Q39610891 | Contribution of autophagic cell death to p53-dependent cell death in human glioblastoma cell line SF126. |
| Q39974501 | Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. |
| Q35603381 | Control of apoptosis by p53. |
| Q24295165 | Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element |
| Q34181478 | Coordination between Cell Cycle Progression and Cell Fate Decision by the p53 and E2F1 Pathways in Response to DNA Damage |
| Q35885647 | Coordination of the nuclear and cytoplasmic activities of p53 in response to DNA damage |
| Q42371971 | Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications. |
| Q40750080 | Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis |
| Q91710593 | Crosstalk between p53 modifiers at PML bodies |
| Q37317313 | Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor |
| Q89608997 | Crotonylation at serine 46 impairs p53 activity |
| Q38045433 | Current treatment of cutaneous squamous cancer and molecular strategies for its sensitization to new target-based drugs. |
| Q34081681 | Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2. |
| Q24682907 | Cyclin K as a direct transcriptional target of the p53 tumor suppressor |
| Q35674559 | Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. |
| Q36851308 | CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress |
| Q36746295 | Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity |
| Q34658518 | Cytokine control of developmental programs in normal hematopoiesis and leukemia |
| Q40729390 | DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. |
| Q64078921 | DNA Damage Stress: Cui Prodest? |
| Q28271163 | DNA damage and the balance between survival and death in cancer biology |
| Q50320380 | DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. |
| Q24338364 | DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation |
| Q24555770 | DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 |
| Q40796673 | DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1. |
| Q40799703 | DNA microarrays identification of primary and secondary target genes regulated by p53. |
| Q24299608 | DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage |
| Q28217065 | Death and anti-death: tumour resistance to apoptosis |
| Q40775865 | Decision Making by p53: Life versus Death |
| Q35116663 | Decision making by p53: life, death and cancer |
| Q42549708 | Decision-making by p53 and mTOR. |
| Q46772713 | Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. |
| Q35184454 | Deoxypodophyllotoxin isolated from Juniperus communis induces apoptosis in breast cancer cells |
| Q40548465 | Dependence of chemotherapy response on p53 mutation status in a panel of human cancer lines maintained in nude mice |
| Q44487712 | Dephosphorylation of p53 during cell death by N-alpha-tosyl-L-phenylalanyl chloromethyl ketone |
| Q24291896 | Differential effect of ik3-1/cables on p53- and p73-induced cell death |
| Q24338676 | Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis |
| Q42044986 | Differential regulation of p53 target genes: it's (core promoter) elementary. |
| Q34443272 | Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. |
| Q53582169 | Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells. |
| Q33738750 | Discovery of Mieap-regulated mitochondrial quality control as a new function of tumor suppressor p53 |
| Q34618921 | Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes |
| Q38755737 | Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage |
| Q40365232 | Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis |
| Q38305680 | Dissecting functional roles of p53 N-terminal transactivation domains by microarray expression analysis |
| Q36423933 | Dissecting p53-dependent apoptosis. |
| Q36117542 | Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate. |
| Q74088930 | Distinct pattern of p53 phosphorylation in human tumors |
| Q40584936 | Down-regulation of survivin in nitric oxide-induced cell growth inhibition and apoptosis of the human lung carcinoma cells |
| Q39161605 | Down-regulation of wild-type p53-induced phosphatase 1 (Wip1) plays a critical role in regulating several p53-dependent functions in premature senescent tumor cells. |
| Q33637053 | Downregulation of the tumor suppressor HSPB7, involved in the p53 pathway, in renal cell carcinoma by hypermethylation |
| Q38191796 | Drugging the p53 pathway: understanding the route to clinical efficacy |
| Q28204132 | Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53 |
| Q38718347 | EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis |
| Q40150740 | Effect of distinct anticancer drugs on the phosphorylation of p53 protein at serine 46 in human MCF-7 breast cancer cells |
| Q50074464 | Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells |
| Q28081810 | Engagement of DYRK2 in proper control for cell division |
| Q40333155 | Epstein-Barr virus selectively deregulates DNA damage responses in normal B cells but has no detectable effect on regulation of the tumor suppressor p53. |
| Q38255676 | Essential role of caspase-8 in p53/p73-dependent apoptosis induced by etoposide in head and neck carcinoma cells |
| Q36402588 | Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope |
| Q33416708 | Evidence for autism spectrum disorder in Jacobsen syndrome: identification of a candidate gene in distal 11q. |
| Q50996270 | Evodiamine Prevents Glioma Growth, Induces Glioblastoma Cell Apoptosis and Cell Cycle Arrest through JNK Activation. |
| Q40290190 | Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. |
| Q40368333 | Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR. |
| Q36659141 | FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage |
| Q45883450 | Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33(ING1) in T.Tn human esophageal carcinoma cells |
| Q37771334 | Forkhead homeobox type O transcription factors in the responses to oxidative stress |
| Q34865226 | Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements |
| Q44039342 | Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract |
| Q34425450 | Functional interactions and signaling properties of mammalian DNA mismatch repair proteins |
| Q44679404 | Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export |
| Q33772124 | Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation. |
| Q33839575 | Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. |
| Q34279589 | Generation and characterization of Smac/DIABLO-deficient mice. |
| Q38796076 | Genetic Modifiers of the p53 Pathway |
| Q34813092 | Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients. |
| Q34963574 | Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
| Q91619371 | Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer |
| Q34417108 | Genotoxic and non-genotoxic pathways of p53 induction |
| Q39362304 | Geranylgeranylacetone attenuates cisplatin-induced reductions in cell viability by suppressing the elevation of intracellular p53 content without heat shock protein induction. |
| Q48082716 | Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A. |
| Q21284181 | Glycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activity |
| Q38867373 | Gradual reduction in rRNA transcription triggers p53 acetylation and apoptosis via MYBBP1A. |
| Q34086208 | Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. |
| Q36657584 | H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation |
| Q34616703 | HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation. |
| Q40421589 | HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage |
| Q33292477 | HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations. |
| Q37402028 | HIPK2 modulates p53 activity towards pro-apoptotic transcription |
| Q24338503 | HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function |
| Q54588191 | HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage. |
| Q36751275 | HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism |
| Q34476585 | HIPK2 sustains apoptotic response by phosphorylating Che-1/AATF and promoting its degradation |
| Q80603062 | HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway |
| Q31122379 | HIPK2: a multitalented partner for transcription factors in DNA damage response and development. |
| Q40535811 | Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner |
| Q34274477 | High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity |
| Q33944653 | High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. |
| Q35613894 | High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2. |
| Q39979219 | Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis |
| Q33564142 | Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival |
| Q34251143 | Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response |
| Q44800950 | Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues. |
| Q37746347 | Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies |
| Q40598361 | Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis |
| Q34108288 | Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. |
| Q38673048 | Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility |
| Q24310662 | How cells switch HIPK2 on and off |
| Q36879036 | How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? |
| Q24294875 | Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response |
| Q35974864 | Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199 |
| Q92962230 | Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine |
| Q52591879 | Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis. |
| Q48341534 | Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein |
| Q31864081 | Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells |
| Q24302481 | IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway |
| Q48028666 | IGF-1 activates p21 to inhibit UV-induced cell death. |
| Q91959958 | Identification and characterization of the binding sequences and target genes of p53 lacking the 1st transactivation domain |
| Q28177158 | Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene |
| Q34301424 | Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses |
| Q34343912 | Identification of SCN3B as a novel p53-inducible proapoptotic gene. |
| Q30163839 | Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway |
| Q28590284 | Identification of a mouse thiamine transporter gene as a direct transcriptional target for p53 |
| Q41348834 | Identification of a p53-repressed gene module in breast cancer cells |
| Q28590032 | Identification of functional p53-binding motifs in the mouse wig-1 promoter |
| Q45073098 | Identification of novel direct transcriptional targets of glucocorticoid receptor |
| Q40257577 | Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis. |
| Q24550987 | Identification of semaphorin3B as a direct target of p53 |
| Q43562946 | Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53. |
| Q38176221 | Illuminating p53 function in cancer with genetically engineered mouse models |
| Q28511162 | Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools |
| Q35664020 | In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation |
| Q42810225 | Increased p53 transcription prior to DNA synthesis is regulated through a novel regulatory element within the p53 promoter |
| Q36214686 | Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. |
| Q40736238 | Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53. |
| Q37495171 | Induction of amphiregulin by p53 promotes apoptosis via control of microRNA biogenesis in response to DNA damage |
| Q35043420 | Induction of apoptosis in cancer: new therapeutic opportunities |
| Q47318324 | Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis. |
| Q40233207 | Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells |
| Q37061407 | Influence of induced reactive oxygen species in p53-mediated cell fate decisions. |
| Q55473369 | Influence of p53 mutations on prognosis of patients with glioblastoma. |
| Q35027581 | Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis |
| Q52579534 | Inhibition of cancer progression by a novel trans-stilbene derivative through disruption of microtubule dynamics, driving G2/M arrest, and p53-dependent apoptosis. |
| Q34650882 | Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. |
| Q43131463 | Insight into the structural basis of pro- and antiapoptotic p53 modulation by ASPP proteins |
| Q34425447 | Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling |
| Q35131580 | Insights into the mitochondrial signaling pathway: what lessons for chemotherapy? |
| Q30453380 | Integrins regulate the apoptotic response to DNA damage through modulation of p53 |
| Q39594930 | Interference with ER-α enhances the therapeutic efficacy of the selective CDK inhibitor roscovitine towards ER-positive breast cancer cells |
| Q33656086 | Interplay between Mdm2 and HIPK2 in the DNA damage response |
| Q37001441 | Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA |
| Q45065720 | Involvement of 14-3-3 signaling protein binding in the functional regulation of the transcriptional activator REPRESSION OF SHOOT GROWTH by gibberellins. |
| Q44593627 | Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks |
| Q33561350 | Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction. |
| Q38162722 | Ionizing radiation-induced responses in human cells with differing TP53 status |
| Q30745027 | Isolation of Temperature-sensitive p53 Mutations from a Comprehensive Missense Mutation Library |
| Q35628056 | Isolation of p53-target genes and their functional analysis |
| Q33558659 | Kinetics of p53 binding to promoter sites in vivo |
| Q39527015 | Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis |
| Q38956592 | Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity |
| Q43938775 | Late resistance to adenoviral p53-mediated apoptosis caused by decreased expression of Coxsackie-adenovirus receptors in human lung cancer cells |
| Q42253318 | Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion |
| Q33749053 | Leptin is an anti-apoptotic effector in placental cells involving p53 downregulation |
| Q37443240 | Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway |
| Q42682133 | Life or death: p53-induced apoptosis requires DNA binding cooperativity. |
| Q29547663 | Live or let die: the cell's response to p53 |
| Q41930575 | Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis. |
| Q33183894 | Low-dose doxorubicin-induced necrosis in Jurkat cells and its acceleration and conversion to apoptosis by antioxidants |
| Q37688946 | MDM2 is a potential therapeutic target and prognostic factor for ovarian clear cell carcinomas with wild type TP53. |
| Q35131665 | MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells |
| Q24337839 | MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway |
| Q36474852 | MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response |
| Q44104450 | MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells |
| Q34504863 | MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway |
| Q39262984 | MYC and AMPK-Save Energy or Die! |
| Q34035891 | Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins |
| Q53389923 | Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. |
| Q55041964 | Markers of Oral Lichen Planus Malignant Transformation. |
| Q34450473 | Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim |
| Q43797734 | Mechanism of p53-dependent apoptosis induced by 3-methylcholanthrene: involvement of p53 phosphorylation and p38 MAPK. |
| Q41681315 | Mechanisms linked to differences in the mutagenic potential of 1,3-dinitropyrene and 1,8-dinitropyrene |
| Q34039841 | Mechanisms of regulatory diversity within the p53 transcriptional network |
| Q38990979 | Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes. |
| Q33683064 | Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways |
| Q24338300 | Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria |
| Q37535535 | Mitochondria and energetic depression in cell pathophysiology |
| Q36558028 | Mitochondria as therapeutic targets for cancer chemotherapy |
| Q40536857 | Mitochondrial p53 levels parallel total p53 levels independent of stress response in human colorectal carcinoma and glioblastoma cells |
| Q46002885 | Mitochondrial translocation of p53 mediates release of cytochrome c and hippocampal CA1 neuronal death after transient global cerebral ischemia in rats. |
| Q37617682 | MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx |
| Q38337938 | Modification of serine 392 is a critical event in the regulation of p53 nuclear export and stability |
| Q44130945 | Modulation of caspase activation and p27(Kip1) degradation in the p53-induced apoptosis in IW32 erythroleukemia cells |
| Q53515893 | Molecular mechanisms of cellular senescence and immortalization of human cells. |
| Q40589278 | Molecular pathways executing the "trophic sentinel" response in HPV-16 E7-expressing normal human diploid fibroblasts upon growth factor deprivation |
| Q39918845 | Monocytic leukemia zinc finger (MOZ) interacts with p53 to induce p21 expression and cell-cycle arrest |
| Q42813449 | Mouse DDA3 gene is a direct transcriptional target of p53 and p73. |
| Q35116669 | Mouse models with modified p53 sequences to study cancer and ageing. |
| Q30354662 | Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers. |
| Q53623512 | Mutational analysis of the p53 core domain L1 loop. |
| Q36403868 | NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope |
| Q36022258 | NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis |
| Q47881235 | Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-Y. |
| Q24303893 | Negative regulation of p53 functions by Daxx and the involvement of MDM2 |
| Q92636054 | Neuroendocrine Aspects of Skin Aging |
| Q34081249 | New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level |
| Q34658879 | Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis |
| Q44555527 | Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis |
| Q34466925 | Nitric oxide-induced cellular stress and p53 activation in chronic inflammation |
| Q51759892 | Notch signaling and neuronal death in stroke. |
| Q37691139 | Notochordal cell disappearance and modes of apoptotic cell death in a rat tail static compression-induced disc degeneration model |
| Q26777988 | Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 |
| Q43652223 | Novel human p53 mutations that are toxic to yeast can enhance transactivation of specific promoters and reactivate tumor p53 mutants |
| Q34393383 | Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. |
| Q38330836 | Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. |
| Q24310705 | Noxa in colorectal cancer: a study on DNA, mRNA and protein expression |
| Q28396642 | Nuclear DNA damage signalling to mitochondria in ageing |
| Q36325686 | Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms |
| Q34207985 | Nuclear and mitochondrial apoptotic pathways of p53. |
| Q47918094 | Nuclear localization of Y-box factor YB1 requires wild-type p53 |
| Q37269134 | Nucleophosmin blocks mitochondrial localization of p53 and apoptosis |
| Q41906667 | On the intrinsic disorder status of the major players in programmed cell death pathways |
| Q38662850 | On the role of classical and novel forms of vitamin D in melanoma progression and management |
| Q40430266 | Oncogenic Ras increases sensitivity of colon cancer cells to 5-FU-induced apoptosis |
| Q34279104 | Oncogenic ras and p53 cooperate to induce cellular senescence |
| Q34443559 | Organelle-specific initiation of cell death pathways |
| Q40787327 | Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20. |
| Q24306435 | Overexpression of BLCAP induces S phase arrest and apoptosis independent of p53 and NF-kappaB in human tongue carcinoma : BLCAP overexpression induces S phase arrest and apoptosis |
| Q42678605 | Overexpression of DRAM enhances p53-dependent apoptosis |
| Q39994304 | Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells |
| Q91691987 | Overexpression of Tumor Protein p53-regulated Apoptosis-inducing Protein 1 Regulates Proliferation and Apoptosis of Breast Cancer Cells through the PI3K/Akt Pathway |
| Q28505801 | Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals |
| Q37184726 | Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival |
| Q36559717 | Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner |
| Q35208809 | P53 and radiation responses |
| Q37465994 | PARP1 regulates the protein stability and proapoptotic function of HIPK2. |
| Q61449898 | PDCD4 Knockdown Induces Senescence in Hepatoma Cells by Up-Regulating the p21 Expression |
| Q35006415 | PERP expression stabilizes active p53 via modulation of p53-MDM2 interaction in uveal melanoma cells. |
| Q36129082 | PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response |
| Q38882236 | PI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer. |
| Q28205765 | PUMA in head and neck cancer |
| Q24291462 | PUMA induces the rapid apoptosis of colorectal cancer cells |
| Q24291463 | PUMA, a novel proapoptotic gene, is induced by p53 |
| Q27326861 | PX-RICS-deficient mice mimic autism spectrum disorder in Jacobsen syndrome through impaired GABAA receptor trafficking |
| Q38997112 | Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage |
| Q39348556 | Pathway Based Toxicology and Fit-for-Purpose Assays |
| Q36390329 | Pathways involved in sunburn cell formation: deregulation in skin cancer |
| Q44687763 | Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription |
| Q40181461 | Phenol red in the culture medium strongly affects the susceptibility of human MCF-7 cells to roscovitine. |
| Q28214608 | Phosphorylation and hsp90 binding mediate heat shock stabilization of p53 |
| Q36926753 | Phosphorylation of Thr18 and Ser20 of p53 in Ad-p53-induced apoptosis |
| Q40432782 | Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. |
| Q38291171 | Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. |
| Q35756204 | Phytometabolite Dehydroleucodine Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Human Astrocytoma Cells through p73/p53 Regulation |
| Q28215975 | Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway |
| Q40568036 | Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo |
| Q36426763 | Polymorphisms in the p53 pathway. |
| Q56979045 | Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer |
| Q36527456 | Posttranslational phosphorylation of mutant p53 protein in tumor development |
| Q36601890 | Potential of Radiation-Induced Cellular Stress for Reactivation of Latent HIV-1 and Killing of Infected Cells |
| Q36581671 | Pro- and anti-apoptotic effects of p53 in cisplatin-treated human testicular cancer are cell context-dependent. |
| Q34483943 | Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage |
| Q45148170 | Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma |
| Q40670082 | Proliferation and death of conditionally immortalized neural cells from murine neocortex: p53 alters the ability of neuron-like cells to re-enter the cell cycle |
| Q34212196 | Prostate cancer risk is not altered by TP53AIP1 germline mutations in a German case-control series |
| Q37375309 | Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells |
| Q46665793 | Protein kinase C delta induces apoptosis of vascular smooth muscle cells through induction of the tumor suppressor p53 by both p38-dependent and p38-independent mechanisms |
| Q24299870 | Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage |
| Q39892741 | Protein kinase C-dependent phosphorylation regulates the cell cycle-inhibitory function of the p73 carboxy terminus transactivation domain |
| Q42800738 | Protein kinase inhibitor 2-aminopurine overrides multiple genotoxic stress-induced cellular pathways to promote cell survival |
| Q34958999 | Proteomic analysis in the neurosciences |
| Q30333446 | Proteomics in the postgenomic age. |
| Q42414248 | Putting the brakes on p53-driven apoptosis |
| Q24322861 | RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest |
| Q39157254 | RNAi screening identifies KAT8 as a key molecule important for cancer cell survival |
| Q38147113 | RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response |
| Q47629190 | Radiation-induced apoptosis in scid mice spleen after low dose irradiation |
| Q37074063 | Radiation-induced salivary gland dysfunction results from p53-dependent apoptosis. |
| Q24349073 | Reactive oxygen species in the activation and regulation of intracellular signaling events |
| Q38433099 | Real-time and simultaneous monitoring of the phosphorylation and enhanced interaction of p53 and XPC acidic domains with the TFIIH p62 subunit. |
| Q39631323 | Reconstitution of human MCF‐7 breast cancer cells with caspase‐3 does not sensitize them to action of CDK inhibitors |
| Q81326626 | Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization |
| Q39615561 | Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277 |
| Q34245385 | Regulation and function of the p53 tumor suppressor protein |
| Q61207292 | Regulation of histone modification and chromatin structure by the p53–PADI4 pathway |
| Q38820048 | Regulation of iron homeostasis by the p53-ISCU pathway |
| Q37761824 | Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells. |
| Q28210189 | Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2 |
| Q35962630 | Regulation of the DNA damage response by p53 cofactors |
| Q38294763 | Regulation of the accumulation and function of p53 by phosphorylation of two residues within the domain that binds to Mdm2. |
| Q35116649 | Renewing the debate over the p53 apoptotic response |
| Q40273238 | Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis. |
| Q33725442 | Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences |
| Q34650413 | Requirement of clathrin heavy chain for p53-mediated transcription |
| Q33644048 | Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis |
| Q43861811 | Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis |
| Q40747748 | Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1. |
| Q36710840 | Restoration of wild-type p53 function in human cancer: relevance for tumor therapy. |
| Q35910747 | Role of DNA mismatch repair in apoptotic responses to therapeutic agents |
| Q45281370 | Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage |
| Q38161342 | Role of p53 in Cell Death and Human Cancers |
| Q33843352 | Role of p53 serine 46 in p53 target gene regulation |
| Q24310790 | Role of p53/FAK association and p53Ser46 phosphorylation in staurosporine-mediated apoptosis: wild type versus mutant p53-R175H |
| Q38320046 | Runt-related transcription factor 1 (RUNX1) stimulates tumor suppressor p53 protein in response to DNA damage through complex formation and acetylation |
| Q24550864 | SAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencing |
| Q31814769 | SVH-B interacts directly with p53 and suppresses the transcriptional activity of p53. |
| Q28507684 | Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane |
| Q37706903 | Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells |
| Q35518170 | Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. |
| Q83855474 | Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis |
| Q46302815 | Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis |
| Q38225143 | ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair |
| Q43058589 | Silymarin exacerbates p53-mediated tubular apoptosis in glycerol-induced acute kidney injury in rats |
| Q42454028 | Simultaneous exposure to dietary acrylamide and corn oil developed carcinogenesis through cell proliferation and inhibition of apoptosis by regulating p53-mediated mitochondria-dependent signaling pathway |
| Q39862428 | Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes |
| Q30446685 | Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A |
| Q38300297 | Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein |
| Q38195691 | Sphingolipids: key regulators of apoptosis and pivotal players in cancer drug resistance |
| Q41904105 | Stimulus-specific transcriptional regulation within the p53 network |
| Q35567287 | Strategies for reversing drug resistance |
| Q34429414 | Stress and testicular germ cell apoptosis |
| Q40102569 | Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells |
| Q50932128 | Structural Insight into the Mechanism of Dibenzo[a,l]pyrene and Benzo[a]pyrene-Mediated Cell Proliferation Using Molecular Docking Simulations. |
| Q51017453 | Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS). |
| Q43942753 | Suppression of postmitochondrial signaling and delayed response to UV-induced nuclear apoptosis in HeLa cells |
| Q35967111 | Surf the post-translational modification network of p53 regulation |
| Q28032484 | Surfing the p53 network |
| Q39464436 | Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway |
| Q40509371 | Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells |
| Q34064732 | Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. |
| Q53350855 | T cell deficiency leads to liver carcinogenesis in azoxymethane-treated rats. |
| Q33351996 | TAF6delta controls apoptosis and gene expression in the absence of p53. |
| Q50290200 | TP53 binds the TP53AIP1 gene |
| Q33685392 | TP53 mutations in human cancers: origins, consequences, and clinical use |
| Q50290201 | TP53 stimulates and ZNF420 inhibits TP53AIP1 expression |
| Q34568607 | TP53: a key gene in human cancer. |
| Q28476020 | Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha |
| Q43119952 | Targeting ncRNAs in the 3q26.2 amplicon |
| Q38059739 | Targeting the ubiquitin-mediated proteasome degradation of p53 for cancer therapy |
| Q35991955 | The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage |
| Q38756911 | The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression |
| Q38704734 | The DNA damage-induced cell death response: a roadmap to kill cancer cells |
| Q41687394 | The IGF-1R/AKT pathway determines cell fate in response to p53. |
| Q24676133 | The ORF3 protein of porcine circovirus type 2 interacts with porcine ubiquitin E3 ligase Pirh2 and facilitates p53 expression in viral infection |
| Q39447003 | The Polyphenol Oleuropein Aglycone Modulates the PARP1-SIRT1 Interplay: An In Vitro and In Vivo Study |
| Q41084526 | The Transcriptional Landscape of p53 Signalling Pathway |
| Q36291117 | The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo |
| Q37687474 | The cell death machinery governed by the p53 tumor suppressor in response to DNA damage |
| Q46455258 | The codon 47 polymorphism in p53 is functionally significant. |
| Q42806263 | The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. |
| Q34487385 | The evolution of diverse biological responses to DNA damage: insights from yeast and p53. |
| Q40021220 | The fusion protein of respiratory syncytial virus triggers p53-dependent apoptosis |
| Q24311659 | The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4 |
| Q92062954 | The multiple mechanisms that regulate p53 activity and cell fate |
| Q28585698 | The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression |
| Q37264822 | The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon |
| Q54979108 | The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. |
| Q37310208 | The p53 family and programmed cell death |
| Q34555517 | The potential role of DFNA5, a hearing impairment gene, in p53-mediated cellular response to DNA damage |
| Q43854589 | The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells |
| Q24295229 | The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP |
| Q39288084 | The prolyl-isomerase Pin1 activates the mitochondrial death program of p53 |
| Q35193741 | The relevance of alternative RNA splicing to pharmacogenomics |
| Q38331206 | The role of DNA damage responses in p53 biology |
| Q34983628 | The role of human papillomavirus oncoproteins E6 and E7 in apoptosis |
| Q35058584 | The role of p53 in determining sensitivity to radiotherapy |
| Q39271171 | The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence |
| Q35991071 | The strength of indecisiveness: oscillatory behavior for better cell fate determination |
| Q64377884 | The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression |
| Q36546440 | The tissue dependent interactions between p53 and Bcl-2 in vivo |
| Q24273295 | The transcription factor p53: not a repressor, solely an activator |
| Q56378380 | Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update |
| Q30380490 | Therapeutic considerations for Mdm2: not just a one trick pony |
| Q36202761 | Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells |
| Q38042630 | Therapeutic strategies for head and neck cancer based on p53 status |
| Q40118357 | Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity |
| Q34838208 | Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function |
| Q35102824 | To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways |
| Q28255819 | To die or not to die: how does p53 decide? |
| Q38838992 | Toxoplasma gondii Rhoptry Protein ROP16 Mediates Partially SH-SY5Y Cells Apoptosis and Cell Cycle Arrest by Directing Ser15/37 Phosphorylation of p53 |
| Q34278037 | Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway |
| Q45286095 | Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes |
| Q40038493 | Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity |
| Q40449440 | Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria. |
| Q29617650 | Transcriptional control of human p53-regulated genes |
| Q40251375 | Transcriptional regulation by p53 and p73. |
| Q37777267 | Transcriptional regulation by p53. |
| Q39984512 | Transcriptional repression by p53 promotes a Bcl-2-insensitive and mitochondria-independent pathway of apoptosis |
| Q35116644 | Transcriptional repression mediated by the p53 tumour suppressor |
| Q39748548 | Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53. |
| Q47557700 | Truncating mutations of TP53AIP1 gene predispose to cutaneous melanoma. |
| Q36839372 | Tumor Protein 53-Induced Nuclear Protein 1 Enhances p53 Function and Represses Tumorigenesis |
| Q37412688 | Tumor suppressive functions of p53 |
| Q58781156 | Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis |
| Q44608082 | Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. |
| Q38996596 | Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage |
| Q35022037 | Two-phase dynamics of p53 in the DNA damage response. |
| Q40116480 | Tyrosine kinase inhibitor, methyl 2,5-dihydromethylcinnimate, induces PML nuclear body formation and apoptosis in tumor cells |
| Q28205533 | UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts |
| Q96816336 | Ubiquitin-proteasome system-targeted therapy for uveal melanoma: what is the evidence? |
| Q35089377 | Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation |
| Q35168290 | Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis |
| Q53193985 | Upregulated p53 expression activates apoptotic pathways in wild-type p53-bearing mesothelioma and enhances cytotoxicity of cisplatin and pemetrexed. |
| Q38064783 | Various modes of cell death induced by DNA damage |
| Q37087404 | Versatile functions of p53 protein in multicellular organisms |
| Q42697057 | WDNfinder: A method for minimum driver node set detection and analysis in directed and weighted biological network |
| Q24672918 | WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase |
| Q40362917 | WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53. |
| Q40323754 | WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization. |
| Q37788083 | Whether to target single or multiple CDKs for therapy? That is the question |
| Q36618628 | Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9 |
| Q44601920 | Wild-type p53 induced sensitization of mutant p53 TNF-resistant cells: role of caspase-8 and mitochondria |
| Q38562746 | Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53. |
| Q38352979 | XEDAR as a putative colorectal tumor suppressor that mediates p53-regulated anoikis pathway |
| Q39523533 | XIAP-associated factor 1 (XAF1), a novel target of p53, enhances p53-mediated apoptosis via post-translational modification |
| Q28578217 | Y-box factor YB1 controls p53 apoptotic function |
| Q34349271 | YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets. |
| Q24314457 | Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage |
| Q21262994 | Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response |
| Q74403161 | Zinc inhibits the nuclear translocation of the tumor suppressor protein p53 and protects cultured human neurons from copper-induced neurotoxicity |
| Q55447436 | [Research progress and application of the homeodomain-interacting protein kinase-2]. |
| Q24535925 | hADA3 is required for p53 activity |
| Q38353313 | hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. |
| Q92508193 | iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition |
| Q24537301 | mRTVP-1, a novel p53 target gene with proapoptotic activities |
| Q33591648 | miR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma |
| Q34280222 | mtCLIC/CLIC4, an organellular chloride channel protein, is increased by DNA damage and participates in the apoptotic response to p53 |
| Q53564942 | p16INK4A-silencing augments DNA damage-induced apoptosis in cervical cancer cells. |
| Q40796687 | p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents |
| Q24319790 | p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production |
| Q33734522 | p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation. |
| Q64071826 | p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX |
| Q34641149 | p53 accumulates but is functionally impaired when DNA synthesis is blocked |
| Q37602510 | p53 and E2f: partners in life and death |
| Q36149069 | p53 and the pathogenesis of skin cancer |
| Q74073155 | p53 contains a DNA break-binding motif similar to the functional part of BRCT-related region of Rb |
| Q33972469 | p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. |
| Q35116655 | p53 downstream targets and chemosensitivity. |
| Q28569720 | p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC |
| Q28483922 | p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors |
| Q38740246 | p53 oligomerization status modulates cell fate decisions between growth, arrest and apoptosis. |
| Q48618075 | p53 potentiates hippocampal neuronal death caused by global ischemia |
| Q42777419 | p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics. |
| Q36997572 | p53 regulation upon genotoxic stress: intricacies and complexities |
| Q42269771 | p53 signalling controls cell cycle arrest and caspase-independent apoptosis in macrophages infected with pathogenic Leptospira species |
| Q63408383 | p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation |
| Q37049524 | p53 tumor suppressor gene: a critical molecular target for UV induction and prevention of skin cancer |
| Q36092830 | p53, apoptosis and axon-guidance molecules |
| Q41279239 | p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions |
| Q34547830 | p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma |
| Q35066712 | p53-dependent cell death signaling in neurons |
| Q77099494 | p53-dependent pathways of apoptosis |
| Q40720509 | p53-independent apoptosis is induced by the p19ARF tumor suppressor |
| Q24596239 | p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation |
| Q37760789 | p53-mediated neuronal cell death in ischemic brain injury |
| Q53380051 | p53: 25 years of research and more questions to answer. |
| Q34103258 | p53: death star |
| Q28609684 | p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis |
| Q28211258 | p53RDL1 regulates p53-dependent apoptosis |
| Q24307639 | p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1 |
| Q36694173 | p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis. |
Search more.