Characterization of the p53 response to oncogene-induced senescence

scientific article

Characterization of the p53 response to oncogene-induced senescence is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2008PLoSO...3.3230R
P356DOI10.1371/JOURNAL.PONE.0003230
P932PMC publication ID2535567
P698PubMed publication ID18800172
P5875ResearchGate publication ID23264838

P50authorAmancio CarneroQ56468043
Irene FerrerQ57415858
Juan F M LealQ57966866
Lidia RuizQ57975534
P2093author name stringMagali Traskine
Estrella Castro
Marcelline Kaufman
P2860cites workPremature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalingQ22003910
PML regulates p53 acetylation and premature senescence induced by oncogenic RasQ22254666
p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53Q24290402
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
A biomarker that identifies senescent human cells in culture and in aging skin in vivoQ24562644
Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosisQ24594034
p53-independent functions of the p19(ARF) tumor suppressorQ24600863
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationQ24669694
p53, the cellular gatekeeper for growth and divisionQ27860990
Atmospheric carbon dioxide concentrations over the past 60 million yearsQ28144787
Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancersQ28237942
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrityQ28594156
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumorsQ29614399
p53-dependent apoptosis modulates the cytotoxicity of anticancer agentsQ29615031
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescenceQ29620428
The retinoblastoma tumor-suppressor gene, the exception that proves the ruleQ33562001
The cellular response to p53: the decision between life and deathQ33771774
Regulation and function of the p53-related proteins: same family, different rulesQ33885465
Tumor suppressors and oncogenes in cellular senescence.Q33930350
Oncogenic ras and p53 cooperate to induce cellular senescenceQ34279104
PPP1CA contributes to the senescence program induced by oncogenic Ras.Q53325013
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.Q53505779
The senescent side of tumor suppressionQ53648671
Suppressing cancer: the importance of being senescentQ53663083
Tumour biology: Policing of oncogene activity by p53Q57562778
p19ARF links the tumour suppressor p53 to RasQ57562848
Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damageQ59081725
PML NBs associate with the hMre11 complex and p53 at sites of irradiation induced DNA damageQ64387887
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cellsQ71618789
Protein phosphatase type 1, the product of the retinoblastoma susceptibility gene, and cell cycle controlQ77625348
Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemiaQ81318088
Modeling the therapeutic efficacy of p53 restoration in tumorsQ34593294
The RB and p53 pathways in cancerQ34804764
Decision making by p53: life, death and cancerQ35116663
Analysis of p53-regulated gene expression patterns using oligonucleotide arraysQ35191756
PML is induced by oncogenic ras and promotes premature senescenceQ35201220
Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformationQ35861554
Functional activation of p53 via phosphorylation following DNA damage by UV but not γ radiationQ35973184
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.Q36050995
The complexity of p53 stabilization and activationQ36443523
Oncogene-dependent tumor suppression: using the dark side of the force for cancer therapy.Q36547736
Oncogene-induced cell senescence--halting on the road to cancerQ36587198
p53: guardian of the genome and policeman of the oncogenes.Q36800812
Of mice without pockets: mouse models to study the function of Rb family proteins.Q36814044
From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathwayQ36989718
Impairment of p53 acetylation, stability and function by an oncogenic transcription factorQ37258978
Ultraviolet radiation, but not γ radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389Q37413761
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damageQ39452086
Loss-of-function genetics in mammalian cells: the p53 tumor suppressor modelQ39542680
Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) geneQ39659874
Threshold level of p53 required for the induction of apoptosis in X-irradiated MOLT-4 cellsQ40125026
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.Q40933283
High molecular weight protein phosphatase type 1 dephosphorylates the retinoblastoma proteinQ41127793
Temporal dissection of p53 function in vitro and in vivoQ44365729
Constitutively active protein phosphatase 1alpha causes Rb-dependent G1 arrest in human cancer cellsQ46808819
Cellular senescence induced by p53-ras cooperation is independent of p21waf1 in murine embryo fibroblastsQ47445812
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)e3230
P577publication date2008-09-18
P1433published inPLOS OneQ564954
P1476titleCharacterization of the p53 response to oncogene-induced senescence
P478volume3

Reverse relations

cites work (P2860)
Q38506086ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas
Q28397132Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Q37763785Bypassing cellular senescence by genetic screening tools
Q37828383Cellular senescence as a target in cancer control
Q27026235Disruptive chemicals, senescence and immortality
Q44627811Down-regulation of spinophilin in lung tumours contributes to tumourigenesis
Q36562082Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA.
Q33533301Exploring the gain of function contribution of AKT to mammary tumorigenesis in mouse models
Q37305035Genetic modelling of the PTEN/AKT pathway in cancer research
Q47999229Genome-Wide miRNA Screening for Genes Bypassing Oncogene-Induced Senescence
Q38072352Markers of Cellular Senescence
Q27341883Modeling a New Water Channel That Allows SET9 to Dimethylate p53
Q46891284Modeling of cell culture damage and recovery leads to increased antibody and biomass productivity in CHO cell cultures
Q50575186Nuclear Protein Phosphatase 1 α (PP1A) Expression is Associated with Poor Prognosis in p53 Expressing Glioblastomas
Q42722283Nutlin-3, the small-molecule inhibitor of MDM2, promotes senescence and radiosensitises laryngeal carcinoma cells harbouring wild-type p53.
Q40066192Oncogenic KRAS sensitises colorectal tumour cells to chemotherapy by p53-dependent induction of Noxa
Q37362503Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival
Q38236704Protein phosphatase 1 catalytic isoforms: specificity toward interacting proteins
Q52715352The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest
Q39739160The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway
Q39408183p38α limits the contribution of MAP17 to cancer progression in breast tumors

Search more.