| scholarly article | Q13442814 |
| P356 | DOI | 10.1101/GAD.10.19.2438 |
| P698 | PubMed publication ID | 8843196 |
| P2093 | author name string | C Prives | |
| L J Ko | |||
| X Chen | |||
| L Jayaraman | |||
| P2860 | cites work | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death | Q24312211 |
| Tight control of gene expression in mammalian cells by tetracycline-responsive promoters | Q24564850 | ||
| p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts | Q33986335 | ||
| P433 | issue | 19 | |
| P921 | main subject | apoptotic process | Q14599311 |
| P304 | page(s) | 2438-2451 | |
| P577 | publication date | 1996-10-01 | |
| P1433 | published in | Genes & Development | Q1524533 |
| P1476 | title | p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells | |
| P478 | volume | 10 |
| Q39995807 | 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest |
| Q36066054 | A Homogeneous Polysaccharide from Fructus Schisandra chinensis (Turz.) Baill Induces Mitochondrial Apoptosis through the Hsp90/AKT Signalling Pathway in HepG2 Cells |
| Q30886208 | A comparative analysis of the time-dependent antiproliferative effects of daunorubicin and WP631. |
| Q37249372 | A complex barcode underlies the heterogeneous response of p53 to stress |
| Q22010639 | A novel cofactor for p300 that regulates the p53 response |
| Q28574858 | A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis |
| Q36754697 | A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides |
| Q34582602 | A role for p53 in base excision repair. |
| Q24299489 | A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response |
| Q39458140 | A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain |
| Q39246185 | A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways |
| Q36678322 | A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis |
| Q49247817 | APTM, a Thiophene Heterocyclic Compound, Inhibits Human Colon Cancer HCT116 Cell Proliferation Through p53-Dependent Induction of Apoptosis |
| Q28366563 | Activation and activities of the p53 tumour suppressor protein |
| Q40954121 | Activation of an MDM2-specific caspase by p53 in the absence of apoptosis |
| Q55261427 | Activation of caspases in p53-induced transactivation-independent apoptosis. |
| Q49129538 | Adenoviral vector-mediated gene transfer: timing of wild-type p53 gene expression in vivo and effect of tumor transduction on survival in a rat glioma brachytherapy model |
| Q36496709 | Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma |
| Q45884349 | Adenoviruses with Tcf binding sites in multiple early promoters show enhanced selectivity for tumour cells with constitutive activation of the wnt signalling pathway |
| Q47759705 | Altered expression of mitochondrial 16S ribosomal RNA in p53-deficient mouse embryos revealed by differential display |
| Q34612731 | Altered processing of amyloid precursor protein in cells undergoing apoptosis |
| Q34258948 | Alveolar type II cell apoptosis |
| Q27026310 | Another fork in the road--life or death decisions by the tumour suppressor p53 |
| Q78192930 | Anti-apoptotic activity of p53 maps to the COOH-terminal domain and is retained in a highly oncogenic natural mutant |
| Q40518865 | Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines |
| Q41737530 | Apoptosis by p53: mechanisms, regulation, and clinical implications |
| Q35131718 | Apoptosis inhibition by the human DEK oncoprotein involves interference with p53 functions. |
| Q33185094 | Apoptosis: biochemical aspects and clinical implications |
| Q38815435 | Application of eupatilin in the treatment of osteosarcoma |
| Q36806673 | Asperolide A, a marine-derived tetranorditerpenoid, induces G2/M arrest in human NCI-H460 lung carcinoma cells, is mediated by p53-p21 stabilization and modulated by Ras/Raf/MEK/ERK signaling pathway. |
| Q52528383 | Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathways. |
| Q38282236 | Battle against cancer: an everlasting saga of p53. |
| Q28510439 | Bax involvement in p53-mediated neuronal cell death |
| Q28506493 | Bax suppresses tumorigenesis and stimulates apoptosis in vivo |
| Q28137887 | Bcl-2, survivin and variant CD44 v7-v10 are downregulated and p53 is upregulated in breast cancer cells by progesterone: inhibition of cell growth and induction of apoptosis |
| Q24312018 | Binding and modulation of p53 by p300/CBP coactivators |
| Q33221159 | Biological activities of a recombinant adenovirus p53 (SCH 58500) administered by hepatic arterial infusion in a Phase 1 colorectal cancer trial |
| Q35064987 | Blockade of Hsp90 by 17AAG antagonizes MDMX and synergizes with Nutlin to induce p53-mediated apoptosis in solid tumors |
| Q100295956 | Brca2 deficiency drives gastrointestinal tumor formation and is selectively inhibited by mitomycin C |
| Q40737382 | C-terminus of p53 is required for G(2) arrest |
| Q90475758 | CHRONIC KIDNEY DISEASE: A VICARIOUS RELATION TO PREMATURE CELL SENESCENCE? |
| Q31137946 | CSF1 is a novel p53 target gene whose protein product functions in a feed-forward manner to suppress apoptosis and enhance p53-mediated growth arrest |
| Q33775049 | Calcium and S100B regulation of p53-dependent cell growth arrest and apoptosis |
| Q51129313 | Cardiocyte nuclear chromatin density correlates with transplanted heart left ventricular mass. |
| Q43919094 | Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. |
| Q40744879 | Cell cycle arrest is sufficient for p53-mediated tumor regression |
| Q37341740 | Cell cycle regulatory protein expression profiles by adenovirus p53 infection in human papilloma virus-associated cervical cancer cells |
| Q28240722 | Cell death: critical control points |
| Q104795043 | Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway |
| Q53338395 | Cell-cycle inhibition by TNP-470 in an in vivo model of hepatocarcinoma is mediated by a p53 and p21WAF1/CIP1 mechanism. |
| Q37566689 | Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. |
| Q33735445 | Cellular responses to radiation and risk of breast cancer |
| Q48089331 | Cellular senescence in the aging and diseased kidney |
| Q53615595 | Cellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner. |
| Q33825155 | Characterization of functional domains necessary for mutant p53 gain of function |
| Q51158606 | Characterization of new-generation aminoglycoside promoting premature termination codon readthrough in cancer cells. |
| Q33774492 | Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest |
| Q33370291 | Characterization of the p53 response to oncogene-induced senescence |
| Q39441552 | Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity |
| Q33896638 | Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo |
| Q40789611 | Cisplatin chemotherapy plus adenoviral p53 gene therapy in EBV-positive and -negative nasopharyngeal carcinoma |
| Q28363906 | Cisplatinum and taxol induce different patterns of p53 phosphorylation |
| Q41003479 | Comparison of bax, waf1, and IMP dehydrogenase regulation in response to wild-type p53 expression under normal growth conditions |
| Q34282082 | Conditional derepression of ferritin synthesis in cells expressing a constitutive IRP1 mutant |
| Q73212113 | Conformational and molecular basis for induction of apoptosis by a p53 C-terminal peptide in human cancer cells |
| Q35170092 | DECOD: fast and accurate discriminative DNA motif finding |
| Q36732878 | DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. |
| Q34353609 | DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. |
| Q39640818 | DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development |
| Q40768679 | DNA repair is activated in early stages of p53-induced apoptosis |
| Q38530549 | DTIE, a novel core promoter element that directs start site selection in TATA-less genes |
| Q41874557 | Daunorubicin-induced variations in gene transcription: commitment to proliferation arrest, senescence and apoptosis |
| Q28143960 | Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains |
| Q55475779 | Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. |
| Q35788252 | Different responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction |
| Q40238869 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein |
| Q77733994 | Differential regulation of cellular target genes by p53 devoid of the PXXP motifs with impaired apoptotic activity |
| Q34443272 | Differential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence. |
| Q36094396 | Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. |
| Q56966045 | Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate |
| Q39848157 | Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein |
| Q42808722 | Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress |
| Q74187550 | Distinctive patterns of Her-2/neu, c-myc, and cyclin D1 gene amplification by fluorescence in situ hybridization in primary human breast cancers |
| Q43591191 | Distinguishing luminal breast cancer subtypes by Ki67, progesterone receptor or TP53 status provides prognostic information |
| Q34785151 | Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis. |
| Q38191796 | Drugging the p53 pathway: understanding the route to clinical efficacy |
| Q37135628 | EWS-FLI1 suppresses NOTCH-activated p53 in Ewing's sarcoma |
| Q43583217 | Early stages of p53-induced apoptosis are reversible |
| Q52575059 | Ectopic expression of human p53 inhibits entry into S phase and induces apoptosis in the Drosophila eye imaginal disc. |
| Q28611456 | Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication |
| Q34308600 | Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. |
| Q79610624 | Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus |
| Q30658609 | Enhanced repair of benzo(a)pyrene-induced DNA damage in human cells treated with thymidine dinucleotides |
| Q39685569 | Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes. |
| Q40290190 | Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription. |
| Q42413751 | Expanding the reach of the p53 tumor suppressor network |
| Q49610684 | Exploring the molecular aspects associated with testicular germ cell tumors: a review |
| Q24336210 | FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression |
| Q28594239 | Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response |
| Q38349795 | Functional dissection of p53 tumor suppressor protein |
| Q34010086 | Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis |
| Q22009111 | GADD45 induction of a G2/M cell cycle checkpoint |
| Q35596405 | Gene transfer: Bax to the future for cancer therapy |
| Q35268497 | Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study |
| Q33659512 | Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. |
| Q34338748 | Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53 |
| Q40720204 | HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis |
| Q24301527 | HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53 |
| Q36839039 | Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells |
| Q36151062 | Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria |
| Q36830710 | Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis |
| Q40760811 | Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines |
| Q34091002 | Heterochromatin silencing of p53 target genes by a small viral protein |
| Q36210446 | Heterogeneity of p53-pathway Protein Expression in Chemosensitive Chronic Lymphocytic Leukemia: A Pilot Study |
| Q59091869 | How cells choose to die |
| Q28202210 | Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator |
| Q31864081 | Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells |
| Q52535973 | Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. |
| Q40718202 | IGFBP-3 mediates p53-induced apoptosis during serum starvation. |
| Q33778826 | Id2 promotes apoptosis by a novel mechanism independent of dimerization to basic helix-loop-helix factors |
| Q34079194 | Identification and characterization of Dicer1e, a Dicer1 protein variant, in oral cancer cells |
| Q52720485 | Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells. |
| Q35886717 | Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen |
| Q28588449 | Identification of a novel mouse p53 target gene DDA3 |
| Q39450966 | Identification of a sequence element from p53 that signals for Mdm2-targeted degradation |
| Q28752006 | In vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinase |
| Q35664020 | In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation |
| Q33802926 | Inactivation of HAUSP in vivo modulates p53 function |
| Q77329613 | Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53 |
| Q42630918 | Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53 |
| Q41961964 | Induction of DNA synthesis and apoptosis by regulated inactivation of a temperature-sensitive retinoblastoma protein |
| Q63457241 | Induction of G2/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes |
| Q45861528 | Induction of apoptosis and G2/M arrest by infection with replication-deficient adenovirus at high multiplicity of infection |
| Q24293008 | Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53 |
| Q35043420 | Induction of apoptosis in cancer: new therapeutic opportunities |
| Q37061407 | Influence of induced reactive oxygen species in p53-mediated cell fate decisions. |
| Q36132787 | Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097 |
| Q36052583 | Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner |
| Q92209964 | Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers |
| Q36105141 | Inhibition of tumor angiogenesis and growth by nanoparticle-mediated p53 gene therapy in mice |
| Q36847869 | Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation |
| Q34490979 | Involvement of mitochondria in apoptosis |
| Q41592444 | Involvement of p53 in cell differentiation and development |
| Q36535351 | Killin is a p53-regulated nuclear inhibitor of DNA synthesis |
| Q42682133 | Life or death: p53-induced apoptosis requires DNA binding cooperativity. |
| Q29547663 | Live or let die: the cell's response to p53 |
| Q45393476 | Loss of Genome Fidelity: Beta HPVs and the DNA Damage Response |
| Q38263504 | Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice |
| Q38168223 | Lysine-specific modifications of p53: a matter of life and death? |
| Q38769335 | Lysines in the tetramerization domain of p53 selectively modulate G1 arrest |
| Q36253975 | MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia |
| Q24552865 | MCG10, a novel p53 target gene that encodes a KH domain RNA-binding protein, is capable of inducing apoptosis and cell cycle arrest in G(2)-M |
| Q24301309 | MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis |
| Q37364177 | Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy |
| Q24804223 | Measuring a cell's response to stress: the p53 pathway |
| Q24654806 | Mechanisms of G2 arrest in response to overexpression of p53 |
| Q24319736 | Mechanistic differences in the transcriptional activation of p53 by 14-3-3 isoforms |
| Q39556526 | Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells |
| Q40399548 | Mitochondrial localization of p53 during adenovirus infection and regulation of its activity by E1B-19K. |
| Q41856021 | Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase |
| Q64379754 | Mitomycin C and cisplatin enhanced the antitumor activity of p53-expressing adenovirus in cervical cancer cells |
| Q53438921 | Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate. |
| Q53623512 | Mutational analysis of the p53 core domain L1 loop. |
| Q73341662 | Mutations in exons 5-8 of the p53 gene, independent of their type and location, are associated with increased apoptosis and mitosis in invasive breast carcinoma |
| Q24306104 | Myosin VI is a mediator of the p53-dependent cell survival pathway. |
| Q45856234 | New p53-based anti-cancer therapeutic strategies |
| Q41037556 | Nitric oxide inhibits the degradation of IRP2. |
| Q28589090 | Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) |
| Q26777988 | Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 |
| Q34207985 | Nuclear and mitochondrial apoptotic pathways of p53. |
| Q42593996 | Nuclear localization of the caspase-3-cleaved form of p73 in anoikis |
| Q37269134 | Nucleophosmin blocks mitochondrial localization of p53 and apoptosis |
| Q34279104 | Oncogenic ras and p53 cooperate to induce cellular senescence |
| Q40843237 | Oral administration of an estrogen metabolite-induced potentiation of radiation antitumor effects in presence of wild-type p53 in non-small-cell lung cancer |
| Q31927261 | Overexpression of retinoic acid receptor beta induces growth arrest and apoptosis in oral cancer cell lines |
| Q38361828 | P130 and its truncated form mediate p53-induced cell cycle arrest in Rb(-/-) Saos2 cells |
| Q39321762 | PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy. |
| Q37318470 | PRMT5 is required for cell-cycle progression and p53 tumor suppressor function |
| Q40939584 | Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation |
| Q44687763 | Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription |
| Q39242984 | Pharmacological inhibition of GSK3 attenuates DNA damage-induced apoptosis via reduction of p53 mitochondrial translocation and Bax oligomerization in neuroblastoma SH-SY5Y cells. |
| Q78093548 | Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells |
| Q36511204 | Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models. |
| Q33966216 | Pro-proliferative FoxM1 is a target of p53-mediated repression |
| Q42780791 | Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues |
| Q33801981 | Productive replication of adeno-associated virus can occur in human papillomavirus type 16 (HPV-16) episome-containing keratinocytes and is augmented by the HPV-16 E2 protein |
| Q64381365 | Promoter specificity and stability control of the p53-related protein p73 |
| Q38343171 | Proteolytic cleavage of the mdm2 oncoprotein during apoptosis |
| Q40637727 | Radiation induces p53-dependent cell apoptosis in bladder cancer cells with wild-type- p53 but not in p53-mutated bladder cancer cells |
| Q42850882 | Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest. |
| Q35073239 | Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model |
| Q39970436 | Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer |
| Q35879963 | Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21 |
| Q43771754 | Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis |
| Q40591829 | Recombinant adenovirus-p53 gene transfer and cell-specific growth suppression of human cervical cancer cells in vitro and in vivo |
| Q41007095 | Regulation of ES cell differentiation by functional and conformational modulation of p53. |
| Q34011633 | Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. |
| Q40794508 | Regulation of the cell cycle by p53 after DNA damage in an amphibian cell line |
| Q35116649 | Renewing the debate over the p53 apoptotic response |
| Q33865835 | Replicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathway |
| Q35020290 | Replicating parvoviruses that target colon cancer cells |
| Q34650413 | Requirement of clathrin heavy chain for p53-mediated transcription |
| Q39621228 | Rescue of non-sense mutated p53 tumor suppressor gene by aminoglycosides |
| Q93095094 | Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses |
| Q36710840 | Restoration of wild-type p53 function in human cancer: relevance for tumor therapy. |
| Q35091138 | Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7. |
| Q34389406 | Retracted: The Effect of miR-338-3p on HBx Deletion-Mutant (HBx-d382) Mediated Liver-Cell Proliferation through CyclinD1 Regulation |
| Q35910747 | Role of DNA mismatch repair in apoptotic responses to therapeutic agents |
| Q57248006 | Role of NF-κB in p53-mediated programmed cell death |
| Q35486110 | Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. |
| Q24317608 | Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells. |
| Q39047050 | Role of p53, PUMA, and Bax in wogonin-induced apoptosis in human cancer cells |
| Q37518662 | Rotational positioning of nucleosomes facilitates selective binding of p53 to response elements associated with cell cycle arrest |
| Q37857744 | S-phase-coupled apoptosis in tumor suppression |
| Q42833128 | Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage, SAPK activation and p53 response |
| Q37650965 | Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis |
| Q91643997 | Stochastic fluctuations in apoptotic threshold of tumour cells can enhance apoptosis and combat fractional killing |
| Q24537692 | Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation |
| Q33630785 | Stress-specific response of the p53-Mdm2 feedback loop |
| Q35124429 | Structure and function of latency-associated nuclear antigen |
| Q35204136 | Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function |
| Q47302512 | Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy |
| Q38732652 | TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression |
| Q44203431 | Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells |
| Q91701493 | Taking up the reins of power: metabolic functions of p53 |
| Q26785508 | Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility? |
| Q45869144 | Targeted-simultaneous expression of Gas1 and p53 using a bicistronic adenoviral vector in gliomas |
| Q40749229 | Termination of lifespan of SV40-transformed human fibroblasts in crisis is due to apoptosis |
| Q73270745 | Testicular wild-type p53 expression in transgenic mice induces spermiogenesis alterations ranging from differentiation defects to apoptosis |
| Q24556628 | The C terminus of p53 family proteins is a cell fate determinant |
| Q28507164 | The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo |
| Q38756911 | The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression |
| Q24537123 | The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. |
| Q39013660 | The Transactivation Domains of the p53 Protein |
| Q37109768 | The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest |
| Q33771774 | The cellular response to p53: the decision between life and death |
| Q53059668 | The chemosensitivity of testicular germ cell tumors. |
| Q40203781 | The codon 72 polymorphism-specific effects of human p53 are absent in mouse cells: implications on generation of mouse models |
| Q36259624 | The contribution of transactivation subdomains 1 and 2 to p53-induced gene expression is heterogeneous but not subdomain-specific |
| Q24291244 | The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation |
| Q39457241 | The double benefit of Spalax p53: surviving underground hypoxia while defying lung cancer cells in vitro via autophagy and caspase-dependent cell death |
| Q35540219 | The effect of desacetyluvaricin on the expression of TLR4 and P53 protein in Hepg 2.2.15. |
| Q45856904 | The effects of combining ionizing radiation and adenoviral p53 therapy in nasopharyngeal carcinoma |
| Q34402080 | The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth |
| Q28206046 | The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis |
| Q36736035 | The intrinsic radioresistance of glioblastoma-derived cell lines is associated with a failure of p53 to induce p21(BAX) expression |
| Q73673966 | The loss of mdm2 induces p53-mediated apoptosis |
| Q92062954 | The multiple mechanisms that regulate p53 activity and cell fate |
| Q58430752 | The p53 C terminus controls site-specific DNA binding and promotes structural changes within the central DNA binding domain |
| Q37310208 | The p53 family and programmed cell death |
| Q40932287 | The p53 tumor suppressor protein reduces point mutation frequency of a shuttle vector modified by the chemical mutagens (+/-)7, 8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene, aflatoxin B1 and meta-chloroperoxybenzoic acid |
| Q33724426 | The p53 tumor suppressor protein represses human snRNA gene transcription by RNA polymerases II and III independently of sequence-specific DNA binding |
| Q41693154 | The p53/IGF-1 receptor axis in the regulation of programmed cell death |
| Q46111122 | The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality |
| Q37142886 | The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63 |
| Q43854589 | The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells |
| Q24533291 | The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression |
| Q99592090 | The role of apatinib combined with paclitaxel (aluminum binding type) in platinum-resistant ovarian cancer |
| Q36524070 | The transcriptional regulator gene E2 of the Human Papillomavirus (HPV) 16 influences the radiosensitivity of cervical keratinocytes |
| Q34737062 | The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis |
| Q42484376 | Tissue and cell-specific expression of the p53-target genes: bax, fas, mdm2 and waf1/p21, before and following ionising irradiation in mice |
| Q40762117 | Trail activity in human ovarian cancer cells: potentiation of the action of cytotoxic drugs |
| Q36438161 | Transcription abnormalities potentiate apoptosis of normal human fibroblasts. |
| Q28190792 | Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1 |
| Q37412688 | Tumor suppressive functions of p53 |
| Q47681263 | Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. |
| Q73703327 | Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain |
| Q33807787 | Twenty years of p53 research: structural and functional aspects of the p53 protein |
| Q24599468 | Twist is a potential oncogene that inhibits apoptosis |
| Q39030008 | Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3σ. |
| Q36573040 | Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. |
| Q35872729 | Wild-type tumor repressor protein 53 (Trp53) promotes ovarian cancer cell survival |
| Q22010923 | ei24, a p53 response gene involved in growth suppression and apoptosis |
| Q24338336 | hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes |
| Q24317330 | hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer |
| Q33807825 | mdm2: a bridge over the two tumour suppressors, p53 and Rb. |
| Q43890977 | p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family |
| Q35587605 | p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer |
| Q90726562 | p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression |
| Q64379190 | p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death |
| Q52192096 | p53 activity is essential for normal development in Xenopus. |
| Q53862852 | p53 and cell-cycle-regulated protein expression in small intestinal cells after fast-neutron irradiation in mice. |
| Q74604690 | p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor |
| Q40348690 | p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines |
| Q36052576 | p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes |
| Q33569713 | p53 binding to nucleosomal DNA depends on the rotational positioning of DNA response element |
| Q39935200 | p53 controls hPar1 function and expression |
| Q39526736 | p53 down-regulates CHK1 through p21 and the retinoblastoma protein |
| Q24298888 | p53 has a direct apoptogenic role at the mitochondria |
| Q38540071 | p53 in survival, death and metabolic health: a lifeguard with a licence to kill |
| Q73318914 | p53 induces TAP1 and enhances the transport of MHC class I peptides |
| Q33885642 | p53 inhibition by the LANA protein of KSHV protects against cell death |
| Q47274923 | p53 is a regulator of macrophage differentiation. |
| Q33958575 | p53 mediates apoptotic crisis in primary Abelson virus-transformed pre-B cells |
| Q39450667 | p53 mutants have selective dominant-negative effects on apoptosis but not growth arrest in human cancer cell lines |
| Q42829713 | p53 protein accumulation in addition to the transactivation activity is required for p53-dependent cell cycle arrest after treatment of cells with camptothecin. |
| Q39579847 | p53 protein is a suppressor of papillomavirus DNA amplificational replication |
| Q24553136 | p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation |
| Q28259206 | p53 regulates maternal reproduction through LIF |
| Q39758897 | p53 represses RNA polymerase III transcription by targeting TBP and inhibiting promoter occupancy by TFIIIB. |
| Q40717571 | p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy |
| Q42463636 | p53 suppresses cytokine induced, Stat5 mediated activation of transcription |
| Q63408383 | p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation |
| Q35577259 | p53's believe it or not: lessons on transcription-independent death |
| Q40926717 | p53-dependent apoptosis or growth arrest induced by different forms of radiation in U2OS cells: p21WAF1/CIP1 repression in UV induced apoptosis |
| Q34305233 | p53-dependent apoptosis pathways. |
| Q77099494 | p53-dependent pathways of apoptosis |
| Q40635072 | p53-independent induction of p21(waf1/cip1) contributes to the activation of caspases in GTP-depletion-induced apoptosis of insulin-secreting cells |
| Q40797005 | p53-interacting protein 53BP2 inhibits clonogenic survival and sensitizes cells to doxorubicin but not paclitaxel-induced apoptosis |
| Q28609219 | p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation |
| Q43652191 | p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes |
| Q43700522 | p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner |
| Q53625386 | p73 cooperates with Ras in the activation of MAP kinase signaling cascade. |
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