A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells

scientific article published on March 2004

A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1017665005
P356DOI10.1038/SJ.ONC.1207293
P698PubMed publication ID14647426

P50authorKevin R. CoombesQ30505720
P2093author name stringTimothy J McDonnell
Christopher J Logothetis
David L Gold
Kevin B Spurgers
Raymond E Meyn
Terry J Johnson
P2860cites workCovalent and noncovalent modifiers of the p53 proteinQ22009048
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Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathwayQ28215330
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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivationQ28280958
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Bcl-2 expression causes redistribution of glutathione to the nucleusQ35975065
Role of cysteine residues in regulation of p53 functionQ36552986
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Redox state of tumor suppressor p53 regulates its sequence-specific DNA binding in DNA-damaged cells by cysteine 277Q39615561
A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosisQ40019792
TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2.Q40794513
Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domainQ40970925
Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stressQ40976420
Wild-type p53 negatively regulates the expression of a microtubule-associated proteinQ41148864
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.Q41414258
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p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.Q41723055
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Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical resultsQ45863348
Biological activity and safety of adenoviral vector-expressed wild-type p53 after intratumoral injection in melanoma and breast cancer patients with p53-overexpressing tumorsQ45869523
A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivityQ45888474
Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae.Q47939174
Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinomaQ47976180
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.Q50335767
Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation.Q52190269
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Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)Q59085244
Mechanisms of p53-dependent apoptosisQ63408390
INGN 201: Ad-p53, Ad5CMV-p53, Adenoviral p53, INGN 101, p53 gene therapy--Introgen, RPR/INGN 201Q64377713
Molecular determinants of cell death induction following adenovirus-mediated gene transfer of wild-type p53 in prostate cancer cellsQ64380177
Two prostate carcinoma cell lines demonstrate abnormalities in tumor suppressor genesQ68180257
Safety evaluation of Ad5CMV-p53 in vitro and in vivoQ72202236
Bcl-2 accelerates multistep prostate carcinogenesis in vivoQ73187748
Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiolsQ73794417
Bcl-2 Suppresses Apoptosis Resulting from Disruption of the NF-κB Survival Pathway☆Q74000214
Deletion of the Saccharomyces cerevisiae TRR1 Gene Encoding Thioredoxin Reductase Inhibits p53-dependent Reporter Gene ExpressionQ74263605
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Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53Q77764263
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectAdenoviridaeQ193447
P304page(s)1712-1723
P577publication date2004-03-01
P1433published inOncogeneQ1568657
P1476titleA comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells
P478volume23

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cites work (P2860)
Q33983097A resource for discovering specific and universal biomarkers for distributed stem cells
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Q40439945Down-regulation of BRCA2 expression by collagen type I promotes prostate cancer cell proliferation
Q91796711Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
Q40263007Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression
Q39570732PI3 Kinase inhibition on TRAIL-induced apoptosis correlates with androgen-sensitivity and p21 expression in prostate cancer cells
Q38805972Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and γ-radiation on Na(+)/K(+)-ATPase and cell survival
Q37145192The adenoviral E1B 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription
Q35919370The direct p53 target gene, FLJ11259/DRAM, is a member of a novel family of transmembrane proteins
Q40271317Up-regulation of Skp2 after prostate cancer cell adhesion to basement membranes results in BRCA2 degradation and cell proliferation

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