NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

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NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.827700
P3181OpenCitations bibliographic resource ID172489
P932PMC publication ID316937
P698PubMed publication ID10995386

P50authorDavid A BarbieQ106943892
P2093author name stringB K Kennedy
E Harlow
J A Fletcher
A G Matera
J Zhao
B D Lawrence
P2860cites workPRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesisQ22008655
Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrestQ22008677
Structure and Function in the NucleusQ22065563
Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteinsQ22253968
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcriptionQ24290273
Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteinsQ24307868
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsQ24314293
The human histone gene cluster at the D6S105 locusQ24322592
BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation siteQ24554478
Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNAQ24554504
Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factorsQ24555701
Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cellsQ24563398
Structure and in vitro transcription of a human H4 histone geneQ24604124
Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entryQ24607291
H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor involved in histone H1 cell cycle regulationQ24607656
Human cyclin E, a nuclear protein essential for the G1-to-S phase transitionQ24652527
Cyclin-dependent kinase control of centrosome duplicationQ24673544
Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilinQ24680842
Cell cycle-dependent localization of the CDK2-cyclin E complex in Cajal (coiled) bodiesQ28140953
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1Q28145116
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycleQ28189224
Rb interacts with histone deacetylase to repress transcriptionQ28263985
Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6Q28290494
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21Q28505037
Formation of the 3' end of histone mRNAQ28610112
Distinct roles for cyclin-dependent kinases in cell cycle controlQ29616480
Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosomeQ29618064
Regulation of retinoblastoma protein functions by ectopic expression of human cyclinsQ29618320
Transcriptional silencing in yeast is associated with reduced nucleosome acetylationQ29618497
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleusQ29620277
A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoproteinQ29620737
Nuclear bodies: multifaceted subdomains of the interchromatin space.Q33688028
Association between the nucleolus and the coiled bodyQ34140980
Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extractsQ34491024
Delineation of a human histone H4 cell cycle element in vivo: the master switch for H4 gene transcriptionQ35236320
The cytoplasmic synthesis of histones in hela cells and its temporal relationship to DNA replicationQ35968802
Chromosome-specific alpha satellite DNA: nucleotide sequence analysis of the 2.0 kilobasepair repeat from the human X chromosomeQ36139991
Regulation of histone gene expressionQ36183700
Microinjection of anti-coilin antibodies affects the structure of coiled bodiesQ36255640
Histone 3' ends: essential and regulatory functionsQ36333814
Early events in DNA replication require cyclin E and are blocked by p21CIP1Q36382696
The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycleQ36558850
Proviral inactivation of the Npat gene of Mpv 20 mice results in early embryonic arrestQ36569398
An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcriptionQ36765388
U1 and U2 small nuclear RNAs are present in nuclear specklesQ36770130
Overlapping and CpG methylation-sensitive protein-DNA interactions at the histone H4 transcriptional cell cycle domain: distinctions between two human H4 gene promoters.Q36819683
Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B geneQ36897138
RNA polymerase II transcription factors H4TF-1 and H4TF-2 require metal to bind specific DNA sequencesQ36926084
Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblastsQ37256512
CDP/cut is the DNA-binding subunit of histone gene transcription factor HiNF-D: a mechanism for gene regulation at the G1/S phase cell cycle transition point independent of transcription factor E2FQ37256817
The regulation of histone synthesis in the cell cycleQ37285335
Quantitative and qualitative changes in histone gene expression during early mouse embryo developmentQ37529725
The regulation of histone gene expression during the cell cycleQ37691722
Mitotic Phosphorylation of the Oct-1 Homeodomain and Regulation of Oct-1 DNA Binding ActivityQ38331736
Purification of the human histone H4 gene-specific transcription factors H4TF-1 and H4TF-2.Q38345991
Accumulation of E2F-4.DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transitionQ39457727
Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cellsQ39575492
Identification of AP-2 as an interactive target of Rb and a regulator of the G1/S control element of the hamster histone H3.2 promoter.Q39725498
Identification of promoter elements necessary for transcriptional regulation of a human histone H4 gene in vitroQ40665751
Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivatorQ41133317
Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2.Q41293458
p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.Q41325340
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible systemQ41483751
The cdk2 kinase is required for the G1-to-S transition in mammalian cells.Q41548648
Cyclin-dependent regulation of G1 in mammalian fibroblasts.Q41565162
Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotesQ41894756
Cyclin E-CDK2 is a regulator of p27Kip1.Q42800258
Regulation of the Mouse Histone H2A.X Gene Promoter by the Transcription Factor E2F and CCAAT Binding ProteinQ42825245
Developmental regulation of chromatin composition during mouse embryogenesis: somatic histone H1 is first detectable at the 4-cell stageQ43685996
Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b geneQ45283630
Changes in histone synthesis and modification at the beginning of mouse development correlate with the establishment of chromatin mediated repression of transcription.Q48958554
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.Q54048106
Cell-cycle regulatory sequences in a hamster histone promoter and their interactions with cellular factorsQ58973696
Association of human cyclin E with a periodic G1-S phase protein kinaseQ67505073
Histone H1 subtype-specific consensus elements mediate cell cycle-regulated transcription in vitroQ69440258
Cell-cycle regulation of histone gene expressionQ69509244
Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus elementQ70383880
Immunological analysis of chromatin: FIS and CHIPSQ77724511
P433issue18
P407language of work or nameEnglishQ1860
P304page(s)2283-97
P577publication date2000-09-15
P1433published inGenes & DevelopmentQ1524533
P1476titleNPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
P478volume14

Reverse relations

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Q43718785The C-terminus of mutant p53 is necessary for its ability to interfere with growth arrest or apoptosis
Q24669553The Cyclin E/Cdk2 Substrate and Cajal Body Component p220NPATActivates Histone Transcription through a Novel LisH-Like Domain
Q36867931The HIST1 Locus Escapes Reprogramming in Cloned Bovine Embryos.
Q42705246The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing
Q34560247The Trp53 hemizygous mouse in pharmaceutical development: points to consider for pathologists
Q82363604The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes
Q38885465The Working Modules of Long Noncoding RNAs in Cancer Cells
Q36886887The abbreviated pluripotent cell cycle.
Q28609122The architectural organization of human stem cell cycle regulatory machinery
Q35157537The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
Q33752620The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs
Q35191541The complex interactions of p53 with target DNA: we learn as we go.
Q38027976The control of histone gene expression.
Q24648864The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cells
Q34487385The evolution of diverse biological responses to DNA damage: insights from yeast and p53.
Q37602507The expanding universe of p53 targets
Q77368785The expression of genes induced in melanocytes by exposure to 365-nm UVA: study by cDNA arrays and real-time quantitative RT-PCR
Q24645732The first 30 years of p53: growing ever more complex
Q28140732The function of PML in p53-dependent apoptosis
Q40851854The gene encoding p202, an interferon-inducible negative regulator of the p53 tumor suppressor, is a target of p53-mediated transcriptional repression
Q28588582The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles
Q24321813The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif
Q41142269The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT.
Q28818369The histone genes cluster in Rhynchosciara americana and its transcription profile in salivary glands during larval development
Q41953832The osmoregulatory and the amino acid-regulated responses of system A are mediated by different signal transduction pathways.
Q33757941The p53 tumour suppressor inhibits glucocorticoid-induced proliferation of erythroid progenitors.
Q43682294The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G(1) is controlled by a deacetylase- and E2F-associated bipartite repressor element
Q35105986The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor.
Q34564813The retinoblastoma protein regulates pericentric heterochromatin
Q34038183The role of nuclear bodies in gene expression and disease
Q35196996The subnuclear organization of histone gene regulatory proteins and 3' end processing factors of normal somatic and embryonic stem cells is compromised in selected human cancer cell types
Q40667908The transcriptional response after oxidative stress is defective in Cockayne syndrome group B cells
Q34086453Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.
Q93088610Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress
Q36421122Transcriptional activation of histone genes requires NPAT-dependent recruitment of TRRAP-Tip60 complex to histone promoters during the G1/S phase transition
Q40698245Transcriptional activation of the MUC2 gene by p53.
Q36116613Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition
Q29617650Transcriptional control of human p53-regulated genes
Q36436698Transcriptional regulation by p53: one protein, many possibilities
Q28190792Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1
Q50335767Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.
Q34286036Transcriptomes, transcription activators and microarrays
Q93229535Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
Q24794459Transforming growth factor-beta induces Cdk2 relocalization to the cytoplasm coincident with dephosphorylation of retinoblastoma tumor suppressor protein
Q44418346Transgenic expression of prothymosin alpha on zebrafish epidermal cells promotes proliferation and attenuates UVB-induced apoptosis
Q40752768Tumor suppressor p53 mediates apoptotic cell death triggered by cyclosporin A.
Q40568020Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.
Q37591937Tumour suppression by p53: a role for the DNA damage response?
Q35889316U7 small nuclear ribonucleoprotein represses histone gene transcription in cell cycle-arrested cells.
Q39745903UV-induced fragmentation of Cajal bodies.
Q35681983Validation of a liquid chromatography-triple quadrupole mass spectrometric method for the determination of 5-nitro-5'-hydroxy-indirubin-3'-oxime (AGM-130) in human plasma and its application to microdose clinical trial
Q36538369Versican: signaling to transcriptional control pathways.
Q34335765WEE1 tyrosine kinase, a novel epigenetic modifier
Q38241194When genome integrity and cell cycle decisions collide: roles of polo kinases in cellular adaptation to DNA damage
Q37367277Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.
Q44720926X-irradiated human lymphocytes with unstable aberrations and their preferential elimination by p53/survivin-dependent apoptosis
Q31060526Xic1 degradation in Xenopus egg extracts is coupled to initiation of DNA replication
Q83790495[Technology of analysis of epigenetic and structural changes of epithelial tumors genome with NotI-microarrays by the example of human chromosome]
Q44208216cAMP-dependent reorganization of the Cajal bodies and splicing machinery in cultured Schwann cells
Q34482630miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
Q33344707microRNAs join the p53 network--another piece in the tumour-suppression puzzle
Q40647697p21/CDKN1A mediates negative regulation of transcription by p53.
Q33842575p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7.
Q37832072p53 and its mutants in tumor cell migration and invasion
Q36180705p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency
Q35116655p53 downstream targets and chemosensitivity.
Q34173945p53 dynamics control cell fate
Q36423948p53 in recombination and repair
Q40842648p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway
Q33819326p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling
Q37622549p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression
Q42941221p53 regulates myogenesis by triggering the differentiation activity of pRb.
Q38704009p53 responsive elements in human retrotransposons.
Q40810981p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
Q36133972p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses
Q34305233p53-dependent apoptosis pathways.
Q28394092p53/PUMA expression in human pulmonary fibroblasts mediates cell activation and migration in silicosis
Q36028209p53: traffic cop at the crossroads of DNA repair and recombination
Q36163707p53: twenty five years understanding the mechanism of genome protection
Q33933714p53CP is p51/p63, the third member of the p53 gene family: partial purification and characterization
Q24307639p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1
Q39121067p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells
Q45050263string(cdc25) and cyclin E are required for patterned histone expression at different stages of Drosophila embryonic development.

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