Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73

scientific article published in Journal of Biological Chemistry

Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M208233200
P698PubMed publication ID12519788

P50authorKarim BensaadQ114431408
Morgane Le BrasQ41585977
Thierry SoussiQ43186376
P2093author name stringGiovanni Blandino
Sabrina Strano
Dany Rouillard
Osamu Tominaga
Keziban Unsal
P2860cites workp63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53Q22010134
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damageQ22010200
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damageQ22010201
NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcriptionQ24600573
Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutationsQ27730815
Prediction of complete gene structures in human genomic DNAQ27860780
p53, the cellular gatekeeper for growth and divisionQ27860990
A common polymorphism acts as an intragenic modifier of mutant p53 behaviourQ28118809
Interaction of c-Abl and p73alpha and their collaboration to induce apoptosisQ28138604
Definition of a consensus binding site for p53Q28207794
Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human CancersQ29616471
p53: puzzle and paradigmQ29618407
p53 family genes: structural comparison, expression and mutationQ30833177
A "no-hybrids" screen for functional antagonizers of human p53 transactivator function: dominant negativity in fission yeast.Q31015221
Structure, function and regulation of p63 and p73.Q33818611
P63 and P73: P53 mimics, menaces and moreQ34185768
Assessing TP53 status in human tumours to evaluate clinical outcomeQ34570100
Identification and classification of p53-regulated genesQ36747355
AIS is an oncogene amplified in squamous cell carcinomaQ36978000
Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.Q38291171
Regulation of the specific DNA binding function of p53Q38324290
Identification of a sequence element from p53 that signals for Mdm2-targeted degradationQ39450966
A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domainQ39458140
p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.Q39610993
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapyQ40774297
Structural aspects of the p53 protein in relation to gene evolution: a second look.Q41034333
Allosteric regulation of the thermostability and DNA binding activity of human p53 by specific interacting proteins. CRC Cell Transformation GroupQ41227408
Temperature sensitivity for conformation is an intrinsic property of wild-type p53.Q42590443
Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytesQ51231745
Regulation of the specific DNA binding activity of Xenopus laevis p53: evidence for conserved regulation through the carboxy-terminus of the proteinQ52561980
Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.Q53505779
Small peptides activate the latent sequence-specific DNA binding function of p53.Q54601436
Monoclonal antibodies raised against Xenopus p53 interact with human p73Q57778803
Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73Q58073315
p63 and p73 are required for p53-dependent apoptosis in response to DNA damageQ59065672
Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformationQ70168032
Flexibility: the key to p53 function?Q72121789
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)10546-10555
P577publication date2003-01-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleChange of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73
P478volume278

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cites work (P2860)
Q38934098Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?
Q36777361Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?
Q73342473Chemosensitivity linked to p73 function
Q54328419Correlation between low-level expression of the tumor suppressor gene TAp73 and the chemoresistance of human glioma stem cells
Q42819037Differential effects of novel tumour-derived p53 mutations on the transformation of NIH-3T3 cells
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Q57670523Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
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Q35119547p53 mutations and resistance to chemotherapy: A stab in the back for p73