Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis

scientific article published on 03 September 2018

Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41388-018-0478-7
P932PMC publication ID6355650
P698PubMed publication ID30177839

P2093author name stringLun Song
Meiru Hu
Ming Gao
Xiaoguang Li
Huan Xu
Jiannan Feng
Rui Jin
Chen Xing
Hongli Wang
Shuxian Zou
Yongliang Hu
Qiyu Wang
P2860cites workDiverse roles of GADD45alpha in stress signaling.Q53377169
A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expressionQ24603716
GADD45 proteins: central players in tumorigenesisQ24608649
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor geneQ28118453
Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogeneQ28143662
Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1Q28190792
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expressionQ28300071
Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradationQ28383493
p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiationQ28513416
Blinded by the Light: The Growing Complexity of p53Q29547590
p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrestQ33925109
Gadd45 proteins: relevance to aging, longevity and age-related pathologiesQ34222845
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancerQ34457367
The IκB kinase complex in NF-κB regulation and beyondQ35001723
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expressionQ35568362
IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivationQ35888836
IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite responseQ36119216
Molecular basis of NF-κB signalingQ36918115
Both IKKalpha and IKKbeta are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-kappaB activity-independent mannerQ36983249
TP53-dependent autophagy links the ATR-CHEK1 axis activation to proinflammatory VEGFA production in human bronchial epithelial cells exposed to fine particulate matter (PM2.5).Q37365438
The NF-kappaB-independent functions of IKK subunits in immunity and cancerQ37569263
Transcriptional regulation by p53.Q37777267
Signaling via the NFκB system.Q38779804
Census and evaluation of p53 target genes.Q38911126
DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.Q40485978
Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectivelyQ40506975
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylationQ40550797
Tumor suppressor p53 inhibits transcriptional activation of invasion gene thromboxane synthase mediated by the proto-oncogenic factor ets-1.Q40621413
p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapyQ40717571
Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.Q42724753
Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cellsQ45000475
IKKβ downregulation is critical for triggering JNKs-dependent cell apoptotic response in the human hepatoma cells under arsenite exposureQ46916858
Mechanisms of transcriptional regulation by p53.Q47416965
Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.Q50335767
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P304page(s)731-746
P577publication date2018-09-03
P1433published inOncogeneQ1568657
P1476titleTranscriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis
P478volume38

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