hERG1 potassium channel in cancer cells: a tool to reprogram immortality

scientific article published on 20 September 2016

hERG1 potassium channel in cancer cells: a tool to reprogram immortality is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00249-016-1169-3
P8608Fatcat IDrelease_k2rauqzfejbkljfhrf2yiijfle
P698PubMed publication ID27649700

P2093author name stringSaverio Gentile
P2860cites workUpdate on the evaluation of a new drug for effects on cardiac repolarization in humans: issues in early drug developmentQ24646866
hERG channel function: beyond long QTQ27008078
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2Q28145423
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINSQ28202269
Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytesQ28291447
Mutational landscape and significance across 12 major cancer typesQ28300353
A structural basis for drug-induced long QT syndromeQ28344808
HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cellsQ28539628
Regulation of an ERG K+ current by Src tyrosine kinaseQ28581012
Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality.Q30491532
Sudden arrhythmia death syndrome: importance of the long QT syndrome.Q33149251
Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks).Q33661049
Four faces of cellular senescence.Q34025754
Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1.Q34152898
Expression and role of hERG channels in cancer cells.Q34437815
hERG potassium channels and cardiac arrhythmiaQ34504394
Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patientsQ34621219
Stimulation of hERG1 channel activity promotes a calcium-dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cellsQ35176400
ERG conductance expression modulates the excitability of ventral horn GABAergic interneurons that control rhythmic oscillations in the developing mouse spinal cordQ79655193
[Novel methylation and expression markers associated with breast cancer]Q81441557
Is erythromycin therapy teratogenic in humans?Q81770658
Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbitsQ82768867
E- and A-type cyclins as markers for cancer diagnosis and prognosisQ35543902
Choosing the right cell line for breast cancer researchQ35608671
Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugsQ36849934
Potassium channel activation inhibits proliferation of breast cancer cells by activating a senescence programQ36973723
Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channelQ36975149
Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanomaQ37225455
Targeting ion channels in cancer: a novel frontier in antineoplastic therapyQ37370358
Assessing proarrhythmic potential of drugs when optimal studies are infeasible.Q37450211
Voltage-gated potassium channels as therapeutic targetsQ37464784
hERG1/Kv11.1 activation stimulates transcription of p21waf/cip in breast cancer cells via a calcineurin-dependent mechanismQ37644785
Role of autophagy in cancer preventionQ37898320
hERG K(+) channels: structure, function, and clinical significanceQ38044402
Role of autophagy in cancer prevention, development and therapyQ38144288
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cellsQ38361021
Inhibition of HERG1 K+ channel protein expression decreases cell proliferation of human small cell lung cancer cellsQ39444757
Human ether-à-go-go-related gene expression is essential for cisplatin to induce apoptosis in human gastric cancerQ39454149
Electrophysiological effects of the anti-cancer drug lapatinib on cardiac repolarizationQ39712812
Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migrationQ39797663
Silencing of herg gene by shRNA inhibits SH-SY5Y cell growth in vitro and in vivoQ40058589
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human isletsQ42060620
Arsenic trioxide-induced hERG K(+) channel deficiency can be rescued by matrine and oxymatrine through up-regulating transcription factor Sp1 expressionQ42715022
Regulation of the voltage-insensitive step of HERG activation by extracellular pH.Q43110152
Erg K+ currents modulate excitability in mouse mitral/tufted neuronsQ43290379
Blocking of the human ether-à-go-go-related gene channel by imatinib mesylateQ43514924
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?Q44004456
ERG K+ channel blockade enhances firing and epinephrine secretion in rat chromaffin cells: the missing link to LQT2-related sudden death?Q44254910
Expression and function of KCNH2 (HERG) in the human jejunumQ44433185
Effect of Arsenic Trioxide on QT Interval in Patients With Advanced MalignanciesQ44598288
Ether-à-go-go-related gene K+ channels contribute to threshold excitability of mouse auditory brainstem neuronsQ46054857
The potent inhibitory effects of cisapride, a specific blocker for human ether-a-go-go-related gene (HERG) channel, on gastric cancer cellsQ46450387
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndromeQ46681639
Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogsQ46807818
HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivativesQ48501900
herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?Q48945547
erg gene(s) expression during development of the nervous and muscular system of quail embryos.Q52166642
Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.Q52590496
Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells.Q53564372
HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.Q53866705
Imatinib has the potential to exert its antileukemia effects by down-regulating hERG1 K+ channels in chronic myelogenous leukemia.Q54334505
Expression and Role of hERG Channels in Cancer CellsQ56420805
Screening for mutations and polymorphisms in the genes KCNH2 and KCNE2 encoding the cardiac HERG/MiRP1 ion channel: implications for acquired and congenital long Q-T syndromeQ57807317
Glucose- and arginine-induced insulin secretion by human pancreatic beta-cells: the role of HERG K(+) channels in firing and releaseQ73251237
P433issue7
P304page(s)649-655
P577publication date2016-09-20
P1433published inEuropean Biophysics JournalQ5412316
P1476titlehERG1 potassium channel in cancer cells: a tool to reprogram immortality
P478volume45