The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents

scientific article published on 20 March 2020

The Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2020.00343
P932PMC publication ID7100275
P698PubMed publication ID32265714

P50authorYu KangQ51301642
P2093author name stringHua Wang
Lu Chen
Su Zeng
Lushan Yu
Junqing Liu
Jiabei Zhou
P2860cites workHuman copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptakeQ24654300
Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancerQ26747806
Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signalingQ93179119
Omeprazole protects against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and transporter-mediated cisplatin accumulation in rats and HK-2 cellsQ93212716
Therapy resistance mediated by cancer stem cellsQ93339813
The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and PerspectiveQ26766916
Resistance and gain-of-resistance phenotypes in cancers harboring wild-type p53Q27006998
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2Q27642888
Crystal Structures of Cisplatin Bound to a Human Copper ChaperoneQ27657700
A common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapyQ27853206
An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelQ27853369
The status of platinum anticancer drugs in the clinic and in clinical trialsQ28286605
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulationQ28289092
Glutathione in cancer biology and therapyQ28300422
Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cellsQ28533746
Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane VesiclesQ28546068
Dihydromyricetin Enhances the Chemo-Sensitivity of Nedaplatin via Regulation of the p53/Bcl-2 Pathway in Hepatocellular Carcinoma CellsQ28546762
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian CancerQ28833833
Functional activation of mutant p53V172F by platinum analogs in cisplatin-resistant human tumor cells is dependent on serine-20 phosphorylationQ29248201
The mutational landscape of head and neck squamous cell carcinomaQ29614654
Modes of p53 regulationQ29615657
Transcriptional control of human p53-regulated genesQ29617650
The impact of O2 availability on human cancerQ29619884
Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgeryQ30932207
Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J.Q32182056
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.Q33209208
Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells.Q33345021
A phase 2 study of nanoparticle albumin-bound paclitaxel plus nedaplatin for patients with advanced, recurrent, or metastatic cervical carcinomaQ33435722
Multi-institutional prospective study of nedaplatin plus S-1 chemotherapy in recurrent and metastatic nasopharyngeal carcinoma patients after failure of platinum-containing regimensQ33439361
Comparative adverse effect profiles of platinum drugs.Q33495298
Differential transport of platinum compounds by the human organic cation transporter hOCT2 (hSLC22A2).Q33523365
Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cellsQ33560646
Wwox-Brca1 interaction: role in DNA repair pathway choiceQ33585936
Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaBQ33656653
USP13 regulates the RAP80-BRCA1 complex dependent DNA damage responseQ33770883
Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and CarboplatinQ33822719
Copper transporter CTR1 expression and tissue platinum concentration in non-small cell lung cancerQ33875938
Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomesQ33934039
Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas.Q33944203
Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelatorQ33986172
Association between the level of ERCC-1 expression and the repair of cisplatin-induced DNA damage in human ovarian cancer cells.Q52168383
Targeting the microenvironment in solid tumors.Q52368266
Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.Q52584568
MiR-216b increases cisplatin sensitivity in ovarian cancer cells by targeting PARP1.Q52679638
Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapyQ37811966
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosisQ37977244
Prostate cancer, miRNAs, metallothioneins and resistance to cytostatic drugs.Q38060257
In brief: BRCA1 and BRCA2.Q38101887
Targeting apoptosis pathways for new cancer therapeutics.Q38159798
Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin.Q38348095
Targeting autophagy to overcome drug resistance in cancer therapyQ38579547
Hypoxia-inducible factor 3 biology: complexities and emerging themesQ38631669
Lung cancer stem cells: The root of resistanceQ38706873
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stressQ38713515
PGRMC1-dependent autophagy by hyperoside induces apoptosis and sensitizes ovarian cancer cells to cisplatin treatmentQ38716461
Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signalingQ38716472
XPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF.Q38719028
The role of Nrf2 and ATF2 in resistance to platinum-based chemotherapyQ38719571
ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cellsQ38719990
miR-148a increases the sensitivity to cisplatin by targeting Rab14 in renal cancer cellsQ38720776
The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional GenomicsQ38726035
HIF-1 in cancer therapy: two decade long story of a transcription factor.Q38737693
Lobaplatin induces BGC-823 human gastric carcinoma cell apoptosis via ROS- mitochondrial apoptotic pathway and impairs cell migration and invasionQ38738592
Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cellsQ38739426
Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinomaQ38750997
miR-374a-CCND1-pPI3K/AKT-c-JUN feedback loop modulated by PDCD4 suppresses cell growth, metastasis, and sensitizes nasopharyngeal carcinoma to cisplatinQ38766169
miR-133a enhances the sensitivity of Hep-2 cells and vincristine-resistant Hep-2v cells to cisplatin by downregulating ATP7B expressionQ38775007
Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovarian cancer via regulation of the STAT3 and PI3K/Akt signaling pathwaysQ38785774
Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagyQ38788700
miR-409-3p sensitizes colon cancer cells to oxaliplatin by inhibiting Beclin-1-mediated autophagyQ38789468
Enhancement of Drug Sensitivity by Knockdown of HIF-1α in Gastric Carcinoma CellsQ38789826
miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cellsQ38792994
NF-κB signaling plays irreplaceable roles in cisplatin-induced bladder cancer chemoresistance and tumor progressionQ38813417
Autophagic flux promotes cisplatin resistance in human ovarian carcinoma cells through ATP-mediated lysosomal function.Q38833368
MiR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2.Q38839310
Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.Q38839750
miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced CytotoxicityQ38848758
Recent advance in the pharmacogenomics of human Solute Carrier Transporters (SLCs) in drug disposition.Q38870052
Autophagy regulates cisplatin-induced stemness and chemoresistance via the upregulation of CD44, ABCB1 and ADAM17 in oral squamous cell carcinomaQ47368849
MicroRNA-195 acts as an anti-proliferative miRNA in human melanoma cells by targeting Prohibitin 1.Q47616712
MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.Q47709751
MicroRNA-148a-3p enhances cisplatin cytotoxicity in gastric cancer through mitochondrial fission induction and cyto-protective autophagy suppressionQ47719136
MRP4/ABCC4 as a new therapeutic target: meta-analysis to determine cAMP binding sites as a tool for drug design.Q47760720
Mxd1 mediates hypoxia-induced cisplatin resistance in osteosarcoma cells by repression of the PTEN tumor suppressor gene.Q47881043
RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistanceQ47955849
Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy.Q48521717
Knockdown of long non-coding RNA HOTAIR inhibits cisplatin resistance of gastric cancer cells through inhibiting the PI3K/Akt and Wnt/β-catenin signaling pathways by up-regulating miR-34aQ50101496
Relevance of copper transporter 1 and organic cation transporters 1-3 for oxaliplatin uptake and drug resistance in colorectal cancer cells.Q50123707
Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells.Q50639517
Autophagy contributes to the enrichment and survival of colorectal cancer stem cells under oxaliplatin treatment.Q51000986
A HIF-independent, CD133-mediated mechanism of cisplatin resistance in glioblastoma cells.Q51746123
A family of drug transporters: the multidrug resistance-associated proteins.Q34004952
Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovaryQ34103978
Role of Glutathione in the Regulation of Cisplatin Resistance in Cancer ChemotherapyQ34159386
Recognition of cisplatin adducts by cellular proteinsQ34282236
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammalsQ34393336
Copper Transporter 2 Regulates Endocytosis and Controls Tumor Growth and Sensitivity to Cisplatin In VivoQ34458507
DNA strand breaks and apoptosis induced by oxaliplatin in cancer cellsQ34534850
Classification Systems of Secondary Active Transporters.Q34547030
Role of multidrug resistance protein 2 (MRP2) in chemoresistance and clinical outcome in oesophageal squamous cell carcinomaQ34627891
Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriersQ34663583
Role of endonucleases XPF and XPG in nucleotide excision repair of platinated DNA and cisplatin/oxaliplatin cytotoxicity.Q34842777
An adsorptive transfer technique coupled with brdicka reaction to reveal the importance of metallothionein in chemotherapy with platinum based cytostatics.Q35002247
Current status of the molecular mechanisms of anticancer drug-induced apoptosis. The contribution of molecular-level analysis to cancer chemotherapyQ35002472
Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4.Q35173275
Pharmacogenetics of the DNA repair pathways in advanced non-small cell lung cancer patients treated with platinum-based chemotherapyQ35214307
Copper transporters and the cellular pharmacology of the platinum-containing cancer drugsQ35454498
EGCG Enhances Cisplatin Sensitivity by Regulating Expression of the Copper and Cisplatin Influx Transporter CTR1 in Ovary CancerQ35558444
Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS GenerationQ35738714
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.Q35921211
Recognition and processing of cisplatin- and oxaliplatin-DNA adductsQ35988488
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting AutophagyQ36070533
HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathwayQ36212999
JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cellsQ36291991
miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway.Q36293209
Role of mismatch repair proteins in the processing of cisplatin interstrand cross-linksQ36296744
CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair geneQ36370912
'BRCAness' and its implications for platinum action in gynecologic cancerQ36380704
Molecular mechanisms of mammalian global genome nucleotide excision repair.Q36389623
miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterinQ36499755
Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathwaysQ36592296
Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapyQ36611274
Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolismQ36626694
The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatinQ36650582
Autophagic control of cell 'stemness'.Q36685927
A phosphotyrosine switch regulates organic cation transportersQ36704820
Tumor microenvironment: the role of the tumor stroma in cancerQ36709404
Protein turnover via autophagy: implications for metabolismQ36740463
Direct cellular responses to platinum-induced DNA damageQ36800400
Mitochondria and reactive oxygen species in renal cancer.Q36804989
The role of ubiquitination in the direct mitochondrial death program of p53.Q36881193
Overcoming platinum resistance through the use of a copper-lowering agentQ36886892
Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian CancerQ36922131
The role of cellular accumulation in determining sensitivity to platinum-based chemotherapyQ36971805
Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response.Q36980048
Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.Q37065664
Impaired glutathione synthesis in neurodegenerationQ37291406
Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagyQ37365307
Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinomaQ37376917
Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathwayQ37476178
MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1.Q37513892
Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancerQ37602926
Chk1/2 inhibition overcomes the cisplatin resistance of head and neck cancer cells secondary to the loss of functional p53.Q37638784
Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.Q37682756
Ammonium tetrathiomolybdate treatment targets the copper transporter ATP7A and enhances sensitivity of breast cancer to cisplatinQ37686235
The relationship between cisplatin-induced reactive oxygen species, glutathione, and BCL-2 and resistance to cisplatinQ37693895
Copper transporter 2 regulates intracellular copper and sensitivity to cisplatinQ37696191
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancerQ37707832
Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repairQ37736667
Human copper transporters: mechanism, role in human diseases and therapeutic potentialQ37747071
Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistanceQ38877475
MEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma.Q38879231
miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNA (cytosine-5)-methyltransferase 1(DNMT1) expressionQ38880588
MiR-205 and miR-218 expression is associated with carboplatin chemoresistance and regulation of apoptosis via Mcl-1 and Survivin in lung cancer cellsQ38881755
The anti-malarial chloroquine suppresses proliferation and overcomes cisplatin resistance of endometrial cancer cells via autophagy inhibition.Q38890954
The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axisQ38912419
Pseudohypoxia induced by miR-126 deactivation promotes migration and therapeutic resistance in renal cell carcinoma.Q38930757
Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell linesQ38949945
Induction of autophagy counteracts the anticancer effect of cisplatin in human esophageal cancer cells with acquired drug resistanceQ38955141
miR-let-7f-1 regulates SPARC mediated cisplatin resistance in medulloblastoma cellsQ38976273
Epithelial-mesenchymal status renders differential responses to cisplatin in ovarian cancer.Q38992054
Zinc chelation: a metallothionein 2A's mechanism of action involved in osteosarcoma cell death and chemotherapy resistance.Q39070928
miR-495 enhances the sensitivity of non-small cell lung cancer cells to platinum by modulation of copper-transporting P-type adenosine triphosphatase A (ATP7A).Q39095757
Hypoxia inducible factor-1α induces chemoresistance phenotype in non-Hodgkin lymphoma cell line via up-regulation of Bcl-xL.Q39271109
The African-specific S47 polymorphism of p53 alters chemosensitivityQ39532523
Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatinQ39578254
Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.Q39711077
The internalization and degradation of human copper transporter 1 following cisplatin exposureQ39774950
Silencing MRP4 by small interfering RNA reverses acquired DDP resistance of gastric cancer cellQ39780172
Copper transporters and chaperones CTR1, CTR2, ATOX1, and CCS as determinants of cisplatin sensitivityQ39785045
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-linksQ39807128
Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotypeQ40002565
Transport of cisplatin by the copper efflux transporter ATP7B.Q40058081
Differential contribution of organic cation transporters, OCT2 and MATE1, in platinum agent-induced nephrotoxicityQ40117154
ABCC2 (MRP2, cMOAT) can be localized in the nuclear membrane of ovarian carcinomas and correlates with resistance to cisplatin and clinical outcomeQ40200907
Augmentation of cisplatin sensitivity in cisplatin-resistant human bladder cancer cells by modulating glutathione concentrations and glutathione-related enzyme activitiesQ40433330
Cellular accumulation of the anticancer agent cisplatin: a reviewQ40917698
Oxaliplatin-Based Chemotherapy in Advanced Neuroendocrine Tumors: Clinical Outcomes and Preliminary Correlation with Biological FactorsQ40963478
Sensitivity of testis tumour cells to chemotherapeutic drugs: role of detoxifying pathwaysQ41194881
Cytoplasmic fragment of CD147 generated by regulated intramembrane proteolysis contributes to HCC by promoting autophagyQ41335207
ZBTB7A Enhances Osteosarcoma Chemoresistance by Transcriptionally Repressing lncRNALINC00473-IL24 ActivityQ41667208
Downregulation of YEATS4 by miR-218 sensitizes colorectal cancer cells to L-OHP-induced cell apoptosis by inhibiting cytoprotective autophagyQ41914079
Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour modelsQ41978951
miR-34a mediates oxaliplatin resistance of colorectal cancer cells by inhibiting macroautophagy via transforming growth factor-β/Smad4 pathwayQ42316098
GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagyQ42330104
Microenvironmental InterFereNce of metabolism regulates chemosensitivity.Q42381317
CRISPR-Cas9-based target validation for p53-reactivating model compounds.Q42577802
MiR-200c regulates tumor growth and chemosensitivity to cisplatin in osteosarcoma by targeting AKT2Q42659697
Cisplatin interaction with amino acids cysteine and methionine from gas phase to solutions with constant pH.Q42966354
Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B.Q43415914
Formation and repair of cisplatin-induced adducts to DNA in cultured normal and repair-deficient human fibroblasts.Q43484172
Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cellsQ45213244
Increased levels of copper efflux transporter ATP7B are associated with poor outcome in colorectal cancer patients receiving oxaliplatin-based chemotherapy.Q46083726
Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.Q46268407
Xc- inhibitor sulfasalazine sensitizes colorectal cancer to cisplatin by a GSH-dependent mechanismQ46687271
Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistanceQ47135415
LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expressionQ47159465
miR-181 regulates cisplatin-resistant non-small cell lung cancer via downregulation of autophagy through the PTEN/PI3K/AKT pathway.Q52683993
Downregulation of HIF-2α Reverse the Chemotherapy Resistance of Lung Adenocarcinoma A549 Cells to Cisplatin.Q52731051
LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis.Q52753259
Histone Methyltransferase G9a Drives Chemotherapy Resistance by Regulating the Glutamate-Cysteine Ligase Catalytic Subunit in Head and Neck Squamous Cell Carcinoma.Q52895624
Reversal of cisplatin resistance by microRNA-139-5p-independent RNF2 downregulation and MAPK inhibition in ovarian cancer.Q53689012
Competitive reactions among glutathione, cisplatin and copper-phenanthroline complexes.Q53740004
Kidney cancer: OCT2 demethylation cracks open oxaliplatin resistance.Q53774743
KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension.Q53804088
Inhibition of cisplatin-resistance by RNA interference targeting metallothionein using reducible oligo-peptoplex.Q53830353
ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.Q54195051
Phase II study of adjuvant chemotherapy with paclitaxel and nedaplatin for uterine cervical cancer with lymph node metastasis.Q54249091
Structure, Recognition, and Processing of Cisplatin-DNA Adducts.Q55035583
Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway.Q55280857
MicroRNA-125a-5p enhances the sensitivity of esophageal squamous cell carcinoma cells to cisplatin by suppressing the activation of the STAT3 signaling pathway.Q55419057
miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1Q57476082
Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione BiosynthesisQ58103531
LncRNA MALAT1 potentiates autophagy‑associated cisplatin resistance by regulating the microRNA‑30b/autophagy‑related gene 5 axis in gastric cancerQ58543570
Knockdown of galectin-1 facilitated cisplatin sensitivity by inhibiting autophagy in neuroblastoma cellsQ58570966
miR‑34a regulates the chemosensitivity of retinoblastoma cells via modulation of MAGE‑A/p53 signalingQ58584892
LncRNA BLACAT1 is involved in chemoresistance of non‑small cell lung cancer cells by regulating autophagyQ58584902
A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder CancerQ58595174
Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to CisplatinQ58710535
Comparison of efficacy and toxicity between nedaplatin and cisplatin in treating malignant pleural effusionQ58762812
LncRNA HOXA11-AS drives cisplatin resistance of human LUAD cells via modulating miR-454-3p/Stat3Q58769775
Oxaliplatin-induced damage of cellular DNAQ60641674
Tetrathiomolybdate induces dimerization of the metal-binding domain of ATPase and inhibits platination of the proteinQ60909406
Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5Q61448904
HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic SignificanceQ61799540
BRCA1/2 mutations and expression: Response to platinum chemotherapy in patients with advanced stage epithelial ovarian cancerQ62112707
Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significanceQ72932284
Metallothionein expression correlates with the pathological response of patients with esophageal cancer undergoing preoperative chemoradiation therapyQ77796057
Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatinQ79922423
Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)Q80128982
Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an indQ80445905
Immunohistochemical expression of MRP2 and clinical resistance to platinum-based chemotherapy in small cell lung cancerQ80536626
Low ERCC1 expression is associated with prolonged survival in patients with bladder cancer receiving platinum-based neoadjuvant chemotherapyQ84730836
Serum metallothionein in patients with testicular cancerQ86786642
Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivoQ87126485
MircroRNA-139 sensitizes ovarian cancer cell to cisplatin-based chemotherapy through regulation of ATP7A/BQ88208744
DUOXA1-mediated ROS production promotes cisplatin resistance by activating ATR-Chk1 pathway in ovarian cancerQ88500255
Gambogic Acid Inhibits Melanoma through Regulation of miR-199a-3p/ZEB1 SignallingQ89360330
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cellsQ90277883
BRCA Mutation and Its Association With Colorectal CancerQ90392429
Emerging platinum(iv) prodrugs to combat cisplatin resistance: from isolated cancer cells to tumor microenvironmentQ90999761
Profiling of apoptosis- and autophagy-associated molecules in human lung cancer A549 cells in response to cisplatin treatment using stable isotope labeling with amino acids in cell cultureQ91139685
miR-137 mediates the functional link between c-Myc and EZH2 that regulates cisplatin resistance in ovarian cancerQ91239726
Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balanceQ91971712
Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinomaQ92016223
Cisplatin resistance involves a metabolic reprogramming through ROS and PGC-1α in NSCLC which can be overcome by OXPHOS inhibitionQ92422009
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)343
P577publication date2020-03-20
P1433published inFrontiers in PharmacologyQ2681208
P1476titleThe Drug-Resistance Mechanisms of Five Platinum-Based Antitumor Agents
P478volume11

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