The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.

scientific article published on September 2007

The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1158/1535-7163.MCT-07-0186
P932PMC publication ID2627774
P698PubMed publication ID17876045
P5875ResearchGate publication ID5967087

P2093author name stringFang Fang
Daret K St Clair
Peter A Crooks
Graham W Warren
Vivek M Rangnekar
William H St Clair
Yulan Sun
P2860cites workSuppressed NF-kB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-a induced apoptosis in human cancer cellsQ23921490
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The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cellsQ24670343
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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor-signaling pathwaysQ33715487
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progressionQ33944717
IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapyQ34048503
Radiation-induced activation of nuclear factor-kappaB involves selective degradation of plasma membrane-associated I(kappa)B(alpha)Q34167705
Molecular characterization of human prostate carcinoma cell linesQ34266176
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-kappa B by targeting the I kappa B kinase complex.Q34505685
Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactonesQ34516946
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinaseQ34517140
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Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responsesQ34784364
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Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiationQ35208812
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancerQ36349294
NF-kappaB modulation and ionizing radiation: mechanisms and future directions for cancer treatment.Q36363022
Nuclear factor-kappaB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate.Q38337372
Inhibition of mammalian target of rapamycin or apoptotic pathway induces autophagy and radiosensitizes PTEN null prostate cancer cellsQ40218958
Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanismQ40357398
Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosisQ40396786
NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiationQ40440521
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.Q40529884
Feverfew: chemistry and biological activityQ40550993
Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cellsQ40556114
Survival and cell cycle kinetics of human prostate cancer cell lines after single- and multifraction exposures to ionizing radiationQ40565350
Adenoviral-mediated PTEN transgene expression sensitizes Bcl-2-expressing prostate cancer cells to radiationQ40591981
Two waves of nuclear factor kappaB recruitment to target promotersQ40798242
Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses.Q40946010
Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation.Q41575182
A role for manganese superoxide dismutase in radioprotection of hematopoietic stem cells by interleukin-1.Q41575771
RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cellsQ41867756
Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cellsQ44010963
Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolideQ44085055
Cell cycle effects and caspase-dependent and independent death of HL-60 and Jurkat cells treated with the inhibitor of NF-kappaB parthenolide.Q44506997
Superoxide dismutase. Organelle specificity.Q54277328
Inhibition of DNA biosynthesis in HeLa cells by cytotoxic and antitumor sesquiterpene lactonesQ70701439
Loss of the chromosomal region 10q23-25 in prostate cancerQ71804687
Helenanolide-type sesquiterpene lactones--III. Rates and stereochemistry in the reaction of helenalin and related helenanolides with sulfhydryl containing biomoleculesQ73354884
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolideQ74234923
The role of IKK in constitutive activation of NF-kappaB transcription factor in prostate carcinoma cellsQ77522595
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)2477-2486
P577publication date2007-09-01
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleThe radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.
P478volume6

Reverse relations

cites work (P2860)
Q39726912A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
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Q37665033Can the therapeutic gain of radiotherapy be increased by concurrent administration of Asian botanicals?
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Q58572024Effects of FOXM1 inhibition and ionizing radiation on melanoma cells
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Q34427403microRNA-222 targeting PTEN promotes neurite outgrowth from adult dorsal root ganglion neurons following sciatic nerve transection

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