Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor

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Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor is …
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scholarly articleQ13442814

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P356DOI10.1186/1471-2199-3-11
P932PMC publication ID117602
P698PubMed publication ID12113656
P5875ResearchGate publication ID11264349

P2093author name stringRay-Chang Wu
Xinwei Li
Axel H Schönthal
Martina Blumenthal
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1Q22254699
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Cyclin A is required at two points in the human cell cycleQ24329048
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayQ24653458
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
WAF1, a potential mediator of p53 tumor suppressionQ27861121
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathwayQ28139300
Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell deathQ73400418
Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivoQ74234906
Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 geneQ74608375
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogeneQ77726383
PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flowQ28202778
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Pten is essential for embryonic development and tumour suppressionQ28509238
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Regulation of PTEN transcription by p53Q28646911
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movementQ30306561
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Autoregulation of fos: the dyad symmetry element as the major target of repression.Q33576167
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayQ33599964
p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblastsQ33986335
Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylationQ34050342
Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequencesQ34220845
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosisQ34371260
Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma proteinQ36236717
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1Q37396761
Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitroQ37459913
Anchorage-dependent transcription of the cyclin A geneQ40019663
Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs).Q40453377
Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressorQ40892936
Induction of protein phosphatase type 2A in response to disruption of cell-matrix interactionsQ40917032
Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cellsQ41033252
Activation of p53-p21waf1 pathway in response to disruption of cell-matrix interactionsQ41079834
Dependence of cyclin E-CDK2 kinase activity on cell anchorage.Q41237386
Analysis of the p53 gene and its expression in human glioblastoma cellsQ41488834
A link between cyclin A expression and adhesion-dependent cell cycle progressionQ41509705
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexesQ41667743
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cellsQ42481082
Inhibition of histone H1 kinase expression, retinoblastoma protein phosphorylation, and cell proliferation by the phosphatase inhibitor okadaic acid.Q42812378
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.Q42824933
PTEN: sometimes taking it off can be better than putting it on.Q43104730
Role of cell shape in growth controlQ44152787
Cyclin a is required for the onset of DNA replication in mammalian fibroblastsQ44752373
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer.Q45029660
Growth suppression of human ovarian cancer cells by adenovirus-mediated transfer of the PTEN geneQ45864448
Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.Q45881488
Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating proteinQ46082251
p27Kip1 is required for PTEN-induced G1 growth arrest.Q46585082
Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathwayQ48046157
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.Q48331127
Apoptosis. Till death us do partQ48800657
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.Q52180037
Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells.Q55476962
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)11
P577publication date2002-07-12
P1433published inBMC Molecular BiologyQ15760954
P1476titleLoss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor
P478volume3

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cites work (P2860)
Q24816886Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation
Q35435345Down-regulation of PTEN expression due to loss of promoter activity in human hepatocellular carcinoma cell lines

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