PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow

scientific article (publication date: 21 February 2002)

PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1053442094
P356DOI10.1038/SJ.ONC.1205213
P698PubMed publication ID11857088
P5875ResearchGate publication ID11504927

P50authorGarth L. NicolsonQ17489765
P2093author name stringJörg Haier
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionQ22010498
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Q22253866
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motilityQ24554511
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathwayQ28139300
Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinasesQ28255035
Direct association of protein-tyrosine phosphatase PTP-PEST with paxillinQ28264272
Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activityQ28300726
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Pten is essential for embryonic development and tumour suppressionQ28509238
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cellsQ33586807
PTEN: a tumour suppressor that functions as a phospholipid phosphataseQ33594251
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayQ33599964
PTEN/MMAC1/TEP1 in signal transduction and tumorigenesisQ33723736
PTEN gene and integrin signaling in cancerQ33765703
The multiple roles of PTEN in tumor suppressionQ33849727
The tumor suppressor PTEN regulates T cell survival and antigen receptor signaling by acting as a phosphatidylinositol 3-phosphataseQ33888694
Protein tyrosine phosphatases in signal transduction.Q34419522
Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposisQ35250337
Novel tyrosine kinase substrates from Rous sarcoma virus-transformed cells are present in the membrane skeletonQ36220765
Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathwaysQ36256326
Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B.Q36288200
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.Q36301565
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Different adhesion properties of highly and poorly metastatic HT-29 colon carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal componentsQ38273491
Protein tyrosine phosphatases in cell transformationQ40813403
Integrin transmembrane signaling and cytoskeletal controlQ40952551
Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesionQ41018719
Signaling through focal adhesion kinaseQ41359146
Role of the cytoskeleton in adhesion stabilization of human colorectal carcinoma cells to extracellular matrix components under dynamic conditions of laminar flowQ41751721
Influence of phosphotyrosine kinase inhibitors on adhesive properties of highly and poorly metastatic HT-29 colon carcinoma cells to collagenQ45298448
Beta1-integrin-mediated dynamic adhesion of colon carcinoma cells to extracellular matrix under laminar flowQ45299813
Tumor cell adhesion of human colon carcinoma cells with different metastatic properties to extracellular matrix under dynamic conditions of laminar flowQ45302100
PTEN/MMAC1/TEP1 involvement in primary prostate cancers.Q47814101
Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome.Q51996177
PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.Q55476772
Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strainQ71435733
Differential regulation of protein-tyrosine phosphatases by integrin alpha IIb beta 3 through cytoskeletal reorganization and tyrosine phosphorylation in human plateletsQ71692364
Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tractQ73008420
Allelic loss of the PTEN region (10q23) in breast carcinomas of poor pathophenotypeQ73316223
Endothelial gene regulation by laminar shear stressQ73788938
PTEN germ-line mutations in juvenile polyposis coliQ74026971
Mutational abrogation of the PTEN/MMAC1 gene in gastrointestinal polyps in patients with Cowden diseaseQ77494213
PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulationQ78026206
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcell adhesionQ187640
fluid flowQ12142910
colon carcinomaQ18554829
P304page(s)1450-60
P577publication date2002-02-21
P1433published inOncogeneQ1568657
P1476titlePTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow
P478volume21

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cites work (P2860)
Q30442233A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer
Q34717955Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis
Q35943250Clinical implications of PTEN and VEGF expression status, as well as microvessel density in esophageal squamous cell carcinoma
Q40241749Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2.
Q54976490Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development.
Q36956729Focal adhesion kinase: a promising target for anticancer therapy
Q26797287Focus on PTEN Regulation
Q81471088Genetic and pathologic changes associated with lymphovascular invasion of colorectal adenocarcinoma
Q33569192In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell--endothelial cell interaction
Q45178212Integrins can directly mediate metastatic tumor cell adhesion within the liver sinusoids
Q52559414Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion.
Q24797910Loss of cellular adhesion to matrix induces p53-independent expression of PTEN tumor suppressor
Q39868557Metastatic tumor cell arrest in the liver-lumen occlusion and specific adhesion are not exclusive
Q35256204NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.
Q54295478Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats.
Q30478479Organ-specific metastatic tumor cell adhesion and extravasation of colon carcinoma cells with different metastatic potential
Q37290801PCR-SSCP-DNA sequencing method in detecting PTEN gene mutation and its significance in human gastric cancer
Q38198345PTEN function: the long and the short of it.
Q35721747Phosphatase and Tensin Homolog (PTEN) Represses Colon Cancer Progression through Inhibiting Paxillin Transcription via PI3K/AKT/NF-κB Pathway
Q59304352Resveratrol inhibits Erk1/2-mediated adhesion of cancer cells via activating PP2A-PTEN signaling network
Q38723005Role of key genetic mutations on increasing migration of brain cancer cells through confinement.
Q33784365The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression

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