PTEN at a glance

scientific article

PTEN at a glance is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1242/JCS.093765
P932PMC publication ID3517091
P698PubMed publication ID23223894

P2093author name stringXinjiang Wang
Xuejun Jiang
Yuji Shi
Benjamin E Paluch
P2860cites workmiR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kineticsQ21091130
Phosphorylation of the PTEN tail regulates protein stability and functionQ22254305
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradationQ24290417
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTENQ24292919
Ubiquitination regulates PTEN nuclear import and tumor suppressionQ24292946
PCAF modulates PTEN activityQ24296629
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
Rak functions as a tumor suppressor by regulating PTEN protein stability and functionQ24312999
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalizationQ24314543
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent mannerQ24337323
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2aQ24613036
Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2Q24623513
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanomaQ24629400
E3 ligase Nedd4 promotes axon branching by downregulating PTENQ24630190
A coding-independent function of gene and pseudogene mRNAs regulates tumour biologyQ24632651
The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivoQ24657924
Critical role of PICT-1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5-trisphosphate signals and tumorigenic transformationQ24673801
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Crucial role of the C-terminus of PTEN in antagonizing NEDD4-1-mediated PTEN ubiquitination and degradationQ28281043
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.Q28305284
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegenerationQ28384823
Essential role for nuclear PTEN in maintaining chromosomal integrityQ28513781
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphataseQ28567492
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancerQ29547523
Reversible inactivation of the tumor suppressor PTEN by H2O2Q29615204
Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinaseQ30156937
Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.Q30494717
Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN.Q33514644
Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zincQ33744696
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathwayQ34173253
Regulation of PTEN by Rho small GTPasesQ34406790
Tumor suppressor PTEN acts through dynamic interaction with the plasma membraneQ34574432
The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell deathQ34656554
PTEN acetylation modulates its interaction with PDZ domainQ34817146
On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)Q35064223
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cellsQ35096583
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progressionQ35223274
Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stressQ35379204
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemiaQ35666277
Redox regulation of PI 3-kinase signalling via inactivation of PTENQ36266420
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.Q36301565
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemiaQ37009642
New insights into PTEN.Q37011116
Portrait of PTEN: messages from mutant mice.Q37059129
Tenets of PTEN tumor suppressionQ37154214
PTEN and the PI3-kinase pathway in cancerQ37259680
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue surveyQ37270420
The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cellsQ37452295
WWP2 is an E3 ubiquitin ligase for PTEN.Q37588182
Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factorsQ37693081
PTEN level in tumor suppression: how much is too little?Q37832338
E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via β-catenin-Egr1-mediated PTEN expression.Q39597035
Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.Q39736424
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML networkQ39948774
PTEN is destabilized by phosphorylation on Thr366.Q40143795
CBF-1 (RBP-J kappa) binds to the PTEN promoter and regulates PTEN gene expressionQ40179833
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.Q40198370
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3betaQ40384036
Increased protein expression of the PTEN tumor suppressor in the presence of constitutively active Notch-1.Q40386132
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.Q40587498
Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domainQ42827470
Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins.Q42865771
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophilsQ44857079
Mechanistic insights into maintenance of high p53 acetylation by PTEN.Q46035699
Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool.Q46779760
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.Q52180037
P433issuePt 20
P407language of work or nameEnglishQ1860
P304page(s)4687-4692
P577publication date2012-10-01
P1433published inJournal of Cell ScienceQ1524177
P1476titlePTEN at a glance
P478volume125