| P50 | author | Pier Paolo Pandolfi | Q7191735 |
| | Jason A Koutcher | Q89439009 |
| | Eric C Holland | Q89747805 |
| P2093 | author name string | Yi Li | |
| | Xiaoyi Hu | |
| | Marc Rosenblum | |
| P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
| | Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 |
| | The PI3K-PDK1 connection: more than just a road to PKB | Q24531972 |
| | Cancerous stem cells can arise from pediatric brain tumors | Q24569653 |
| | RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 | Q24682697 |
| | Pten dose dictates cancer progression in the prostate | Q24791909 |
| | Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. | Q27824772 |
| | PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 |
| | TOR, a central controller of cell growth | Q27933354 |
| | Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B | Q28116107 |
| | Identification of a cancer stem cell in human brain tumors | Q28131688 |
| | TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Q28131740 |
| | PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms | Q28181035 |
| | Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 | Q28181376 |
| | PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model | Q28202775 |
| | Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro | Q28219465 |
| | The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas | Q28267034 |
| | Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 |
| | Pten is essential for embryonic development and tumour suppression | Q28509238 |
| | Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 |
| | Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 |
| | Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | Q28646376 |
| | The phosphatidylinositol 3-Kinase AKT pathway in human cancer | Q29547860 |
| | Regulation of translation initiation by FRAP/mTOR | Q29620398 |
| | Immunocytochemical study of the glial fibrillary acidic protein in human neoplasms of the central nervous system | Q33277842 |
| | Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells | Q33930407 |
| | An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice | Q33943166 |
| | Role of S6 phosphorylation and S6 kinase in cell growth | Q34047808 |
| | Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy | Q34306865 |
| | Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification | Q34350623 |
| | Mammalian TOR: a homeostatic ATP sensor | Q34519173 |
| | mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo | Q34542438 |
| | A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. | Q34585873 |
| | Pten signaling in gliomas | Q34707865 |
| | The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats. | Q34768422 |
| | PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo | Q35080265 |
| | A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice | Q35211546 |
| | Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice | Q35801259 |
| | Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. | Q36269892 |
| | Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. | Q36301565 |
| | Structural alterations of the epidermal growth factor receptor gene in human gliomas | Q36930689 |
| | Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice | Q40881142 |
| | MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials | Q41687215 |
| | Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. | Q42824933 |
| | Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic | Q43882655 |
| | Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo | Q44462995 |
| | mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways | Q44905183 |
| | Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease | Q47198015 |
| | Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease | Q47198022 |
| | Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes | Q47421825 |
| | Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas. | Q48220724 |
| | Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. | Q48230264 |
| | Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors | Q48445033 |
| | Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. | Q48476506 |
| | Proliferation of human malignant astrocytomas is dependent on Ras activation | Q48570270 |
| | Somatic mutations of PTEN in glioblastoma multiforme | Q48618632 |
| | Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo | Q48722189 |
| | OLIG2 as a specific marker of oligodendroglial tumour cells. | Q55474179 |
| | The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. | Q55476352 |
| | CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. | Q55480139 |
| | High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 |
| P433 | issue | 4 | |
| P304 | page(s) | 356-368 | |
| P577 | publication date | 2005-04-01 | |
| P1433 | published in | Neoplasia | Q2962042 |
| P1476 | title | mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma | |
| P478 | volume | 7 | |