scholarly article | Q13442814 |
P50 | author | Pier Paolo Pandolfi | Q7191735 |
Jason A Koutcher | Q89439009 | ||
Eric C Holland | Q89747805 | ||
P2093 | author name string | Yi Li | |
Xiaoyi Hu | |||
Marc Rosenblum | |||
P2860 | cites work | The lipid phosphatase activity of PTEN is critical for its tumor supressor function | Q22007981 |
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN | Q24322051 | ||
The PI3K-PDK1 connection: more than just a road to PKB | Q24531972 | ||
Cancerous stem cells can arise from pediatric brain tumors | Q24569653 | ||
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1 | Q24682697 | ||
Pten dose dictates cancer progression in the prostate | Q24791909 | ||
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. | Q27824772 | ||
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
TOR, a central controller of cell growth | Q27933354 | ||
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B | Q28116107 | ||
Identification of a cancer stem cell in human brain tumors | Q28131688 | ||
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling | Q28131740 | ||
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms | Q28181035 | ||
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 | Q28181376 | ||
PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model | Q28202775 | ||
Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro | Q28219465 | ||
The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas | Q28267034 | ||
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
Pten is essential for embryonic development and tumour suppression | Q28509238 | ||
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems | Q28586004 | ||
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B | Q28646376 | ||
The phosphatidylinositol 3-Kinase AKT pathway in human cancer | Q29547860 | ||
Regulation of translation initiation by FRAP/mTOR | Q29620398 | ||
Immunocytochemical study of the glial fibrillary acidic protein in human neoplasms of the central nervous system | Q33277842 | ||
Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells | Q33930407 | ||
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice | Q33943166 | ||
Role of S6 phosphorylation and S6 kinase in cell growth | Q34047808 | ||
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy | Q34306865 | ||
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification | Q34350623 | ||
Mammalian TOR: a homeostatic ATP sensor | Q34519173 | ||
mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo | Q34542438 | ||
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt. | Q34585873 | ||
Pten signaling in gliomas | Q34707865 | ||
The characteristics of astrocytomas and oligodendrogliomas are caused by two distinct and interchangeable signaling formats. | Q34768422 | ||
PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo | Q35080265 | ||
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice | Q35211546 | ||
Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice | Q35801259 | ||
Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development. | Q36269892 | ||
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. | Q36301565 | ||
Structural alterations of the epidermal growth factor receptor gene in human gliomas | Q36930689 | ||
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice | Q40881142 | ||
MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials | Q41687215 | ||
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. | Q42824933 | ||
Mammalian target of rapamycin (mTOR): pro- and anti-apoptotic | Q43882655 | ||
Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo | Q44462995 | ||
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways | Q44905183 | ||
Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease | Q47198015 | ||
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease | Q47198022 | ||
Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes | Q47421825 | ||
Basic fibroblast growth factor and fibroblast growth factor receptor I are implicated in the growth of human astrocytomas. | Q48220724 | ||
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. | Q48230264 | ||
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors | Q48445033 | ||
Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. | Q48476506 | ||
Proliferation of human malignant astrocytomas is dependent on Ras activation | Q48570270 | ||
Somatic mutations of PTEN in glioblastoma multiforme | Q48618632 | ||
Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo | Q48722189 | ||
OLIG2 as a specific marker of oligodendroglial tumour cells. | Q55474179 | ||
The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells. | Q55476352 | ||
CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. | Q55480139 | ||
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice | Q58378937 | ||
P433 | issue | 4 | |
P304 | page(s) | 356-368 | |
P577 | publication date | 2005-04-01 | |
P1433 | published in | Neoplasia | Q2962042 |
P1476 | title | mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma | |
P478 | volume | 7 |