Structural alterations of the epidermal growth factor receptor gene in human gliomas

scientific article published on April 1, 1992

Structural alterations of the epidermal growth factor receptor gene in human gliomas is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode1992PNAS...89.2965W
P356DOI10.1073/PNAS.89.7.2965
P953full work available at URLhttps://europepmc.org/articles/PMC48784
https://europepmc.org/articles/PMC48784?pdf=render
P932PMC publication ID48784
P698PubMed publication ID1557402
P5875ResearchGate publication ID21599130

P50authorBert VogelsteinQ827502
P2093author name stringJ. M. Ruppert
A. J. Wong
S. H. Bigner
P. A. Humphrey
C. H. Grzeschik
D. S. Bigner
P2860cites workAn analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAsQ22066003
A simple and very efficient method for generating cDNA librariesQ27860461
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cellsQ29616544
Ligand activation of overexpressed epidermal growth factor receptors transforms NIH 3T3 mouse fibroblastsQ33556637
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastomaQ33610591
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomasQ33881165
A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumorsQ33937136
Differences in sequences encoding the carboxyl-terminal domain of the epidermal growth factor receptor correlate with differences in the disease potential of viral erbB genesQ34162385
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplificationQ34350623
Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.Q36599081
Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumorsQ36787477
Structure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cellsQ36903694
Characterization and sequence of the promoter region of the human epidermal growth factor receptor geneQ37524558
A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-Ki-ras allele in human tumor cellsQ37554584
An improved method for directly sequencing PCR amplified material using dimethyl sulphoxideQ40521534
Localization of a major receptor-binding domain for epidermal growth factor by affinity labelingQ40649589
Anti-idiotypic monoclonal antibody to a T-cell chronic lymphatic leukemia. Characterization of the antibody, in vitro effector functions and results of therapyQ40779148
Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptorsQ42054821
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cellsQ42805935
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogeneQ42806006
Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell linesQ42813360
Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviationsQ42819438
Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB proteinQ44629218
Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.Q48088104
The human EGF receptor gene: structure of the 110 kb locus and identification of sequences regulating its transcriptionQ48338976
Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial originQ48536258
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.Q53554133
Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.Q55486297
Clonal analysis using recombinant DNA probes from the X-chromosomeQ69904084
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectneoplasm genesQ70691924
P304page(s)2965-2969
P577publication date1992-04-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleStructural alterations of the epidermal growth factor receptor gene in human gliomas
P478volume89

Reverse relations

cites work (P2860)
Q426850373' end structure and rearrangements of EGFR in glioblastomas
Q93133060A Characterization of Dendritic Cells and Their Role in Immunotherapy in Glioblastoma: From Preclinical Studies to Clinical Trials
Q36414254A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies
Q46093038A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma.
Q33811568A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor
Q38683823A brief perspective of drug resistance toward EGFR inhibitors: the crystal structures of EGFRs and their variants
Q24647081A census of human cancer genes
Q98303321A compendium of mutational cancer driver genes
Q35211546A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
Q40280414A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
Q73046729A friendly signal
Q39168444A minority subpopulation of CD133(+) /EGFRvIII(+) /EGFR(-) cells acquires stemness and contributes to gefitinib resistance.
Q39496576A monoclonal antibody targeted against epidermal growth factor receptor variant III enhances cisplatin efficiency
Q35660849A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
Q36010772A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors
Q42831336A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo
Q24293746A quantitative protein interaction network for the ErbB receptors using protein microarrays
Q35146077A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
Q33888193A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor
Q35103401ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor
Q30155872ARAP1 association with CIN85 affects epidermal growth factor receptor endocytic trafficking
Q27853013AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
Q39411416Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma.
Q31867049Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications
Q35838855Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases
Q36995979Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism
Q39346046Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The "Rotation Model".
Q45916176Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation.
Q38921652Advances and challenges: dendritic cell vaccination strategies for glioblastoma.
Q38014949Advances in malignant glioma drug discovery
Q37527117Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.
Q55479603Alteration of c-fos gene methylation in human gliomas.
Q48877020Alterations of cell cycle regulators in gliomatosis cerebri
Q48462937Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: association with clinicopathological features and patient survival
Q33665884An EGFRvIII-targeted bispecific T-cell engager overcomes limitations of the standard of care for glioblastoma.
Q90215360An Innovative Immunotherapy Vaccine with Combination Checkpoint Blockade as a First Line Treatment for Glioblastoma in the Context of Current Treatments
Q34346944An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme
Q40859402An oncogenic epidermal growth factor receptor signals via a p21-activated kinase-caldesmon-myosin phosphotyrosine complex
Q27024830An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma
Q47974745Analysis of Constitutive EGFR Signaling Regulating IRF3 Transcriptional Activity in Cancer Cells
Q53465061Analysis of Epidermal Growth Factor Receptor Gene Amplification and Alteration in Stereotactic Biopsies of Brain Tumors
Q31037039Analysis of differentially expressed genes based on microarray data of glioma
Q34629812Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.
Q33795137Anti-EGFRvIII Chimeric Antigen Receptor-Modified T Cells for Adoptive Cell Therapy of Glioblastoma
Q64244828Anti-Invasion and Antiangiogenic Effects of Stellettin B through Inhibition of the Akt/Girdin Signaling Pathway and VEGF in Glioblastoma Cells
Q34120472Antibody-based immunotherapy for malignant glioma
Q88664225Antigenic targets of CAR T Cell Therapy. A retrospective view on clinical trials
Q38990233Autophagy contributes to gefitinib-induced glioma cell growth inhibition.
Q26825496Biomarkers for glioma immunotherapy: the next generation
Q35576526Brain tumours: classification and genes
Q35812538Cancer therapeutics: understanding the mechanism of action
Q40120655Cell cycle-related kinase: a novel candidate oncogene in human glioblastoma
Q37362563Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.
Q34983621Cellular mechanisms targeted during astrocytoma progression
Q36003118Cellular responses to EGFR inhibitors and their relevance to cancer therapy
Q30440490Cellular signaling molecules as therapeutic targets in glioblastoma multiforme
Q34285619Central role of the EGF receptor in neurometabolic aging
Q88580999Challenges and prospects of chimeric antigen receptor T cell therapy in solid tumors
Q38187480Challenges in the development of a survivin vaccine (SurVaxM) for malignant glioma
Q35800492Chaperone proteins and brain tumors: potential targets and possible therapeutics
Q42811147Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling
Q47561397Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications
Q28345662Chromosome 7 aneusomy. A marker for metastatic melanoma? Expression of the epidermal growth factor receptor gene and chromosome 7 aneusomy in nevi, primary malignant melanomas and metastases
Q39770397Cilengitide: an RGD pentapeptide ανβ3 and ανβ5 integrin inhibitor in development for glioblastoma and other malignancies
Q30784536Clinical immunotherapy for brain tumors
Q33628302Clinical significance of EGFR amplification and the aberrant EGFRvIII transcript in conventionally treated astrocytic gliomas.
Q80100938Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal growth factor receptor for lung adenocarcinoma
Q39156727Clustered localization of EGFRvIII in glioblastoma cells as detected by high precision localization microscopy.
Q35505109Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells
Q71646343Comparative analysis of epidermal growth factor receptor gene expression and protein product in benign, premalignant, and malignant prostate tissue
Q35834190Comparative genomic hybridization of human malignant gliomas reveals multiple amplification sites and nonrandom chromosomal gains and losses
Q35643021Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization
Q28083888Concepts of immunotherapy for glioma
Q42816271Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2).
Q42450037Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor
Q41067751Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
Q39933616Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators
Q37174174Control of glioblastoma tumorigenesis by feed-forward cytokine signaling.
Q48112680Copy number alterations unmasked as enhancer hijackers
Q37256658Coronavirus genetically redirected to the epidermal growth factor receptor exhibits effective antitumor activity against a malignant glioblastoma
Q38810064Current and future strategies for treatment of glioma
Q38313826Current challenges in designing GBM trials for immunotherapy
Q38012438Current clinical development of PI3K pathway inhibitors in glioblastoma
Q41611838Current perspectives in gliomas
Q26828965Current vaccine trials in glioblastoma: a review
Q92350809DNMT3A co-mutation in an IDH1-mutant glioblastoma
Q34584728Dacomitinib, an irreversible Pan-ErbB inhibitor significantly abrogates growth in head and neck cancer models that exhibit low response to cetuximab
Q42493708Deletion and tandem duplication of exons 2 - 7 in the epidermal growth factor receptor gene of a human malignant glioma
Q28087485Dendritic Cell-Based Immunotherapy Treatment for Glioblastoma Multiforme
Q26829873Deregulated signaling pathways in glioblastoma multiforme: molecular mechanisms and therapeutic targets
Q58126050Development and Analytical Validation of a BT-474 Anti-Proliferation Assay Targeting HER2
Q33711627Development of an EGFRvIII specific recombinant antibody
Q54539724Development of novel tumor imaging agents with phage-display combinatorial peptide libraries.
Q48961381Diagnosis of malignant glioma: role of neuropathology
Q36201368Differences in the skeletal muscle transcriptome profile associated with extreme values of fatty acids content
Q47200263Differential Characterization of Temozolomide-Resistant Human Glioma Cells.
Q42512929Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor
Q39068923Direct inhibition of retinoblastoma phosphorylation by nimbolide causes cell-cycle arrest and suppresses glioblastoma growth.
Q39354630Dissecting Pin1 and phospho-pRb regulation.
Q90103140Drosophila melanogaster as a Model System for Human Glioblastomas
Q37259602EGF receptor variant III as a target antigen for tumor immunotherapy
Q26853549EGFR Amplification and Glioblastoma Stem-Like Cells
Q39416297EGFR Intron Recombination in Human Gliomas: Inappropriate Diversion of V(D)J Recombination?
Q54700951EGFR and EGFRvIII expression in primary breast cancer and cell lines.
Q33872371EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.
Q39578900EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis
Q36733618EGFR and HER2 signaling in breast cancer brain metastasis
Q37205334EGFR and KRAS mutations in patients with adenocarcinoma of the lung
Q40405623EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway
Q24338526EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
Q38171032EGFR signaling and autophagy dependence for growth, survival, and therapy resistance
Q34016908EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing
Q36780907EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis
Q30456087EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance
Q37686698EGFR/EGFRvIII-targeted immunotoxin therapy for the treatment of glioblastomas via convection-enhanced delivery
Q64120766EGFRvIII Is Expressed in Cellular Areas of Tumor in a Subset of Glioblastoma
Q38261455EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells.
Q39314446EGFRvIII gene rearrangement is an early event in glioblastoma tumorigenesis and expression defines a hierarchy modulated by epigenetic mechanisms.
Q38765219EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.
Q89748217EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma
Q50335608EGFRvIII-mediated radioresistance through a strong cytoprotective response.
Q35145144EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma
Q33758459EGFRvIII-targeted vaccination therapy of malignant glioma
Q89848700EGFRvIII: An Oncogene with Ambiguous Role
Q37369449Effect of blockade of the EGF system on wound healing in patients vaccinated with CIMAvax® EGF.
Q39953614Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells
Q33890758Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer
Q37025105Emerging immunotherapies for glioblastoma
Q36616502Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR
Q37544152Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases
Q34105339Epidermal Growth Factor Receptor in Glioma: Signal Transduction, Neuropathology, Imaging, and Radioresistance
Q39584506Epidermal growth factor induces matrix metalloproteinase-1 (MMP-1) expression and invasion in glioma cell lines via the MAPK pathway.
Q41718736Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials
Q27865182Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
Q46679323Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors
Q35782309Epidermal growth factor receptor expression in oligodendroglial tumors.
Q88485834Epidermal growth factor receptor in glioblastoma
Q48463583Epidermal growth factor receptor in proliferating reactive glia following transient focal ischemia in the rat brain
Q36504349Epidermal growth factor receptor inhibition and non-small cell lung cancer
Q39472366Epidermal growth factor receptor mutation status and rad51 determine the response of glioblastoma to multimodality therapy with cetuximab, temozolomide, and radiation
Q40759593Epidermal growth factor receptor mutation type III transfected into a small cell lung cancer cell line is predominantly localized at the cell surface and enhances the malignant phenotype
Q30164745Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization
Q34589789Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors
Q30450853Epidermal growth factor receptor-mediated regulation of urokinase plasminogen activator expression and glioblastoma invasion via C-SRC/MAPK/AP-1 signaling pathways
Q40038133Epidermal growth factor receptor-targeted therapy.
Q40641352Epidermal growth factor receptor: association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand
Q37301207Epigenetic markers in human gliomas: prospects for therapeutic intervention
Q37970020ErbB family receptor inhibitors as therapeutic agents in breast cancer: current status and future clinical perspective
Q33959306ErbB receptors and EGF-like ligands: cell lineage determination and oncogenesis through combinatorial signaling
Q39121775Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110δ.
Q41908287Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer
Q31045910Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis
Q33923950Evolution of malignant glioma treatment: from chemotherapy to vaccines to viruses
Q38781031ExRNA in Biofluids as Biomarkers for Brain Tumors
Q37038397Exomic sequencing of four rare central nervous system tumor types
Q37576033Exploiting the curative potential of adoptive T-cell therapy for cancer
Q35669708Expression of EGFRvIII in glioblastoma: prognostic significance revisited
Q41811462Expression of epidermal growth factor variant III (EGFRvIII) in pediatric diffuse intrinsic pontine gliomas
Q33941154Expression of the neural RNA-binding protein Musashi1 in human gliomas
Q36006446Extracellular RNAs: development as biomarkers of human disease
Q44559511Extracellular domain determinants of LET-23 (EGF) receptor tyrosine kinase activity in Caenorhabditis elegans
Q35237503Extracellular molecules involved in cancer cell invasion
Q38309871FAM190A rearrangements provide a multitude of individualized tumor signatures and neo-antigens in cancer.
Q92632517Factors That Govern the Induction of Long-Lived Antibody Responses
Q64883724Fire in the Smoke: Battling Brain Tumors.
Q55093479From mono- to bivalent: improving theranostic properties of target modules for redirection of UniCAR T cells against EGFR-expressing tumor cells in vitro and in vivo.
Q28186796Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)
Q26825769G protein-coupled receptors as oncogenic signals in glioma: emerging therapeutic avenues
Q37694758GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity
Q39509236Gefitinib induces apoptosis in human glioma cells by targeting Bad phosphorylation
Q40961519Gene amplification in human gliomas
Q83139511Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma
Q35553140Gene therapy of gliomas
Q34984218Genetic alterations associated with adult diffuse astrocytic tumors
Q38161344Genetic alterations in glioma
Q35117832Genetic alterations of human brain tumors as molecular prognostic factors
Q36021580Genetic and hypoxic regulation of angiogenesis in gliomas
Q36115735Genetic changes in squamous cell lung cancer: a review
Q34291055Genetic variation in the EGFR gene and the risk of glioma in a Chinese Han population
Q37348716Genetically engineered mouse models of brain cancer and the promise of preclinical testing
Q40686977Genetics of primary brain tumors: a review
Q49678076Genomic alterations of ERBB receptors in cancer: clinical implications
Q48365352Glioblastoma multiforme in an Asian population: evidence for a distinct genetic pathway
Q39908058Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress
Q38460865Glioblastoma: pathology, molecular mechanisms and markers
Q33746514Glioma diagnostics and biomarkers: an ongoing challenge in the field of medicine and science
Q34366431Glioma models
Q37752381Glioma stem cell signaling: therapeutic opportunities and challenges
Q34186001Gliomagenesis: genetic alterations and mouse models
Q38983559Glutamate and α-ketoglutarate: key players in glioma metabolism
Q27863678Glycosylation-induced conformational modification positively regulates receptor-receptor association: a study with an aberrant epidermal growth factor receptor (EGFRvIII/DeltaEGFR) expressed in cancer cells
Q34722415Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma
Q55476334Growth inhibition of astrocytoma cells by farnesyl transferase inhibitors is mediated by a combination of anti-proliferative, pro-apoptotic and anti-angiogenic effects.
Q34105503Growth inhibition of glioblastoma cells by human Pur(alpha).
Q35627691Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma
Q39679566Helianthin induces antiproliferative effect on human glioblastoma cells in vitro
Q92811985Heterogeneous EGFR, CDK4, MDM4, and PDGFRA Gene Expression Profiles in Primary GBM: No Association with Patient Survival
Q33721106Highly Specific and Effective Targeting of EGFRvIII-Positive Tumors with TandAb Antibodies
Q46581912Hyperdiploid tumor cells increase phenotypic heterogeneity within Glioblastoma tumors
Q24648948IDH1 and IDH2 mutations in gliomas
Q53890346INK4a/Arf is required for suppression of EGFR/DeltaEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma.
Q24650927Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway
Q40198860Identification of a novel EGF-sensitive cell cycle checkpoint
Q34168243Identification of an alternatively spliced RNA for the Ras suppressor RSU-1 in human gliomas
Q40568272Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor
Q28389919Immunoglobulin genes implicated in glioma risk
Q39399928Immunohistochemical discrimination of wild-type EGFR from EGFRvIII in fixed tumour specimens using anti-EGFR mAbs ICR9 and ICR10.
Q34488771Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma
Q38358124Immunotherapeutic advancements for glioblastoma.
Q35778576Immunotherapeutic strategies for malignant glioma
Q26866513Immunotherapy advances for glioblastoma
Q42396502Immunotherapy for glioblastoma: are we finally getting closer?
Q56890737Immunotherapy in Glioblastoma
Q36162929Immunotherapy of malignant brain tumors
Q43851121Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate
Q36081599In vitro and in vivo stability and anti-tumour efficacy of an anti-EGFR/anti-CD3 F(ab')2 bispecific monoclonal antibody
Q35440540Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.
Q35374492Innovative Therapies against Human Glioblastoma Multiforme
Q40684830Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.
Q38303924Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma.
Q54289713Ionizing radiation-inducible miR-30e promotes glioma cell invasion through EGFR stabilization by directly targeting CBL-B.
Q35831012Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
Q38829322Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses
Q35859194Ligand-independent dimerization of oncogenic v-erbB products involves covalent interactions.
Q33808359Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression
Q30425201Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib
Q59159123Lipoprotein-Based Nanoplatforms for Cancer Molecular Imaging
Q41144733Long-term survivors of glioblastoma multiforme: clinical and molecular characteristics.
Q55475127Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma.
Q30495880MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.
Q37432305Mammalian target of rapamycin (mTOR) pathways in neurological diseases
Q37476857Management of newly diagnosed glioblastoma: guidelines development, value and application
Q88371746Mapping of genomic EGFRvIII deletions in glioblastoma: insight into rearrangement mechanisms and biomarker development
Q91592481Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM
Q38786526Mechanistic interrogation of combination bevacizumab/dual PI3K/mTOR inhibitor response in glioblastoma implementing novel MR and PET imaging biomarkers
Q40554514Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation
Q28473229Mesenchymal stem cells modified with a single-chain antibody against EGFRvIII successfully inhibit the growth of human xenograft malignant glioma
Q34283477Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas.
Q36734908Modification of the primary tumor microenvironment by transforming growth factor alpha-epidermal growth factor receptor signaling promotes metastasis in an orthotopic colon cancer model
Q35104265Molecular abnormalities and correlations with tumor response and outcome in glioma patients
Q36478640Molecular biology of human gliomas
Q26822717Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date
Q32062433Molecular mechanisms underlying endocytosis and sorting of ErbB receptor tyrosine kinases
Q41687849Molecular neuropathology of astrocytic brain tumors
Q36021558Molecular pathogenesis of astrocytic tumours
Q37858944Molecular subclassification of diffuse gliomas: seeing order in the chaos
Q33911283Molecular targeting of glioblastoma: Drug discovery and therapies
Q33644407Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies
Q36135157Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor
Q36032533Multi-Center Randomized Phase II Study Comparing Cediranib plus Gefitinib with Cediranib plus Placebo in Subjects with Recurrent/Progressive Glioblastoma
Q40568043Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
Q28365260Mutant epidermal growth factor receptor enhances induction of vascular endothelial growth factor by hypoxia and insulin-like growth factor-1 via a PI3 kinase dependent pathway
Q44454339N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At
Q38070655Neuro-oncologic applications of exosomes, microvesicles, and other nano-sized extracellular particles
Q36081073New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells
Q89759447Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer
Q53616086Novel amplicons on the short arm of chromosome 7 identified using high resolution array CGH contain over expressed genes in addition to EGFR in glioblastoma multiforme.
Q48647863Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene
Q39043417Novel vaccines for glioblastoma: clinical update and perspective
Q30416775Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter
Q37115208Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
Q55476021Oncogenic epidermal growth factor receptor mutants with tandem duplication: gene structure and effects on receptor function.
Q33943421Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy
Q38017366Oncogenic regulation of tissue factor and thrombosis in cancer
Q53803471Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors.
Q38003175PDGF and PDGF receptors in glioma.
Q35080265PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo
Q34164924PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas
Q46592704PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells
Q37808385PI3Kinase signaling in glioblastoma
Q24650475PTPmu suppresses glioma cell migration and dispersal
Q93104522Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue
Q40633474Pathophysiology of glial growth factor receptors
Q33346827Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma
Q33834813Phenotype vs genotype in the evolution of astrocytic brain tumors
Q30434083Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II.
Q30393905Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells
Q72007934Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta
Q37579647Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer
Q42834600Production of a single-chain variable fragment antibody recognizing type III mutant epidermal growth factor receptor
Q48347971Prognostic significance of Ki67, p53 and epidermal growth factor receptor immunostaining in human glioblastomas.
Q38107462Progress on molecular biomarkers and classification of malignant gliomas
Q55480092Proliferation and motility responses of primary and recurrent gliomas related to changes in epidermal growth factor receptor expression.
Q58700626Proscillaridin A exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastoma
Q38748694Prospect of rindopepimut in the treatment of glioblastoma.
Q34507561Prospects for gene-engineered T cell immunotherapy for solid cancers.
Q34627812Proteases and the biology of glioma invasion
Q41679383Protein tyrosine kinases and cancer
Q34303359Quantitative proteomic analysis reveals effects of epidermal growth factor receptor (EGFR) on invasion-promoting proteins secreted by glioblastoma cells
Q55457286Quo Vadis-Do Immunotherapies Have a Role in Glioblastoma?
Q40484644RNA interference against a glioma-derived allele of EGFR induces blockade at G2M.
Q38431453Radiation therapy for glioma stem cells
Q48238155Radioimmunoscintigraphy of intracranial glioma xenograft with a technetium-99m-labeled mouse monoclonal antibody specifically recognizing type III mutant epidermal growth factor receptor
Q35659088Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors
Q37701607Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts
Q26752579Radioresistance of Brain Tumors
Q35624032Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor
Q38398440ReACT Phase II trial: a critical evaluation of the use of rindopepimut plus bevacizumab to treat EGFRvIII-positive recurrent glioblastoma.
Q34789569Reassessing target antigens for adoptive T-cell therapy
Q42004592Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII).
Q38130137Receptor tyrosine kinase alterations and therapeutic opportunities in squamous cell carcinoma of the lung
Q36321176Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma
Q100750414Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma
Q33775591Relationships linking amplification level to gene over-expression in gliomas
Q34201954Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents
Q54640393Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP.
Q36414279Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging
Q37775494Ribozyme-mediated inhibition of 801-bp deletion-mutant epidermal growth factor receptor mRNA expression in glioblastoma multiforme.
Q38534723Rindopepimut vaccine and bevacizumab combination therapy: improving survival rates in relapsed glioblastoma patients?
Q38245925Rindopepimut: a promising immunotherapeutic for the treatment of glioblastoma multiforme
Q38051323Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma
Q52663432Role of Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme.
Q40038376SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients
Q36351195STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3
Q34480613Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: another inflammation-cancer link.
Q44526164Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells
Q37847104Signal transduction inhibitors and antiangiogenic therapies for malignant glioma
Q40872114Signal transduction pathways and their relevance in human astrocytomas
Q35987785Signaling multiplex of the epidermal growth factor receptor
Q40472879Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with speci
Q38218129Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer.
Q26750970Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical Relevance
Q28732052Specific and sensitive hydrolysis probe-based real-time PCR detection of epidermal growth factor receptor variant III in oral squamous cell carcinoma
Q41270902Specific targeting of a mutant, activated egf receptor found in glioblastoma using a monoclonal antibody
Q37930388Standard of care therapy for malignant glioma and its effect on tumor and stromal cells
Q26771706Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts
Q27678732Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains
Q36683851Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6
Q55363919Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models.
Q52682275T-lymphokine-activated killer cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in glioma.
Q33700160Take your partners, please--signal diversification by the erbB family of receptor tyrosine kinases
Q38752350Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma.
Q64242208Target selection of CAR T cell therapy in accordance with the TME for solid tumors
Q94545537Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells
Q37981764Targeting EGF receptor variant III: tumor-specific peptide vaccination for malignant gliomas.
Q37405633Targeting EGFR resistance networks in head and neck cancer.
Q42602597Targeting a glioblastoma cancer stem-cell population defined by EGF receptor variant III.
Q37736255Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma
Q38233105Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.
Q27022941Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma
Q33574021Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors
Q36564975Targeting the epidermal growth factor receptor in the treatment of colorectal cancer: state of the art.
Q38598710The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors
Q41738022The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands
Q42448523The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells.
Q33957440The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
Q24657924The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo
Q41687874The autocrine loop of TGF-alpha/EGFR and brain tumors
Q34949693The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells
Q38349130The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling
Q34610495The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications
Q27015045The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered
Q38255481The future of glioblastoma therapy: synergism of standard of care and immunotherapy
Q35114090The future of high-grade glioma: Where we are and where are we going
Q38248990The genetic signatures of pediatric high-grade glioma: no longer a one-act play
Q35210456The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors
Q35120839The interface between ErbB and non-ErbB receptors in tumor invasion: clinical implications and opportunities for target discovery
Q38155656The molecular landscape of diffuse glioma and prospects for biomarker development
Q29614654The mutational landscape of head and neck squamous cell carcinoma
Q28118814The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines
Q40491226The polymerase chain reaction: Application to nervous system disease
Q28144437The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling
Q34267620The receptor tyrosine kinases: role in cancer progression.
Q51416808The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes.
Q38132400The role of epidermal growth factor receptor in cancer metastasis and microenvironment
Q38204718The role of neuropathology in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
Q34775279The tumor suppressor CDKN3 controls mitosis
Q34325749The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy
Q91675856Theranostic Nanomedicine for Malignant Gliomas
Q35341639Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma
Q42139529Therapeutic efficacy of SYM004, a mixture of two anti-EGFR antibodies in human colorectal cancer with acquired resistance to cetuximab and MET activation
Q57092293Tissue, cell and stage specificity of (epi)mutations in cancers
Q37533657Toward effective immunotherapy for the treatment of malignant brain tumors
Q36083914Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains.
Q27329613Transmigration of neural stem cells across the blood brain barrier induced by glioma cells
Q33243912Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol
Q40758885Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptor
Q38312987Triplex-forming oligonucleotide binding represses transcription of the human c-erbB gene in glioma
Q40596817Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.
Q40961498Tumor antigens in astrocytic gliomas
Q37186248Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma
Q26741318Tyrosine Kinase Receptor Landscape in Lung Cancer: Therapeutical Implications
Q38303832Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity
Q35589206Tyrosine kinase inhibitors as cancer therapy
Q35162055Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors
Q27860884Untangling the ErbB signalling network
Q38081910Vaccine strategies for glioblastoma: progress and future directions
Q38243975Vaccine therapies for patients with glioblastoma
Q26829328Vaccine therapies in malignant glioma
Q38826168Valproic acid sensitizes human glioma cells to gefitinib-induced autophagy
Q33951992What role(s) for TGFalpha in the central nervous system?
Q38053857What underlies the diversity of brain tumors?
Q38882167Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways
Q30303932c-Src, receptor tyrosine kinases, and human cancer
Q38099450iNOS: a potential therapeutic target for malignant glioma
Q40407116mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma

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