scholarly article | Q13442814 |
P819 | ADS bibcode | 1992PNAS...89.2965W |
P356 | DOI | 10.1073/PNAS.89.7.2965 |
P953 | full work available at URL | https://europepmc.org/articles/PMC48784 |
https://europepmc.org/articles/PMC48784?pdf=render | ||
P932 | PMC publication ID | 48784 |
P698 | PubMed publication ID | 1557402 |
P5875 | ResearchGate publication ID | 21599130 |
P50 | author | Bert Vogelstein | Q827502 |
P2093 | author name string | J. M. Ruppert | |
A. J. Wong | |||
S. H. Bigner | |||
P. A. Humphrey | |||
C. H. Grzeschik | |||
D. S. Bigner | |||
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P433 | issue | 7 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | neoplasm genes | Q70691924 |
P304 | page(s) | 2965-2969 | |
P577 | publication date | 1992-04-01 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Structural alterations of the epidermal growth factor receptor gene in human gliomas | |
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Q39043417 | Novel vaccines for glioblastoma: clinical update and perspective |
Q30416775 | Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter |
Q37115208 | Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis |
Q55476021 | Oncogenic epidermal growth factor receptor mutants with tandem duplication: gene structure and effects on receptor function. |
Q33943421 | Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy |
Q38017366 | Oncogenic regulation of tissue factor and thrombosis in cancer |
Q53803471 | Overexpression of the epidermal growth factor receptor confers migratory properties to nonmigratory postnatal neural progenitors. |
Q38003175 | PDGF and PDGF receptors in glioma. |
Q35080265 | PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo |
Q34164924 | PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas |
Q46592704 | PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells |
Q37808385 | PI3Kinase signaling in glioblastoma |
Q24650475 | PTPmu suppresses glioma cell migration and dispersal |
Q93104522 | Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue |
Q40633474 | Pathophysiology of glial growth factor receptors |
Q33346827 | Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma |
Q33834813 | Phenotype vs genotype in the evolution of astrocytic brain tumors |
Q30434083 | Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II. |
Q30393905 | Pigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells |
Q72007934 | Possible role of variant RNA transcripts in the regulation of epidermal growth factor receptor expression in human placenta |
Q37579647 | Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer |
Q42834600 | Production of a single-chain variable fragment antibody recognizing type III mutant epidermal growth factor receptor |
Q48347971 | Prognostic significance of Ki67, p53 and epidermal growth factor receptor immunostaining in human glioblastomas. |
Q38107462 | Progress on molecular biomarkers and classification of malignant gliomas |
Q55480092 | Proliferation and motility responses of primary and recurrent gliomas related to changes in epidermal growth factor receptor expression. |
Q58700626 | Proscillaridin A exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastoma |
Q38748694 | Prospect of rindopepimut in the treatment of glioblastoma. |
Q34507561 | Prospects for gene-engineered T cell immunotherapy for solid cancers. |
Q34627812 | Proteases and the biology of glioma invasion |
Q41679383 | Protein tyrosine kinases and cancer |
Q34303359 | Quantitative proteomic analysis reveals effects of epidermal growth factor receptor (EGFR) on invasion-promoting proteins secreted by glioblastoma cells |
Q55457286 | Quo Vadis-Do Immunotherapies Have a Role in Glioblastoma? |
Q40484644 | RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. |
Q38431453 | Radiation therapy for glioma stem cells |
Q48238155 | Radioimmunoscintigraphy of intracranial glioma xenograft with a technetium-99m-labeled mouse monoclonal antibody specifically recognizing type III mutant epidermal growth factor receptor |
Q35659088 | Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors |
Q37701607 | Radiolabeled novel mAb 4G1 for immunoSPECT imaging of EGFRvIII expression in preclinical glioblastoma xenografts |
Q26752579 | Radioresistance of Brain Tumors |
Q35624032 | Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor |
Q38398440 | ReACT Phase II trial: a critical evaluation of the use of rindopepimut plus bevacizumab to treat EGFRvIII-positive recurrent glioblastoma. |
Q34789569 | Reassessing target antigens for adoptive T-cell therapy |
Q42004592 | Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). |
Q38130137 | Receptor tyrosine kinase alterations and therapeutic opportunities in squamous cell carcinoma of the lung |
Q36321176 | Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma |
Q100750414 | Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma |
Q33775591 | Relationships linking amplification level to gene over-expression in gliomas |
Q34201954 | Rerouting lipoprotein nanoparticles to selected alternate receptors for the targeted delivery of cancer diagnostic and therapeutic agents |
Q54640393 | Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP. |
Q36414279 | Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging |
Q37775494 | Ribozyme-mediated inhibition of 801-bp deletion-mutant epidermal growth factor receptor mRNA expression in glioblastoma multiforme. |
Q38534723 | Rindopepimut vaccine and bevacizumab combination therapy: improving survival rates in relapsed glioblastoma patients? |
Q38245925 | Rindopepimut: a promising immunotherapeutic for the treatment of glioblastoma multiforme |
Q38051323 | Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma |
Q52663432 | Role of Chimeric Antigen Receptor T Cell Therapy in Glioblastoma Multiforme. |
Q40038376 | SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients |
Q36351195 | STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 |
Q34480613 | Secreted PLA2 induces proliferation in astrocytoma through the EGF receptor: another inflammation-cancer link. |
Q44526164 | Selective abrogation of the proinvasive activity of the trefoil peptides pS2 and spasmolytic polypeptide by disruption of the EGF receptor signaling pathways in kidney and colonic cancer cells |
Q37847104 | Signal transduction inhibitors and antiangiogenic therapies for malignant glioma |
Q40872114 | Signal transduction pathways and their relevance in human astrocytomas |
Q35987785 | Signaling multiplex of the epidermal growth factor receptor |
Q40472879 | Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with speci |
Q38218129 | Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer. |
Q26750970 | Soluble Epidermal Growth Factor Receptors (sEGFRs) in Cancer: Biological Aspects and Clinical Relevance |
Q28732052 | Specific and sensitive hydrolysis probe-based real-time PCR detection of epidermal growth factor receptor variant III in oral squamous cell carcinoma |
Q41270902 | Specific targeting of a mutant, activated egf receptor found in glioblastoma using a monoclonal antibody |
Q37930388 | Standard of care therapy for malignant glioma and its effect on tumor and stromal cells |
Q26771706 | Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts |
Q27678732 | Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains |
Q36683851 | Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6 |
Q55363919 | Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models. |
Q52682275 | T-lymphokine-activated killer cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in glioma. |
Q33700160 | Take your partners, please--signal diversification by the erbB family of receptor tyrosine kinases |
Q38752350 | Tamoxifen Induces Cytotoxic Autophagy in Glioblastoma. |
Q64242208 | Target selection of CAR T cell therapy in accordance with the TME for solid tumors |
Q94545537 | Targeting Cancer Stem Cells by Genetically Engineered Chimeric Antigen Receptor T Cells |
Q37981764 | Targeting EGF receptor variant III: tumor-specific peptide vaccination for malignant gliomas. |
Q37405633 | Targeting EGFR resistance networks in head and neck cancer. |
Q42602597 | Targeting a glioblastoma cancer stem-cell population defined by EGF receptor variant III. |
Q37736255 | Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma |
Q38233105 | Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux. |
Q27022941 | Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma |
Q33574021 | Targeting the dimerization of epidermal growth factor receptors with small-molecule inhibitors |
Q36564975 | Targeting the epidermal growth factor receptor in the treatment of colorectal cancer: state of the art. |
Q38598710 | The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors |
Q41738022 | The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands |
Q42448523 | The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells. |
Q33957440 | The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells |
Q24657924 | The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo |
Q41687874 | The autocrine loop of TGF-alpha/EGFR and brain tumors |
Q34949693 | The coupling of epidermal growth factor receptor down regulation by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S checkpoint in ovarian cancer cells |
Q38349130 | The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling |
Q34610495 | The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications |
Q27015045 | The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered |
Q38255481 | The future of glioblastoma therapy: synergism of standard of care and immunotherapy |
Q35114090 | The future of high-grade glioma: Where we are and where are we going |
Q38248990 | The genetic signatures of pediatric high-grade glioma: no longer a one-act play |
Q35210456 | The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors |
Q35120839 | The interface between ErbB and non-ErbB receptors in tumor invasion: clinical implications and opportunities for target discovery |
Q38155656 | The molecular landscape of diffuse glioma and prospects for biomarker development |
Q29614654 | The mutational landscape of head and neck squamous cell carcinoma |
Q28118814 | The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines |
Q40491226 | The polymerase chain reaction: Application to nervous system disease |
Q28144437 | The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling |
Q34267620 | The receptor tyrosine kinases: role in cancer progression. |
Q51416808 | The role of PTRF/Cavin1 as a biomarker in both glioma and serum exosomes. |
Q38132400 | The role of epidermal growth factor receptor in cancer metastasis and microenvironment |
Q38204718 | The role of neuropathology in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline |
Q34775279 | The tumor suppressor CDKN3 controls mitosis |
Q34325749 | The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy |
Q91675856 | Theranostic Nanomedicine for Malignant Gliomas |
Q35341639 | Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma |
Q42139529 | Therapeutic efficacy of SYM004, a mixture of two anti-EGFR antibodies in human colorectal cancer with acquired resistance to cetuximab and MET activation |
Q57092293 | Tissue, cell and stage specificity of (epi)mutations in cancers |
Q37533657 | Toward effective immunotherapy for the treatment of malignant brain tumors |
Q36083914 | Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains. |
Q27329613 | Transmigration of neural stem cells across the blood brain barrier induced by glioma cells |
Q33243912 | Treatment of primary glioblastoma multiforme with cetuximab, radiotherapy and temozolomide (GERT)--phase I/II trial: study protocol |
Q40758885 | Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-alpha and the epidermal growth factor receptor |
Q38312987 | Triplex-forming oligonucleotide binding represses transcription of the human c-erbB gene in glioma |
Q40596817 | Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. |
Q40961498 | Tumor antigens in astrocytic gliomas |
Q37186248 | Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma |
Q26741318 | Tyrosine Kinase Receptor Landscape in Lung Cancer: Therapeutical Implications |
Q38303832 | Tyrosine kinase activity may be necessary but is not sufficient for c-erbB1-mediated tissue-specific tumorigenicity |
Q35589206 | Tyrosine kinase inhibitors as cancer therapy |
Q35162055 | Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors |
Q27860884 | Untangling the ErbB signalling network |
Q38081910 | Vaccine strategies for glioblastoma: progress and future directions |
Q38243975 | Vaccine therapies for patients with glioblastoma |
Q26829328 | Vaccine therapies in malignant glioma |
Q38826168 | Valproic acid sensitizes human glioma cells to gefitinib-induced autophagy |
Q33951992 | What role(s) for TGFalpha in the central nervous system? |
Q38053857 | What underlies the diversity of brain tumors? |
Q38882167 | Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways |
Q30303932 | c-Src, receptor tyrosine kinases, and human cancer |
Q38099450 | iNOS: a potential therapeutic target for malignant glioma |
Q40407116 | mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma |
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