EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma

scientific article

EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CCR.2013.09.004
P8608Fatcat IDrelease_ot7p37trujhsbk66cpje6nhlme
P3181OpenCitations bibliographic resource ID1818312
P932PMC publication ID3819146
P698PubMed publication ID24135280
P5875ResearchGate publication ID258054598

P50authorMichael WellerQ2779469
Guido ReifenbergerQ30004009
P2093author name stringChristiane Knobbe-Thomsen
Christine K Cheng
Elizabeth Charron
Jasmine Lau
Justin Chen
Kevan M Shokat
Natalia Jura
Petra Zipper
Qi-Wen Fan
Robyn A Wong
W Clay Gustafson
William A Weiss
P2860cites workNonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3Q39560754
Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells.Q40327533
RNA interference against a glioma-derived allele of EGFR induces blockade at G2M.Q40484644
The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR.Q40541045
Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFRQ40619097
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptorQ42799161
STAT3 tyrosine phosphorylation influences survival in glioblastomaQ43068296
Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma NetworkQ43266785
Effects of transient changes in silage dry matter concentration on lactating dairy cowsQ43542897
Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomasQ47357523
Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastomaQ49068065
Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients.Q55471514
The Efficacy of Epidermal Growth Factor Receptor-Specific Antibodies against Glioma Xenografts Is Influenced by Receptor Levels, Activation Status, and HeterodimerizationQ62746688
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segmentQ24309071
Structure-guided development of affinity probes for tyrosine kinases using chemical geneticsQ27643967
Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiformeQ27824801
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.Q27824850
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteinsQ27860890
A chemical switch for inhibitor-sensitive alleles of any protein kinaseQ29614785
Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant gliomaQ33370229
Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axesQ33669979
Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomasQ33881165
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastomaQ34069375
Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed GlioblastomaQ34488771
Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in gliomaQ36179166
Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activationQ36288511
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.Q36631618
Perturbation of Staphylococcus aureus Gene Expression by the Enoyl-Acyl Carrier Protein Reductase Inhibitor AFN-1252Q36785831
Structural alterations of the epidermal growth factor receptor gene in human gliomasQ36930689
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant gliomaQ37003323
The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas.Q37020840
The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signalingQ38349130
Phosphorylation of tyrosine 992, 1068, and 1086 is required for conformational change of the human epidermal growth factor receptor c-terminal tailQ38609896
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
phosphorylationQ242736
glioblastomaQ282142
epidermal growth factor receptorQ424401
identical protein bindingQ14762994
P304page(s)438-49
P577publication date2013-10-14
P1433published inCancer CellQ280018
P1476titleEGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
P478volume24

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