Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways

scientific article published on 22 April 2015

Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/MD13042505
P932PMC publication ID4413223
P698PubMed publication ID25913706
P5875ResearchGate publication ID275720545

P2093author name stringJames T Rutka
Zhong-Ping Feng
Christopher L F Sun
Ji-Sun Kim
Ekaterina Turlova
Guan-Lei Wang
Hong-Shuo Sun
Xiao Zhong
Wen-Liang Chen
Yong-Yuan Guan
Sammen Huang
P2860cites workTRPM7 is required for ovarian cancer cell growth, migration and invasion.Q55069713
Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma.Q55469941
Design and synthesis of novel xyloketal derivatives and their vasorelaxing activities in rat thoracic aorta and angiogenic activities in zebrafish angiogenesis screenQ84248713
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.Q27824850
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemiaQ28583854
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trialQ29547224
Calcium signalling: dynamics, homeostasis and remodellingQ29547635
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitroQ29617927
Malignant astrocytic glioma: genetics, biology, and paths to treatmentQ29618156
Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinaseQ33726066
Molecular interaction and functional regulation of ClC-3 by Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma.Q33799622
Recent advances in diagnosis and treatment of gliomas using chlorotoxin-based bioconjugatesQ34066507
Involvement of Kv1.5 Protein in Oxidative Vascular Endothelial Cell InjuryQ34490473
Clonogenic assay of cells in vitro.Q34615431
Xyloketal B, a marine compound, acts on a network of molecular proteins and regulates the activity and expression of rat cytochrome P450 3a: a bioinformatic and animal studyQ34742606
Trabectedin therapy as an emerging treatment strategy for recurrent platinum-sensitive ovarian cancerQ34996149
Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injuryQ35015296
TRPM7 regulates vascular endothelial cell adhesion and tube formationQ35086271
Development of novel targeted therapies in the treatment of malignant gliomaQ35770177
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylationQ35971600
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.Q36003549
Xyloketal B exhibits its antioxidant activity through induction of HO-1 in vascular endothelial cells and zebrafish.Q36806721
Molecularly targeted therapy for malignant gliomaQ36829847
Structural alterations of the epidermal growth factor receptor gene in human gliomasQ36930689
Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasisQ37019730
Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels.Q37187698
Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathwayQ37258758
Designer therapies for glioblastoma multiformeQ37319650
Synthesis and neuroprotective action of xyloketal derivatives in Parkinson's disease modelsQ37425008
Standards of care and novel approaches in the management of glioblastoma multiformeQ37525881
Targeting the AKT Pathway in GlioblastomaQ37914262
Ion channels and transporters in cancer. 5. Ion channels in control of cancer and cell apoptosis.Q37937313
RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and TherapyQ37947586
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.Q37996420
Current clinical development of PI3K pathway inhibitors in glioblastomaQ38012438
The physiological roles of primary phospholipase C.Q38138205
Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in CancerQ38235597
Suppression of TRPM7 inhibits proliferation, migration, and invasion of malignant human glioma cellsQ38936421
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathwaysQ38959442
ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activityQ39084326
TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathwaysQ39108244
Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblastsQ39112299
TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathwayQ39204198
Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration.Q39398553
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.Q39653276
A Ras inhibitor tilts the balance between Rac and Rho and blocks phosphatidylinositol 3-kinase-dependent glioblastoma cell migrationQ40192946
Activation of TRPM7 channels by phospholipase C-coupled receptor agonistsQ40210138
A key role for TRPM7 channels in anoxic neuronal deathQ40603687
Genetic aberrations in human brain tumorsQ40659282
Protective effects of xyloketal B against MPP+-induced neurotoxicity in Caenorhabditis elegans and PC12 cellsQ43116591
Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast.Q43739167
Overexpression of TRPM7 is associated with poor prognosis in human ovarian carcinomaQ44064344
Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cellsQ44409595
A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitroQ44815754
Synthesis of xyloketal A, B, C, D, and G analoguesQ46936418
Intrathecal combination of ziconotide and morphine for refractory cancer pain: a rapidly acting and effective choiceQ48214498
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumorsQ48445033
Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damageQ48455374
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P921main subjectglioblastomaQ282142
P304page(s)2505-2525
P577publication date2015-04-22
P1433published inMarine DrugsQ2122804
P1476titleXyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways
P478volume13

Reverse relations

cites work (P2860)
Q92876695A Systematic Review of Recently Reported Marine Derived Natural Product Kinase Inhibitors
Q38722636Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells
Q88211297Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo
Q37359778Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways.
Q90335558Ion channels as therapeutic antibody targets
Q43239058Marine Compounds and Cancer: Where Do We Stand?
Q58588275Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels
Q33851509Role of TRPM7 in Cancer: Potential as Molecular Biomarker and Therapeutic Target
Q48195180Role of TRPM7 in cerebral ischaemia and hypoxia.
Q48161755Swelling-induced chloride current in glioblastoma proliferation, migration, and invasion
Q55251510TGFβ-induced epithelial-to-mesenchymal transition in prostate cancer cells is mediated via TRPM7 expression.
Q89290583Transcriptional repression of human epidermal growth factor receptor 2 by ClC-3 Cl- /H+ transporter inhibition in human breast cancer cells
Q100385988Waixenicin A, a marine-derived TRPM7 inhibitor: a promising CNS drug lead
Q64112588Wound Healing Potential of Spirulina Protein on CCD-986sk Cells
Q36383780Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway
Q88211300Xyloketal B exerts antihypertensive effect in renovascular hypertensive rats via the NO-sGC-cGMP pathway and calcium signaling

Search more.