| scholarly article | Q13442814 |
| P2093 | author name string | David R Clemmons | |
| Xinchun Shen | |||
| Gang Xi | |||
| P2860 | cites work | Sos-mediated activation of rac1 by p66shc | Q24306686 |
| EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis | Q24316344 | ||
| The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions | Q24322004 | ||
| Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation | Q24322598 | ||
| A family of proteins that inhibit signalling through tyrosine kinase receptors | Q24336010 | ||
| Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 | Q24336357 | ||
| A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction | Q24338592 | ||
| Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation | Q24646756 | ||
| A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion | Q24647689 | ||
| Signaling via Shc family adapter proteins | Q28199357 | ||
| Direct interaction between Shc and the platelet-derived growth factor beta-receptor | Q28254337 | ||
| Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling | Q28268458 | ||
| Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling | Q28291363 | ||
| The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 | Q28511655 | ||
| The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation | Q28570576 | ||
| P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction | Q28570648 | ||
| Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor | Q28577647 | ||
| Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts | Q28578240 | ||
| Not all Shc's roads lead to Ras | Q28609214 | ||
| Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling | Q28610830 | ||
| Insulin signalling | Q28611467 | ||
| The p66shc adaptor protein controls oxidative stress response and life span in mammals | Q29614553 | ||
| SH3 domains direct cellular localization of signaling molecules | Q30194915 | ||
| A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos. | Q30195071 | ||
| Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2. | Q30453611 | ||
| Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival | Q33292261 | ||
| Role of SHPS-1 in the regulation of insulin-like growth factor I-stimulated Shc and mitogen-activated protein kinase activation in vascular smooth muscle cells | Q33877092 | ||
| Adaptor protein Shc undergoes translocation and mediates up-regulation of the tyrosine kinase c-Src in EGF-stimulated A431 cells | Q33916435 | ||
| Evolution of Shc functions from nematode to human | Q34087836 | ||
| The association between integrin-associated protein and SHPS-1 regulates insulin-like growth factor-I receptor signaling in vascular smooth muscle cells | Q35973076 | ||
| p66SHC: the apoptotic side of Shc proteins | Q36042477 | ||
| Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. | Q36301565 | ||
| Blocking ligand occupancy of the alphaVbeta3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells | Q36308611 | ||
| Phosphorylation of p66Shc and forkhead proteins mediates Abeta toxicity | Q36321606 | ||
| Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. | Q36375906 | ||
| A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. | Q36709674 | ||
| The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway | Q36888154 | ||
| Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor | Q37695701 | ||
| Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors | Q38292293 | ||
| Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer | Q38450346 | ||
| Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation. | Q40018683 | ||
| Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells. | Q40371697 | ||
| Inhibition of Shc/Grb2 protein-protein interaction suppresses growth of B104-1-1 tumors xenografted in nude mice | Q40376499 | ||
| p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. | Q40583604 | ||
| Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila | Q40668333 | ||
| Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis. | Q40768067 | ||
| Elevated levels of p66 Shc are found in breast cancer cell lines and primary tumors with high metastatic potential | Q40890386 | ||
| Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts | Q40891235 | ||
| Relative involvement of Shc tyrosine 239/240 and tyrosine 317 on insulin induced mitogenic signaling in rat1 fibroblasts expressing insulin receptors. | Q40995133 | ||
| Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway | Q41927046 | ||
| Tyrosine phosphorylation of the beta3-subunit of the alphaVbeta3 integrin is required for embrane association of the tyrosine phosphatase SHP-2 and its further recruitment to the insulin-like growth factor I receptor | Q42442596 | ||
| The mammalian longevity-associated gene product p66shc regulates mitochondrial metabolism | Q42490911 | ||
| p66Shc isoform down-regulated and not required for HER-2/neu signaling pathway in human breast cancer cell lines with HER-2/neu overexpression | Q42518710 | ||
| Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation | Q42518876 | ||
| Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. | Q42610778 | ||
| The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes | Q42801077 | ||
| Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway | Q43909621 | ||
| The heparin binding domain of vitronectin is the region that is required to enhance insulin-like growth factor-I signaling | Q46830967 | ||
| Shc signaling in differentiating neural progenitor cells | Q48871945 | ||
| Hyperglycemia alters the responsiveness of smooth muscle cells to insulin-like growth factor-I. | Q51800274 | ||
| The role of Src kinase in insulin-like growth factor-dependent mitogenic signaling in vascular smooth muscle cells. | Q52571988 | ||
| Insulin-like growth factor-I signaling in smooth muscle cells is regulated by ligand binding to the 177CYDMKTTC184 sequence of the beta3-subunit of alphaVbeta3. | Q53655401 | ||
| Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis | Q58454329 | ||
| Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways | Q71583368 | ||
| Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II | Q71708761 | ||
| Thrombospondin and osteopontin bind to insulin-like growth factor (IGF)-binding protein-5 leading to an alteration in IGF-I-stimulated cell growth | Q73500705 | ||
| Differential utilization of ShcA tyrosine residues and functional domains in the transduction of epidermal growth factor-induced mitogen-activated protein kinase activation in 293T cells and nerve growth factor-induced neurite outgrowth in PC12 cell | Q73618027 | ||
| Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic acid synthesis by insulin-like growth factor-I | Q78180958 | ||
| Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc | Q79711268 | ||
| P433 | issue | 9 | |
| P921 | main subject | preproinsulin | Q7240673 |
| P304 | page(s) | 2162-2175 | |
| P577 | publication date | 2008-07-07 | |
| P1433 | published in | Molecular Endocrinology | Q3319475 |
| P1476 | title | p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 mem | |
| P478 | volume | 22 |
| Q33874358 | AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation |
| Q48523634 | Acute Ethanol Increases IGF-I-Induced Phosphorylation of ERKs by Enhancing Recruitment of p52-Shc to the Grb2/Shc Complex |
| Q100946066 | CELF2 regulates the species-specific alternative splicing of TREM2 |
| Q50311288 | Down-regulation of Insulin Receptor Substrate 1 during Hyperglycemia Induces Vascular Smooth Muscle Cell Dedifferentiation |
| Q35612393 | Hyperglycemia enhances IGF-I-stimulated Src activation via increasing Nox4-derived reactive oxygen species in a PKCζ-dependent manner in vascular smooth muscle cells |
| Q90711245 | Hyperglycemia induces vascular smooth muscle cell dedifferentiation by suppressing insulin receptor substrate-1-mediated p53/KLF4 complex stabilization |
| Q36299841 | Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle |
| Q34132479 | Hyperglycemia-induced p66shc inhibits insulin-like growth factor I-dependent cell survival via impairment of Src kinase-mediated phosphoinositide-3 kinase/AKT activation in vascular smooth muscle cells |
| Q36431813 | IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast Differentiation |
| Q37425907 | IGFBP-2 directly stimulates osteoblast differentiation |
| Q37258075 | Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells |
| Q36276736 | Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling |
| Q33846069 | Insulin-like growth factor 1 physiology: lessons from mouse models |
| Q37994048 | Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity |
| Q36890211 | Iron modulates cell survival in a Ras- and MAPK-dependent manner in ovarian cells |
| Q34767374 | Mitochondrial longevity pathways |
| Q64107680 | Modulation of Obesity and Insulin Resistance by the Redox Enzyme and Adaptor Protein p66 |
| Q38779697 | New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases |
| Q42573184 | Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor |
| Q33588755 | P66Shc signals to age. |
| Q34121608 | PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival |
| Q38132066 | Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development |
| Q36890594 | Recruitment of Nox4 to a plasma membrane scaffold is required for localized reactive oxygen species generation and sustained Src activation in response to insulin-like growth factor-I. |
| Q54669359 | Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells. |
| Q24598828 | Signal regulatory protein alpha (SIRPalpha)/CD47 interaction and function |
| Q24304872 | SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells |
| Q35110805 | Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells |
| Q34147884 | The Shc locus regulates insulin signaling and adiposity in mammals |
| Q34663562 | The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism |
| Q37608462 | The adaptor proteins p66Shc and Grb2 regulate the activation of the GTPases ARF1 and ARF6 in invasive breast cancer cells |
| Q37240147 | The heparin-binding domains of IGFBP-2 mediate its inhibitory effect on preadipocyte differentiation and fat development in male mice |
| Q54120433 | The role of the ShcD and RET interaction in neuroblastoma survival and migration. |
| Q33747925 | p66shc inhibits insulin-like growth factor-I signaling via direct binding to Src through its polyproline and Src homology 2 domains, resulting in impairment of Src kinase activation |
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