Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin

scientific article

Substrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1005493252
P356DOI10.1038/SREP23258
P3181OpenCitations bibliographic resource ID2967931
P932PMC publication ID4796868
P698PubMed publication ID26987342
P5875ResearchGate publication ID298914463

P50authorJoachim P. SpatzQ20742670
Carolina DíazQ80968266
P2093author name stringHorst Kessler
Dimitris Missirlis
Florian Rechenmacher
Stefanie Neubauer
Tamás Haraszti
Tina Wiegand
Catharina v C Scheele
P2860cites workSrc kinase activation by direct interaction with the integrin β cytoplasmic domainQ24298960
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alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration.Q24305037
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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppressionQ24627446
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migrationQ24678443
Syndecan-4 signaling at a glanceQ26865478
Comparative dynamics of retrograde actin flow and focal adhesions: formation of nascent adhesions triggers transition from fast to slow flowQ27300187
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Cell migration: integrating signals from front to backQ27860670
Integrins: bidirectional, allosteric signaling machinesQ27860700
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.Q44630472
A comparison of the biological activities of the cell-adhesive proteins vitronectin and fibronectin.Q44660046
Activation of integrin function by nanopatterned adhesive interfacesQ44832858
Early molecular events in the assembly of the focal adhesion-stress fiber complex during fibroblast spreadingQ44898321
An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cellsQ45118374
A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesionsQ51926838
Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing.Q54550204
Dynamics and segregation of cell–matrix adhesions in cultured fibroblastsQ58022582
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complexQ58549456
Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell CycleQ63681525
The distribution of distinct integrins in focal contacts is determined by the substratum compositionQ69099668
Polystyrene chemistry affects vitronectin activity: an explanation for cell attachment to tissue culture polystyrene but not to unmodified polystyreneQ72092877
The 12th-14th type III repeats of fibronectin function as a highly promiscuous growth factor-binding domainQ84617570
Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxisQ39386624
Polymerizing actin fibers position integrins primed to probe for adhesion sitesQ40170442
Cell distribution of stress fibres in response to the geometry of the adhesive environmentQ40301712
Cortactin promotes cell motility by enhancing lamellipodial persistenceQ40392234
Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src.Q40918530
Optimal matrix rigidity for stress fiber polarization in stem cells.Q41073509
The alphavbeta3 integrin regulates alpha5beta1-mediated cell migration toward fibronectinQ41079791
Beta 1 integrin-dependent and -independent polymerization of fibronectinQ41254786
Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cellsQ41561676
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cellsQ41768080
The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrinsQ41874995
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forcesQ42811729
Syndecan-4 phosphorylation is a control point for integrin recycling.Q43219412
Microfilament-dependent movement of the beta3 integrin subunit within focal contacts of endothelial cellsQ43967700
Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling.Q43969963
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaQ27861126
Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioningQ28478399
Nonmuscle myosin IIb is involved in the guidance of fibroblast migrationQ28513074
Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblastsQ28576503
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylationQ28586815
Integrins in cancer: biological implications and therapeutic opportunitiesQ29614536
Environmental sensing through focal adhesionsQ29615211
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent mannerQ29616027
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassemblyQ29616029
Random versus directionally persistent cell migrationQ29616686
Cell adhesion: integrating cytoskeletal dynamics and cellular tensionQ29618066
Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesivenessQ29620446
Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cellsQ30175229
Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesionsQ30371366
A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.Q30407809
Activation of beta 1 but not beta 3 integrin increases cell traction forcesQ30414199
Cross-correlated fluctuation analysis reveals phosphorylation-regulated paxillin-FAK complexes in nascent adhesionsQ30428454
Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cellsQ30430251
Integrin signalling in directed cell migration.Q30441276
The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesisQ30441899
Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cellsQ30441980
Cellular characterization of a novel focal adhesion kinase inhibitorQ30443304
Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPasesQ30480443
Spatial organization of the extracellular matrix regulates cell-cell junction positioning.Q30505114
Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chainQ30528218
A role for actin arcs in the leading-edge advance of migrating cellsQ30539600
Lamellipodial actin mechanically links myosin activity with adhesion-site formationQ30834196
Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migrationQ32084197
Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migrationQ33799228
Ligand binding to integrinsQ33912940
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migrationQ34543645
Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungsQ34608570
High resolution traction force microscopy based on experimental and computational advancesQ34683049
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape.Q34793769
Cortactin: a multifunctional regulator of cellular invasivenessQ34891306
Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasionQ34990234
Rac1-dependent phosphorylation and focal adhesion recruitment of myosin IIA regulates migration and mechanosensingQ34995897
Pharmacophoric modifications lead to superpotent αvβ3 integrin ligands with suppressed α5β1 activityQ35127140
Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocationQ35651291
Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrixQ35828567
The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migrationQ35894249
Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.Q36097899
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamicsQ36117925
Decoupling Substrate Stiffness, Spread Area, and Micropost Density: A Close Spatial Relationship between Traction Forces and Focal AdhesionsQ36238160
Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.Q36301565
A Rac switch regulates random versus directionally persistent cell migrationQ36320639
Integrins control motile strategy through a Rho-cofilin pathway.Q36321708
Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migrationQ36325064
Integrin dynamics and matrix assembly: tensin-dependent translocation of alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesisQ36326968
ILK, PINCH and parvin: the tIPP of integrin signallingQ36403372
The tension mounts: Stress fibers as force-generating mechanotransducersQ36525640
Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: collaborative interactions among integrinsQ36530834
Subcellular spatial segregation of integrin subtypes by patterned multicomponent surfacesQ36651543
p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4.Q36718359
Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformationQ36847018
Guiding cell migration by tuggingQ37307604
Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behaviorQ37354717
Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviourQ37513952
Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: a new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins.Q37558694
Unique and redundant functions of integrins in the epidermis.Q37772021
Bio-inspired materials for parsing matrix physicochemical control of cell migration: a review.Q37949268
Assembly and disassembly of cell matrix adhesionsQ38028168
Steering cell migration: lamellipodium dynamics and the regulation of directional persistenceQ38242035
Persistent cell migration and adhesion rely on retrograde transport of β(1) integrin.Q38814024
Segregation versus colocalization: orthogonally functionalized binary micropatterned substrates regulate the molecular distribution in focal adhesions.Q38873940
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironmentsQ39147447
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent mannerQ39200700
Functionalizing αvβ3- or α5β1-selective integrin antagonists for surface coating: a method to discriminate integrin subtypes in vitroQ39205680
Combined effects of PEG hydrogel elasticity and cell-adhesive coating on fibroblast adhesion and persistent migrationQ39307980
P407language of work or nameEnglishQ1860
P304page(s)23258
P577publication date2016-01-01
P1433published inScientific ReportsQ2261792
P1476titleSubstrate engagement of integrins α5β1 and αvβ3 is necessary, but not sufficient, for high directional persistence in migration on fibronectin
P478volume6

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cites work (P2860)
Q92871717Adhesion Stabilized en Masse Intracellular Electrical Recordings from Multicellular Assemblies
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Q41670915Exploring the Role of RGD-Recognizing Integrins in Cancer
Q42119753Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains
Q37581720IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules
Q30252508Inhibition of αvβ3 integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC)
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Q41461098Mechanoepigenetics
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Q27342564Persistence of fan-shaped keratocytes is a matrix-rigidity-dependent mechanism that requires α5β1 integrin engagement
Q39113994Silencing the roadblocks to effective triple-negative breast cancer treatments by siRNA nanoparticles
Q37613896The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes
Q91985657The role of nonmuscle myosin 2A and 2B in the regulation of mesenchymal cell contact guidance
Q87933698Vitronectin as a Micromanager of Cell Response in Material-Driven Fibronectin Nanonetworks
Q37622390αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin.
Q38852942αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating

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