Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN (scientific article)

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

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Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry

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Phosphoproteomic analysis of the developing mouse brain

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Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease

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Pten regulates neuronal arborization and social interaction in mice

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PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression

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Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis

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Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones

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Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons

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Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

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Drebrin A regulates dendritic spine plasticity and synaptic function in mature cultured hippocampal neurons

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Interaction of Cupidin/Homer2 with two actin cytoskeletal regulators, Cdc42 small GTPase and Drebrin, in dendritic spines

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Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.

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Pten and the brain: sizing up social interaction

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The nuclear affairs of PTEN.

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Down-regulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones

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Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase

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Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex.

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Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration

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MyosinV controls PTEN function and neuronal cell size.

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Proteomic analysis of in vivo phosphorylated synaptic proteins.

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Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices.

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Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis

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Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa

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Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways.

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PTEN couples Sema3A signalling to growth cone collapse.

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Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

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Phosphoinositide-3-Kinase Activation Controls Synaptogenesis and Spinogenesis in Hippocampal Neurons

Q62608643

P275

Creative Commons Attribution 4.0 International

copyrighted

issue

language of work or name

English

Q1860

P921

main subject

phosphorylation

Q242736

P304

page(s)

e71957

P577

publication date

2013-08-05

P1433

published in

PLOS One

Q564954

P1476

title

Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

P478

volume

Reverse relations

cites work (P2860)

Q39032854	A cluster of protein kinases and phosphatases modulated in fetal Down syndrome (trisomy 21) brain
Q61806357	ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans
Q38702491	Cytoskeletal social networking in the growth cone: How +TIPs mediate microtubule-actin cross-linking to drive axon outgrowth and guidance
Q90509513	Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis
Q38287450	Drebrin E regulates neuroblast proliferation and chain migration in the adult brain.
Q38597051	Drebrin and Spermatogenesis
Q41639990	Drebrin coordinates the actin and microtubule cytoskeleton during the initiation of axon collateral branches
Q47866827	Drebrin in Neuronal Migration and Axonal Growth
Q35048620	Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes
Q89576661	Genetic and molecular basis of epilepsy-related cognitive dysfunction
Q47866769	Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain.
Q37642673	Investigation of hippocampal synaptic transmission and plasticity in mice deficient in the actin-binding protein Drebrin.
Q38815063	Organization and dynamics of the actin cytoskeleton during dendritic spine morphological remodeling
Q92785842	PEBP1/RKIP behavior: a mirror of actin-membrane organization
Q49550289	PTEN Inhibition in Human Disease Therapy
Q92707729	PTEN in Autism and Neurodevelopmental Disorders
Q28267704	PTEN regulates cilia through Dishevelled
Q52805958	PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.
Q26826900	PTEN: A master regulator of neuronal structure, function, and plasticity
Q38406254	PTEN: a yin-yang master regulator protein in health and disease
Q47866889	Phosphorylation of Drebrin and Its Role in Neuritogenesis
Q45345908	Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins.
Q27022790	Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders
Q91269310	The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
Q48462069	The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer's disease

P819	ADS bibcode	2013PLoSO...871957K
P356	DOI	10.1371/JOURNAL.PONE.0071957
P932	PMC publication ID	3733845
P698	PubMed publication ID	23940795
P5875	ResearchGate publication ID	255791279