PTEN regulates cilia through Dishevelled

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PTEN regulates cilia through Dishevelled is …
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scholarly articleQ13442814

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P819ADS bibcode2015NatCo...6.8388S
P6179Dimensions Publication ID1013682151
P356DOI10.1038/NCOMMS9388
P932PMC publication ID4598566
P698PubMed publication ID26399523
P5875ResearchGate publication ID282247801

P50authorGlenn R MassonQ56810216
Jeffrey L. WranaQ92537055
Roger L. WilliamsQ30106740
P2093author name stringHong Wu
Jing Jiao
Rudolf Winklbauer
Sherly Mosessian
Laurence Pelletier
Miriam Barrios-Rodiles
Gerald Gish
Eduardo Aguiar Cabeza
Abiodun A Ogunjimi
Calley L Hirsch
Mikhail Bashkurov
Daniel Trcka
Iryna Shnitsar
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTENQ24317335
Regulation of planar cell polarity by Smurf ubiquitin ligasesQ24317525
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromesQ24320313
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouseQ24323384
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathwayQ24323675
E3 ligase Nedd4 promotes axon branching by downregulating PTENQ24630190
HEF1-dependent Aurora A activation induces disassembly of the primary ciliumQ24647111
Structure and function of mammalian ciliaQ24654284
Switching on cilia: transcriptional networks regulating ciliogenesisQ26822532
Crystal structure of a conformation-selective casein kinase-1 inhibitorQ27622090
Fiji: an open-source platform for biological-image analysisQ27860912
PTEN is required for the normal progression of gastrulation by repressing cell proliferation after MBT in Xenopus embryos.Q52009461
Analysis of Dishevelled signalling pathways during Xenopus development.Q52199252
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathwayQ28139300
High-throughput mapping of a dynamic signaling network in mammalian cellsQ28239249
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.Q28305284
Pten is essential for embryonic development and tumour suppressionQ28509238
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalusQ28511503
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphataseQ28567492
The ciliary rootlet maintains long-term stability of sensory ciliaQ28593255
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)Q28640016
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cellsQ30491381
Cilia organize ependymal planar polarityQ30494596
PI3K class II α controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium functionQ33701751
A dual role for planar cell polarity genes in ciliated cellsQ34002370
Cilia in the CNS: the quiet organelle claims center stageQ34173153
A positive feedback mechanism governs the polarity and motion of motile cilia.Q34621438
PTEN hamartoma tumor syndrome: an overviewQ34996547
Modeling human disease in humans: the ciliopathiesQ35453921
Lung development and repair: contribution of the ciliated lineageQ35546713
Stages of ciliogenesis and regulation of ciliary lengthQ35718497
Ciliopathies: the central role of cilia in a spectrum of pediatric disordersQ35764547
Cilia: tuning in to the cell's antenna.Q36557175
Ciliary dysfunction in developmental abnormalities and diseasesQ37369355
Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephalyQ37493061
Dishevelled: The hub of Wnt signalingQ37652897
Planar cell polarity signaling, cilia and polarized ciliary beatingQ37785373
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.Q39222362
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activityQ39388363
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.Q39774233
A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).Q40180547
Hydrocephalus caused by conditional ablation of the Pten or beta-catenin geneQ42262204
Striated rootlet and nonfilamentous forms of rootletin maintain ciliary functionQ42445932
Fine structural aspects of the development and aging of the tracheal epithelium of mice.Q42460274
Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile ciliaQ42469073
Planar polarity of multiciliated ependymal cells involves the anterior migration of basal bodies regulated by non-muscle myosin II.Q42475347
Radial intercalation of ciliated cells during Xenopus skin developmentQ42496019
Ciliary regulation: disassembly takes the spotlightQ44088498
Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis.Q45213360
Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis.Q45980748
Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene.Q46011005
A two-step mechanism generates the spacing pattern of the ciliated cells in the skin of Xenopus embryosQ47921580
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)8388
P577publication date2015-09-24
P1433published inNature CommunicationsQ573880
P1476titlePTEN regulates cilia through Dishevelled
P478volume6

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cites work (P2860)
Q64917283Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility.
Q28067455Cilium assembly and disassembly
Q91592115Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled
Q39137312Mechanisms for nonmitotic activation of Aurora-A at cilia.
Q92906114Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions
Q50090959PP5 (PPP5C) is a phosphatase of Dvl2.
Q50117668PTEN silencing enhances neuronal proliferation and differentiation by activating PI3K/Akt/GSK3β pathway in vitro
Q99706571Phosphoinositide lipids in primary cilia biology
Q58754551Regulation of PTEN expression by noncoding RNAs
Q38826623Role of phosphatase and tensin homolog in hypoxic pulmonary vasoconstriction
Q50280734Signaling through the Primary Cilium
Q28269344The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity
Q37683931The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L.

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