The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling

scientific article

The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling is …
instance of (P31):
scholarly articleQ13442814
retracted paperQ45182324

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P356DOI10.1371/JOURNAL.PBIO.0050005
P3181OpenCitations bibliographic resource ID278488
P932PMC publication ID1702562
P698PubMed publication ID17177604
P5875ResearchGate publication ID6621829

P50authorPaola BriataQ30089832
Roberto GherziQ91623926
Roberto GherziQ30089833
Marco PonassiQ30089835
Tina RuggieroQ30089837
P2093author name stringJens S Andersen
Ching-Yi Chen
Giorgio Corte
Christoph Moroni
Michele Trabucchi
Khalid S Khabar
P2860cites workAU binding proteins recruit the exosome to degrade ARE-containing mRNAsQ24291926
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 bindingQ24302401
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decayQ24316111
Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decayQ24548948
The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase BQ24558903
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayQ24653458
Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR.Q24816506
ARED 3.0: the large and diverse AU-rich transcriptome.Q25257878
Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1Q28118675
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growthQ28187862
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during developmentQ28216579
A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machineryQ28264688
Messenger RNA turnover in eukaryotes: pathways and enzymesQ28298137
p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcriptsQ28594660
Role of translocation in the activation and function of protein kinase BQ28609902
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)Q28640016
The structural basis for 14-3-3:phosphopeptide binding specificityQ29547190
Wnt signaling: a common theme in animal developmentQ29547527
Wnt signalling in stem cells and cancerQ29547862
HuR and mRNA stabilityQ29615185
Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor.Q54395492
Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activationQ73787446
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and traffickingQ42125847
Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activationQ42809920
Quantitative phosphoproteomics applied to the yeast pheromone signaling pathwayQ45234630
Molecular determinants of Akt-induced keratinocyte transformationQ46772716
Activation of the Wnt signaling pathway: a molecular mechanism for lithium actionQ48958687
A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.Q52831298
Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage displayQ30776583
Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.Q34330731
Protein kinase B/Akt at a glanceQ34474692
p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcriptsQ34811464
Role of Akt/protein kinase B in metabolism.Q34997136
Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activationQ35193952
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neuronsQ35563894
Advances in protein kinase B signalling: AKTion on multiple frontsQ35766370
The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.Q35829153
Bringing the role of mRNA decay in the control of gene expression into focusQ35885699
Recent advances in the protein kinase B signaling pathwayQ36076055
Control of mRNA stability in eukaryotesQ36295604
MAPKAP kinases - MKs - two's company, three's a crowdQ36371939
Yin-yang 1 activates the c-myc promoterQ36827465
Proteomic analysis identifies that 14-3-3zeta interacts with beta-catenin and facilitates its activation by Akt.Q37593591
Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.Q38319485
Role of the RNA-binding protein HuR in colon carcinogenesisQ38349167
Signal transduction through beta-catenin and specification of cell fate during embryogenesisQ38530598
Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinaseQ39460786
Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signalingQ40279493
AU-rich elements and alternative splicing in the beta-catenin 3'UTR can influence the human beta-catenin mRNA stabilityQ40280621
Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factorsQ40486178
The Wnt/beta-catenin-->Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAsQ40613619
Akt participation in the Wnt signaling pathway through DishevelledQ40817549
Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signalingQ40866028
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectRNA-binding proteinsQ3928341
P304page(s)e5
P577publication date2006-12-01
P1433published inPLOS BiologyQ1771695
P1476titleThe RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling
P478volume5

Reverse relations

cites work (P2860)
Q358947625-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats
Q37014717A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells
Q37749080A review of methods to monitor the modulation of mRNA stability: a novel approach to drug discovery and therapeutic intervention
Q40675814A versatile ribosomal protein promoter-based reporter system for selective assessment of RNA stability and post-transcriptional control
Q28588044AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking
Q43127498AU-rich elements regulate Drosophila gene expression.
Q35902641Above genetics: lessons from cerebral development in autism
Q53190419Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β-Catenin and RANKL/OPG.
Q45328178Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics
Q28583125Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain
Q39932300Akt phosphorylation of La regulates specific mRNA translation in glial progenitors
Q39761766Akt2-mediated phosphorylation of Pitx2 controls Ccnd1 mRNA decay during muscle cell differentiation
Q28510351Arginine methylation of G3BP1 in response to Wnt3a regulates β-catenin mRNA
Q37958686BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype
Q30992379BRCA1 modulates the expression of hnRNPA2B1 and KHSRP.
Q39239904Bone morphogenetic protein/SMAD signaling orients cell fate decision by impairing KSRP-dependent microRNA maturation
Q46183168CD28 signaling in T regulatory precursors requires p56lck and rafts integrity to stabilize the Foxp3 message
Q34343685Complete deletion of Apc results in severe polyposis in mice
Q35816361Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells
Q34984530DEAD box protein DDX1 regulates cytoplasmic localization of KSRP
Q33817646Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation
Q43251969Differential mechanism of NF-kappaB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts
Q54648889Differential modulation of the cytokine-induced MMP-9/TIMP-1 protease-antiprotease system by the mTOR inhibitor rapamycin.
Q33763825Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA.
Q37739651Diversity in post-transcriptional control of neutrophil chemoattractant cytokine gene expression
Q38572889Does miRNA-155 Promote Cyclooxygenase-2 Expression in Cancer?
Q39100118Downregulation of Sfrp5 promotes beta cell proliferation during obesity in the rat.
Q36751314Exploring the RNA world in hematopoietic cells through the lens of RNA-binding proteins.
Q42413090FasL expression in activated T lymphocytes involves HuR-mediated stabilization
Q30480964Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets
Q38062295Functional and molecular insights into KSRP function in mRNA decay
Q34675049Genome-wide RNAi screening identifies genes inhibiting the migration of glioblastoma cells
Q34601079H19 long noncoding RNA controls the mRNA decay promoting function of KSRP.
Q42421191HnRNP A1 tethers KSRP to an exon splicing silencer that inhibits an erythroid-specific splicing event in PU.1-induced erythroleukemia
Q38342449IL-1-induced post-transcriptional mechanisms target overlapping translational silencing and destabilizing elements in IκBζ mRNA.
Q33694001IL-17 regulates CXCL1 mRNA stability via an AUUUA/tristetraprolin-independent sequence
Q28222344Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling
Q38797458Identification of an RNA-binding protein that is phosphorylated by PTH and potentially mediates PTH-induced destabilization of Npt2a mRNA.
Q55052910Identification of autoantigens in pediatric opsoclonus-myoclonus syndrome.
Q33399670Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements
Q47433840Inflammation-regulated mRNA stability and the progression of vascular inflammatory diseases.
Q37560020Inflammation: cytokines and RNA-based regulation
Q41458214Integrative analysis of cancer-related signaling pathways
Q39941914Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules.
Q38675443Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism
Q30496858Intracellular localization and interaction of mRNA binding proteins as detected by FRET
Q36144919KH domains with impaired nucleic acid binding as a tool for functional analysis
Q42697394KH-type splicing regulatory protein is a new component of chromatoid body
Q42704822KHSRP participates in manganese-induced neurotoxicity in rat striatum and PC12 cells
Q89496313KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer
Q84557073KSRP Promotes the Maturation of a Group of miRNA Precuresors
Q50295847KSRP binds AU-rich element in 3' UTR of mRNA
Q38213168KSRP controls pleiotropic cellular functions
Q35014217KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression.
Q46061449KSRP promotes the maturation of a group of miRNA precursors.
Q39332374Knockdown of hMex-3A by small RNA interference suppresses cell proliferation and migration in human gastric cancer cells
Q34979721LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages
Q21563369Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP
Q39074804Lysophosphatidic acid activates β-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells
Q28564755Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs
Q26823168Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) is a novel multifunctional modulator of inflammatory reactions
Q39934586NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.
Q37940393Networks controlling mRNA decay in the immune system.
Q36802838Nuclear HuR accumulation through phosphorylation by Cdk1
Q37103971Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma
Q46843731Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis
Q52695010P38 activation induces the dissociation of tristetraprolin from Argonaute 2 to increase ARE-mRNA stabilization.
Q39480671PI3K/AKT signaling determines a dynamic switch between distinct KSRP functions favoring skeletal myogenesis
Q39096070Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated BST-2/tetherin regulation
Q36960953Phosphorylated HuR shuttles in cycles
Q34485096Phosphorylation of Tristetraprolin by MK2 Impairs AU-Rich Element mRNA Decay by Preventing Deadenylase Recruitment
Q27653675Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding
Q51306606Post-Translational Modifications and RNA-Binding Proteins.
Q34065213Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements
Q37113415Post-transcriptional control of cytokine production
Q90456271Post-transcriptional mechanisms regulating parathyroid hormone gene expression in secondary hyperparathyroidism
Q42103783Posttranscriptional control of type I interferon genes by KSRP in the innate immune response against viral infection
Q37051346Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence
Q35667581Posttranscriptional regulation of miRNAs in the DNA damage response
Q34281170PreImplantation factor promotes neuroprotection by targeting microRNA let-7
Q50295849Protein Kinase B (AKT) phosphorylates KSRP
Q38216092Protein folding dynamics in the cell
Q39485236Proteomic analysis of 1α,25-dihydroxyvitamin D3 action on human colon cancer cells reveals a link to splicing regulation.
Q87687655RNA-binding protein-mediated post-transcriptional controls of gene expression: integration of molecular mechanisms at the 3' end of mRNAs?
Q41998210RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways
Q36776927Rapid transit in the immune cells: the role of mRNA turnover regulation.
Q36983557Regulated unfolding of proteins in signaling
Q53083286Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer.
Q27023916Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1
Q36647195Reprogramming of the microRNA transcriptome mediates resistance to rapamycin
Q43173072Retraction: The RNA-Binding Protein KSRP Promotes Decay of β-Catenin mRNA and Is Inactivated by PI3K-AKT Signaling
Q26860434Role of KSRP in control of type I interferon and cytokine expression
Q36870110SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis
Q35142761Signaling-mediated regulation of MicroRNA processing
Q45093146Spatiotemporal expression of KHSRP modulates Schwann cells and neuronal differentiation after sciatic nerve injury
Q35213072Structural basis for regulation of RNA-binding proteins by phosphorylation
Q33704980Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.
Q35043572The ATM kinase induces microRNA biogenesis in the DNA damage response.
Q28118107The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2
Q37401219The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
Q34143021The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer.
Q34024670The exozyme model: a continuum of functionally distinct complexes.
Q52887347The far-upstream element-binding protein 2 is correlated with proliferation and doxorubicin resistance in human breast cancer cell lines.
Q39434281The interplay between transcription and mRNA degradation in Saccharomyces cerevisiae
Q28573676The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels
Q39796772The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism.
Q35095098The ribonome: a dominant force in co-ordinating gene expression
Q37936370The role of KSRP in mRNA decay and microRNA precursor maturation
Q37492933The role of mammalian ribonucleases (RNases) in cancer
Q27644470The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation
Q39144733Transcriptional and post-transcriptional regulation of IκB-ζ upon engagement of the BCR, TLRs and FcγR.
Q37940420Turnover of AU-rich-containing mRNAs during stress: a matter of survival.
Q34654416Understanding the somitogenesis clock: what's missing?
Q38076192Wnt/β-catenin signalling: from plasma membrane to nucleus
Q42910783ZBP2 facilitates binding of ZBP1 to beta-actin mRNA during transcription
Q39653613mRNA Degradation Plays a Significant Role in the Program of Gene Expression Regulated by Phosphatidylinositol 3-Kinase Signaling
Q36773503mRNA stability control: a clandestine force in normal and malignant hematopoiesis
Q37860250β-catenin as a potential key target for tumor suppression

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