Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells

scientific article

Biphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1091/MBC.E02-09-0621
P932PMC publication ID194905
P698PubMed publication ID12808053

P2093author name stringFilippo Acconcia
Maria Marino
Anna Trentalance
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayQ24653458
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activationQ28214415
Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouseQ28252945
PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cellsQ28363087
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase BQ28646131
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
A nonclassical estrogen membrane receptor triggers rapid differential actions in the endocrine pancreasQ32064845
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Non-transcriptional action of oestradiol and progestin triggers DNA synthesis.Q33890864
Steroids conjugated to bovine serum albumin as tools to demonstrate specific steroid neuronal membrane binding sites.Q33921734
PI3-kinase inhibition: a target for drug development?Q34011982
Distinct nongenomic signal transduction pathways controlled by 17beta-estradiol regulate DNA synthesis and cyclin D(1) gene transcription in HepG2 cells.Q34168767
Estrogens and cell-cycle regulation in breast cancerQ34336956
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosisQ34371260
PKB/AKT: functional insights from genetic modelsQ34389540
Cellular functions of plasma membrane estrogen receptorsQ34605439
Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calciumQ35136963
Estrogen induction of the cyclin D1 promoter: involvement of a cAMP response-like elementQ35644045
Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signalingQ35754878
Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cellsQ35846108
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Estrogen receptor-alpha detected on the plasma membrane of aldehyde-fixed GH3/B6/F10 rat pituitary tumor cells by enzyme-linked immunocytochemistryQ38322118
Immunolocalisation of oestrogen receptor beta in human tissuesQ38466031
Effects of oestrogens on cell proliferation and cell cycle kinetics. A hypothesis on the cell cycle effects of antioestrogensQ40151163
17beta-Estradiol promotes the up-regulation of SR-BII in HepG2 cells and in rat livers.Q40784361
Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.Q40894248
Differential effects of estradiol and estradiol-BSA conjugatesQ40920935
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cellsQ40993616
The significance of heregulin in breast cancer tumor progression and drug resistanceQ41126011
Orphan receptor hepatocyte nuclear factor-4 antagonizes estrogen receptor alpha-mediated induction of human coagulation factor XII geneQ42463195
Inducible regulatory elements in the human cyclin D1 promoterQ42498965
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.Q42991716
Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elementsQ43643514
beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cellsQ43652288
Estradiol-induced IP(3) mediates the estrogen receptor activity expressed in human cellsQ43704087
Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.Q43708526
Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expressionQ43709177
Estrogens do not modify MAP kinase-dependent nuclear signaling during stimulation of early G(1) progression in human breast cancer cells.Q43719902
ERs associate with and regulate the production of caveolin: implications for signaling and cellular actionsQ43843581
Evaluation of potential implication of membrane estrogen binding sites on ERE-dependent transcriptional activity and intracellular estrogen receptor-alpha regulation in MCF-7 breast cancer cellsQ43897870
Rapid stimulation of the PI3-kinase/Akt signalling pathway in developing midbrain neurones by oestrogen.Q43923550
Estrogen memory effect in human hepatocytes during repeated cell division without hormoneQ44809266
Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors.Q53399983
The plasma membrane estrogen receptor: nuclear or unclear?Q58875403
Insulin-like growth factors and breast cancerQ62267742
Apolipoprotein C-II mRNA levels in primate liver. Induction by estrogen in the human hepatocarcinoma cell line, HepG2Q70077959
Kinetics of estrogen-dependent modulation of apolipoprotein A-I synthesis in human hepatoma cellsQ70134339
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cellsQ71124075
Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cellsQ73054399
Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl estradiol treatmentQ73135830
P433issue6
P921main subjectphosphorylationQ242736
P1104number of pages9
P304page(s)2583-2591
P577publication date2003-02-06
P1433published inMolecular Biology of the CellQ2338259
P1476titleBiphasic estradiol-induced AKT phosphorylation is modulated by PTEN via MAP kinase in HepG2 cells
P478volume14

Reverse relations

cites work (P2860)
Q4328181117beta-Estradiol regulates the first steps of skeletal muscle cell differentiation via ER-alpha-mediated signals
Q44948703Bcl-x(S) induces an NGF-inhibitable cytochrome c release
Q58762425Beyond the Antioxidant Activity of Dietary Polyphenols in Cancer: the Modulation of Estrogen Receptors (ERs) Signaling
Q39963624CCL2 protects prostate cancer PC3 cells from autophagic death via phosphatidylinositol 3-kinase/AKT-dependent survivin up-regulation
Q33631719Clathrin Heavy Chain Interacts With Estrogen Receptor α and Modulates 17β-Estradiol Signaling
Q39863634Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis
Q35969254Effects of Combination of Estradiol with Selective Progesterone Receptor Modulators (SPRMs) on Human Breast Cancer Cells In Vitro and In Vivo
Q40230900Effects of pharmacological concentrations of estrogens on growth of 3AO human ovarian cancer cells
Q38046498Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer
Q33770684Estrogen rapidly activates the PI3K/AKT pathway and hypoxia-inducible factor 1 and induces vascular endothelial growth factor A expression in luminal epithelial cells of the rat uterus
Q64280861Estrogen receptor signaling mechanisms
Q47820890Estrogen receptor β-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis
Q36499769Estrogen signaling multiple pathways to impact gene transcription
Q92240915Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression
Q37616780Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells
Q33403307Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor
Q36236071Hormonal influences on cancer progression and prognosis
Q42042194Human myeloblastic leukemia cells (HL-60) express a membrane receptor for estrogen that signals and modulates retinoic acid-induced cell differentiation
Q41971722Inhibition of transfected PTEN on human colon cancer
Q36663178Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta
Q37432589Luteinizing hormone-induced Akt phosphorylation and androgen production are modulated by MAP Kinase in bovine theca cells
Q100162255Membrane estrogen receptors bind SRC
Q34760746Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1).
Q40305115Normal human immune cells are sensitive to telomerase inhibition by Brassica-derived 3,3-diindolylmethane,partly mediated via ERα/β-AP1 signaling
Q36267925Nutritional flavonoids impact on nuclear and extranuclear estrogen receptor activities
Q54411913PTEN suppression promotes neurite development exclusively in differentiating PC12 cells via PI3‐kinase and MAP kinase signaling
Q33564705Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol
Q39841354Placenta growth factor is a survival factor for human malignant mesothelioma cells
Q36321931Rapid activation of ERK1/2 and AKT in human breast cancer cells by cadmium
Q35263224Rapid non-genomic signalling by 17β-oestradiol through c-Src involves mTOR-dependent expression of HIF-1α in breast cancer cells
Q35603632Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells
Q28396388Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
Q35084708The Effects of 17β-estradiol in Cancer are Mediated by Estrogen Receptor Signaling at the Plasma Membrane.
Q36002446The elements of human cyclin D1 promoter and regulation involved
Q46424872The localization and non-genomic function of the membrane-associated estrogen receptor in oligodendrocytes.
Q34197932The pro-apoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals.
Q33928558Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor
Q37640131Xenoestrogens challenge 17β-estradiol protective effects in colon cancer

Search more.