Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells

scientific article published on October 2000

Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1027527751
P356DOI10.1054/BJOC.2000.1400
P932PMC publication ID2363557
P698PubMed publication ID10993660
P5875ResearchGate publication ID12328856

P50authorNorman MaitlandQ37392064
P2093author name stringR M Sharrard
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionQ22010498
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayQ24653458
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin VQ28294206
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Q30472730
Precise microdissection of human prostate cancers reveals genotypic heterogeneityQ34451842
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domainQ36818855
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTENQ39711051
Genetic aspects of prostate cancerQ40853536
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cellsQ40993616
Integrins and anoikisQ41612562
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexesQ41667743
Immortalization of Human Adult Normal Prostatic Epithelial Cells by Liposomes Containing Large T-SV40 GeneQ41667803
Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic-resistant cells to express recombinant protein.Q42637004
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.Q42815905
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer.Q45029660
PTEN/MMAC1/TEP1 involvement in primary prostate cancers.Q47814101
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomasQ48045473
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.Q48331127
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.Q48566471
Deletion mapping of chromosomes 8, 10, and 16 in human prostatic carcinomaQ48731724
The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.Q55476352
Frequent inactivation of PTEN/MMAC1 in primary prostate cancerQ57240096
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTENQ64381461
Allelic loss on chromosome 10 in prostate adenocarcinomaQ71046868
Distinct areas of allelic loss on chromosomal regions 10p and 10q in human prostate cancerQ71067591
Loss of the chromosomal region 10q23-25 in prostate cancerQ71804687
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignanciesQ73722520
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissuesQ74093343
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)1102-1109
P577publication date2000-10-01
P1433published inBritish Journal of CancerQ326309
P1476titlePhenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells
P478volume83