CRM1 Inhibitors for Antiviral Therapy

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CRM1 Inhibitors for Antiviral Therapy is …
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scholarly articleQ13442814

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P356DOI10.3389/FMICB.2017.01171
P932PMC publication ID5487384
P698PubMed publication ID28702009

P2093author name stringReena Ghildyal
Cynthia Mathew
P2860cites workEmerging roles for the influenza A virus nuclear export protein (NEP)Q21089600
Transport between the cell nucleus and the cytoplasmQ22065411
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplicationQ24309486
Influenza B and C virus NEP (NS2) proteins possess nuclear export activitiesQ24529536
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathwayQ24653458
Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved regionQ24685870
Structural Basis of Targeting the Exportin CRM1 in CancerQ26781513
Nuclear export of proteins and drug resistance in cancerQ27012444
Recent Advances in Deciphering Viral and Host Determinants of Dengue Virus Replication and PathogenesisQ27477646
CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus ProductionQ27488888
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTPQ27655147
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1Q27675810
Inhibition of nuclear export of ribonucleoprotein complexes of influenza virus by leptomycin B.Q27863701
Assembly and budding of influenza virusQ27863797
Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complexQ27863801
Nuclear traffic of influenza virus proteins and ribonucleoprotein complexesQ27864127
HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral ReplicationQ28066382
Nucleocytoplasmic transport: the soluble phaseQ28131723
A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expressionQ28238195
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expressionQ28250231
APC mutations occur early during colorectal tumorigenesisQ28274764
Taxonomy of the order Mononegavirales: update 2016Q28275807
Nucleocytoplasmic transportQ28275907
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1Q28277890
The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitorQ28539308
In vitro anti-influenza virus activities of a new lignan glycoside from the latex of Calotropis giganteaQ28541723
Phase I trial of elactocinQ36135821
A novel nuclear trafficking module regulates the nucleocytoplasmic localization of the rabies virus interferon antagonist, P proteinQ36201908
Viral interactions with the nuclear transport machinery: discovering and disrupting pathwaysQ36203647
NESdb: a database of NES-containing CRM1 cargoesQ36234505
Plumbagin inhibits tumorigenesis and angiogenesis of ovarian cancer cells in vivoQ36395163
Central role of the respiratory syncytial virus matrix protein in infection.Q36566590
CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cellsQ36627593
"Spicing up" of the immune system by curcuminQ36702820
Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions.Q36836542
Identification of nuclear export inhibitors with potent anticancer activity in vivoQ37081966
Viral subversion of the nuclear pore complexQ37142582
Tegument proteins of human cytomegalovirusQ37183914
The respiratory syncytial virus matrix protein possesses a Crm1-mediated nuclear export mechanismQ37191929
Involvement of the rabies virus phosphoprotein gene in neuroinvasivenessQ37254274
CRM1-mediated nuclear export of proteins and drug resistance in cancerQ37320237
Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibitionQ37347745
Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon responseQ37568171
KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.Q37693609
Protein localization in disease and therapy.Q37947248
Protein-protein interactions in RSV assembly: potential targets for attenuating RSV strains.Q37984106
Overview of the therapeutic potential of piplartine (piperlongumine).Q38067223
Promising SINEs for embargoing nuclear-cytoplasmic export as an anticancer strategyQ38205335
Clinical translation of nuclear export inhibitors in cancerQ38206324
Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agentsQ38260357
Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancerQ38359505
Selective inhibitors of nuclear export (SINE) in hematological malignanciesQ38368605
The dengue virus NS5 protein as a target for drug discoveryQ38442511
The antiviral and antimicrobial activities of licorice, a widely-used Chinese herbQ38636996
CBS9106-induced CRM1 degradation is mediated by cullin ring ligase activity and the neddylation pathway.Q38953484
CRM1 is a direct cellular target of the natural anti-cancer agent plumbaginQ39003453
Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells.Q39004520
The myxobacterial metabolite ratjadone A inhibits HIV infection by blocking the Rev/CRM1-mediated nuclear export pathway.Q39029310
CRM1 is a cellular target of curcumin: new insights for the myriad of biological effects of an ancient spiceQ39129924
Water extract of licorice had anti-viral activity against human respiratory syncytial virus in human respiratory tract cell linesQ39156494
CRM1 and BRAF inhibition synergize and induce tumor regression in BRAF-mutant melanomaQ39161114
Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitroQ39195555
Ge-Gen-Tang has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell linesQ39436827
Nuclear Export as a Novel Therapeutic Target: The CRM1 ConnectionQ29036286
Transport into and out of the nucleusQ29615611
Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycleQ29619289
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
Challenges and opportunities in developing respiratory syncytial virus therapeuticsQ30300567
Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo.Q30363986
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transportQ33292269
Piperlongumine inhibits NF-κB activity and attenuates aggressive growth characteristics of prostate cancer cellsQ33738321
Piperlongumine inhibits migration of glioblastoma cells via activation of ROS-dependent p38 and JNK signaling pathwaysQ33748476
Role of the influenza virus M1 protein in nuclear export of viral ribonucleoproteinsQ33797502
Production of HIV particles is regulated by altering sub-cellular localization and dynamics of Rev induced by double-strand RNA binding proteinQ33834106
The Thr205 phosphorylation site within respiratory syncytial virus matrix (M) protein modulates M oligomerization and virus productionQ33887779
Atomic basis of CRM1-cargo recognition, release and inhibitionQ33940712
Toward antiviral strategies that resist viral escapeQ33979280
Curcumin: the Indian solid goldQ34004696
Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transportQ34008468
KPT-330 inhibitor of XPO1-mediated nuclear export has anti-proliferative activity in hepatocellular carcinomaQ34098446
Emerging anticancer potentials of goniothalamin and its molecular mechanisms.Q34177051
CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activityQ34207970
A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear exportQ34394284
Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agentsQ34410193
Nucleo-cytoplasmic transport as a therapeutic target of cancerQ34452108
Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoningQ34554323
Curcumin disrupts the Mammalian target of rapamycin-raptor complex.Q34603763
Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1Q34685189
Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I studyQ35087639
Nuclear envelope and genome interactions in cell fateQ35194606
Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effectsQ35288598
Protein quality control at the inner nuclear membraneQ35527818
Infectious disease. Combating emerging viral threatsQ35569547
Physiology and pharmacology of the prostaglandin J2 familyQ35616285
Piperlongumine is a novel nuclear export inhibitor with potent anticancer activityQ35647146
Characterization of BRCA1 protein targeting, dynamics, and function at the centrosome: a role for the nuclear export signal, CRM1, and Aurora A kinaseQ35801868
A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replicationQ35943682
The human T-cell leukemia virus Rex proteinQ35969160
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.Q39457088
Liu-He-Tang inhibited plaque formation by human respiratory syncytial virus infection in cell lines of the human respiratory tractQ39496308
Sheng-Ma-Ge-Gen-Tang (Shoma-kakkon-to) inhibited cytopathic effect of human respiratory syncytial virus in cell lines of human respiratory tractQ39564800
The phosphoprotein of rabies virus is phosphorylated by a unique cellular protein kinase and specific isomers of protein kinase CQ39588524
Interaction of the influenza virus nucleoprotein with the cellular CRM1-mediated nuclear export pathwayQ39601251
Plumbagin-induced apoptosis of human breast cancer cells is mediated by inactivation of NF-kappaB and Bcl-2.Q39922091
MD-2 as the target of curcumin in the inhibition of response to LPS.Q40112020
Goniothalamin induces cell cycle-specific apoptosis by modulating the redox status in MDA-MB-231 cellsQ40366203
Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3.Q40416432
Crm1 is a mitotic effector of Ran-GTP in somatic cellsQ40418909
Nucleocytoplasmic shuttling of the rabies virus P protein requires a nuclear localization signal and a CRM1-dependent nuclear export signalQ40444617
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection.Q40448705
CRM1-dependent nuclear export of dengue virus type 2 NS5.Q40457090
The cytoplasmic trafficking of DNA topoisomerase IIalpha correlates with etoposide resistance in human myeloma cellsQ40565443
Multi parameter in vitro testing of ratjadone using flow cytometryQ40657878
New Rev-transport inhibitor with anti-HIV activity from Valerianae RadixQ40702077
The CRM1 nuclear export protein in normal development and disease.Q41860863
Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporterQ41994064
The anti-inflammatory prostaglandin 15-deoxy-delta(12,14)-PGJ2 inhibits CRM1-dependent nuclear protein exportQ42057495
Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1Q42140112
Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnoverQ42796363
The nucleocytoplasmic rabies virus P protein counteracts interferon signaling by inhibiting both nuclear accumulation and DNA binding of STAT1.Q42797122
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.Q42801742
Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris FructusQ43056689
The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transportQ43104351
Bioisostere of valtrate, anti-HIV principle by inhibition for nuclear export of Rev.Q43140683
Anguinomycins and derivatives: total syntheses, modeling, and biological evaluation of the inhibition of nucleocytoplasmic transportQ43200620
Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.Q44245356
HIV-1 Rev and related inhibitorsQ44477426
Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microgliaQ44666530
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cellsQ44714283
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms.Q45097896
The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation.Q46668855
Human cytomegalovirus UL94 is a nucleocytoplasmic shuttling protein containing two NLSs and one NES.Q48025655
CRM1-mediated nuclear export: to the pore and beyond.Q50336102
Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain.Q54786854
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirusQ56956215
Cytotoxicity and antimicrobial activity of goniothalamin isolated fromBryonopsis laciniosaQ57931787
Cytomegalovirus selectively blocks antigen processing and presentation of its immediate–early gene productQ59098221
Synergistic stimulation of HIV-1 rev-dependent export of unspliced mRNA to the cytoplasm by hnRNP A1Q77928316
Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cellsQ83248574
Anti-influenza viral effects of novel nuclear export inhibitors from Valerianae Radix and Alpinia galangaQ83784151
[Organization and regulation of nucleocytoplasmic transport]Q84496516
Inhibiting cancer cell hallmark features through nuclear export inhibitionQ89700428
P304page(s)1171
P577publication date2017-06-28
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleCRM1 Inhibitors for Antiviral Therapy
P478volume8

Reverse relations

cites work (P2860)
Q59813350Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport
Q57454827In vitro toxicity and efficacy of verdinexor, an exportin 1 inhibitor, on opportunistic viruses affecting immunocompromised individuals
Q100384122Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review
Q104795052Targeting XPO1 enhances innate immune response and inhibits KSHV lytic replication during primary infection by nuclear stabilization of the p62 autophagy adaptor protein
Q90434268Verdinexor (KPT-335), a Selective Inhibitor of Nuclear Export, Reduces Respiratory Syncytial Virus Replication In Vitro
Q47549703Verdinexor Targeting of CRM1 is a Promising Therapeutic Approach against RSV and Influenza Viruses
Q66679726Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery

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