Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.

scientific article published on 11 September 2012

Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00430-012-0269-7
P698PubMed publication ID22965172

P50authorThomas StammingerQ89549865
P2093author name stringPeter Lischka
Bodo Plachter
Nadine Frankenberg
Sandra Pepperl-Klindworth
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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I moleculesQ28248180
A novel transferable nuclear export signal mediates CRM1-independent nucleocytoplasmic shuttling of the human cytomegalovirus transactivator protein pUL69Q28366352
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hMSH5 is a nucleocytoplasmic shuttling protein whose stability depends on its subcellular localizationQ33922440
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CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoproteinQ40006400
Processing and MHC class I presentation of human cytomegalovirus pp65-derived peptides persist despite gpUS2-11-mediated immune evasionQ40148627
NK cell activity during human cytomegalovirus infection is dominated by US2-11-mediated HLA class I down-regulationQ40635405
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Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damageQ40757254
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Generation and TAP-mediated transport of peptides for major histocompatibility complex class I molecules.Q41722133
The UL69 transactivator protein of human cytomegalovirus interacts with DEXD/H-Box RNA helicase UAP56 to promote cytoplasmic accumulation of unspliced RNA.Q41807684
The CRM1 nuclear export protein in normal development and disease.Q41860863
Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporterQ41994064
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Cytomegalovirus (CMV) phosphoprotein 65 makes a large contribution to shaping the T cell repertoire in CMV-exposed individualsQ44042248
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Human cytomegalovirus protein pp65 mediates accumulation of HLA-DR in lysosomes and destruction of the HLA-DR alpha-chain.Q54786854
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Cytomegalovirus selectively blocks antigen processing and presentation of its immediate–early gene productQ59098221
Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiationQ61719005
The lower matrix protein pp65 is the principal viral antigen present in peripheral blood leukocytes during an active cytomegalovirus infectionQ67506329
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Direct visualization of the dynamics of antigen presentation in human cells infected with cytomegalovirus revealed by antibodies mimicking TCR specificityQ83817150
P433issue4
P921main subjectCytomegalovirusQ6946
P304page(s)567-579
P577publication date2012-09-11
P1433published inMedical Microbiology and ImmunologyQ15760239
P1476titleNucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.
P478volume201

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cites work (P2860)
Q39431526CRM1 Inhibitors for Antiviral Therapy
Q60913862Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the "Test of Time"
Q37611838Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.
Q27015069Role of human cytomegalovirus tegument proteins in virion assembly

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