CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model

scientific article published on 15 March 2008

CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00430-008-0093-2
P8608Fatcat IDrelease_hjiqhb5auvdrndli3a4bcfwx5y
P698PubMed publication ID18343947
P5875ResearchGate publication ID5508299

P50authorMatthias J ReddehaseQ62925338
Rafaela HoltappelsQ92198001
P2093author name stringJürgen Podlech
Verena Böhm
P2860cites workThe murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL but does not alter the immunodominance of the M45-specific CD8 T cell response in vivoQ31084489
Genome-wide analysis reveals a highly diverse CD8 T cell response to murine cytomegalovirusQ33235520
Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sortingQ33755031
Preemptive CD8 T-cell immunotherapy of acute cytomegalovirus infection prevents lethal disease, limits the burden of latent viral genomes, and reduces the risk of virus recurrenceQ33782273
Control of murine cytomegalovirus in the lungs: relative but not absolute immunodominance of the immediate-early 1 nonapeptide during the antiviral cytolytic T-lymphocyte response in pulmonary infiltratesQ33783800
Control of cytomegalovirus in bone marrow transplantation chimeras lacking the prevailing antigen-presenting molecule in recipient tissues rests primarily on recipient-derived CD8 T cellsQ33784524
The putative natural killer decoy early gene m04 (gp34) of murine cytomegalovirus encodes an antigenic peptide recognized by protective antiviral CD8 T cellsQ33797749
Suppression of murine cytomegalovirus (MCMV) replication with a DNA vaccine encoding MCMV M84 (a homolog of human cytomegalovirus pp65)Q33802461
Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: persistence of protective pulmonary CD8-T-cell infiltrates after clearance of acute infectionQ33809769
Enrichment of immediate-early 1 (m123/pp89) peptide-specific CD8 T cells in a pulmonary CD62L(lo) memory-effector cell pool during latent murine cytomegalovirus infection of the lungsQ33812288
OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism.Q43644014
Development of a treatment regimen for human cytomegalovirus (CMV) infection in bone marrow transplantation recipients by adoptive transfer of donor-derived CMV-specific T cell clones expanded in vitroQ44551855
Immunotherapy of cytomegalovirus infection after stem-cell transplantation: a new option?Q44636718
Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infectionQ59057908
Coordinated Function of Murine Cytomegalovirus Genes Completely Inhibits CTL LysisQ60214617
Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clonesQ67518698
Lack of MHC class I complex expression has no effect on spread and control of cytomegalovirus infection in vivoQ71071690
Reconstitution of Cellular Immunity against Cytomegalovirus in Recipients of Allogeneic Bone Marrow by Transfer of T-Cell Clones from the DonorQ72059554
Reconstitution of CD8 T cells is essential for the prevention of multiple-organ cytomegalovirus histopathology after bone marrow transplantationQ77331536
Antigens and immunoevasins: opponents in cytomegalovirus immune surveillanceQ78471193
Adoptive CD8 T cell control of pathogens cannot be improved by combining protective epitope specificitiesQ80609133
Experimental preemptive immunotherapy of murine cytomegalovirus disease with CD8 T-cell lines specific for ppM83 and pM84, the two homologs of human cytomegalovirus tegument protein ppUL83 (pp65).Q33843590
Role of specific cytotoxic lymphocytes in cellular immunity against murine cytomegalovirusQ33900303
Frequent coinfection of cells explains functional in vivo complementation between cytomegalovirus variants in the multiply infected hostQ33908684
Haematopoietic cell transplantation as immunotherapyQ34253590
Principles for adoptive T cell therapy of human viral diseasesQ34300059
Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotypeQ34327234
Development of a vaccine against murine cytomegalovirus (MCMV), consisting of plasmid DNA and formalin-inactivated MCMV, that provides long-term, complete protection against viral replicationQ34338715
Role of T lymphocytes in recovery from murine cytomegalovirus infectionQ34413619
Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infectionQ34647659
Strong CD8 T-cell responses following coimmunization with plasmids expressing the dominant pp89 and subdominant M84 antigens of murine cytomegalovirus correlate with long-term protection against subsequent viral challengeQ34970937
Cytomegalovirus encodes a positive regulator of antigen presentationQ35023830
CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivationQ35139332
Clinical aspects of CMV infection after stem cell transplantationQ35789339
DNA immunization confers protection against murine cytomegalovirus infectionQ35872388
DNA immunization using highly conserved murine cytomegalovirus genes encoding homologs of human cytomegalovirus UL54 (DNA polymerase) and UL105 (helicase) elicits strong CD8 T-cell responses and is protective against systemic challenge.Q35914513
Cellular immunotherapy for viral infection after HSC transplantationQ35998792
In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infectionQ36352435
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjectsQ36402863
Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramersQ36403280
Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cellsQ36403419
Dominant-negative FADD rescues the in vivo fitness of a cytomegalovirus lacking an antiapoptotic viral geneQ36483846
Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape.Q36619640
Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytesQ36793382
Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirusQ36857050
Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungsQ36903040
CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunityQ36919192
Murine model of cytomegalovirus latency and reactivation.Q37220009
Multiple epitopes in the murine cytomegalovirus early gene product M84 are efficiently presented in infected primary macrophages and contribute to strong CD8+-T-lymphocyte responses and protection following DNA immunizationQ37567900
Target structures of the CD8(+)-T-cell response to human cytomegalovirus: the 72-kilodalton major immediate-early protein revisited.Q39595809
Role of murine cytomegalovirus US22 gene family members in replication in macrophagesQ39748997
Adoptive immunotherapy of murine cytomegalovirus adrenalitis in the immunocompromised host: CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors.Q40130010
Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infectionQ40130284
Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infectionQ40592122
Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines.Q40621588
Pathogenesis of cytomegalovirus pneumonia in immunocompromised hosts.Q41007762
Human cytomegalovirus-specific cytotoxic T cells. Relative frequency of stage-specific CTL recognizing the 72-kD immediate early protein and glycoprotein B expressed by recombinant vaccinia virusesQ42120952
Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissuesQ42753262
P433issue2
P921main subjectCytomegalovirusQ6946
immunotherapyQ1427096
cytomegaloviral diseaseQ2076966
murine modelQ122890741
P304page(s)125-134
P577publication date2008-03-15
P1433published inMedical Microbiology and ImmunologyQ15760239
P1476titleCD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model
P478volume197

Reverse relations

cites work (P2860)
Q42278604Adoptive transfer of cytomegalovirus-specific effector CD4+ T cells provides antiviral protection from murine CMV infection
Q84952536Antigen presentation under the influence of 'immune evasion' proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells
Q36397454Antiviral T cell response triggers cytomegalovirus hepatitis in mice
Q64450813CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model
Q64123448Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells
Q33813837Comparison of multiple DNA vaccines for protection against cytomegalovirus infection in BALB/c mice
Q57278728Control of primary mouse cytomegalovirus infection in lung nodular inflammatory foci by cooperation of interferon-gamma expressing CD4 and CD8 T cells
Q38703382Cytomegalovirus and immunotherapy: opportunistic pathogen, novel target for cancer and a promising vaccine vector.
Q37559627Cytomegalovirus and varicella-zoster virus vaccines in hematopoietic stem cell transplantation
Q94564147Cytomegalovirus-Associated Inhibition of Hematopoiesis Is Preventable by Cytoimmunotherapy With Antiviral CD8 T Cells
Q47556818Editorship for Medical Microbiology and Immunology: the baton has been passed on.
Q37651700Enforced OX40 Stimulation Empowers Booster Vaccines to Induce Effective CD4+ and CD8+ T Cell Responses against Mouse Cytomegalovirus Infection
Q35693349Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice
Q55002157HCMV triggers frequent and persistent UL40-specific unconventional HLA-E-restricted CD8 T-cell responses with potential autologous and allogeneic peptide recognition.
Q35585875Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities.
Q84971601Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells
Q37356040Immune evasion proteins enhance cytomegalovirus latency in the lungs.
Q33614398Immune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes
Q37773240Immune-based therapies for cytomegalovirus infection
Q37798997In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.
Q34556966Is human cell therapy research caught in a mousetrap?
Q38342824Mast cells: innate attractors recruiting protective CD8 T cells to sites of cytomegalovirus infection.
Q58801058Maternal Immunity and the Natural History of Congenital Human Cytomegalovirus Infection
Q36384572Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios.
Q60913862Mouse Model of Cytomegalovirus Disease and Immunotherapy in the Immunocompromised Host: Predictions for Medical Translation that Survived the "Test of Time"
Q38041963Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions
Q26740328Mutual Interference between Cytomegalovirus and Reconstitution of Protective Immunity after Hematopoietic Cell Transplantation
Q37611838Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.
Q44245356Nucleocytoplasmic shuttling and CRM1-dependent MHC class I peptide presentation of human cytomegalovirus pp65.
Q37387045Oncomodulation by human cytomegalovirus: evidence becomes stronger.
Q34145201Oncomodulation by human cytomegalovirus: novel clinical findings open new roads
Q38042835Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.
Q38381730Principles for studying in vivo attenuation of virus mutants: defining the role of the cytomegalovirus gH/gL/gO complex as a paradigm.
Q34360228Recombinant mouse cytomegalovirus expressing a ligand for the NKG2D receptor is attenuated and has improved vaccine properties.
Q36999665Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.
Q38931391Refining human T-cell immunotherapy of cytomegalovirus disease: a mouse model with 'humanized' antigen presentation as a new preclinical study tool
Q34495529Reverse genetics modification of cytomegalovirus antigenicity and immunogenicity by CD8 T-cell epitope deletion and insertion
Q35382729Reversible inhibition of murine cytomegalovirus replication by gamma interferon (IFN-γ) in primary macrophages involves a primed type I IFN-signaling subnetwork for full establishment of an immediate-early antiviral state
Q36673260Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination
Q33806000Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease.
Q33845720Systemic hematogenous maintenance of memory inflation by MCMV infection.
Q38815977T cell responses to cytomegalovirus
Q40211958TLR3-independent activation of mast cells by cytomegalovirus contributes to control of pulmonary infection.
Q41887918The efficacy of antigen processing is critical for protection against cytomegalovirus disease in the presence of viral immune evasion proteins.
Q36974716The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance priming of CD8 T cells by preventing negative feedback regulation.
Q36934001Transactivation of cellular genes involved in nucleotide metabolism by the regulatory IE1 protein of murine cytomegalovirus is not critical for viral replicative fitness in quiescent cells and host tissues
Q37632938γδ T Cell-Mediated Immunity to Cytomegalovirus Infection.

Search more.