The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

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The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions is …
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scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2009.11.028
P932PMC publication ID2796127
P698PubMed publication ID20005845
P5875ResearchGate publication ID40683659

P2093author name stringJun Qin
Chuanyue Wu
Sudhiranjan Gupta
Ka Chen
Koichi Fukuda
P2860cites workStructural basis for activation of the titin kinase domain during myofibrillogenesisQ22004264
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreadingQ24291182
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2Q24291461
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADQ24305094
Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinaseQ24312707
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinaseQ24314398
CASK Functions as a Mg2+-independent neurexin kinaseQ24323323
The protein kinase complement of the human genomeQ24324497
The structural basis of integrin-linked kinase-PINCH interactionsQ24324678
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interactionQ24679147
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
The Structure of  -Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion AssemblyQ27650706
Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein KinaseQ27651185
Structural Analysis of the Interactions Between Paxillin LD Motifs and α-ParvinQ27652592
Structure of the Pseudokinase VRK3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding SiteQ27653415
ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activityQ27653416
Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitorsQ27653491
ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour SuppressorQ27655851
The atomic structure of protein-protein recognition sitesQ27861113
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343Q28213632
Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repairQ28295270
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulationQ28585627
Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulationQ28610904
Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKAQ28910196
Regulation of protein kinases; controlling activity through activation segment conformationQ29620471
Ca2+-independent smooth muscle contraction. a novel function for integrin-linked kinaseQ30661698
Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN.Q33762935
Emerging roles of pseudokinasesQ34552850
The PINCH-ILK-parvin complexes: assembly, functions and regulation.Q35832718
Integrin-linked kinase: a cancer therapeutic target unique among its ILK.Q35998768
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membraneQ36379951
ILK, PINCH and parvin: the tIPP of integrin signallingQ36403372
A helix scaffold for the assembly of active protein kinasesQ36871421
Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migrationQ37216047
Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulusQ41869916
cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransferQ42844060
C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexesQ43996515
Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1.Q44101117
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertensionQ44970101
How does the cAMP-dependent protein kinase catalyze the phosphorylation reaction: an ab initio QM/MM studyQ45247730
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitorQ46127942
Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival.Q52564100
Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling.Q52572083
Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKRQ57236274
A modular polycistronic expression system for overexpressing protein complexes in Escherichia coliQ73404849
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)819-30
P577publication date2009-12-11
P1433published inMolecular CellQ3319468
P1476titleThe Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions
P478volume36

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cites work (P2860)
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