ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling

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ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CEB.2012.06.003
P932PMC publication ID3467332
P698PubMed publication ID22763012

P2093author name stringJun Qin
Chuanyue Wu
P2860cites workParvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamilyQ24290812
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreadingQ24291182
Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motilityQ24295189
PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expressionQ24296236
Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinaseQ24312707
EphA1 interacts with integrin-linked kinase and regulates cell morphology and motilityQ24312896
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinaseQ24314398
Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationQ24314737
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sitesQ24318346
The protein kinase complement of the human genomeQ24324497
The structural basis of integrin-linked kinase-PINCH interactionsQ24324678
Integrin-linked kinase--essential roles in physiology and cancer biology.Q37272385
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tailsQ37360853
Pseudokinases-remnants of evolution or key allosteric regulators?Q37809200
How integrins control mammary epithelial differentiation: a possible role for the ILK-PINCH-Parvin complexQ37875475
Integrin-linked kinase: not so 'pseudo' after all.Q37878251
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cellsQ39656305
Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failureQ41866389
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolaeQ42066604
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturationQ42164315
C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivoQ42442207
C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexesQ43996515
Analysis of PINCH function inDrosophilademonstrates its requirement in integrin-dependent cellular processesQ44433257
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertensionQ44970101
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
UNC-97/PINCH is involved in the assembly of integrin cell adhesion complexes in Caenorhabditis elegans body wall muscleQ47068850
Functional analysis of parvin and different modes of IPP-complex assembly at integrin sites during Drosophila development.Q47072405
Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor.Q54527822
The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cellsQ24554520
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organizationQ24655829
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interactionQ24679147
The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal AdhesionsQ27646573
The Structure of  -Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion AssemblyQ27650706
Structural Analysis of the Interactions Between Paxillin LD Motifs and α-ParvinQ27652592
PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and SurvivalQ28208706
Integrin-linked kinase is an adaptor with essential functions during mouse developmentQ28261429
Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinaseQ28297327
Integrin signalling adaptors: not only figurants in the cancer storyQ28299126
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulationQ28585627
Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethalityQ28586464
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stageQ28586746
PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytesQ28586847
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signallingQ28588987
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylationQ28749480
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!Q33668166
Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathyQ33916456
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alphaQ33968025
Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.Q34039002
Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survivalQ34337340
Emerging roles of pseudokinasesQ34552850
A central multifunctional role of integrin-linked kinase at muscle attachment sites.Q34727923
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase.Q35065294
The PINCH-ILK-parvin complexes: assembly, functions and regulation.Q35832718
Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexesQ35941444
LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.Q35987858
The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.Q36082636
Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscleQ36095693
PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesionsQ36220227
CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/AktQ36323145
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membraneQ36379951
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegalyQ37002952
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)607-13
P577publication date2012-10-01
P1433published inCurrent Opinion in Cell BiologyQ13505682
P1476titleILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling
P478volume24

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cites work (P2860)
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